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| 1 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 2 | Electrochemical Surface Restructuring of Phosphorus-Doped Carbon@MoP Electrocatalysts for Hydrogen Evolution显示文摘The hydrogen evolution reaction(HER) through electrocatalysis is promising for the production of clean hydrogen fuel. However,designing the structure of catalysts,controlling their electronic properties,and manipulating their catalytic sites are a significant challenge in this field. Here,we propose an electrochemical surface restructuring strategy to design synergistically interactive phosphorus-doped carbon@MoP electrocatalysts for the HER. A simple electrochemical cycling method is developed to tune the thickness of the carbon layers that cover on MoP core,which significantly influences HER performance. Experimental investigations and theoretical calculations indicate that the inactive surface carbon layers can be removed through electrochemical cycling,leading to a close bond between the MoP and a few layers of coated graphene. The electronsdonated by the MoP core enhance the adhesion and electronegativity of the carbon layers;the negatively charged carbon layers act as an active surface. The electrochemically induced optimization of the surface/interface electronic structures in the electrocatalysts significantly promotes the HER. Using this strategy endows the catalyst with excellent activity in terms of the HER in both acidic and alkaline environments(current density of 10 mA cm^(-2) at low overpotentials,of 68 mV in 0.5 M H_(2)SO_(4) and 67 mV in 1.0 M KOH). | Huimin Jiang Liting Yan Shuo Zhang Yanchao Zhao Xue Yang Yameng Wang Jianxing Shen Xuebo Zhao Lianzhou Wang | 2021 | Nano-Micro Letters2021，13，12： | 3 |
| 3 | Thermal and mechanical properties of epoxy resin toughened with epoxidized soybean oil显示文摘 | Chen Yan Yang Liting Wu Jiahui | 2013 | Journal of Thermal Analysis and Calorimetor2013，113，2： | 1 |
| 4 | Gastroenterology Nursing teaching a new concept显示文摘 | Yan Feng high piano Wang Liting | 2012 | Critical Care Medicine2012，11，19： | 1 |
| 5 | High-resolution crustal velocity structure in the Shanxi rift zone and its tectonic implications显示文摘The Shanxi rift zone,located in the Trans-North China Orogen(TNCO)of the North China Craton(NCC),is wellknown for hosting large intraplate earthquakes in continental China.The TNCO is a suture zone formed by the amalgamation of the eastern and the western blocks of the NCC.After its formation,it was reactived and deformed by later tectonic activities,which result in complex lithospheric heterogeneities.Thus,the detailed crustal structure of the Shanxi rift zone is critical for understanding the tectonics and seismogenic mechanism in this area,which will shed new lights on the formation and dynamic evolution of the NCC.In this study,we applied ambient noise tomography based on 18 months continuous records from 108 seismic stations located in Shanxi and its surroundings,in order to constrain its detailed crustal structure.We measured 4437 Rayleigh wave phase velocity dispersion curves in the period of 5–45 s from the cross-correlation functions.Next,a surface wave direct inversion algorithm based on surface-wave ray tracing was used to resolve a 3-D S-wave velocity model in the upper 60 km with lateral resolution of~50–80 km.The tomographic images show that the sedimentary thickness of the Taiyuan Basin is less than 5 km.At depth of 0–10 km,we observe a good correlation between the imaged structural variations with geological and topographic features at the surface.For example,the center of rift shows low-velocity anomalies and the uplifting areas on both sides are characterized by high velocity anomalies.The western and eastern boundaries of the slow materials coincide with the faults that control the basin.The slow material extends from the shallow surface to depth of about 15 km but it getting smaller in shape at deeper depth.For the Taiyuan Basin,Linfen Basin,and Yuncheng Basin in the central and southern parts,the structure is dominant by slow materials in the upper crust but changes to strong high-velocity anomalies in the lower crust and the uppermost mantle at depth deeper than 25 km.We interprete these high-velocity anomalies