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| 1 | Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA显示文摘光周期敏感、 thermo 敏感的遗传因子的男绝育(PGMS 和 TGMS ) 是为在庄稼的混合繁殖的核心部件。基于使用的较普通活字大一倍的系统, PGMS 和 TGMS 衬里的混合大米是成功地在农业广泛地发展了并且适用。然而,位于 PGMS 和 TGMS 的控制下面的分子的机制仍然保持阴暗。在这研究,我们印射并且克隆一个主要地点, p/tms12-1 (染色体 12 上的感光性或 thermo 敏感的遗传因子的男绝育地点) 它在装饰用的梨树米饭线 Nongken 58S (NK58S ) 授与 PGMS 和在 indica 米饭的 TGMS 衬里 Peiai 64S (PA64S,源于 NK58S ) 。包含野类型的等位基因 P/TMS12-1 的 A 2.4-kb DNA 碎片能在基因互补恢复 NK58S 和 PA64S 植物的花粉富饶。P/TMS12-1 编码唯一的 noncoding RNA,它生产 21 核苷酸我们说出 osa-smR5864w 的小 RNA。在 p/tms12-1 的 C-to-G 的替换,相对 P/TMS12-1 的唯一的多型性,在变异的小 RNA 是在场的,也就是 osa-smR5864m。而且,在转基因的 NK58S 和 PA64S 植物的 P/TMS12-1 的一个 375-bp 序列的 overexpression 也生产了 osa-smR5864w 并且恢复了花粉富饶。小 RNA 在年轻圆锥花序优先地被表示,但是它的表示没被不同的天长度或温度显著地影响。我们的结果表明在 p/tms12-1 的点变化,可能为 osa-smR5864m 导致 loss-of-function,分别地在装饰用的梨树和 indica 线为 PGMS 和 TGMS 组成一个普通原因。我们的调查结果因此建议那小 RNA 基因是的这 noncoding 男开发的一个重要管理者由在基因网络和环境条件之间的串音控制了。 | Hai Zhou Qinjian Liu Jing Li Dagang Jiang Lingyan Zhou Ping Wu Sen Lu Feng Li Liya Zhu Zhenlan Liu Letian Chen Yao-Guang Liu Chuxiong Zhuang | 2012 | Cell Research2012，22，4： | 99 |
| 2 | Adsorption of heavy metal ions from aqueous solution by carboxylated cellulose nanocrystals显示文摘A novel nanoadsorbent for the removal of heavy metal ions is reported.Cotton was first hydrolyzed to obtain cellulose nanocrystals(CNCs).CNCs were then chemically modified with succinic anhydride to obtain SCNCs.The sodic nanoadsorbent(NaSCNCs) was further prepared by treatment of SCNCs with saturated NaHCO 3 aqueous solution.Batch experiments were carried out with SCNCs and NaSCNCs for the removal of Pb 2+ and Cd 2+.The effects of contact time,pH,initial adsorption concentration,coexisting ions and the regeneration performance were investigated.Kinetic studies showed that the adsorption equilibrium time of Pb 2+ and Cd 2+ was reached within 150 min on SCNCs and 5 min on NaSCNCs.The adsorption capacities of Pb 2+ and Cd 2+ on SCNCs and NaSCNCs increased with increasing pH.The adsorption isotherm was well fitted by the Langmuir model.The maximum adsorption capacities of SCNCs and NaSCNCs for Pb 2+ and Cd 2+ were 367.6 mg/g,259.7 mg/g and 465.1 mg/g,344.8 mg/g,respectively.SCNCs and NaSCNCs showed high selectivity and interference resistance from coexisting ions for the adsorption of Pb 2+.NaSCNCs could be efficiently regenerated with a mild saturated NaCl solution with no loss of capacity after two recycles.The adsorption mechanisms of SCNCs and NaSCNCs were discussed. | Xiaolin Yu Shengrui Tong Maofa Ge Lingyan Wu Junchao Zuo Changyan Cao Weiguo Song | 2013 | Journal of Environmental Sciences2013，25，5： | 29 |
| 3 | Source apportionment and secondary organic aerosol estimation of PM_(2.5) in an urban atmosphere in China显示文摘PM2.5 is the key pollutant in atmospheric pollution in China.With new national air quality standards taking effect,PM2.5 has become a major issue for future pollution control.To effectively prevent and control PM2.5,its emission sources must be precisely and thoroughly understood.However,there are few publications reporting comprehensive and systematic results of PM2.5 source apportionment in the country.Based on PM2.5 sampling during 2009 in Shenzhen and follow-up investigation,positive matrix factorization(PMF)analysis has been carried out to understand the major sources and their temporal and spatial variations.The results show that in urban Shenzhen(University Town site),annual mean PM2.5 concentration was 42.2μg m?3,with secondary sulfate,vehicular emission,biomass burning and secondary nitrate as major sources;these contributed30.0%,26.9%,9.8%and 9.3%to total PM2.5,respectively.Other sources included high chloride,heavy oil combustion,sea salt,dust and the metallurgical