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| 1 | Bone Morphogenetic Protein (BMP) signaling in development and human diseases显示文摘Bone Morphogenetic Proteins(BMPs)are a group of signaling molecules that belongs to the Transforming Growth Factor-b(TGF-b)superfamily of proteins.Initially discovered for their ability to induce bone formation,BMPs are now known to play crucial roles in all organ systems.BMPs are important in embryogenesis and development,and also in maintenance of adult tissue homeostasis.Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects,highlighting the essential functions of BMPs.In this review,we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development.A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling. | Richard N.Wang Jordan Green Zhongliang Wang Youlin Deng Min Qiao Michael Peabody Qian Zhang Jixing Ye Zhengjian Yan Sahitya Denduluri Olumuyiwa Idowu Melissa Li Christine Shen Alan Hu Rex C.Haydon Richard Kang James Mok Michael J.Lee Hue L.Luu Lewis L.Shi | 2014 | Genes & Diseases2014，1，1： | 47 |
| 2 | Cervical cancer: Epidemiology, risk factors and screening显示文摘Cervical cancer is one of the leading causes of cancer death among females worldwide and its behavior epidemiologically likes a venereal disease of low infectiousness. Early age at first intercourse and multiple sexual partners have been shown to exert strong effects on risk. The wide differences in the incidence among different countries also influenced by the introduction of screening. Although the general picture remains one of decreasing incidence and mortality, there are signs of an increasing cervical cancer risk probably due to changes in sexual behavior. Smoking and human papillomavirus(HPV) 16/18 are currently important issues in a concept of multifactorial, stepwise carcinogenesis at the cervix uteri. Therefore, society-based preventive and control measures, screening activities and HPV vaccination are recommended. Cervical cancer screening methods have evolved from cell morphology observation to molecular testing. High-risk HPV genotyping and liquid-based cytology are common methods which have been widely recommended and used worldwide. In future, accurate,cheap, fast and easy-to-use methods would be more popular. Artificial intelligence also shows to be promising in cervical cancer screening by integrating image recognition with big data technology. Meanwhile, China has achieved numerous breakthroughs in cervical cancer prevention and control which could be a great demonstration for other developing and resource-limited areas. In conclusion, although cervical cancer threatens female health, it could be the first cancer that would be eliminated by human beings with comprehensive preventive and control strategy. | Shaokai Zhang Huifeng Xu Luyao Zhang Youlin Qiao | 2020 | Chinese Journal of Cancer Research2020，32，6： | 25 |
| 3 | Diversity characterization and association analysis of agronomic traits in a Chinese peanut (Arachis hypogaea L.) mini-core collection显示文摘Association mapping is a powerful approach for exploring the molecular basis of phenotypic variations in plants.A peanut(Arachis hypogaea L.)mini-core collection in China comprising 298 accessions was genotyped using 109 simple sequence repeat(SSR)markers,which identified 554 SSR alleles and phenotyped for 15 agronomic traits in three different environments,exhibiting abundant genetic and phenotypic diversity within the panel.A model-based structure analysis assigned all accessions to three groups.Most of the accessions had the relative kinship of less than 0.05,indicating that there were no or weak relationships between accessions of the mini-core collection.For 15 agronomic traits in the peanut panel,generally the Q t K model exhibited the best performance to eliminate the false associated positives compared to the Q model and the general linear model-simple model.In total,89SSR alleles were identified to be associated with 15 agronomic traits of three environments by the Q t K model-based association analysis.Of these,eight alleles were repeatedly detected in two or three environments,and 15 alleles were commonly detected to be associated with multiple agronomic traits.Simple sequence repeat allelic effects confirmed significant differences between different genotypes of these repeatedly detected markers.Our results demonstrate the great potential of integrating the association analysis and marker-assisted breeding by utilizing the peanut mini-core collection. | Huifang Jiang Li Huang Xiaoping Ren Yuning Chen Xiaojing Zhou Youlin Xia Jiaquan Huang Yong Lei Liying Yan Liyun Wan Boshou Liao | 2014 | Journal of Integrative Plant Biology2014，56，2： | 14 |
