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| 1 | Inhibitory effect of recombinant adenovirus carrying melittin gene on hepatocellular carcinoma显示文摘 | Ling CQ Li B Zhang C Zhu DZ Huang XQ Gu W Li SX | 2005 | 第二军医大学学报2005，26，10： | 30 |
| 2 | Nitric oxide synthase distribution in esophageal mucosa and hemodynamic changes in rats with cirrhosis显示文摘AIM To observe the nitric oxide synthase (NOS) distribution in the esophageal mucosa andhemodynamic changes in cirrhotic rats.METHODS NOS distribution in the loweresophagus of rats with carbon tetrachlorideinduced cirrhosis was assessed by using NADPHdiaphorase (NADPH-d ) histochemical method.Concentration of NO in serum were measured byfluorometric assay. Mean arterial pressure(MAP), cardiac output (CO), cardiac index (CI),splanchnic vascular resistance (SVR ), andsplanchnic blood flow (SBF ) were alsodetermined using 5’CO-labeled microspheretechnique.RESULTS Intensity of NOS staining in theesophageal epithelium of cirrhotic rats wassignificantly stronger than that in controls.There was a NOS--positive staining area in theendothelia of esophageal submucosal vessels ofcirrhotic rats, but the NOS staining was negativein normal rats. NO concentration of serum incirrhotic rats were significantly higher incomparison with that of controls. Cirrhotic ratshad significantly lower MAP, SVR and higherSBF than those of the controls.CONCLUSION SPlanchnic hyperdynamiccirculatory state was observed in rats withcirrhosis. The endogenous NO may play animportant role in development of esophagealvarices and in changes of hemodynamics incirrhosis. | Huang YQ Xiao SD Zhang DZ Mo JZ | 1999 | World Journal of Gastroenterology1999，5，3： | 22 |
| 3 | Effects and mechanisms of acupuncture and electroacupuncture for functional dyspepsia:A systematic review显示文摘BACKGROUND Functional dyspepsia(FD)is a common digestive disease with limited therapeutic options.According to evidence-based clinical practice,acupuncture or electroacupuncture(EA)seems to be a promising therapy for patients with FD.However,there is still a lack of systematic reviews that have analyzed current clinical trials for a better understanding of mechanisms involved in the ameliorating effect of acupuncture and EA on FD.AIM To evaluate the results and qualities of existing clinical evidence for researching the underlying mechanisms of acupuncture/EA in treating FD.METHODS A systematic search of the literature was performed to identify randomized controlled trials in which research on the mechanism of acupuncture or EA was conducted in FD patients.Databases searched included PubMed,EMBASE,Cochrane Library,and Web of Science.Data extraction and quality assessment were completed by two investigators independently and the results of quality evaluation were exported through Review Manager V5.3.RESULTS Eight studies were included in this review with a total of 17 items for detecting techniques for mechanistic research.Positive effects of acupuncture and EA were observed in regulating gastric motility,gastric accommodation,mental status,gastrointestinal hormones,and central and autonomic functions while improving dyspeptic symptoms and quality of life.CONCLUSION The key findings of this systematic review support the potential of acupuncture and EA in altering the heterogeneous pathophysiology in patients with FD.However,high-quality studies with well-planned designs are necessary to provide more credible evidence. | Yu Guo Wei Wei Jiande DZ Chen | 2020 | World Journal of Gastroenterology2020，26，19： | 17 |
