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| 1 | Current therapeutic strategies for advanced pancreatic cancer: A review for clinicians显示文摘Pancreatic cancer(PC) would become the second leading cause of cancer death in the near future, despite representing only 3% of new cancer diagnosis. Survival improvement will come from a better knowledge of risk factors, earlier diagnosis, better integration of locoregional and systemic therapies, as well as the development of more efficacious drugs rising from a deeper understanding of disease biology. For patients with unresectable, non-metastatic disease, combined strategies encompassing primary chemotherapy and radiation seems to be promising. In fit patients, new polychemotherapy regimens can lead to better outcomes in terms of slight but significant survival improvement associated with a positive impact on quality of life. The upfront use of these regimes can also increase the rate of radical resections in borderline resectable and locally advanced PC. Second line treatments showed to positively affect both overall survival and quality of life in fit patients affected by metastatic disease. At present, oxaliplatin-based regimens are the most extensively studied. Nonetheless, other promising drugs are currently under evaluation. Presently, in addition to surgery and conventional radiation therapy, new locoregional treatment techniques are emerging as alternative options in the multimodal approach to patients or diseases not suitable for radical surgery. As of today, in contrast with other types of cancer, targeted therapies failed to show relevant activity either alone or in combination with chemotherapy and, thus, current clinical practice does not include them. Up to now, despite the fact of extremely promising results in different tumors, also immunotherapy is not in the actual therapeutic armamentarium for PC. In the present paper, we provide a comprehensive review of the current state of the art of clinical practice and research in PC aiming to offer a guide for clinicians on the most relevant topics in the management of this disease. | Rosella Spadi Federica Brusa Agostino Ponzetti Isabella Chiappino Nadia Birocco Libero Ciuffreda Maria Antonietta Satolli | 2016 | World Journal of Clinical Oncology2016，7，1： | 15 |
| 2 | Active suspension in railway vehicles:a literature survey显示文摘Since the concept of active suspensions appeared,its large possible benefits has attracted continuous exploration in the field of railway engineering.With new demands of higher speed,better ride comfort and lower maintenance cost for railway vehicles,active suspensions are very promising technologies.Being the starting point of commercial application of active suspensions in rail vehicles,tilting trains have become a great success in some countries.With increased technical maturity of sensors and actuators,active suspension has unprecedented development opportunities.In this work,the basic concepts are summarized with new theories and solutions that have appeared over the last decade.Experimental studies and the implementation status of different active suspension technologies are described as well.Firstly,tilting trains are briefly described.Thereafter,an indepth study for active secondary and primary suspensions is performed.For both topics,after an introductory section an explanation of possible solutions existing in the literature is given.The implementation status is reported.Active secondary suspensions are categorized into active and semi-active suspensions.Primary suspensions are instead divided between acting on solid-axle wheelsets and independently rotating wheels.Lastly,a brief summary and outlook is presented in terms of benefits,research status and challenges.The potential for active suspensions in railway applications is outlined. | Bin Fu Rocco Libero Giossi Rickard Persson Sebastian Stichel Stefano Bruni Roger Goodall | 2020 | Railway Engineering Science2020，28，1： | 8 |
| 3 | Distributed simulation of modular time Petri nets: an approach and a case study exploiting temporal uncertainty显示文摘 | Franco C Angelo F Libero N | 2007 | Real-time System2007，35，1： | 1 |
| 4 | Idiopathic ventricular tachy-cardia with onset in the verapamil-sensitive left ventricle:theclinical characteristics and long-term follow-up of 37 pa-tients显示文摘 | Gaita F Giustetto C Libero L | 1995 | Ital Cardiol1995，25，6： | 1 |
| 5 | Prevention of flare recurrences in childhood-refrac- tory chronic uveit is:an open-label comparative study of adali- mumab versus infliximab 显示文摘 | Simonini G Taddio A Cattalini M Caputo R De Libero C Nav- iglio S | 2011 | Arthritis CareRes ( Hoboken )2011，63，4： | 1 |
| 6 | Adsorptionand partitioning of surfactants in liquid-liquid systems显示文摘 | Michele Ferrari Libero Liggieri | 2000 | Advances in Colloid and Interface Science2000，88，： | 1 |
| 7 | Factors influencingseverity and recovery from anisometropic amblyopia显示文摘 | Caputo R Frosini R De Libero C | 2007 | Strabis mus2007，15，4： | 1 |
| 8 | Cat scratch disease presenting as breast cancer:a report of an unusual case显示文摘 | Iannace C Lo Conte D Di Libero L | 2013 | Case Rep Oncol Med2013，，50： | 1 |
| 9 | Development of virtual data acquisition systems based on multimedia intemetworking显示文摘 | Giancarlo Fortino Libero Nigro | 1999 | Computer Standard & Interfaces1999，，21： | 1 |
| 10 | Cellular Signaling Pathway Alterations and Potential Targeted Therapies for Medullary Thyroid Carcinoma显示文摘 | Serena Giunti Alessandro Antonelli Andrea Amorosi Libero Santarpia Eleonore Fr?hlich | 2013 | International Journal of Endocrinology2013，，： | 1 |
| 11 | Stability of emotion experiences and their relations to traits of personality显示文摘 | Izard CE Libero DZ Putnam P | | 0，，： | 1 |
| 12 | MW-assisted synthesis of LiFePO4 for high power applications显示文摘 | Sabina B Libero D Marina M | 2008 | Journal of Power Sources2008，180，2： | 1 |
| 13 | The role of innate immunity in autoimmunity显示文摘 | Bach JF Bendelac A Brenner MB Cantor H De Libero G Kronenberg M | | 0，，： | 1 |
| 14 | Strengths of early physical reha-bilitation programs in surgical breast cancer patients : results of arandomized controlled study 显示文摘 | Testa A Iannace C Di Libero L | 2014 | Eur J Phys Rehabil Med2014，50，3： | 1 |
| 15 | Recognition of lipid antigens by T cells显示文摘 | De Libero G Mori L | 2005 | Nature Rev Immunol2005，5，6： | 1 |
| 16 | Development of Virtual Data Acquisition Systems Based on Multimedia Internetworking 显示文摘 | Fortino Giancarlo Nigro Libero | 1999 | Computer Standards & Interfaces1999，21，5： | 1 |
| 17 | Stability of Emotion Experiences and Their Relations to Traits of Per- sonality 显示文摘 | IZARD C E LIBERO D Z PUTNAM P | 1993 | Journal of Personality and Social Psychology1993，64，： | 1 |
| 18 | Surface-based morphometry of the cortical architecture of autism spectrum dis- orders: volume, thickness, area, and gyrification显示文摘 | Libero LE DeRamus TP Deshpande HD | 2014 | Neuropsycholo- gia2014，62，9： | 1 |
| 19 | Factors influem'ing- severity and recovery from anisometropic amblyopia 显示文摘 | Caputo R Frosini R De Libero C | 2007 | Strabis- mus2007，15，4： | 1 |
| 20 | Identifica- tion of neural connectivity signatures of autism using ma- chine learning显示文摘 | Deshpande G Libero LE Sreenivasan KR | 2013 | Front Hum Neurosei2013，7，： | 1 |
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