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| 1 | Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia显示文摘Microglia 玩在由降级的 A 的清理的一个枢轴的角色他们在 lysosomes,在 Alzheimers 疾病(广告) 阻止淀粉的匾致病。最近的证据建议那个 lysosomal 机能障碍导致有毒的蛋白质总数的不够的消除。我们测试了是否与抄写因素 EB (TFEB ) 提高 lysosomal 功能,必要管理者 modulating lysosomal 小径,将在 microglia 支持一个清理。这里,我们证明 TFEB 的那 microglial 表情便于降级和还原剂扔了的纤丝状的 A (fA ) 淀粉的匾,它被 TFEB 的 deacetylation 进一步提高。用集体 spectrometry 分析,我们第一证实了是的 acetylation 一以前 TFEB 的 unreported 修正并且发现那 SIRT1 直接交往了与并且在离氨酸残余 116 点的 deacetylated TFEB。随后,当 TFEB 被击倒时, SIRT1 overexpression 由 TFEB 下游的目标的 upregulating transcriptional 层次提高了 lysosomal 功能和 fA 降级,它能被禁止。而且,在在 microglia 变异的 K116R 的 deacetylated TFEB 的 overexpression 由刺激 lysosomal 生物的续生说加速了细胞内部的 fA 降级并且极大地在 APP/PS1 转基因的老鼠的大脑片减少了扔的淀粉的匾。我们的调查结果表明 TFEB 的 deacetylation 能调整 lysosomal 生物的续生说和 fA 降级,为 attenuating 使 TFEB 的 microglial 激活成为可能的策略在广告的淀粉的匾免职。 | Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji | 2016 | Protein & Cell2016，7，6： | 10 |
| 2 | Efficacy and safety of chemotherapy combined with bevacizumab in Chinese patients with metastatic colorectal cancer:A prospective,multicenter,observational,non-interventional phaseⅣtrial显示文摘Objective:Bevacizumab has an important and evolving role in improving outcomes in patients with metastatic colorectal cancer(mCRC)worldwide and was approved in China in 2010.However,there are limited real-world data on the efficacy and safety of chemotherapy regimens combined with bevacizumab in Chinese patients with mCRC.This observational,phase IV trial study aimed to obtain more experience on the efficacy and safety of bevacizumab combined with chemotherapy in Chinese mCRC patients.Methods:Between September 2013 and November 2016,patients with histologically confirmed mCRC were enrolled in a prospective,multicenter,observational,non-interventional phase IV trial at 26 centers across China.Eligible patients received different chemotherapeutic regimens combined with bevacizumab.The efficacy and safety data in the intention-to-treat study population were analyzed.Results:A total of 611 patients were included in the efficacy analysis.The median overall survival and median progression-free survival was 18.00 and 10.05 months,respectively.The objective response rate was 21.00%and disease control rate was 89.40%.In subgroup analyses,the survival differences were observed according to metastatic status,duration of treatment and elevation in blood pressure.A total of 613 patients were evaluable for safety assessments.And 569(92.82%)patients reported at least one adverse event(AE),and 151(24.63%)experienced grade 3 or higher AEs.The incidence of bevacizumab-associated AEs of special interest was reported in 31(5.06%)patients with hypertension(n=12),abscesses and fistulae(n=7),bleeding(n=6),proteinuria(n=3),gastrointestinal perforation(n=2)and venous thrombotic events(n=1).Conclusions:This observational phase IV trial broadens our experience and knowledge of bevacizumab in the Chinese population and provides a good indication of its overall efficacy and safety.Bevacizumab in combination with chemotherapy offers clinical benefits to Chinese patients with mCRC and has an acceptable and manageable safety profile. | Fenghua Wang Guanghai Dai Yanhong Deng Yong Tang Wei Wang Zuoxing Niu Feng Bi Liangjun Zhu Zengqing Guo Jin Yan Bing Hu Min Tao Shujun Yang Suzhan Zhang Lu Wen Ruihua Xu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 2 |
| 3 | Carbon-Based Electrode Materials for Supercapacitor: Progress, Challenges and Prospective Solutions显示文摘 | Xian Jian Shiyu Liu Yuqi Gao Wei Tian Zhicheng Jiang Xiangyun Xiao Hui Tang Liangjun Yin | 2016 | Journal of Electrical Engineering2016，4，2： | 2 |
| 4 | Emergence of photoluminescence on bulk MoS2 by laser thinning and gold particle decoration显示文摘 | Lili Gong Qi Zhang Liangjun Wang Jianfeng Wu Cheng Han Bo Lei Wei Chen Goki Eda Kuan Eng Johnson Goh Chorng Haur Sow | 2018 | Nano Research2018，11，9： | 1 |