to be associated with the cold remnant of the underplated basalt in the lower crust that were formed in early Tertiary before the basin was stretched.We also observe the low-velocity anomaly beneath the Datong volcanic area,which extends from the uppermost mantle to a depth of 20 km vertically and migrates from west to east laterally.It may reflect the upwelling channel of the magmatic material in Datong.Moreover,the strong low-velocity anomalies presented north of 38°N could be related to the heated crustal materials with paritial melting as a result of the intensive magmatic activities of the Datong Volcano since the Cenozoic.In our study region,seismicity mainly concentrates in the depth range of 5–20 km and we find that most earthquakes appear to occur in places where velocity changes from high to low rapidly,with slight higher concentration in the faster material areas.In summary,our high-resolution 3-D crustal velocity model provides important seismological constraints to understand the tectonic evolution and seismicity across the Shanxi rift zone. | Liting DOU Huajian YAO Lihua FANG Song LUO Meiqin SONG Xiaomei YAN Cheng CHENG | 2021 | Science China Earth Sciences2021，64，5： | 1 |
| 6 | Auricular vagus nerve acupressure for patients with emotional distress under the COVID-19 pandemic:A smartphone-based,randomized controlled trial显示文摘Objective: To confirm whether self-administered AVNA treatment is effective in improving emotional distressunder the COVID-19 pandemic.Methods: A smartphone-based online, randomized, controlled trial was designed from 26 February 2020 to 28April 2020 in four study sites, including Wuhan, Beijing, Shenyang, and Guangzhou of China. Local residentswho had considerable emotional distress with a score of the Hospital Anxiety and Depression Scale (HADS) ≥9 were recruited. Participants were randomly assigned to three times of AVNA (n = 191) per day, in morning,around noon, and in evening or usual care (UC, n = 215) once daily for 14 days. The primary outcome was theresponse rate, which was the proportion of participants whose Hospital Anxiety and Depression Scale (HADS)score reduced from baseline by ≥ 50%. The assessment was conducted at baseline, 3 days, and 14 days.Results: The AVNA group had a markedly higher response rate than the UC group at 3 days (35.6% vs. 24.9%,P = 0.02) and at 14 days (70.7% vs. 60.6%, P = 0.02). The AVNA group showed significantly greater reductionin scores of HADS at the two measurement points and BAI at 3 days (P ≤ 0.03), with average respective effectsize of 0.217 and 0.195. Participants with AVNA spent less time falling asleep and rated their sleep qualitybeing remarkably higher than those with UC at endpoint.Conclusion: During COVID-19 pandemic period, treatment with self-administrated AVNA was more effectivethan UC in reducing emotional distress of isolated populations. These findings support self-administered AVNAas a treatment option for patients with emotional distress under the COVID-19 pandemic or other emergentevents. | Peijing Rong Lei Wang Lingling Yu Junying Wang Yan Ma Liting Wang Suxia Li Chunzhi Tang Liming Lu Liang Li Jiazi Dong Jiliang Fang Liwei Hou Zongshi Qin Xiaolan Su Zhangjin Zhang | 2021 | TMR Modern Herbal Medicine2021，4，2： | 1 |
| 7 | Metastable Phase Equilibrium of the Quaternary System Na^+, Rb^+, Mg^+//Cl^--H2O at 298.2 K显示文摘 | WU Liting ZENG Ying YAN Dongming FENG Shan YU Xudong | 2018 | Chemical Research in Chinese Universities2018，34，5： | 1 |
| 8 | Study on Influencing Factors of Methane Production Efficiency of Microbial Electrolytic Cell with CO_(2) as Carbon Source显示文摘Reducing CO_(2) to produce methane through microbial electrolytic cell(MEC)is one of the important methods of CO_(2) resource utilization.In view of the problem of low methanogenesis rate and weak CO_(2) conversion rate in the reduction process,theflowfield environment of the cathode chamber is changed by changing the upper gas cir-culation rate and the lower liquid circulation rate of the cathode chamber to explore the impact on the reactor startup and operation and products.The results showed that under certain conditions,the CO_(2) consumption and methane production rate could be increased by changing the upper gas recirculation rate alone,but