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| 1 | De novo characterization of the root transcriptome of a traditional Chinese medicinal plant Polygonum cuspidatum显示文摘Various active components have been extracted from the root of Polygonum cuspidatum.However,the genetic basis for their activity is virtually unknown.In this study,25600002 short reads (2.3 Gb) of P.cuspidatum root transcriptome were obtained via Illumina HiSeq 2000 sequencing.A total of 86418 unigenes were assembled de novo and annotated.Twelve,18,60 and 54 unigenes were respectively mapped to the mevalonic acid (MVA),methyl-D-erythritol 4-phosphate (MEP),shikimate and resveratrol biosynthesis pathways,suggesting that they are involved in the biosynthesis of pharmaceutically important anthraquinone and resveratrol.Eighteen potential UDP-glycosyltransferase unigenes were identified as the candidates most likely to be involved in the biosynthesis of glycosides of secondary metabolites.Identification of relevant genes could be important in eventually increasing the yields of the medicinally useful constituents of the P.cuspidatum root.From the previously published transcriptome data of 19 non-model plant taxa,1127 shared orthologs were identified and characterized.This information will be very useful for future functional,phylogenetic and evolutionary studies of these plants. | HAO DaCheng MA Pei MU Jun CHEN ShiLin XIAO PeiGen PENG Yong HUO Li XU LiJia SUN Chao | 2012 | Science China(Life Sciences)2012，55，5： | 36 |
| 2 | Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats显示文摘AIM:To investigate the effects of blueberry on hepatic fibrosis and NF-E2-related factor 2(Nrf2) transcription factor in rats.METHODS:Forty-five male Sprague-Dawley rats were randomly divided into control group(A);CCl4-induced hepatic fibrosis group(B);blueberry prevention group(C);Dan-shao-hua-xian capsule(DSHX) prevention group(D);and blueberry + DSHX prevention group(E).Liver fibrosis was induced in rats by subcutaneous injection of CCl4 and a high-lipid/low-protein diet for 8 wk(except the control group).The level of hyaluronic acid(HA) and alanine aminotransferase(ALT) in serum was examined.The activity of superoxide dismutase(SOD),glutathione-S-transferase(GST) and malondialdehyde(MDA) in liver homogenates was determined.The degree of hepatic fibrosis was evaluated by hematoxylin and eosin and Masson staining.Expression of Nrf2 and NADPH quinone oxidoreductase 1(Nqo1) was detected by real-time reversed transcribed-polymerase chain reaction,immunohistochemical techniques,and western blotting.RESULTS:Compared with group B,liver indices,levels of serum HA and ALT of groups C,D and E were reduced(liver indices:0.038 ± 0.008,0.036 ± 0.007,0.036 ± 0.005 vs 0.054 ± 0.009,P<0.05;HA:502.33 ± 110.57 ng/mL,524.25 ± 255.42 ng/mL,499.25 ± 198.10 ng/mL vs 828.50 ± 237.83 ng/mL,P<0.05;ALT:149.44 ± 16.51 U/L,136.88 ± 10.07 U/L,127.38 ± 11.03 U/L vs 203.25 ± 31.62 U/L,P<0.05),and SOD level was significantly higher,but MDA level was lower,in liver homogenates(SOD:1.36 ± 0.09 U/mg,1.42 ± 0.13 U/mg,1.50 ± 0.15 U/mg vs 1.08 ± 0.19 U/mg,P<0.05;MDA:0.294 ± 0.026 nmol/mg,0.285 ± 0.025 nmol/mg,0.284 ± 0.028 nmol/mg vs 0.335 ± 0.056 nmol/mg,P<0.05).Meanwhile,the stage of hepatic fibrosis was significantly weakened(P<0.05).Compared with group A,the activity of GST liver homogenates and expression levels of Nrf2 and Nqo1 in group B were elevated(P<0.05).The expression level of Nrf2 and Nqo1 in groups C,D,and E were increased as compared with group B,but the difference was not significant.CONCLUSION:Blueberry has preventive and protective effects on CCl4-induced hepatic fibrosis by reducing hepatocyte injury and lipid peroxidation.However,these effects may not be related to the activation of Nrf2 during long-term of CCl4. | Wang, Yu-Ping Cheng, Ming-Liang Zhang, Bao-Fang Mu, Mao Wu, Jun | 2010 | World Journal of Gastroenterology2010，16，21： | 19 |