| 4 | A multicenter hospital-based diagnosis study of automated breast ultrasound system in detecting breast cancer among Chinese women显示文摘Objective: The automated breast ultrasound system(ABUS) is a potential method for breast cancer detection;however, its diagnostic performance remains unclear. We conducted a hospital-based multicenter diagnostic study to evaluate the clinical performance of the ABUS for breast cancer detection by comparing it to handheld ultrasound(HHUS) and mammography(MG).Methods: Eligible participants underwent HHUS and ABUS testing; women aged 40–69 years additionally underwent MG. Images were interpreted using the Breast Imaging Reporting and Data System(BI-RADS).Women in the BI-RADS categories 1–2 were considered negative. Women classified as BI-RADS 3 underwent magnetic resonance imaging to distinguish true-and false-negative results. Core aspiration or surgical biopsy was performed in women classified as BI-RADS 4–5, followed by a pathological diagnosis. Kappa values and agreement rates were calculated between ABUS, HHUS and MG.Results: A total of 1,973 women were included in the final analysis. Of these, 1,353(68.6%) and 620(31.4%)were classified as BI-RADS categories 1–3 and 4–5, respectively. In the older age group, the agreement rate and Kappa value between the ABUS and HHUS were 94.0% and 0.860(P<0.001), respectively; they were 89.2% and0.735(P<0.001) between the ABUS and MG, respectively. Regarding consistency between imaging and pathology results, 78.6% of women classified as BI-RADS 4–5 based on the ABUS were diagnosed with precancerous lesions or cancer; which was 7.2% higher than that of women based on HHUS. For BI-RADS 1–2, the false-negative rates of the ABUS and HHUS were almost identical and were much lower than those of MG.Conclusions: We observed a good diagnostic reliability for the ABUS. Considering its performance for breast cancer detection in women with high-density breasts and its lower operator dependence, the ABUS is a promising option for breast cancer detection in China. | Xi Zhang Xi Lin Yanjuan Tan Ying Zhu Hui Wang Ruimei Feng Guoxue Tang Xiang Zhou Anhua Li Youlin Qiao | 2018 | Chinese Journal of Cancer Research2018，30，2： | 13 |
| 5 | Existence of Classical Solutions to a Stationary Simplified Quantum Energy-Transport Model in 1-Dimensional Space显示文摘The existence of classical solutions to a stationary simplified quantum energytransport model for semiconductor devices in 1-dimensional space is proved.The model consists of a nonlinear elliptic third-order equation for the electron density,including a temperature derivative,an elliptic nonlinear heat equation for the electron temperature,and the Poisson equation for the electric potential.The proof is based on an exponential variable transformation and the Leray-Schauder fixed-point theorem. | Jianwei DONG Youlin ZHANG Shaohua CHENG | 2013 | Chinese Annals of Mathematics,Series B2013，34，5： | 9 |
| 6 | Running safety analysis of a train on the Tsing Ma Bridge under turbulent winds显示文摘The dynamic responses of the Tsing Ma suspension bridge and the running behaviors of trains on the bridge under turbulent wind actions are analyzed by a three-dimensional wind-train-bridge interaction model.This model consists of a spatial finite element bridge model, a train model composed of eight 4-axle identical coaches of 27 degrees-of-freedom, and a turbulent wind model.The fluctuating wind forces, including the buffeting forces and the self-excited forces, act on the bridge only, since the train runs inside the bridge deck.The dynamic responses of the bridge are calculated and some results are compared with data measured from Typhoon York.The runnability of the train passing through the Tsing Ma suspension bridge at different speeds is researched under turbulent winds with different wind velocities.Then, the threshold curve of wind velocity for ensuring the running safety of the train in the bridge deck is proposed, from which the allowable train speed at different wind velocities can be determined.The numerical results show that rail traffic on the Tsing Ma suspension bridge should be closed as the mean wind velocity reaches 30 m/s. | Guo Weiwei Xia He Xu Youlin | 2010 | Earthquake Engineering and Engineering Vibration2010，9，3： | 9 |
| 7 | 利用远震接收函数揭示的喜马拉雅东构造结台阵下方地壳结构及其动力学意义显示文摘在喜马拉雅造山带的东缘,雅鲁藏布江缝合带在这里发生急剧转折,南迦巴瓦变质体快速隆起,然而关于东构造结的形成机制一直未有定论.利用围绕南迦巴瓦峰的48个宽频带地震台站记录的远震数据提取P波接收函数,采用改进的H-κ叠加方法和共转换点叠加方法综合研究了东构造结的地壳厚度、波速比分布和地壳结构特征.结果表明:研究区平均地壳厚度为64.03 km,大部分台站介于60.48~66.55 km范围;平均波速比为1.728,主要集中范围为1.696~1.742.东构造结地壳厚度横向变化剧烈,构造结西端和北端厚而中间薄,东构造结核部Moho面呈现上隆的构造形态,东西向上隆幅度约为6~7 km,南北向的上隆超过9~10 km.东构造结核部地壳上隆减薄可能由高密度、高波速的岩石圈撕裂残片拆沉到上地幔软流圈后重力失衡所致.平均波速比超过1.8的高值异常展布于东构造结的两侧,推测为环东构造结的壳内部分熔融体.东构造结地壳上隆减薄和壳内部分熔融的存在很可能均与幔源热物质的上涌有关,而软流圈地幔的上涌则可能由印度板片的撕裂引起. | 彭淼 姜枚 Chen Youlin 谭捍东 李庆庆 张立树 许乐红 | 2017 | 地球物理学报2017，60，1： | 7 |