industry,with contributions between 2%–4%.Spatiotemporal variations of various sources show that vehicular emission was mainly a local source,whereas secondary sulfate and biomass burning were mostly regional.Secondary nitrate had both local and regional sources.Identification of secondary organic aerosol(SOA)has always been difficult in aerosol source apportionment.In this study,the PMF model and organic carbon/elemental carbon(OC/EC)ratio method were combined to estimate SOA in PM2.5.The results show that in urban Shenzhen,annual SOA mass concentration was 7.5μg m?3,accounting for 57%of total organic matter,with precursors emitted from vehicles as the major source.This work can serve as a case study for further in-depth research on PM2.5 pollution and source apportionment in China. | HUANG XiaoFeng YUN Hui GONG ZhaoHeng LI Xiang HE LingYan ZHANG YuanHang HU Min | 2014 | Science China Earth Sciences2014，57，6： | 28 |
| 4 | Effects of different dietary energy and protein levels and sex on growth performance,carcass characteristics and meat quality of F1 Angus x Chinese Xiangxi yellow cattle显示文摘Background:The experiment evaluated the effect of nutrition levels and sex on the growth performance,carcass characteristics and meat quality of F1 Angus × Chinese Xiangxi yellow cattle.Methods:During the background period of 184 d,23 steers and 24 heifers were fed the same ration,then put into a2×2×2 factorial arrangement under two levels of- dietary energy(TON:70/80%DM),protein(CP:11.9/14.3%DM)and sex(S:male/female) during the finishing phase of 146 d.The treatments were-(1) high energy/low protein(HELP),(2) high energy/high protein(HEHP),(3) low energy/low protein(LELP) and(4) low energy/high protein(LEHP).Each treatment used 6 steers and 6 heifers,except for HELP- 5 steers and 6 heifers.Results:Growth rate and final carcass weight were unaffected by dietary energy and protein levels or by sex.Compared with the LE diet group,the HE group had significantly lower dry matter intake(DMI,6.76 vs.7.48 kg DM/d),greater chest girth increments(46.1 vs.36.8 cm),higher carcass fat(19.9 vs.16.3%) and intramuscular fat content(29.9 vs.22.8%DM).The HE group also had improved yields of top and medium top grade commercial meat cuts(39.9 vs.36.5%).The dressing percentage was higher for the HP group than the LP group(53.4 vs.54.9%).Steers had a greater length increment(9.0 vs.8.3 cm),but lower carcass fat content(16.8 vs.19.4%) than heifers.The meat quality traits(shear force value,drip loss,cooking loss and water holding capacity) were not affected by treatments or sex,averaging 3.14 kg,2.5,31.5 and 52.9%,respectively.The nutritive profiles(both fatty and amino acid composition) were not influenced by the energy or protein levels or by sex.Conclusions:The dietary energy and protein levels and sex significantly influenced the carcass characteristics and chemical composition of meat but not thegrowth performance,meat quality traits and nutritive profiles. | Lingyan Li Yuankui Zhu Xianyou Wang Yang He Binghai Cao | 2014 | Journal of Animal Science and Biotechnology2014，5，4： | 21 |
| 5 | Toxicities and risk assessment of heavy metals in sediments of Taihu Lake, China, based on sediment quality guidelines显示文摘The occurrence, toxicities, and ecological risks of five heavy metals(Pb, Cu, Cd, Zn and Ni) in the sediment of Taihu Lake were investigated in this study. To evaluate the toxicities caused by the heavy metals, the toxicities induced by organic contaminants and ammonia in the sediments were screened out with activated carbon and zeolite. The toxicities of heavy metals in sediments were tested with benthic invertebrates(tubificid and chironomid).The correlations between toxicity of sediment and the sediment quality