the increase effect was not obvious,but the by-product hydrogen production decreased significantly.Changing the lower liquid circulation rate alone can effectively promote the growth of biofilm,and change the properties of biofilm at the later stage of the experiment,with the peak current density increased by 16%;The methanogenic rate decreased from the peak value of 0.561 to 0.3 mmol/d,and the CO_(2) consumption did not change signifi-cantly,which indicated that CO_(2) was converted into other organic substances instead of methane.The data after coupling the upper gas circulation rate with the lower liquid circulation rate is similar to that of only changing the lower liquid circulation rate,but changing the upper gas circulation rate can alleviate the decline of methane pro-duction rate caused by the change of biofilm properties,which not only improves the current density,but also increases the methane production rate by 0.05 mmol/d in the stable period.This study can provide theoretical and technical support for the industrial application scenario offlowfield regulation intervention of microbial elec-trolytic cell methanogenesis. | Qifen Li Yuanbo Hou Yongwen Yang Liting Zhang Xiaoxiao Yan | 2023 | Journal of Renewable Materials2023，11，8： | 0 |
| 9 | Optimisation Strategy of Carbon Dioxide Methanation Technology Based on Microbial Electrolysis Cells显示文摘Microbial Electrolytic Cell(MEC)is an electrochemical reaction device that uses electrical energy as an energy input and microorganisms as catalysts to produce fuels and chemicals.The regenerative electrochemical system is a MEC improvement system for methane gas produced by biological carbon sequestration technology using renewable energy sources to provide a voltage environment.In response to the influence of fluctuating disturbances of renewable electricity and the long system start-up time,this paper analyzes the characteristics of two strategies,regulating voltage parameter changes and activated sludge pretreatment,on the methane production efficiency of the renewable gas electrochemical system.In this system,the methane production rate of regenerative electrochemical system is increased by 1.4 times through intermittent boosting start-up strategy;based on intermittent boosting,the methane production rate of regenerative electrochemical system is increased by 2 times through sludge pyrolysis pretreatment start-up strategy,and the start-up time is reduced to 10 days.Meanwhile,according to the simulation test results of power input fluctuation and intermittency,the stability standard deviation of its system operation is 75%of the original one,and the recovery rate is about 1 times higher.This study can provide a theoretical basis and technical reference for the early industrial application of microbial CO_(2)methanation technology based on renewable energy. | Qifen Li Xiaoxiao Yan Yongwen Yang Liting Zhang Yuanbo Hou | 2023 | Journal of Renewable Materials2023，11，7： | 0 |
| 10 | Establishment of a prognostic scoring model for regional recurrent nasopharyngeal carcinoma after neck dissection显示文摘Objective:The main aim of this study was to establish a scoring model to predict risk of progression and survival in patients with regionally recurrent nasopharyngeal carcinoma(NPC).Methods:Three hundred and forty-eight patients subjected to neck dissection from 2003 to 2017 were included for study.Clinicopathologic information for each patient was analyzed.Independent prognostic factors were selected using the Cox proportional hazards model and incorporated into the scoring model.Concordance index(C-index)and calibration curves were used to verify discrimination and calibration,respectively and the results validated using bootstrap resampling.Results:Microscopic positive lymph node>2[hazard ratio(HR),2.19;95%confidence interval(CI),1.30–3.68;P=0.003],extranodal extension(HR,2.75;95%CI,1.69–4.47;P<0.001),and lower neck involvement(HR,1.78;95%CI,1.04–3.04;P=0.034)were identified from multivariate analysis as independent factors for overall survival(OS).A qualitative 4-point scale was generated to stratify patients into 4 risk groups for predicting OS and progression-free survival(PFS).The novel scoring model demonstrated enhanced discrimination(C-index=0.69;95%CI,0.62–0.76)relative