| 8 | Accuracy of triage strategies for human papillomavirus DNA-positive women in low-resource settings:A cross-sectional study in China显示文摘Objective: Care HPV is a human papillomavirus(HPV) DNA test for low-resource settings(LRS).This study assesses optimum triage strategies for care HPV-positive women in LRS.Methods: A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid(VIA),liquid-based cytology and HPV testing by physician-and self-collected care HPV,and physician-collected Hybrid Capture 2(HC2).Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary.HPV-positivity was defined as ≥1.0 relative light units/cutoff(RLU/CO) for both care HPV and HC2.Primary physician-HC2,physician-care HPV and self-care HPV and in sequential screening with cytology,VIA,or increased HPV test-positivity performance,stratified by age,were assessed for cervical intraepithelial neoplasia(CIN) grade 2/3 or worse(CIN2/3+) detection.Results: The sensitivities and specificities of primary HPV testing for CIN2+ were: 83.8%,88.1% for physiciancare HPV; 72.1%,88.2% for self-care HPV; and 97.1%,86.0% for HC2.Physician-care HPV test-positive women with VIA triage had a sensitivity of 30.9% for CIN2+ versus 80.9% with cytology triage.Self-care HPV testpositive women with VIA triage was 26.5% versus 66.2% with cytology triage.The sensitivity of HC2 test-positive women with VIA triage was 38.2% versus 92.6% with cytology triage.The sensitivity of physician-care HPV testing for CIN2+ decreased from 83.8% at ≥1.0 RLU/CO to 72.1% at ≥10.00 RLU/CO,while the sensitivity of selfcare HPV testing decreased from 72.1% at ≥1.0 RLU/CO to 32.4% at ≥10.00 RLU/CO; similar trends were seen with age-stratification.Conclusions: VIA and cytology triage improved specificity for CIN2/3 than no triage.Sensitivity with VIA triage was unsuitable for a mass-screening program.VIA provider training might improve this strategy.Cytology triage could be feasible where a high-quality cytology program exists.Triage of HPV test-positive women by increased test positivity cutoff adds another LRS triage option. | Margaret Wang Shangying Hu Shuang Zha o Wenhua Zhang Qinjing Pan Xun Zhang FengChen Jinxiu Han Junfei Ma Jennifer S.Smith Youlin Qiao Caihong Zhou Fanghui Zhao | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 9 | CFD–DEM–CVD multi-physical field coupling model for simulating particle coating process in spout bed显示文摘Particle coating is a very important step in many industrial production processes as the particle coating layers may fix surfaces with unique advantages. Given the limitation and disadvantages of the existing simulation methods, a coupled CFD–DEM–CVD multi-physical field model for particle-coating simulations has been established taking into account the velocity field, temperature field, concentration field, and deposition model. In this model, gas behavior and chemical reactions are simulated in the CFD frame based on the conservation laws of mass, momentum, and energy. The particle behavior is simulated in the DEM frame based on the gas–solid interphase force model and contact force model. The deposition behavior is simulated in the CVD frame based on the particle movement–adhesion–deposition model. The coupled model can be implemented in Fluent-EDEM software with their user definition function and application programming interface. The particle coating process involving the pyrolysis of acetylene was investigated, and the effect of bed temperature and inlet gas velocity on deposition rate and coating efficiency were investigated based on the proposed model with adjustable deposition coefficients. Both the average deposition layer mass and the average deposition layer thickness were found to be proportional to the elapsed time and increased at the rate of about 1.05 × 10^-2 mg/s and 3.45 × 10^-4 mm/s, respectively, setting the inlet gas velocity to 11 m/s and bed temperature to 1680 K. A higher temperature and larger inlet gas velocity lead to a larger deposition rate, but the coating efficiency decreases because of limits imposed by the chemical reaction. At a bed temperature of 1280 K, the average deposition rate is 7.40 × 10?3 mg/s when the inlet gas velocity is set to 11 m/s, which is about double the deposition rate when the inlet gas velocity is set as 5 m/s. The proposed model can provide some guidance for the operating conditions and parameters design of the spouted bed in actual coating settings and can also be further developed as a basic model of mechanisms to integrate detailed information across multiple scales. | Malin Liu Meng Chen Tianjin Li Yaping Tang Rongzheng Liu Youlin Shao Bing Liu Jiaxing Chang | 2019 | Particuology2019，17，1： | 6 |