guidelines(SQGs)derived previously were evaluated. There were significant correlations(p < 0.0001) between the observed toxicities and the total risk quotients of the heavy metals based on SQGs,indicating that threshold effect level(TEL) and probable effect level(PEL) were reliable to predict the toxicities of heavy metals in the sediments of Taihu Lake. By contrast, the method based on acid volatile sulfides(AVS) and simultaneously extracted metals(SEM),such as ∑SEM/AVS and ∑SEM-AVS, did not show correlations with the toxicities. Moreover,the predictive ability of SQGs was confirmed by a total predicting accuracy of 77%. Ecological risk assessment based on TELs and PELs showed that the contaminations of Pb, Cu, Cd and Zn in the sediments of Taihu Lake were at relatively low or medium levels. The risks caused by heavy metals in the sediments of northern bay of the lake, which received more wastewater discharge from upper stream, were higher than other area of the lake. | Yanfeng Zhang Yuwei Han Jinxi Yang Lingyan Zhu Wenjue Zhong | 2017 | Journal of Environmental Sciences2017，29，12： | 16 |
| 6 | Polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition显示文摘OBJECTIVE: Few studies have investigated the effects produced by combinations of polysaccharides and chemotherapeutic drugs in cancer treatment.We hypothesized that a combinationo fpolysaccha rides(COP) from Lentinus edodes and Tricholoma matsutake would improve the efficacy of 5-fluorouracil(5-FU)-mediated inhibition of H22 cell growth.METHODS: Mice were injected H22 cells and then treated with either 5-FU, polysaccharides from Tricholoma matsutake(PTM), polysaccharides from Lentinus edodes(PL), PTM+PL, 5-FU+PTM, 5-FU+PL, or 5-FU+COP. The tumor weight and volume,and splenic CD4 + and CD8 + T cell frequencies,were determined. Additionally, splenic natural killer(NK) cell and cytotoxic Tlymphocyte (CTL) activities were assessed and the serum levels of tumor necrosis factor-α(TNF-α),Interleukin-2(IL-2),and Interferon-γ (IFN-γ) were measured. 5-FU, PL, PTM, PTM+PL, 5-FU+PL, and 5-FU+PTM groups, mice treated with 5-FU+COP showed:(a)significantly reduced tumor weight and volume(P<0.05);(b) significantly higher serum levels ofTNF-α,IL-2, and IFN-γ(P<0.05);(c) significantly increased CD4+andCD8+Tcell frequencies in the spleen(P<0.05); and(d) significantly increased splenic NK cell and CTL activities(P<0.05). The tumor weight and volume in mice treated with 5-FU+PL or 5-FU+PTM were significantly reduced compared with mice treated with 5-FU alone(P<0.05). Serum levels of TNF-α, IL-2, and IFN-γ, frequencies of CD4 + and CD8+T cells in the spleen, and splenic NK and CTL activities were also significantly increased in mice treated with 5-FU+PL or 5-FU+PTM compared with mice treated with 5-FU alone (P<0.05).CONCLUSION: Polysaccharides from Lentinus edodes and Tricholoma matsutake could enhance the efficacy of 5-FU-mediated H22 cell growth inhibition. | Ming Ren Lingyan Ye Xiaoshi Hao Zhixing Ren Shuping Ren Kun Xu Juan Li | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 15 |
| 7 | The Antagonistic Action of Abscisic Acid and Cytokinin Signaling Mediates Drought Stress Response in Arabidopsis显示文摘 | Xiaozhen Huang Lingyan Hou Jingjing Meng Huiwen You Zhen Li Zhizhong Gong Shuhua Yang Yiting Shi | 2018 | Molecular Plant2018，11，7： | 15 |