| 4 | 自适应性生物反馈训练对出口梗阻型便秘患者临床疗效、心理状况和生命质量的影响显示文摘目的探讨自适应性生物反馈训练(ABF)对出口梗阻型便秘(OOC)患者临床症状疗效、心理状况和生命质量的改善程度。方法纳入2011年6月至2014年10月就诊的OCC患者206例,分成ABF组和固定式生物反馈训练(FBF)组。观察治疗前和治疗后8周患者便秘临床症状、临床疗效、心理状态和生命质量情况。统计学分析采用卡方检验或t检验。结果共有138例完成了生物反馈治疗,其中ABF组76例,FBF组62例。ABF组和FBF组治疗前便秘临床症状总积分分别为10.95±2.86和¨.20±2.23,治疗后分别为2.02±1.10和2.98±I.19,两组治疗后症状总积分均下降(t=2.60、2.45,P均〈0.05);ABF组治疗前后的总积分差值为8.93±0.37,高于FBF组的8.24±0.29,差异有统计学意义(t=2.53,P〈0.05)。ABF组总有效率为94.7%(72/76),高于FBF组的85.5%(53/62),差异有统计学意义(X^2=3.426,P〈0.05)。治疗后,ABF组焦虑自评量表(SAS)和抑郁自评量表(SDS)评分分别为37.7±9.1和41.4±7.4,低于治疗前的48.2±II.7和50.7±9.6,差异均有统计学意义(t=9.54、5.01,P均〈0.05);FBF组SAS和SDS评分分别为37.8士10.3和39.8±11.2,低于治疗前的49.1±9.9和53.i±9.6,差异均有统计学意义(t=8.95、5.67,P均〈0.05);治疗后两组SAS和SDS评分差异均无统计学意义(P均〉0.05)。ABF组和FBF组治疗后汉化版简明健康调查量表(SF-36)各维度积分均高于治疗前,差异均有统计学意义(P均〈0.05);两组治疗后SF-36各维度积分差异均无统计学意义(P均〉0.05)。结论ABF和FBF治疗均可有效改善OOC患者的临床症状和心理健康状况,并提高其生命质量,但ABF疗效更佳,更有优势。 | 李小平 史久煜 Jiande DZ Chen 徐月梅 史池红 | 2016 | 中华消化杂志2016，36，5： | 11 |
| 5 | Electrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia显示文摘AIM:To evaluate the effect of prokinetic drugs on electrogastrography(EGG) parameters according to symptomatic changes in patients with functional dyspepsia(FD).METHODS:Seventy-four patients with FD were prospectively enrolled in this study between December 2006 and December 2010.We surveyed the patients using a questionnaire on dyspeptic symptoms before and after an 8-wk course of prokinetic drug treatment.We also measured cutaneous pre-prandial and postprandial EGG recordings including percentage of gastric waves(normogastria,bradygastria,tachygastria),dominant frequency(DF),dominant power(DP),dominant frequency instability coefficient(DFIC),dominant power instability coefficient(DPIC),and the ratio of post-prandial to fasting in DP before and after the 8-wk course of prokinetic drug treatment.RESULTS:Fifty-two patients(70%) achieved symptomatic improvement after prokinetic drug treatment.Patients who had normal gastric slow waves showed symptom improvement group after treatment.Postprandial DF showed a downward trend in the symptom improvement group,especially in the itopride group.Post-prandial DP was increased regardless of symptom improvement,especially in the itopride group and mosapride group.Post-prandial DFIC and DPIC in the symptom improvement group were significantly increased after the treatment.The EGG power ratio was increased after treatment in the symptom improvement group(0.50 ± 0.70 vs 0.93 ± 1.77,P = 0.002),especially in the itopride and levosulpiride groups.CONCLUSION:Prokinetics could improve the symptoms of FD by regulating gastric myoelectrical activity,and EGG could be a useful tool in evaluating the effects of various prokinetics. | Hyun Chul Lim Sang In Lee Jiande DZ Chen Hyojin Park | 2012 | World Journal of Gastroenterology2012，18，41： | 11 |