to the original recurrent tumor-node-metastasis(rTNM)staging system(C-index=0.56;95%CI,0.50–0.62),and was internally validated with a bootstrap-adjusted C-index of 0.70.The calibration curve showed good agreement between predicted probabilities and actual observations.Conclusions:The scoring system established in this study based on a large regionally recurrent NPC cohort fills a gap regarding assessment of risk and prediction of survival outcomes after neck dissection in this population and could be further applied to identify high-risk patients who may benefit from more aggressive intervention. | Xiaoyun Li Chao Lin Jinjie Yan Qiuyan Chen Xuesong Sun Sailan Liu Shanshan Guo Liting Liu Haojun Xie Qingnan Tang Yujing Liang Ling Guo Hao Li Xuekui Liu Xiang Guo Linquan Tang Haiqiang Mai | 2020 | Cancer Biology & Medicine2020，17，1： | 0 |
| 11 | Research on Soil Conservation and Improvement Technology in Zhaoyang District显示文摘The environment of tobacco-growing soil directly affects the yield and quality of tobacco leaves.In order to solve problems of tobacco-growing soil degradation,low organic matter content and unbalanced soil nutrient supply and promote sustainable and healthy development of tobacco production,this paper comprehensively discussed conservation and improvement techniques of tobacco-growing soil based on existing problems in Zhaoyang District,aiming to provide reference for tobacco-growing soil conservation. | Jing YANG Shifu ZHONG Liting FANG Wei YAN Shixian PU Dianli MA Wenkai XIA Haohan GONG Mengsheng ZHANG Yeming FU Xia NI | 2024 | Agricultural Biotechnology2024，13，1： | 0 |
| 12 | Cell-cycle dependent nuclear gene delivery enhances the effects of E-cadherin against tumor invasion and metastasis显示文摘Gene delivery is the process by which foreign DNA is transferred to host cells,released from intracellular vesicles,and transported to the nuclei for transcription.This process is frequently inefficient and difficult to control spatiotemporally.We developed a gene delivery strategy that uses ultrasound to directly deliver plasmid DNA into nuclei via gas vesicles(GVs)-based intracellular cavitation.pDNA-binding GVs can be taken up by cells and cause intracellular cavitation when exposed to acoustic irradiation and delivering their pDNA payloads into nuclei.Importantly,GVs can remain stable in the cytoplasm in the absence of acoustic irradiation,allowing for temporally controlled nuclear gene delivery.We were able to achieve spatiotemporal control of E-cadherin nuclear gene delivery in this manner,demonstrating its efficacy in tumor invasion and metastasis inhibition.Interestingly,we discovered that nuclear gene delivery of E-cadherin during the G2/M phase of the cell cycle in C6 tumor cells inhibited tumor invasion and metastasis more effectively than during the G1 and S phases.The gene delivery of E-cadherin at the G2/M phase resulted in significantly lower expression of Fam50a,which reduced Fam50a/Runx2 interaction and led to reduced transactivation of MMP13,an important factor for epithelial-mesenchymal transition,as observed in a molecular mechanism assay.Thus,using remote acoustic control of intracellular cavitation of pDNA-GVs,we developed a high spatiotemporally controllable gene delivery strategy and achieved stronger tumor invasion and metastasis inhibition effects by delivering the E-cadherin gene at the G2/M phase. | Liting Xie Jieqiong Wang Liming Song Tianan Jiang Fei Yan | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 13 | Study on Biological Pathway of Carbon Dioxide Methanation Based on Microbial Electrolysis Cell显示文摘Realization of CO_(2) resource utilization is the main development direction of CO_(2) reduction.The CO_(2) methana-tion technology based on microbial electrolysis cell(MEC)has the characteristics of ambient temperature and pressure,green and low-carbon,which meets the need of low-carbon energy transition.However,the lack of the system such as the change of applied voltage and the reactor amplification will affect the methane production efficiency.In this research,the efficiency of methane production with different applied voltages and different types of reactors was carried out.The results were concluded that the maximum methane production rate of the H-type two-chamber microbial electrolysis cells(MECs)at an applied voltage of 0.8 V was obtained to be 1.15 times higher than that of 0.5 V;under the same conditions of inoculated sludge,the reactor was amplified 2.5 times and the cumulative amount of methane production was 1.04 times higher than the original.This research can provide a theoretical basis and technical reference for the early industrial application of CO_(2) methanation tech-nology based on MEC. | Guanwen Ding Qifen Li Liting Zhang Yuanbo Hou Xiaoxiao Yan | 2023 | Journal of Renewable Materials2023，11，1： | 0 |