| 8 | Correlation between women's sub-health and reproductive diseases with pregnancies and labors显示文摘OBJECTIVE: To investigate whether female sub-health conditions and reproductive diseases areassociated with pregnancies and labors.METHODS: A cross-sectional survey was performed by using a structured questionnaire. A total of 1343 women aged 35 years or younger in six urban areas of Chengdu were included in the study.According to the Screening Criteria of sub-health conditions, these women were categorized into three groups: postpartum healthy group,sub-healthy group, and reproductive disease group. Data were double-entered using EpiData and the nanalyzed by SPSS.RESULTS: Pregnancy and labor were correlated with postpartum sub-health conditions. The number of pregnancies was negatively correlated with women's postnatal health but was positively correlated with the incidence of postpartum reproductive diseases.CONCLUSION: The number of pregnancies and labors is probably an important factor leading to sub-health conditions and the occurrence of reproductive diseases in women. Avoiding or reducing unwanted pregnancies and labors, enhancing the awareness of health among child bearing-age women are effective measures for preventing sub-health conditions. | Xiaojuan Xu Qian Zeng Hong Ding Lingyan Feng Linwen Deng | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 14 |
| 9 | Effects of Tai Ji Quan training on gait kinematics in older Chinese women with knee osteoarthritis: A randomized controlled trial显示文摘Background: Although Tai Ji Quan has been shown to relieve pain and improve functional mobility in people with knee osteoarthritis(OA), little is known about its potential benefits on gait characteristics among older Chinese women who have a high prevalence of both radiographic and symptomatic knee OA. This study aims to assess the efficacy of a tailored Tai Ji Quan intervention on gait kinematics for older Chinese women with knee OA.Methods: A randomized controlled trial involving 46 older women in Shanghai, China, with clinically diagnosed knee OA. Randomized(1:1)participants received either a 60 min Tai Ji Quan session(n = 23) 3 times weekly or a 60 min bi-weekly educational session(n = 23) for 24 weeks.Primary outcomes were changes in gait kinematic measures from baseline to 24 weeks. Secondary outcomes included changes in scores on the Western Ontario and Mc Master University Osteoarthritis Index(WOMAC) and Short Physical Performance Battery(SPPB).Results: After 24 weeks the Tai Ji Quan group demonstrated better performance in gait velocity(mean difference, 8.40 cm/s, p = 0.01), step length(mean difference, 3.52 cm, p = 0.004), initial contact angle(mean difference, 2.19°, p = 0.01), and maximal angle(mean difference, 2.61°,p = 0.003) of flexed knees during stance phase compared to the control group. In addition, the Tai Ji Quan group showed significant improvement in WOMAC scores(p < 0.01)(mean difference,-4.22 points in pain, p = 0.002;-2.41 points in stiffness, p < 0.001;-11.04 points in physical function, p = 0.006) and SPPB scores(mean difference, 1.22 points, p < 0.001).Conclusion: Among older Chinese women with knee OA, a tailored Tai Ji Quan intervention improved gait outcomes. The intervention also improved overall function as indexed by the WOMAC and SPPB. These results support the use of Tai Ji Quan for older Chinese adults with knee OA to both improve their functional mobility and reduce pain symptomatology. | Qingguang Zhu Lingyan Huang Xie Wu Lin Wang Yunya Zhang Min Fang Yu Liu JingXian Li | 2016 | Journal of Sport and Health Science2016，5，3： | 14 |