| 3 | Inorganic Phosphorus Fractions and Phosphorus Availability in a Calcareous Soil Receiving 21-Year Superphosphate Application显示文摘A long-term (21-year) field experiment was performed to study the responses of soil inorganic P fractions and P availability to annual fertilizer P application in a calcareous soil on the Loess Plateau of China. Soil Olsen-P contents increased by 3.7, 5.2, 11.2 and 20.6 mg P kg-1 after 21-year annual fertilizer P application at 20, 39, 59, and 79 kg P ha-1, respectively. Long-term fertilizer P addition also increased soil total P and inorganic P (Pi) contents significantly. The contents of inorganic P fractions were in the order of Ca10-P > Ca8-P > Fe-P > Al-P > occluded P > Ca2-P in the soil receiving annual fertilizer P application. Fertilizer P application increased Ca8-P, Al-P and Ca2-P contents as well as their percentages relative to Pi. Pi application increased Fe-P and occluded P contents but nor their percentages. Soil Ca10-P content remained unchanged after fertilizer P application while its percentage relative to Pi declined with increasing fertilizer P rate. All Pi fractions but Ca10-P were correlated with Olsen-P significantly. 90% of variations in Olsen-P could be explained by Pi fractions, and the direct contribution of Ca8-P was predominant. Long-term annual superphosphate application would facilitate the accumulation of soil Ca8-P, and thus improve soil P availability. | WANG Jun LIU Wen-Zhao MU Han-Feng DANG Ting-Hui | 2010 | Pedosphere2010，20，3： | 16 |
| 4 | Effect of blueberry on hepatic and immunological functions in mice显示文摘BACKGROUND:Conventional drugs used in the treatment and prevention of liver diseases often have side effects,therefore research into natural substances are of significance.This study examined the effects of blueberry on liver protection and cellular immune functions. METHODS:To determine the effects of blueberry on liver protective function,male mice were orally administered blueberry(0.6 g/10 g)or normal saline for 21 days.Hepatic RNA was extracted by Trizol reagent,and the expression of Nrf2,HO-1,and Nqo1 was determined by real-time RT- PCR.Superoxide dismutase(SOD)and malondialdehyde (MDA)in liver homogenate were determined,and liver index was measured.To assess the effects of blueberry on cellular immune function,male mice received blueberry(0.4,0.6,or 0.8 g/10 g)for 35 days,and the percentages of CD3 + ,CD4 + ,and CD8 + T lymphocyte subgroups in peripheral blood were detected by flow cytometry,the index of the thymus and spleen was measured,and lymphocyte proliferation in the spleen was determined by MTT assay. RESULTS:Blueberry treatment significantly increased the expression of Nrf2,HO-1,and Nqo1,the important antioxidant components in the liver.Hepatic SOD in the blueberry group was higher and MDA was lower than that in the control group (P<0.05).Blueberry also increased the index of the spleen and enhanced the proliferation of lymphocytes of the spleen (P<0.05).The percentages of the CD3 + and CD4 + T lymphocyte subsets and the CD4 + /CD8 + ratio were also increased by blueberry(P<0.05). CONCLUSIONS:Blueberry induces expression of Nrf2,HO-1,and Nqo1,which can protect hepatocytes from oxidative stress. In addition,blueberry can modulate T-cell function in mice. | Wang, Yu-Ping Cheng, Ming-Liang Zhang, Bao-Fang Mu, Mao Zhou, Ming-Yu Wu, Jun Li, Cheng-Xiu | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，2： | 15 |
| 5 | High salt primes a specific activation state of macrophages, M(Na)显示文摘 | Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan | 2015 | Cell Research2015，25，8： | 15 |
| 6 | Ginsenoside Rg1 enhances the resistance of hematopoietic stem/progenitor cells to radiation- induced aging in mice显示文摘 | Cui CHEN Xin-yi MU Yue ZHOU Ke SHUN Shan GENG Jun LIU Jian-wei WANG Jie CHEN Tin-yu LI Ya-ping WANG | 2014 | Acta Pharmacologica Sinica2014，35，1： | 15 |
