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| 1 | First light of the 1.8-m solar telescope–CLST显示文摘Large-aperture solar telescopes play an important role in solar observations and research,and require high temporal and spatial resolution[1].To solve some fundamental problems such as the solar dynamo,coronal heating,and the triggering of major solar eruptions,the spatial resolution for solar-atmosphere observation should reach at least 0.1 arcsec[2]. | ChangHui Rao NaiTing Gu XueJun Rao Cheng Li LanQiang Zhang JinLong Huang Lin Kong Ming Zhang YunTao Cheng Yi Pu Hua Bao YouMing Guo YangYi Liu JinSheng Yang LiBo Zhong ChangJun Wang Kai Fang XiaoJun Zhang DongHong Chen Cheng Wang XinLong Fan ZhiWu Yan KeLe Chen XiYa Wei Lei Zhu Hong Liu YongJian Wan Hao Xian WenLi Ma | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 6 |
| 2 | Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo显示文摘肺癌症是在整个世界的癌症相关的死亡的领先的原因。在最近的年里,肺的腺癌在频率超过了有鳞的房间癌并且是在许多国家的肺癌症的占优势的形式。流行病学的调查显示出在消费和死亡从许多癌症评估的大蒜(瞀或蒜之类 sativum ) 之间的一种反的关系。Diallyl trisulfide (DATS ) 是导出大蒜的混合物之一(是也知道:organosulfer 混合物,振荡) 。DATS 能导致 apoptosis 并且禁止许多癌症细胞线的生长。我们的学习证明 DATS 导致的 apoptotic 事件是通过导致了 Bax/Bcl-2 和 caspase-3, -8, 和 -9 的活动的比率的起来规定的 anti-apoptotic Bcl-2 的重要减少的线粒体依赖者 caspase 串联。最后, DATS 导致了 apoptosis 并且在一个集中依赖者和时间依赖者举止禁止了增长。由与 A549 异种皮移植建立女 BALB/c 裸体老鼠的一个动物模特儿,没有与控制组相比引起重量损失或任何另外的副作用,而且,我们在裸体老鼠发现 DATS 的那口头的 gavage A549 异种皮移植的显著地延迟的生长。在 vitro 并且在 vivo 的所有证据建议 DATS 能是理想的反癌症药。 | Wenjun Li Hui Tian Lin Li Shuhai Li Weiming Yue Zhitao Chen Lei Qi Wensi Hu Yingchao Zhu Bin Hao Cun Gao Libo Si Fei Gao | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 6 |
| 3 | 3D bioprinting of a biomimetic meniscal scaffold for application in tissue engineering显示文摘Appropriate biomimetic scaffolds created via 3D bioprinting are promising methods for treating damaged menisci.However,given the unique anatomical structure and complex stress environment of the meniscus,many studies have adopted various techniques to take full advantage of different materials,such as the printing combined with infusion,or electrospining,to chase the biomimetic meniscus,which makes the process complicated to some extent.Some researchers have tried to tackle the challenges only by 3D biopringting,while its alternative materials and models have been constrained.In this study,based on a multilayer biomimetic strategy,we optimized the preparation of meniscus-derived bioink,gelatin methacrylate(GelMA)/meniscal extracellular matrix(MECM),to take printability and cytocompatibility into account together.Subsequently,a customized 3D bioprinting system featuring a dual nozzle+multitemperature printing was used to integrate the advantages of polycaprolactone(PCL)and meniscal fibrocartilage chondrocytes(MFCs)-laden GelMA/MECM bioink to complete the biomimetic meniscal scaffold,which had the best biomimetic features in terms of morphology and components.Furthermore,cell viability,mechanics,biodegradation and tissue formation in vivo were performed to ensure that the scaffold had sufficient feasibility and functionality,thereby providing a reliable basis for its application in tissue engineering. | Zhou Jian Tian Zhuang Tian Qinyu Peng Liqing Li Kun Luo Xujiang Wang Diaodiao Yang Zhen Jiang Shuangpeng Sui Xiang Huang Jingxiang Liu Shuyun Hao Libo Tang Peifu Yao Qi Guo Quanyi | 2021 | Bioactive Materials2021，6，6： | 3 |