| 10 | Combining sum-difference and auxiliary beams for adaptive monopulse in jamming显示文摘Only in the presence of sidelobe jamming(SLJ),can the conventional adaptive monopulse technique null the jamming effectively and maintain the monopulse angle estimation accuracy simultaneously.While mainlobe jamming(MLJ) exists,the mainlobe of adaptive pattern will subject to serious distortion,which results in a failure of detecting and tracking targets by monopulse technique.Therefore,a monopulse angle estimation algorithm based on combining sum-difference beam and auxiliary beam is presented.This algorithm utilizes both high gain difference beams and high gain auxiliary beams for cancelling the mainlobe jammer and multiple sidelobe jammers(SLJs) while keeping an adaptive monopulse ratio.Theoretical analysis and simulation results indicate that the serious invalidation of monopulse technique in MLJ and SLJs scenarios is resolved well,which improves the monopulse angle accuracy greatly.Furthermore,the proposed algorithm is of simple implementation and low computational complexity. | Rongfeng Li Can Rao Lingyan Dai Yongliang Wang | 2013 | Journal of Systems Engineering and Electronics2013，24，3： | 13 |
| 11 | Understanding primary and secondary sources of ambient oxygenated volatile organic compounds in Shenzhen utilizing photochemical age-based parameterization method显示文摘Oxygenated volatile organic compounds(OVOCs) are key intermediates in the atmospheric photooxidation process. To further study the primary and secondary sources of OVOCs,their ambient levels were monitored using a proton-transfer reaction mass spectrometer(PTR-MS) at an urban site in the Pearl River Delta of China. Continuous monitoring campaigns were conducted in the spring, summer, fall, and winter of 2016. Among the six types of OVOC species, the mean concentrations of methanol were the highest in each season(up to 13–20 ppbv), followed by those of acetone, acetaldehyde and acetic acid(approximately 2–4 ppbv), while those of formic acid and methyl ethyl ketone(MEK) were the lowest(approximately 1–2 ppbv). As observed from a diurnal variation chart, the OVOCs observed in Shenzhen may have been affected by numerous factors such as their primary and secondary sources and photochemical consumption. The photochemical age-based parameterization method was used to apportion the sources of ambient OVOCs. Methanol had significant anthropogenic primary sources but negligible anthropogenic secondary sources during all of the seasons. Acetone, MEK and acetic acid were mostly attributed to anthropogenic primary sources during each season with smaller contributions from anthropogenic secondary sources. Acetaldehyde had similar contributions from both anthropogenic secondary and anthropogenic primary sources throughout the year.Meanwhile, anthropogenic primary sources contributed the most to formic acid. | Bo Zhu Yu Han Chuan Wang Xiaofeng Huang Shiyong Xia Yingbo Niu Zixuan Yin Lingyan He | 2019 | Journal of Environmental Sciences2019，31，1： | 13 |
| 12 | Characterizing oxygenated volatile organic compounds and their sources in rural atmospheres in China显示文摘Oxygenated volatile organic compounds(OVOCs) are important precursors and products of atmospheric secondary pollution. The sources of OVOCs, however, are still quite uncertain,especially in the atmosphere with much pollution in China. To study the sources of OVOCs in rural atmospheres, a proton transfer reaction mass spectrometry(PTR-MS) was deployed at a northern rural site(WD) and a southern rural site(YMK) in China during the summer of 2014 and 2016, respectively. The continuous observation showed that the mean concentration of TVOCs(totally 17 VOCs) measured at WD(52.4 ppbv) was far higher than that at YMK(11.1 ppbv), and the OVOCs were the most abundant at both the two sites. The diurnal variations showed that local sources of OVOCs were still prominent at WD, while regional transport influenced YMK much. The photochemical age-based parameterization method was then used to quantitatively apportion the sources of ambient OVOCs. The anthropogenic primary sources at WD and YMK contributed less(2%–16%) to each OVOC species. At both the sites, the atmospheric background had a dominant contribution(~ 50%) to acetone and formic acid, while the anthropogenic secondary formation was the main source(~ 40%) of methanol and MEK. For acetaldehyde and acetic acid, the biogenic sources were their largest source(~ 40%) at WD, while the background(39%) and anthropogenic secondary formation(42%) were their largest sources at YMK, respectively. This study reveals the complexity of sources of OVOCs in China, which urgently needs explored further. | Yu Han Xiaofeng Huang Chuan Wang Bo Zhu Lingyan He | 2019 | Journal of Environmental Sciences2019，31，7： | 12 |