| 7 | Radiofrequency deep hyperthermia combined with chemotherapy in the treatment of advanced non-small cell lung cancer显示文摘Background:In the era of precision medicine,chemotherapy is still considered the cornerstone of treatment for lung cancer patients without gene mutations.How to reduce the toxicity and increase the efficiency of chemotherapy is worth exploring.This study aimed to investigate the curative effects and safety of hyperthermia combined with chemotherapy(HCT)for advanced patients with non-small cell lung cancer(NSCLC),especially those with malignant pleural effusion.Methods:We retrospectively evaluated medical records of 93 patients with advanced NSCLC(stage IIIB-IV)from March 2011 to January 2014.The patients were divided into HCT and chemotherapy(CT)groups.The HCT group was treated with gemcitabine and cisplatin(GP)regimen combined with regional radiofrequency deep hyperthermia,while the CT group was treated with GP regimen only.Those with malignant pleural effusion extra underwent thoracentesis and intrapleural injection chemotherapy combined with hyperthermic or not.Clinical treatment results and adverse reactions were compared and analyzed after treatment.SPSS 19.0 software(SPSS Inc.,USA)was used for statistical data processing.P values less than 0.05 were accepted to be statistically significant.Results:Among the 93 patients,HCT group included 48 patients(16 patients with malignant pleural effusion),CT group included 45 patients(10 patients with malignant pleural effusion).There was no significant difference between the two groups in patient characteristics.The overall response rate(ORR)of pleural effusions was much better in HCT group than that in CT group(81.2%vs.40.0%,P=0.046).The patients in HCT group had lower incidence rate of weakness(12.5%us.46.7%,χ^2=13.16,P<0.001)and gastrointestinal(25.0%vs.77.8%,χ^2=25.88,P<0.001)adverse reactions than that in CT group.The objective tumor response and survival showed no significant differences.Conclusions:Hyperthermia combined with chemotherapy might lead to the development of better therapeutic strategy for advanced NSCLC with malignant pleural effusion patients.Also,it could greatly reduce the chemotherapy toxic effects in the incidence of weakness and gastrointestinal adverse reactions in advanced NSCLC patients. | Wen-Hui Yang Jun Xie Zhi-Yong Lai Mu-Dan Yang Ge-Hong Zhang Yuan Li Jian-Bing Mu Jun Xu | 2019 | Chinese Medical Journal2019，，8： | 15 |
| 8 | Hepatitis B surface antigen clearance in inactive hepatitis B surface antigen carriers treated with peginterferon alfa-2a显示文摘AIM: To examine the association between interferon(IFN) therapy and loss of hepatitis B surface antigen(HBs Ag) in inactive HBs Ag carriers. METHODS: This was a retrospective cohort study in inactive HBs Ag carriers, who were treatment-naive, with a serum HBs Ag level < 100 IU/m L and an undetectable hepatitis B virus(HBV) DNA level(< 100 IU/m L). All the 20 treated patients received subcutaneous PEG-IFN alfa-2a 180 μg/wk for 72 wk and were then followed for 24 wk. There were 40 untreated controls matched with 96 wk of observation. Serum HBs Ag, HBV DNA, and alanine aminotransferases were monitored every 3 mo in the treatment group and every 3-6 mo in the control group. RESULTS: Thirteen(65.0%) of 20 treated patients achieved HBs Ag loss, 12 of whom achieved HBs Ag seroconversion. Mean HBs Ag level in treated patients decreased to 6.69 ± 13.04 IU/m L after 24 wk of treatment from a baseline level of 26.22 ± 33.00 IU/m L. Serum HBV DNA level remained undetectable(< 100 IU/m L) in all treated patients during the study. HBs Ag level of the control group decreased from 25.72 ± 25.58 IU/m L at baseline to 17.11 ± 21.62 IU/m L at week 96(P = 0.108). In the control group, no patient experienced HBs Ag loss/seroconversion, and two(5.0%) developed HBV reactivation.CONCLUSION: IFN treatment results in HBs Ag loss and seroconversion in a considerable proportion of inactive HBs Ag carriers with low HBs Ag concentrations. | Ming-Hui Li Yao Xie Lu Zhang Yao Lu Ge Shen Shu-Ling Wu Min Chang Cai-Qin Mu Lei-Ping Hu Wen-Hao Hua Shu-Jing Song Shu-Feng Zhang Jun Cheng Dao-Zhen Xu | 2016 | World Journal of Hepatology2016，8，15： | 15 |