| 14 | Development of robust perovskite single crystal radiation detectors with high spectral resolution through synergetic trap deactivation and self-healing显示文摘Organic-inorganic halide perovskite single crystals(SCs)are promising materials for detecting ionizing radiation owing to their outstanding photoelectric conversion capability and inexpensive solution processability.However,the accuracy and stability of the detectors have been limited due to the charge traps and defects in SCs,especially when operated under high-precision photon-counting mode for energy spectrum acquisition.Here,we proposed a trap freezing deactivation route,which obviously suppressed dark current and noise by up to 97%and 92%,respectively.Furthermore,the bulk ion migration effect was essential for the ability to instantly self-heal defects induced by radiation damage at temperatures down to30C.Consequently,the detector exhibits a record high energy resolution of 7.5%at 59.5 keV for 241Amγ-ray source,which is the best solution-processed semiconductor radiation detectors at the same energy range.In addition,the detector maintains over 90%of its initial performance after 9 months of storage when tested in the air.Our results will represent a revision of the paradigm that high-spectral-resolution and robust radiation detectors can only be realized with high temperature grown inorganic semiconductor single crystals. | Lixiang Wang Yilong Song Liqi Li Liting Tao Minxing Yan Weihui Bi Xueying Yang Yuan Sun Qingfeng Dong Deren Yang Yanjun Fang | 2023 | InfoMat2023，5，9： | 0 |
| 15 | DICOM Standard and Its Application in PACS System显示文摘PACS is an important link in the rapid development of information technology in contemporary hospitals. DICOM is the standard of PACS TCM medical image format and transmission medical image protocol. This paper describes the status of PACS system based on DICOM standard. In addition, the PACS system is described in detail according to its application classifi cation and the characteristics and signifi cance of DICOM standard are expounded. At the same time, it discusses the long-term prospect of DICOM in PACS. | Liting Yan Yahui Yu Hongliang Ma | 2018 | Medical Imaging Process & Technology2018，1，1： | 0 |
| 16 | Continuous synthesis for zirconium metal-organic frameworks with high quality and productivity via microdroplet flow reaction显示文摘Zirconium metal-organic frameworks(Zr-MOFs) represent the most promising candidates among MOFs for industrial utilizations owing to their high porosity and excellent stability. However, the efficient synthesis of Zr-MOFs combining with continuous production, high productivity and good product quality still remains a critical issue for practical applications. Herein, we report an efficient method of synthesizing a series of Zr-MOFs through a microdroplet flow reaction, which is more accommodate the requirements of industrial production. Four types of Zr-based MOFs with different ligands and topologies(MOF-801, MOF-804, DUT-67 and MOF-808) were produced as a pure phase of high quality crystalline with uniform morphologies. Furthermore, this series of Zr-MOFs were obtained in a continuous way and at a space-time yield(STY) highly up to 367.2 kg m^(-3) d^(-1). These MOFs exhibit the similar pore structure and thermal stability with that prepared from conventional solvothermal synthesis. CO_2 sorption studies on these MOFs demonstrate that the hydroxyl groups on ligand can render MOFs with high CO_2/N_2 selectivity. | Ying Wang Liangjun Li Liting Yan Lei Cao Pengcheng Dai Xin Gu Xuebo Zhao | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
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