| 13 | Cyclostratigraphy of the Induan (Early Triassic) in West Pingdingshan Section,Chaohu,Anhui Province显示文摘The Induan sequence in the West Pingdingshan Section, Chaohu, Anhui Province, displays a series of superimposed mudstone/limestone cycles. The lithological character of the cycles, combined with power spectral and wavelet analysis of magnetic susceptibility readings, reveals 12 short eccentricity and 56 precession Milankovitch cycles - obliquity cycles are not apparent. The uniformity of cycle thicknesses indicates a stable depositional setting making this section ideal to perform various geo-logical studies. Accordingly, the Induan Stage is estimated to have lasted 1.1 Ma, and the depositional rate for this part of the section is about 3.7 cm/ka. This places the Induan-Olenekian boundary in the West Pingdingshan Section at about 251.5 Ma based on an age of 252.6 Ma for the Permian-Triassic boundary. | GUO Gang TONG JinNan ZHANG ShiHong ZHANG Jie BAI LingYan | 2008 | Science China Earth Sciences2008，51，1： | 10 |
| 14 | Enhanced Expression of miR-425 Promotes Esophageal Squamous Cell Carcinoma Tumorigenesis by Targeting SMAD2显示文摘Esophageal squamous cell carcinoma(ESCC) is one of the most common and deadly cancers in the world. Currently, clinical therapy of ESCC remains limited and the five-year survival rate is poor. The function of miR-425 has been reported in multiple human cancers.However, the tumorigenic role and clinical significance of miR-425 in ESCC remains unclear. We found that enhanced expression of miR-425 in ESCC cell lines not only promoted cell proliferation and colony formation, but also increased cellular metastasis. Furthermore, we revealed the mechanism that miR-425 inhibited the expression of SMAD2 by targeting the second binding site in the 30-untranslated region(30-UTR) in ESCC. This mode of action influenced not only SMAD2 mRNA expression but also protein expression. In addition, we detected the expression of miR-425 in ESCC tissues and plasma. Moreover, we analyzed the relationship between miR-425 expression and SMAD2 m RNA expression. We found that miR-425 was overexpressed in ESCC tissues and the plasma relative to adjacent normal tissues and plasma of healthy individuals. Furthermore, there was a negative correlation between miR-425 expression and SMAD2. Taken together, our results show that miR-425 functions as an oncogene by targeting the 30-UTR of SMAD2 and indicate the potential utility of plasma miR-425 as a novel biomarker for ESCC diagnosis. | Lingyan Liu Zitong Zhao Wei Zhou Xinyi Fan Qimin Zhan Yongmei Song | 2015 | Journal of Genetics and Genomics2015，42，11： | 10 |
| 15 | Characterization of submicron aerosols in the urban outflow of the central Pearl River Delta region of China显示文摘 | Zhaoheng GONG Zijuan LAN Lian XUE Liwu ZENG Lingyan HE Xiaofeng HUANG | 2012 | Frontiers of Environmental Science & Engineering2012，6，5： | 9 |