| 9 | Anatomy and influence of the splenic artery in laparoscopic spleen-preserving splenic lymphadenectomy显示文摘AIM: To investigate the splenic hilar vascular anatomy and the influence of splenic artery(Sp A) type in laparoscopic total gastrectomy with spleen-preserving splenic lymphadenectomy(LTGSPL).METHODS:The clinical anatomy data of 317 patients with upper- or middle-third gastric cancer who underwent LTGSPL in our hospital from January 2011 to December 2013 were collected. The patients were divided into two groups(concentrated group vs distributed group) according to the distance between the splenic artery's furcation and the splenic hilar region. Then, the anatomical layout, clinicopathologic characteristics, intraoperative variables, and postoperative variables were compared between the two groups.RESULTS: There were 205 patients with a concentrated type(64.7%) and 112 patients with a distributed type(35.3%) Sp A. There were 22 patients(6.9%) with a single branch of the splenic lobar vessels, 250(78.9%) with 2 branches, 43(13.6%) with 3 branches, and 2 patients(0.6%) with multiple branches. Eighty sevenpatients(27.4%) had type?Ⅰ?splenic artery trunk, 211(66.6%) had type Ⅱ, 13(4.1%) had type Ⅲ, and 6(1.9%) had type Ⅳ. The mean splenic hilar lymphadenectomy time(23.15 ± 8.02 vs 26.21 ± 8.84 min; P = 0.002), mean blood loss resulting from splenic hilar lymphadenectomy(14.78 ± 11.09 vs 17.37 ± 10.62 m L; P = 0.044), and number of vascular clamps used at the splenic hilum(9.64 ± 2.88 vs 10.40 ± 3.57; P = 0.040) were significantly lower in the concentrated group than in the distributed group. However, the mean total surgical time, mean total blood loss, and the mean number of harvested splenic hilar lymph nodes were similar in both groups(P > 0.05 for each comparison). There were also no significant differences in clinicopathological and postoperative characteristics between the groups(P > 0.05).CONCLUSION: It is of value for surgeons to know the splenic hilar vascular anatomy when performing LTGSPL. Patients with concentrated type Sp A may be optimal patients for training new surgeons. | Chao-Hui Zheng Mu Xu Chang-Ming Huang Ping Li Jian-Wei Xie Jia-Bin Wang Jian-Xian Lin Jun Lu Qi-Yue Chen Long-Long Cao Mi Lin | 2015 | World Journal of Gastroenterology2015，21，27： | 14 |
| 10 | Comparative study of minimally invasive versus open esophagectomy for esophageal cancer in a single cancer center显示文摘 | Mu Juwei Yuan Zuyang Zhang Baihua Li Ning Lyu Fang Mao Yousheng Xue Qi Gao Shugeng Zhao Jun Wang Dali Li Zhishan Gao Yushun Zhang Liangze Huang Jinfeng Shao Kang Feng Feiyue Zhao Liang Li Jian Cheng Guiyu Sun Kelin He Jie | 2014 | Chinese Medical Journal2014，，4： | 13 |
| 11 | A Matched Comparison Study of Uniportal Versus Triportal Thoracoscopic Lobectomy and Sublobectomy for Early-stage Nonsmall Cell Lung Cancer显示文摘 | Ju-Wei Mu Shu-Geng Gao Qi Xue Jun Zhao Ning Li Kun Yang Kai Su Zhu-Yang Yuan Jie He | 2015 | Chinese Medical Journal2015，，20： | 12 |
| 12 | Neural stem cells:mechanisms and modeling显示文摘In the adult brain,neural stem cells have been found in two major niches:the hippocampus and the olfactory bulb.Neurons derived from these stem cells contribute to learning,memory,and the autonomous repair of the brain under pathological conditions.Hence,the physi-ology of adult neural stem cells has become a signifi-cant component of research on synaptic plasticity and neuronal disorders.In addition,the recently developed induced pluripotent stem cell technique provides a powerful tool for researchers engaged in the patho-logical and pharmacological study of neuronal disor-ders.In this review,we briefly summarize the research progress in neural stem cells in the adult brain and in the neuropathological application of the induced pluripotent stem cell technique. | Jun Yao Yangling Mu Fred H.Gage | 2012 | Protein & Cell2012，3，4： | 12 |