| 4 | In situ atomic-scale observation of dislocation behaviors in twin-structured Pt nanocrystals显示文摘The deformation mechanisms of twin-structured metallic materials have attracted great interest.Though previous theoretical predictions have suggested that the repulsive force of the twin boundary(TB)can significantly affect the deformation of twinstructured metals,it remains unclear whether this prediction applies to experimental conditions.In this paper,the atomic-scaled deformation process of twin-structured Pt nanocrystals was in situ observed using our home-made device in a high-resolution transmission electron microscope.We have shown that the plastic deformation of the twin-structured Pt nanocrystals was governed by full dislocation generation as well as Lomer dislocation(LD)lock formation and destruction.After LD locks were destructed,these full dislocations tended to move towards the surface of the nanocrystals.The findings revealed that due to the ultra-high repulsive force of TB on dislocation,there was no dislocation-TB reaction during the deformation.These findings can enrich our understanding of the dislocation behaviors of twin-structured nanocrystals. | GUO YiZhong SUN Tao FU LiBo HAO LongHu HUANG Ming WEI RuJian LUO JunFeng HE Xin WANG XingQuan XIONG XiaoDong WANG LiHua HAN XiaoDong | 2021 | Science China(Technological Sciences)2021，64，3： | 2 |
| 5 | Function identifica- tion of bovine Nrampl promoter and intron 1 显示文摘 | Hao Linlin Zhang Libo Li Mingtang el al | 2011 | Animal Cells and Systenrs2011，9，： | 1 |
| 6 | Early Cretaceous A-type Granites in the Dandong Area,NE China and its Geodynamical Implications显示文摘A-type granites,as an important petrologic sign to build up environmental recognition,were mainly formed in extensional tectonic settings.A biotite syenogranite from the Fenghuangshan pluton in Dandong,Liaoning Province gave SHRIMP zircon U-Pb ages of 122.5±1.6 Ma,124.9±1.7 Ma and 126.9±1.1 Ma.The monzogranites have SHRIMP zircon U-Pb ages of 118.2±1.6 Ma,128.1±1.7 Ma and 131.6±1.9 Ma,giving an emplacement age for the pluton in the Early Cretaceous.SiO_(2) is 65.48-74.49 wt%,whereas that of K_(2)O is 4.16-6.44 wt%,and that of Na_(2)O is 2.99-4.70 wt%.They also contain 13.24-15.76 wt% of Al_(2)O_(3),with an A/CNK ratio of 0.92-1.10,averaging 1.02.The alkalinity rate(AR)ranges from 2.68 to 5.12,and this range is within the AR of peraluminous type rocks.The granites of Fenghuangshan pluton are characterized by high contents of Na and K and low contents of Ca(thermophile element)and Mg,which are features of A-type granites.The(Na_(2)O+K_(2)O)-Fe_(2)O_(3)^(*)×5-(CaO+MgO)×5 discrimination diagram also shows that Fenghuangshan pluton is an A2-type granite.The above granite has zircon ε_(Hf)(t)values ranging from-17.06 to-9.09,with single-stage Hf model ages(T_(DM))of 1141 Ma to 1498 Ma and two-stage Hf crustal model ages(T_(DM)^(C))of 1762 Ma to 2263Ma.A comprehensive analysis suggests that the Fenghuangshan pluton might have been formed from the lithospheric-plate sliding during the late stages of evolution of hot rift structures and might have been closely associated with the tectonic settings of Mesozoic Eurasia and the ancient Pacific Plate. | SONG Yunhong HAO Libo YANG Fengchao ZHAO Dongfang ZHANG Zhehuan | 2021 | Acta Geologica Sinica(English Edition)2021，95，5： | 1 |
| 7 | 3D-printed cell-free PCL-MECM scaffold with biomimetic micro-structure and micro-environment to enhance in situ meniscus regeneration显示文摘Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells,meniscus regeneration remains a great challenge in clinic.In this study,we found decellularized meniscal extracellular matrix(MECM)preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem cells.Moreover,MECM significantly promoted meniscal fibrochondrocytes viability and proliferation,increased the expression of type II collagen and proteoglycans in vitro.Meanwhile,we