| 16 | Paleomagnetic results of Late Paleozoic rocks from northern Qiangtang Block in Qinghai-Tibet Plateau, China显示文摘Tectonic evolution of the Tethys and the boundary between the Gondwanaland and the Eurasia during the Carboniferous and Permian remain hotly debated. Qiangtang region in the Qinghai-Tibet Plateau may be a key place to study these problems. A paleomagnetic study was conducted on the Late Paleozoic rocks in the northern Qiangtang region (33.7°N, 86.7°W), Tibet. Two sites (21 samples) in the Upper Carboniferous, eleven sites (101 samples) in the Permian, and two sites (16 samples) in the Lower Triassic were investigated. The rock magnetic data revealed hematite and magnetite as the main magnetic carriers. In stepwise thermal demagnetization and/or combined alternating field (AC) demagnetization, two characteristic components in the majority of the samples were identified as (1) the Low-temperature Component (LTC), characterized by northerly decli- nation and moderate to steep inclination, corresponding to a pole position overlay with the present North Pole. A minority of the samples present single component, and their directions are the same as (2) the High-temperature Component (HTC) of double components. The combined single-component and HTC data of the Permian can pass the R-test at 95% level and the F-test at 99% level, as well as the BC-test. The pole position from the Late Carboniferous is at 31.8°S, 45.7°E with dp=2.1, dm=3.9, that from the Early and Middle (Late) Permian is at 31.7°S, 46.8°E with dp=9.2, dm=16.9 (34.4°N, 54.1°E with dp=6.9, dm=12.5) respectively, and that from the Early Triassic is at 16.9°S, 22.5°E with dp=4.9, dm=9.2. These pole positions are different from the other poles for the Qiangtang Block, which suggests the single-component and HTC directions are probably a primary magnetization and the northern Qiangtang Block was paleogeographically situated at low latitudes in the Northern Hemisphere in the Late Paleozoic. | CHENG Xin WU HanNing GUO Qiang HOU BaoNing XIA LingYan WANG HaiJun DIAO ZongBao HUO FeiFei JI WenHua LI RongShe CHEN ShouJian ZHAO ZhenMing LIU XiaoJi | 2012 | Science China Earth Sciences2012，55，1： | 9 |
| 17 | TRAP1 Shows Clinical Significance and Promotes Cellular Migration and Invasion through STAT3/MMP2 Pathway in Human Esophageal Squamous Cell Cancer显示文摘Tumor necrosis factor receptor-associated protein 1(TRAP1), an important member of mitochondrial heat shock protein 90 family, is involved in multiple biological processes in several types of tumors. However, its pathological role in esophageal squamous cell cancer(ESCC) remains unknown. Herein, we demonstrated the clinical value of TRAP1, and its role in apoptosis and motility in ESCC. The clinical potential of TRAP1 was investigated through immunohistochemical analysis in 328 ESCC samples, which revealed that strong TRAP1 expression was associated with increased risk of lymph node metastasis, while high TRAP1 expression correlated with poor prognosis. Expression of TRAP1 was found to be an independent prognostic factor for patients with ESCC. Additionally, the upregulation of TRAP1 antagonized cisplatin-induced apoptosis while its downregulation sensitized cells to cisplatin-induced apoptosis. As revealed by the transwell assay, TRAP1 overexpression promoted cellular migration and invasion as compared to the control groups. In contrast,silencing of endogenous TRAP1 expression attenuated the ability of migration and invasion. Finally, the molecular mechanism investigated in the present study demonstrated that TRAP1-mediated migration and invasion occurred through STAT3/MMP2 signaling pathway. In conclusion, TRAP1 may be considered as a molecular predictive marker for prognosis and a novel molecular candidate for therapeutic target in ESCC. | Yunwei Ou Lingyan Liu Liyan Xue Wei Zhou Zitong Zhao Bainan Xu Yongmei Song Qimin Zhan | 2014 | Journal of Genetics and Genomics2014，41，10： | 8 |