| 5 | MXene and MXene-based materials for lithium-sulfur batteries显示文摘Lithium-sulfur(Li–S)batteries are regarded as potential alternatives to lithium-ion batteries due to their extremely high theoretical energy density.Nevertheless,Li–S batteries still suffer from low coulombic efficiency,low sulfur utilization,and poor cycling life,which hinder their further applications.To obtain ideal Li–S cells,intensive work has been dedicated to improve the conductivity of the electrode,inhibiting the shuttle of lithium polysulfides,and promoting the redox of sulfur.Two-dimensional transition metal carbides,nitrides or carbonitrides,also known as MXenes,attracting significant research interest in Li–S batteries due to their high conductivity,abundant active sites,layered structure and adjustable surface chemistry.In this review,we summarize the partial etching methods of MXenes with different surface terminations,the role of MXenes in Li–S batteries and MXene-based composites designed for Li–S batteries based on interfacial chemistry and interlayer structure.In the end,we also propose the perspectives of MXenes for Li–S batteries. | Youquan Zhang Cheng Ma Weitao He Chunxiao Zhang Liangjun Zhou Gao Wang Weifeng Wei | 2021 | Progress in Natural Science:Materials International2021，31，4： | 1 |
| 6 | Chemical con-stituents from Monochasma savatieri显示文摘 | Zheng Wei Tan Xingqi Guo Liangjun | 2012 | Chin J Nat Med2012，10，2： | 1 |
| 7 | An antcolony optimization approach for the multidimensional knapsackproblem显示文摘 | Ke Liangjun Feng Zuren Ren Zhigang Wei Xiaoliang | 2010 | Heuristics2010，16，1： | 1 |
| 8 | Monitoring of organochlorine pesticides in the urban air of Dalian, China with semipermeable membrane devices显示文摘The concentrations of 28 organochlorine pesticides(OCPs)in the urban air of Dalian,China were measured using semipermeable membrane devices(SPMDs)for the first time.Alpha-hexachlorocyclohexane(a-HCH),b-HCH,pentachlorobenzene(PentCB),hexachlorobenzene(HexCB),4,40-dichlorodiphenyltrichloroethane(4,40-DDT),4,40-dichlorodiphenyldichloroethene,endosulfan-I and endosulfan-II were the predominant OCPs in the urban air of Dalian.The concentration of OCPs sequestrated by SPMDs(CSPMD)ranged from undetected to 56,772 pg SPMD-1and had a linear correlation with the reciprocal of the average ambient atmospheric temperature(1/T).The CSPMDof PentCB and HexCB had negative correlations with T,whereas the other detected OCPs had a positive correlation.The source of HCHs,DDTs,HexCB,PentCB,chlordane,and endosulfan in the air were also evaluated.The OCPs in the urban air of Dalian could be attributed to the seasonal usage of pesticides,combustion,volatilization of aged OCPs from soil,water,plants,and long-range atmospheric transport. | Xiuhua Zhu Taian Shi Bernhard Henkelmann Gerd Pfister Wei Wang Jun Mu Xiaoxiao Li Liangjun Han Karl-Werner Schramm | 2014 | Chinese Science Bulletin2014，59，24： | 1 |
| 9 | Bone morphogenetic protein 2 inhibits the proliferation and growth ofhuman colorectal cancer cells显示文摘 | Yunyuan Zhang Xian Chen Min Qiao Bing-Qiang Zhang Ning Wang Zhonglin Zhang Zhan Liao Liyi Zeng Youlin Deng Fang Deng Junhui Zhang Liangjun Yin Wei Liu Qian Zhang Zhengjian Ya Jixing Ye Zhongliang Wang Lan Zhou Hue Luu Rex Haydon Tong-Chuan He Hongyu Zhang | 2014 | Oncology Reports2014，，3： | 1 |
| 10 | MORPHOLOGY OF BLACK CARBON AEROSOLS AND UBIQUITY OF 50-NANOMETER BLACK CARBON AEROSOLS IN THE ATMOSPHERE显示文摘Different-sized aerosols were collected by an Andersen air sampler to observe the detailed morphology of the black carbon (BC) aerosols which were separated chemically from the other accompanying aerosols, using a Scan-ning Electron Microscope equipped with an Energy Dispersive X-ray Spectrometer (SEM-EDX). The results indicate that most BC aerosols are spherical particles of about 50 nm in diameter and with a homogeneous surface. Results also show that these particles aggregate with other aerosols or with themselves to form larger agglomerates in the micrometer range. The shape of these 50-nm BC spherical particles was found to be very similar to that of BC particles released from petroleum-powered vehicular internal combustion engines. These spherical BC particles were shown to be different from the previously reported fullerenes found using Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spec-trometry (MALDI-TOF-MS). | Fengfu Fu Liangjun Xu Wei Ye Yiquan Chen Mingyu Jiang Xueqin Xu | 2006 | China Particuology2006，4，6： | 1 |