| 13 | Inflammatory biomarkers and cerebral small vessel disease:a community-based cohort study显示文摘Background and purpose Although inflammation has been proposed to be a candidate risk factor for cerebral small vessel disease(CSVD),previous findings remain largely inconclusive and vary according to disease status and study designs.The present study aimed to investigate possible associations between inflammatory biomarkers and MRI markers of CSVD.Methods A group of 15 serum inflammatory biomarkers representing a variety of those putatively involved in the inflammatory cascade was grouped and assessed in a cross-sectional study involving 960 stroke-free subjects.The biomarker panel was grouped as follows:systemic inflammation(high-sensitivity C reactive protein(hsCRP),interleukin 6 and tumour necrosis factorα),endothelial-related inflammation(E-selectin,P-selectin,intercellular adhesion molecule 1,vascular cell adhesion molecule 1(VCAM-1),CD40 ligand,lipoprotein-associated phospholipase A2,chitinase-3-like 1 protein and total homocysteine(tHCY))and media-related inflammation(matrix metalloproteinases 2,3 and 9,and osteopontin).The association(s)between different inflammatory groups and white matter hyperintensity(WMH),lacunes,cerebral microbleeds(CMBs),enlarged perivascular space(PVS)and the number of deep medullary veins(DMVs)were investigated.Results High levels of serum endothelial-related inflammatory biomarkers were associated with both increased WMH volume(R^(2)=0.435,p=0.015)and the presence of lacunes(R^(2)=0.254,p=0.027).Backward stepwise elimination of individual inflammatory biomarkers for endothelial-related biomarkers revealed that VCAM-1 was significant for WMH(β=0.063,p=0.005)and tHCY was significant for lacunes(β=0.069,p<0.001).There was no association between any group of inflammatory biomarkers and CMBs or PVS.Systemic inflammatory biomarkers were associated with fewer DMVs(R^(2)=0.032,p=0.006),and backward stepwise elimination of individual systemic-related inflammatory biomarkers revealed that hsCRP(β=−0.162,p=0.007)was significant.Conclusion WMH and lacunes were associated with endothelial-related inflammatory biomarkers,and fewer DMVs were associated with systemic inflammation,thus suggesting different underlying inflammatory processes and mechanisms. | Ding-Ding Zhang Yuan Cao Jing-Yu Mu Yi-Ming Liu Feng Gao Fei Han Fei-Fei Zhai Li-Xin Zhou Jun Ni Ming Yao Ming-Li Li Zheng-Yu Jin Shu-Yang Zhang Li-Ying Cui Yong Shen Yi-Cheng Zhu | 2022 | Stroke & Vascular Neurology2022，7，4： | 11 |
| 14 | Updated experiences with minimally invasive Mc Keown esophagectomy for esophageal cancer显示文摘AIM: To update our experiences with minimally invasive Mc Keown esophagectomy for esophageal cancer.METHODS: we retrospectively reviewed the medical records of 445 consecutive patients who underwent minimally invasive Mc Keown esophagectomy between January 2009 and July 2015 at the Cancer Hospital of Chinese Academy of Medical Sciences and used 103 patients who underwent open Mc Keown esophagectomy in the same period as controls. Among 375 patients who underwent total minimally invasive Mc Keown esophagectomy, 180 in the early period were chosen for the study of learning curve of total minimally invasive Mc Keown esophagectomy. These 180 minimally invasive Mc Keown esophagectomies performed by five surgeons were divided into three groups according to time sequence as group 1(n = 60), group 2(n = 60) and group 3(n = 60).RESULTS: Patients who underwent total minimally invasive Mc Keown esophagectomy had significantly less intraoperative blood loss than patients who underwent hybrid minimally invasive Mc Keown esophagectomy or open Mc Keown esophagectomy(100 ml vs 300 ml vs 200 ml, P = 0.001). However, there were no significant differences in operation time, number of harvested lymph nodes, or postoperative morbidity includingincidence of