| 18 | Cocrystallization of N-donor type compounds with 5-sulfosalicylic acid:The effect of hydrogen-bonding supramolecular architectures显示文摘Benzotriazole,N,N'-dimethylpiperazine and N-methylpiperazine were applied to crystallize with 5-sulfosalicylic acid(5-H2SSA),affording three new binary molecular cocrystals [(C6H6N3+).(C7H5O6S-)].H2O(1),[(C6H16N22+)1/2.(C7H5O6S-)].H2O(2) and [(C5H14N22+).(C7H5O6S-)2].3H2O(3) under general conditions.Proton-transferring occurs from acid to nitrogen of N-donor compounds in all compounds 1,2 and 3.Analysis of the hydrogen-bonding synthons and their effects on crystal packing were also presented in the context of crystal engineering and host-guest chemistry.In compound 1,1-D infinite chains are extended to a 2-D layered architecture via strong O-H...O hydrogen bonds and then to a 3-D network by N-H...O interactions.Compound 2 and 3 both have the 1-D chain which is formed by O-H...O bonds and weak C-H...O hydrogen bonds.A common intramolecular S(6) [synthon I] ring is formed by the hydroxyl with the carboxyl group in all three compounds. | WANG Lei XU LingYan XUE RuiFeng LU XiFeng CHEN RuiXin TAO XuTang | 2012 | Science China Chemistry2012，55，1： | 8 |
| 19 | An Energy Efficient Design for UAV Communication With Mobile Edge Computing显示文摘This paper considers a UAV communication system with mobile edge computing(MEC).We minimize the energy consumption of the whole system via jointly optimizing the UAV's trajectory and task assignment as well as CPU's computational speed under the set of resource constrains.To this end,we first derive the energy consumption model of data processing,and then obtain the energy consumption model of fixed-wing UAV's flight.The optimization problem is mathematically formulated.To address the problem,we first obtain the approximate optimization problem by applying the technique of discrete linear state-space approximation,and then transform the non-convex constraints into convex by using linearization.Furthermore,a concave-convex procedure(CCCP) based algorithm is proposed in order to solve the optimization problem approximately.Numerical results show the efficacy of the proposed algorithm. | Lingyan Fan Wu Yan Xihan Chen Zhiyong Chen Qingjiang Shi | 2019 | China Communications2019，16，1： | 8 |
| 20 | Comparative Study of Water-soluble and Alkali-soluble Hemicelluloses Extracted by Hydrothermal Pretreatment显示文摘The purpose of this study was to explore the differences of the hemicelluloses extracted by hydrothermal pretreatment using water and alkaline solutions(Na OH or KOH). The physicochemical properties and structural characteristics of two water-soluble and four alkali-soluble hemicelluloses extracted from the triploid of Populus tomentosa Carr. through the hydrothermal pretreatment were comparatively studied. It was observed that the alkalis(Na OH and KOH) were more effective than distilled water as extractants. Sugar analysis showed that xylose(66.83%~86.49%) was the major constituent, followed by glucose(6.83%~18.49%). Mannose(1.40%~8.42%), galactose(2.17%~4.05%), and arabinose(0.21%~2.26%) were also detected in the hemicellulosic fractions. The results of gelpermeation chromatography(GPC) indicated that the hemicelluloses extracted using the alkaline solutions had relatively higher molecular weights than those solubilized in distilled water. Further, based on spectroscopic ~1Hnuclear magnetic resonance(~1H-NMR) and two-dimensional heteronuclear singular quantum correlation(2D-HSQC) analyses, it was confirmed that the hemicellulosic fractions had a major structure of(1→4)-b-D-xylan and a minor structure of(1→4)-a-D-glucan with small amounts of substituted sugars and glucuronic acid attached. | LianHua Fu LingYan Meng YaYu Li MingGuo Ma | 2017 | Paper And Biomaterials2017，2，1： | 7 |
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