| 11 | Ultra-low-loss multi-layer 8×8 microring optical switch显示文摘Microring-based optical switches are promising for wavelength-selective switching with the merits of compact size and low power consumption.However,the large insertion loss,the high fabrication,and the temperature sensitivity hinder the scalability of silicon microring optical switch fabrics.In this paper,we utilize a three-dimensional(3D)microring-based optical switch element(SE)on a multi-layer Si_(3)N_(4)-on-SOI platform to realize highperformance large-scale optical switch fabrics.The 3D microring-based SE consists of a Si∕Si_(3)N_(4) waveguide overpass crossing in the bottom and the top layers,and Si_(3)N_(4) dual-coupled microring resonators(MRRs)in the middle layer.The switch is calibration-free and has low insertion loss.With the 3D microring-based SEs,we implement an 8×8 crossbar optical switch fabric.As the resonance wavelengths of all SEs are well aligned,only one SE needs to be turned on in each routing path,which greatly reduces the complexity of the switch control.The optical transmission spectra show a box-like shape,with a passband width of~69 GHz and an average on-state loss of~0.37 dB.The chip has a record-low on-chip insertion loss of 0.52-2.66 dB.We also implement a non-duplicate polarization-diversity optical switch by using the bidirectional transmission characteristics of the crossbar architecture,which is highly favorable for practical applications.100 Gb/s dual-polarization quadrature-phase-shift-keying(DP-QPSK)signal is transmitted through the switch without significant degradation.To the best of our knowledge,this is the first time that 3D MRRs have been used to build highly scalable polarization-diversity optical switch fabrics. | XIN LI WEI GAO LIANGJUN LU JIANPING CHEN LINJIE ZHOU | 2023 | Photonics Research2023，11，5： | 0 |
| 12 | Research and Measures on the Security of Internet of Things显示文摘With the development of intelligent perception,recognition technology and pervasive computing,Internet of things( IoT) is widely used,the security problem is also concerned by more and more researchers. IoT is a double-edged sword. On the one hand,it has great potential in simplifying the business process and provides an effective way for the enterprise to interact with the customers. But on the other hand,it also provides convenience for cyber crimes and hackers.First of all,Three layers logic architecture of IoT is introduced,and the security problems at each level and the key points of the research are expounded,and then the security requirements are analyzed. The main causes of security problems are summarized and analyzed: physical attack and the threat of equipment and malware,file attack and hacker attack. Finally,through the application of the existing technology in IoT environment,the exploration of new technology and the security of the hardware related to IoT,the security of the software and the security team,the future research direction of the security of IoT is pointed out. | HU Liangjun WEI Daode LI Xiaofeng WANG Hongmei SONG Rui | 2018 | International Journal of Plant Engineering and Management2018，23，3： | 0 |
| 13 | Total pelvic exenteration and a new model of diversion for giant primitive neuroectodermal tumor of prostate: A case report and review of the literature显示文摘The present study reports a rare primitive neuroectodermal tumor (PNET) of prostate.A 27-year-old male was admitted to Harbin Medical University Cancer Hospital (Harbin,China) for dysuria and dyschezia. Magnetic resonance imaging (MRI) revealed a large mass thatmay involve the bladder and rectum next to the prostate. Histopathological analysis of biopsyof prostate indicated mesenchymal origin tumor, and immunohistochemistric stainingconfirmed diagnosis of PNET of prostate. En bloc total pelvic exenteration and double barrelsigmoidostomy were performed. Double stomas in the skin incision were used for fecal andurinary diversion, respectively. Short-term outcome is satisfactory, while long-term efficacyremains to be poor. Clinical features of PNET of prostate should be paid much more attentionand radical surgery and adjuvant chemotherapy should be recommended. | Lichen Teng Liangjun Wei Li Li Yongpeng Xu Yongsheng Chen Yan Cao Wentao Wang Changfu Li | 2020 | Asian Journal of Urology2020，7，2： | 0 |
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