pulmonary complication and anastomotic leak between total minimally invasive Mc Keown esophagectomy, hybrid minimally invasive Mc Keown esophagectomy and open Mc Keown esophagectomy groups. There were no significant differences in 5-year survival between these three groups(60.5% vs 47.9% vs 35.6%, P = 0.735). Patients in group 1 had significantly longer duration of operation than those in groups 2 and 3. There were no significant differences in intraoperative blood loss, number of harvested lymph nodes, or postoperative morbidity including incidence of pulmonary complication and anastomotic leak between groups 1, 2 and 3.CONCLUSION: Total minimally invasive Mc Keown esophagectomy was associated with reduced intraoperative blood loss and comparable short term and long term survival compared with hybrid minimally invasive Mc Keown esophagectomy or open Mckeown esophagectomy. At least 12 cases are needed to master total minimally invasive Mc Keown esophagectomy in a high volume center. | Ju-wei Mu Shu-geng gao Qi Xue You-Sheng Mao Da-li wang Jun Zhao Yu-Shun gao Jin-feng Huang Jie He | 2015 | World Journal of Gastroenterology2015，21，45： | 10 |
| 15 | Concentrations and gas-particle partitioning of PCDD/Fs in the urban air of Dalian,China显示文摘PCDD/Fs in the urban air of Dalian,China were monitored with high-volume active sampler from November 2009 to October 2010.The concentration of Cl 4-8 DD/Fs ranged from 3065 to 49538 fg m-3,with an average of 10249 fg m-3.The international toxic equivalents(I-TEQ) value of that was 61.8 1182 fg m-3,with an average of 235 fg m-3,which was comparable to those in the other urban locations around the world.It was found that the Cl 4 8 DD/Fs appeared to be present mainly in the particle phase during winter,spring and autumn,while during summer which were dominantly in gas phase.The ratio of Cl 4-8 DD/Fs present in particle phase increased with the increasing level of chlorination.The concentrations of PCDFs and PCDDs decreased with the increase of chlorinated level,while the concentrations of 2,3,7,8-PCDDs congeners increased with the increase of chlorination level.The homolog profiles of the concentrations of PCDFs presented were higher than those of the PCDDs,which indicated the PCDD/Fs pollution source of the air in Dalian was characteristic for thermal source pollution.The correlation analysis of meteorological parameters with the concentrations of Cl 4-8 CDD/Fs was conducted using SPSS packages,and it was found that the ambient temperature and atmospheric pressure were important factors influence the concentration of PCDD/Fs in the air.The respiratory risk and intake dioxins of the residents around the sampling sites were studied in the paper.It was found that Junge-Pankow model was much more accurate in predicting the gas-particle partitioning behavior of PCDD/Fs homologues during winter,while the Harner-Bidleman model shows better agreement with the measured data during winter and summer. | QIN SongTao ZHU XiuHua WANG Wei CHEN JiPing NI YuWen LI XiaoXiao MU Jun Xu Qian SCHRAMM Karl-Werner | 2012 | Chinese Science Bulletin2012，57，26： | 10 |
| 16 | Preventing DC Over-voltage in Multi-terminal HVDC Transmission显示文摘This paper is concerned with power reduction control which is used to avoid DC over-voltage for multiterminal HVDC transmission of offshore wind power.Voltages and frequencies of offshore AC wind farm networks are used for transmitting control signals for the power reduction control.These methods do not require fast communication.Power reduction sharing among the offshore wind farms using the different control signals is analysed.The control systems are also compared against the DC chopper method to prevent a DC overvoltage.Simulation and experiments are carried out to evaluate the control systems. | Oluwole D.Adeuyi Marc Cheah-Mane Jun Liang Luke Livermore Qing Mu | 2015 | CSEE Journal of Power and Energy Systems2015，1，1： | 9 |