| 6 | On the cell biology of pit cells,the liver-specific NK cells显示文摘INTRODUCTION Natural killer (NK) cells are functionally defined by their ability to kill certain tumor cells and virus-infected cells without prior | Luo DZ Vermijlen D Ahishali B Triantis V Plakoutsi G Braet F Vanderkerken K Wisse E | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 7 | 自适应性生物反馈训练对出口梗阻型便秘患者的远期疗效与家庭维持治疗的影响显示文摘目的探讨自适应性生物反馈训练(ABF)对出口梗阻型便秘(OOC)患者远期疗效与家庭维持治疗的影响。方法纳入2010年10月至2013年4月就诊的符合罗马Ⅲ标准的114例OOC患者,进行ABF治疗6周,而后分成家庭维持治疗组和单纯随访观察组,观察ABF治疗后的便秘症状总积分、每周聚乙二醇电解质散剂使用剂量、总有效率和总满意率。统计学分析采用t检验和卡方检验。结果共95例OOC患者被纳入随访研究,其中家庭维持治疗组42例,单纯随访观察组53例。6周ABF治疗后,两组患者便秘症状总积分和每周聚乙二醇电解质散剂使用剂量均较治疗前下降,其中家庭维持治疗组患者6周ABF治疗后36个月的便秘症状总积分、每周聚乙二醇电解质散剂使用剂量分别为(4.86±1.13)分和(5.88±1.14)包,低于治疗前的(11.05±3.26)分和(15.28±4.12)包,差异均有统计学意义(t=2.520,P=0.041;t=3.080,P=0.042);单纯随访观察组患者6周ABF治疗后36个月的便秘症状总积分、每周聚乙二醇电解质散剂使用剂量分别为(7.12±1.25)分和(11.44±2.88)包,与治疗前的(11.07±2.86)分和(15.77±3.78)包相比,差异均无统计学意义(P均〉0.05)。家庭维持治疗组患者6周ABF治疗后36个月的总有效率和总满意率均为71.4%(30/42),与治疗结束时的88.1%(37/42)和83.3%%(35/42)相比,差异均无统计学意义(P均〉0.05);单纯随访观察组6周ABF治疗后12个月的总有效率和总满意率分别为69.8%(37/53)和66.0%(35/53),与治疗结束时的88.7%(47/53)和84.9%(45/53)比较,差异均无统计学意义(P均〉0.05),24个月的总有效率和总满意率分别为49.1%(26/53)和47.2%(25/53),低于治疗结束时,差异均有统计学意义(χ2=1.762,P=0.036;χ2=1.928,P=0.041)。结论ABF治疗OOC患者的疗效维持不满2年;而家庭维持治疗疗效可达3年,故其可能是OOC患者维持远期疗效的有效方法。 | 李小平 Jiande DZ Chen 徐月梅 | 2017 | 中华消化杂志2017，37，7： | 6 |
| 8 | 自适应与固定式生物反馈治疗出口梗阻型便秘的疗效比较显示文摘目的比较自适应式生物反馈与固定式生物反馈治疗出口梗阻型便秘(OOC)的疗效。方法纳入OOC患者120例,按患者来院就诊次序分成两组,其中奇数序列患者编入自适应式生物反馈组,偶数序列患者编入固定式生物反馈组,每组各60例。因失访及中途退出32例,最终88例OOC患者进入研究,其中自适应式生物反馈组48例,固定式生物反馈组40例。完成8周的生物反馈治疗后,比较两组患者肛直肠功能(直肠肛门抑制反射阈、肛管静息压、模拟排便时直肠肛管压力梯度、矛盾性收缩和模拟排便时肛管松弛)、便秘临床症状积分、临床总有效率和总满意率。结果治疗前两组患者肛直肠功能和便秘临床症状积分比较差异均无统计学意义(均P>0.05);治疗后自适应式生物反馈组患者较固定式生物反馈组患者模拟排便时直肠肛管压力梯度增加,矛盾性收缩减少,便秘临床症状积分减少,临床总有效率和总满意率上升(均P<0.05)。治疗后同组患者直肠肛门抑制反射阈、矛盾性收缩和便秘临床症状积分较治疗前明显减少,模拟排便时直肠肛管压力梯度和肛管松弛较治疗前明显增加,差异均有统计学意义(均P<0.05)。结论自适应式生物反馈治疗OOC疗效优于固定式生物反馈。 | 邬怡怡 史久煜 李小平 Jiande DZ Chen | 2018 | 浙江医学2018，40，12： | 6 |
| 9 | Effect of two-channel gastric electrical stimulation with trains of pulses on gastric motility显示文摘AIM:To investigate the effect of two-channel gastric electrical stimulation(GES) with trains of pulses on gastric emptying and slow waves.METHODS:Seven dogs implanted with four pairs of electrodes and equipped with a duodenal cannula were involved in this study.Two experiments were performed.The f irst experiment included a series of sessions in the fasting state with trains of short or long pulses,each lasted 10 min.A 5-min recording without pacing was made between two sessions.The second experiment was performed in three sessions(control,single-channel GES,and two-channel GES) .The stimulus was applied via the 1st pair of electrodes for single-channel GES(GES via one pair of electrodes located at 14 cm above the pylorus) ,and simultaneously via the 1st and 3rd channels for two-channel GES(GES via two pairs of electrodes located at 6 and 14 cm above the pylorus) .Gastric liquid emptying was collected every 15 min via the cannula for 90 min.RESULTS:GES with trains of pulses at a pulse width of 4 ms or higher was able to entrain gastric slow waves.Two-channel GES was about 50% more efficient than single-channel GES in entraining gastric slow waves.Two-channel but not single-channel GES with trains of pulses was capable of accelerating gastric emptying in healthy dogs.Compared with the control session,two-channel GES signif icantly increased gastric emptying of liquids at 15 min(79.0% ± 6.4% vs 61.3% ± 6.1%,P < 0.01) ,30 min(83.2% ± 6.3 % vs 68.2% ± 6.9%,P < 0.01) ,60 min(86.9% ± 5.5 % vs 74.1% ± 5.9%,P < 0.01) ,and 90 min(91.0% ± 3.4% vs 76.5% ± 5.9%,P < 0.01) .CONCLUSION:Two-channel GES with trains of pulses accelerates gastric emptying in healthy dogs and may have a therapeutic potential for the treatment of gastric motility disorders. | Bin Yang Xiao-Hua Hou Geng-Qing Song Jin-Song Liu Jiande DZ Chen | 2009 | World Journal of Gastroenterology2009，15，19： | 4 |