designed 3D-printed polycaprolactone(PCL)scaffolds which mimic the circumferential and radial collagen orientation in native meniscus.Taken these two advantages together,a micro-structure and micro-environment dually biomimetic cell-free scaffold was manipulated.This cell-free PCL-MECM scaffold displayed superior biocompatibility and yielded favorable biomechanical capacities closely to native meniscus.Strikingly,neo-menisci were regenerated within PCL-MECM scaffolds which were transplanted into knee joints underwent medial meniscectomy in rabbits and sheep models.Histological staining confirmed neo-menisci showed meniscus-like heterogeneous staining.Mankin scores showed PCL-MECM scaffold could protect articular cartilage well,and knee X-ray examination revealed same results.Knee magnetic resonance imaging(MRI)scanning also showed some neo-menisci in PCL-MECM scaffold group.In conclusion,PCL-MECM scaffold appears to optimize meniscus regeneration.This could represent a promising approach worthy of further investigation in preclinical applications. | Weimin Guo Mingxue Chen Zhenyong Wang Yue Tian Jinxuan Zheng Shuang Gao Yangyang Li Yufeng Zheng Xu Li Jingxiang Huang Wei Niu Shuangpeng Jiang Chunxiang Hao Zhiguo Yuan Yu Zhang Mingjie Wang Zehao Wang Jiang Peng Aiyuan Wang Yu Wang Xiang Sui Wenjing Xu Libo Hao Xifu Zheng Shuyun Liu Quanyi Guo | 2021 | Bioactive Materials2021，6，10： | 1 |
| 8 | Controlling Ebola: what we can learn from China’s 1911 battle against the pneumonic plague in Manchuria显示文摘 | He Liu Mingli Jiao Siqi Zhao Kai Xing Ye Li Ning Ning Libo Liang Qunhong Wu Yanhua Hao | 2015 | International Journal of Infectious Diseases2015，，： | 1 |
| 9 | Function identification of bovine Nramp1 promoter and intron 1显示文摘 | Linlin Hao Libo Zhang Mingtang Li Nan Wang Songcai Liu Jifeng Zhong | 2011 | Animal Cells and Systems2011，，3： | 1 |
| 10 | Microwave-absorbing characteristics of mixtures of different carbonaceous reducing agents and oxidized ilmenite显示文摘 | Shenghui Guo Wei Li Jinhui Peng Hao Niu Mengyang Huang Libo Zhang Shiming Zhang Ming Huang | 2009 | International Journal of Mineral Processing2009，，3： | 1 |
| 11 | Focal Mechanism Solution of the 2011 M_S4.8 Anqing Earthquake Determined from the CAP Method显示文摘In this article, we have inverted local broadband waveform data to determine the focal mechanism of the 2011 MS4.8 Anqing earthquake. Our results show that the best double couple solution of the MS4.8 event is 16°, 74° and 120° for strike, dip and rake angles of one nodal plane respectively, and 131°, 33°, 30° for the other nodal plane. The estimated focal depth is about 3km. Both strikes of the two nodal planes differ significantly to the strike of Susong-Zongyang fault, along which seismic activity has been at a low level since the Late Quaternary. This implies that this earthquake may not have occurred on the Susong-Zongyang fault, and we infer that a buried fault with strike of NNE may be the seismogenic structure of this event. | Hong Dequan Wang Xingzhou Han Libo Qi Hao Zhang Bing | 2012 | Earthquake Research in China2012，26，2： | 0 |