| 17 | Permian integrative stratigraphy and timescale of China显示文摘A series of global major geological and biological events occurred during the Permian Period. Establishing a highresolution stratigraphic and temporal framework is essential to understand their cause-effect relationship. The official International timescale of the Permian System consists of three series(i.e., Cisuralian, Guadalupian and Lopingian in ascending order) and nine stages. In China, the Permian System is composed of three series(Chuanshanian, Yansingian and Lopingian) and eight stages, of which the subdivisions and definitions of the Chuanshanian and Yangsingian series are very different from the Cisuralian and Guadalupian series. The Permian Period spanned ~47 Myr. Its base is defined by the First Appearance Datum(FAD) of the conodont Streptognathodus isolatus at Aidaralash, Kazakhstan with an interpolated absolute age 298.9±0.15 Ma at Usolka, southern Urals, Russia. Its top equals the base of the Triassic System and is defined by the FAD of the conodont Hindeodus parvus at Meishan D section, southeast China with an interpolated absolute age 251.902±0.024 Ma. Thirty-five conodont, 23 fusulinid, 17 radiolarian and 20 ammonoid zones are established for the Permian in China, of which the Guadalupian and Lopingian conodont zones have been served as the standard for international correlation. The Permian δ13 Ccarbtrend indicates that it is characterized by a rapid negative shift of 3–5‰ at the end of the Changhsingian, which can be used for global correlation of the end-Permian mass extinction interval, but δ13 Ccarbrecords from all other intervals may have more or less suffered subsequent diagenetic alteration or represented regional or local signatures only. Permian δ18 Oapatitestudies suggest that an icehouse stage dominated the time interval from the late Carboniferous to Kungurian(late Cisuralian). However, paleoclimate began to ameriolate during the late Kungurian and gradually shifted into a greenhouse-dominated stage during the Guadalupian.The Changhsingian was a relatively cool stage, followed by a globally-recognizable rapid temperature rise of 8–10°C at the very end of the Changhsingian. The87 Sr/86 Sr ratio trend shows that their values at the beginning of the Permian were between 0.70800,then gradually decreased to the late Capitanian minimum 0.70680–0.70690, followed by a persistent increase until the end of the Permian with the value 0.70708. Magenetostratigraphy suggests two distinct stages separated by the Illawarra Reversal in the middle Wordian, of which the lower is the reverse polarity Kiaman Superchron and the upper is the mixed-polarity Illawarra Superchron. The end-Guadalupian(or pre-Lopingian) biological crisis occurred during the late Capitanian, when faunal changeovers of different fossil groups had different paces, but generally experienced a relatively long time from the Jinogondolella altudensis Zone until the earliest Wuchiapingian. The end-Permian mass extinction was a catastrophic event that is best constrained at the Meishan section, which occurred at 251.941±0.037 Ma and persisted no more than 61±48 kyr. After the major pulse at Bed 25, the extinction patterns are displayed differently in different sections. The global end-Guadalupian regression is manifested between the conodont Jinogondolella xuanhanensis and Clarkina dukouensis zones and the endChanghsingian transgression began in the Hindeodus changxingensis-Clarkina zhejiangensis Zone. The Permian Period is also characterized by strong faunal provincialism in general, which resulted in difficulties in inter-continental and inter-regional correlation of both marine and terrestrial systems. | Shuzhong SHEN Hua ZHANG Yichun ZHANG Dongxun YUAN Bo CHEN Weihong HE Lin MU Wei LIN Wenqian WANG Jun CHEN Qiong WU Changqun CAO Yue WANG Xiangdong WANG | 2019 | Science China Earth Sciences2019，62，1： | 9 |