| 10 | 生物反馈与药物治疗出口梗阻型便秘的临床疗效和心理状况比较显示文摘目的比较生物反馈与药物治疗出口梗阻型便秘(OOC)的临床疗效和心理状况。方法选取OOC患者随机分成生物反馈组和药物组,应用便秘临床症状积分量表、Zung焦虑自评量表(SAS)、抑郁自评量表(SDS)评定两组患者治疗前及治疗8周后的便秘临床症状积分、临床疗效、SAS、SDS的改善情况,并对两组患者治疗前后以上指标进行统计学比较。结果最终进入研究的OOC患者92例,其中生物反馈组48例,药物组44例。两组治疗前各临床症状积分比较差异均无统计学意义(均P> 0.05);治疗后,生物反馈组各临床症状积分及总临床症状积分明显低于药物治疗组(P<0.05)。生物反馈组总有效率及总满意度均高于药物治疗组(均P<0.05)。两组治疗前SDS、SAS评分差异均无统计学意义(均P> 0.05);两组治疗后SDS、SAS评分比较差异均有统计学意义(均P<0.05)。结论生物反馈治疗出口梗阻型便秘疗效明显优于药物治疗。 | 史久煜 邬怡怡 李小平 Jiande DZ Chen | 2018 | 现代实用医学2018，30，11： | 4 |
| 11 | 自适应式生物反馈与复方聚乙二醇电解质散剂治疗出口梗阻型便秘的疗效比较显示文摘目的比较自适应式生物反馈(ABF)与复方聚乙二醇电解质散剂治疗出口梗阻型便秘(OOC)的临床疗效。方法按患者来院就诊次序分成两组,其中奇数序列患者编入ABF组,偶数序列患者编入复方聚乙二醇电解质散剂组,在治疗4、8周后对两组患者的便秘临床症状总积分、临床总疗效及患者满意度自评进行比较。结果最终77例OOC患者完成研究,其中ABF组35例,复方聚乙二醇电解质散剂组42例。治疗前,两组便秘临床症状总积分差异无统计学意义(P>0.05)。治疗4周后,两组便秘临床症状总积分较均治疗前明显下降(均P<0.05),且两组间便秘临床症状总积分、临床总有效率及总满意率差异均无统计学意义(均P>0.05)。治疗8周后,ABF组较治疗4周后便秘临床症状总积分下降,临床总有效率及总满意度提高(均P<0.05);复方聚乙二醇电解质散剂组相应数据差异均无统计学意义(均P>0.05);ABF组便秘临床症状总积分较复方聚乙二醇电解质散剂组低(P<0.05),临床总有效率、总满意率高(均P<0.05)。结论 ABF治疗OOC疗效显著,优于复方聚乙二醇电解质散剂药物。 | 邬怡怡 史久煜 李小平 Jiande DZ Chen | 2018 | 现代实用医学2018，30，2： | 4 |
| 12 | QQuantitative Correlation between Group Connectivity Index and Property of Flotation Reagent显示文摘Topological method is applied firstly to calculate the group connectivity indexes of some flotation reagents for sulfide minerals and oxide minerals. The study reveals that some properties of flotation reagents, such as group electronegativity, energy criterion, solubility product of chemicals and maximum wavelength of ultraviolet absorbency, have linear correlation with the first order group connectivity index (GCI) of polar group, and the related coefficients are all larger than 0.900. The GCI can be used to characterize the structure of groups, and is a sort of new effective structural parameter to study the quantitative structure activity relationship of flotation reagents. | Cao, YC Jiang, YR Xue, YL Wang, DZ | 2000 | Journal of Central South University2000，12，1： | 2 |
| 13 | Prestin is the motor protein of cochlear outer hair cells显示文摘 | Zheng J Shen W He DZ | | 0，，： | 2 |
| 14 | A novel single tetracycline-regulative adenoviral vector for tumer-specific Bax gene expression and cell killing in vitro and in vivo显示文摘 | Jian G Li DZ | 2002 | Oncogene2002，21，： | 2 |
| 15 | Injection following deep brain stimulator implantation performed in the conventional versus magnetic resonance imaging-equipped operating room显示文摘 | Gorgulho A Juillard C Uslan DZ | 2009 | J Neurosurg2009，110，2： | 1 |
| 16 | Pathological laughter and crying in patients with multiple system atrophy-cerebellar type 显示文摘 | Parvizi J Joseph J Press DZ | 2007 | Mov Disord2007，22，6： | 1 |
| 17 | Antioxidant activity of Chinese mei ( Prunus mume) and its active phytoehemicals显示文摘 | Xia DZ Shi JY Gong JY | 2010 | Journal of Medic- inal Plants Research2010，4，12： | 1 |
| 18 | Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice显示文摘 | Zhu M Tang DZ Wu QQ | 2009 | JBMR2009，24，1： | 1 |
| 19 | Clinical significance of low cobalamin levels in older hospital patients显示文摘 | van Asselt DZ Blom H J Zuiderent R | 2000 | Neth J Med2000，57，： | 1 |
| 20 | Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China 显示文摘 | Liu Y Zhou DZ Zhang D | 2009 | Diabetologia2009，52，： | 1 |
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