| 12 | An ultrasensitive and stretchable strain sensor based on a microcrack structure for motion monitoring显示文摘Flexible strain sensors are promising candidates for intelligent wearable devices.Among previous studies,although crack-based sensors have attracted a lot of attention due to their ultrahigh sensitivity,large strain usually causes fractures in the conductive paths.Because of the unstable crack structure,the tradeoff between sensitivity and workable strain range is still a challenge.As carbon nanotubes(CNTs)and silver nanowires(AgNWs)can form a strong interface with the thermoplastic substrate and strengthen the conductive network by capillary force during water evaporation,CNTs and AgNWs were deposited on electrospun TPU fiber mats via vacuum-assisted filtration in this work.The prestretching treatment constructed a microcrack structure that endowed the sensor with the combined characteristics of a wide working range(0~171%strain),ultrahigh sensitivity(a gauge factor of 691 within 0~102%strain,~2×10^(4) within 102~135%strain,and>11×10^(4) within 135~171%strain),a fast response time(~65 ms),small hysteresis,and superior durability(>2000 cycles).Subsequently,the sensing mechanism of the sensor was studied.Distributed microcrack propagation based on the“island-bridge”structure was explained in detail,and its influence on the strain-sensing behavior of the sensor was analyzed.Finally,the sensor was assembled to monitor various vibration signals and human motions,demonstrating its potential applications in the fields of electronic skin and human health monitoring. | Hao Sun Xudong Fang Ziyan Fang Libo Zhao Bian Tian Prateek Verma Ryutaro Maeda Zhuangde Jiang | 2022 | Microsystems & Nanoengineering2022，8，5： | 0 |
| 13 | Geochemical evaluation of phaeozem quality in Northeast China: A case of Dehui County, Jilin Province显示文摘 | Jilong LU Zhiheng PAN Xinmin YU Libo HAO Rongjie BAI Yuyan ZHAO | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 14 | Effects of High Pressure on the Surface Plasmon Resonance of Copper and Silver Nanocrystals显示文摘We used a diamond anvil cell(DAC)to control the deformation of synthesized copper nanorods and silver nanoparticles.And we measured the surface plasmon resonance of copper nanorods and silver nanoparticles,which exhibit redshifts or blueshifts.The surface plasmon resonance shows an abnormal blue shift for both copper nanorods and silver nanoparticles.The solvents of copper nanorods and silver nanoparticles are n-hexane and water,where the pressure loads include quasi-hydrostatic and non-hydrostatic. | LUO Zha LIU Hao SHEN Wei SHI Kun CHEN Ankang SHENG Libo SUI Yongming ZOU Bo | 2022 | Chemical Research in Chinese Universities2022，38，3： | 0 |
| 15 | Contribution of the Chinese Meridian Project to space environment research:Highlights and perspectives显示文摘The Chinese Meridian Project(CMP)is devoted to establishing a comprehensive ground-based monitoring network for China’s space weather research.CMP is a major national science and technology infrastructure project with the participation of more than 10 research institutions and universities led by the National Space Science Center of the Chinese Academy of Sciences.CMP is planned to be constructed in two phases:CMP phasesⅠandⅡ.The first phase(CMP-Ⅰ)started construction in2008 and completed in 2012,after which it entered the operation stage.The 10-year observation of CMP-Ⅰhas made significant scientific discoveries and achievements in the research fields of the middle and upper atmospheric fluctuations,metal layers in the mesosphere and lower thermosphere,ionospheric disturbances and irregularities,geomagnetic disturbances,and influences of solar activity.The review summarizes the main observations and research achievements,space weather forecast modeling and methods based on CMP-Ⅰover the past 10 years,and presents a future extension perspective along with the construction of CMP-Ⅱ. | Chi WANG Jiyao XU Libo LIU Xianghui XUE Qinghe ZHANG Yongqiang HAO Gang CHEN Hui LI Guozhu LI Bingxian LUO Yajun ZHU Jiangyan WANG | 2023 | Science China Earth Sciences2023，66，7： | 0 |
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