| 18 | Distinct element method analysis and field experiment of soil resistance applied on the subsoiler显示文摘Since the design of the subsoiler is a complex work,the interaction between the subsoiler and soil was investigated by using Distinct Element Method(DEM)in this study.Based on the traditional discrete element theory,the 3D model of soil particles and the subsoiler were established after considering the liquid bridge force between soil particles.The operating resistance curves of the subsoiler were achieved after the DEM simulation at a speed of 1 m/s,and three depths of 180 mm,220 mm and 260 mm,respectively.The simulation curves agreed well with the field experimental results based on relative errors of 2.96%,14.95%and 7.15%,respectively,at three depths.All these data proved that it was feasible and favorable to analyze the performance of the subsoiler by using the DEM and it is of important significance for studying and further optimizing the structure of the subsoiler. | Li Bo Liu Fanyi Mu Junying Chen Jun Han Wenting | 2014 | International Journal of Agricultural and Biological Engineering2014，7，1： | 9 |
| 19 | F-structure model of overlying strata for dynamic disaster prevention in coal mine显示文摘The rupture and movement scope of overlying strata upon the longwall mining face increased sharply as the exploitation scale and degree growing recently,and the spatial structure formed by fractured strata became much more complex.The overlying strata above the working face and adjacent gobs would affect each other and move cooperatively because small pillar can hardly separate the connection of overlying strata between two workfaces,which leads to mining seismicity in the gob and induces rockburst disaster that named spatial structure instability rockburst in this paper.Based on the key stratum theory,the F-structure model was established to describe the overlying strata characteristic and rockburst mechanism of workface with one side of gob and the other side un-mined solid coal seam.The results show that F-structure in the gob will re-active and loss stability under the influence of neighboring mining,and fracture and shear slipping in the process of instability is the mechanism of the seismicity in the gob.The F-structure was divided into two categories that short-arm F and long-arm F structure based on the state of strata above the gob.We studied the underground pressure rules of different F-structure and instability mechanism,thus provide the guide for prevention and control of the F-structure spatial instability rockburst.The micro-seismic system is used for on-site monitoring and researching the distribution rules of seismic events,the results confrmed the existence and correct of F-spatial structure.At last specialized methods for prevention seismicity and rockburst induced by F-structure instability are proposed and applied in Huating Coal Mine. | Mu Zonglong Dou Linming He Hu Fan Jun | 2013 | International Journal of Mining Science and Technology2013，23，4： | 8 |
| 20 | Optimizing SSR-PCR system of Panax ginseng by orthogonal design显示文摘An orthogonal design was used to optimize SSR-PCR amplification system using Panax ginseng genomic DNA as template. Four levels of five factors (DNA template, Taq DNA polymerase, Mg^(2+), primer, and dNTP) and annealing temperature have been tested separately in this system. The results demonstrated the reaction efficiency was affected by these factors. Based on the results, a stable, productive and reproducible PCR system and cycling program for amplifying a ginseng SSR locus were obtained: 20 μL system containing 1.0 U Taq DNA polymerase, 2.0 mmol·L^(-1) Mg^(2+), 0.2 mmol·L^(-1) dNTPs, 0.3 μmol·L^(-1) SSR primer, 60 ng·μL^(-1) DNA template, performed with a program of 94°C for 5 min, 94°C for 30 s, annealing at 56.3°C for 30 s, 72°C for 1 min, 37 cycles, finishing at 72°C for 7 min, and storing at 4°C. | YANG Tian-tian MU Li-qiang WANG Jun | 2007 | Journal of Forestry Research2007，18，1： | 8 |
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