| 10 | Tunable Curie temperature and magnetocaloric effect of FeCrMoCBYNi bulk metallic glass with different crystallized phases显示文摘The investigation on Curie temperature and magnetocaloric effect of the FeCrMoCBYNi bulk metallic glass(BMG) with different crystallized phases was carried out by XRD,TEM and PPMS. The experimental results show that the Curie temperature(T_c) of Fe_(45)Cr_(15)Mo_(14)C_(15)B_6 Y_2 Ni_3 BMG with different annealing condition reaches a highest value of 95 K. The value of magnetic entropy change △S_M(T) of Sample 3 reaches a maxima of 0.48 J/(kg·K) at Tc temperature, which result from the interaction among the precipitated phases of(Fe,Cr)_(23)(C,B)_6, Fe_3 Mo_3 C and residual amorphous phase. Based on the experiment results, it can be obtained that the Curie temperature, magnetocaloric effect can reach their optimal value at low temperature, when the content of amorphous phase and precipitated phases type run up to certain value. The magnetic properties of Sample 1 with full amorphous phase and Sample 4 with full crystalline phase will both decrease. | Yuanbin Lv Qingjun Chen Youlin Huang | 2019 | Journal of Rare Earths2019，37，4： | 6 |
| 11 | A study on service capacity of primary medical and health institutions for cervical cancer screening in urban and rural areas in China显示文摘Objective: To provide a decision-making basis for sustainable and effective development of cervical cancer screening.Methods: This cross-sectional study assesses the service capacity to conduct cervical cancer screening with a sample of 310 medical staff, medical institutions and affiliated township health centers from 20 countylevel/district-level areas in 14 Chinese provinces in 2016.Results: The county-level/district-level institutions were the main prescreening institutions for cervical cancer screening. More medical staff have become engaged in screening, with a significantly higher amounts in urban than in rural areas(P<0.05). The number of human papillomavirus(HPV) testers grew the fastest(by 225% in urban and 125% in rural areas) over the course of the project. HPV testing took less time than cytology to complete the same number of screening tasks in both urban and rural areas. The proportion of mid-level professionals was the highest among the medical staff, 40.0% in urban and 44.7% in rural areas(P=0.406), and most medical staff had a Bachelor’s degree, accounting for 76.3% in urban and 52.0% in rural areas(P<0.001). In urban areas, 75.0% were qualified medical staff, compared with 68.0% in rural areas, among which the lowest proportion was observed for rural cytology inspectors(22.7%). The medical equipment for cervical pathology diagnosis in urban areas was better(P<0.001). HPV testing equipment was relatively adequate(typing test equipment was 70% in urban areas, and non-typing testing equipment was 70% in rural areas).Conclusions: The service capacity of cervical cancer screening is insufficient for the health needs of the Chinese population. HPV testing might be an optimal choice to fill the needs of cervical cancer screening given current Chinese medical health service capacity. | Yang Li Li Ma Chunxia Yang Zhangya Chen Yuqian Zhao Le Dang Jinghe Lang Youlin Qiao | 2019 | Chinese Journal of Cancer Research2019，31，5： | 5 |
| 12 | Reaction mechanism and microstructure development of ZrSi_(2) melt-infiltrated C_(f)/SiC-ZrC-ZrB_(2) composites:The influence of preform pore structures显示文摘Reactive melt infiltration(RMI)is an effective method for fabrication of highly dense carbon fiber reinforced ultra-high temperature ceramic matrix composites(Cf/UHTCs).In this work,C_(f)/SiC-ZrC-ZrB_(2)composites were fabricated by infiltrating ZrSi_(2)melt into porous C_(f)/B_(4)C-C preforms,where the physical and chemical reactions involved during the RMI process were identified and analyzed.Inhomogeneous infiltration between the inter-and intra-bundle pores was revealed,and was found to be strongly related to the pore structures of the C_(f)/B_(4)C-C preform.It is indicated that the inhomogeneous infiltration can be mitigated remarkably with increasing porosity and pore size of the preform.The effect of pore size on the RMI process was also investigated by a quantitative model,which agrees very well with the experiment results.It further indicates that the inhomogeneous infiltration can also be relieved at elevated RMI temperature.However,excessive infiltration at elevated temperature or more porous preform may cause serious erosion on interphase and fibers,leading to mechanical properties deterioration of the final composites. | Xiaowu Chen Dewei Ni Yanmei Kan Youlin Jiang Haijun Zhou Zhen Wang Shaoming Dong | 2018 | Journal of Materiomics2018，4，3： | 5 |
| 13 | Calibration of microwave network analyzer显示文摘This paper presents a systematic description of the methods for calibrating microwave network analyzer and test fixtures, and discusses the problems arising in the calibration. The general criteria for choosing calibration standards and corresponding algorithms are discussed and suggestions to overcome these problems and improve the calibration accuracy are also given. It has been found that for reciprocal test fixtures, the four equations obtained with the thru standard can be used at the same time. Meanwhile,the calibration accuracy can be improved. It has been shown that using the same calibration procedures but different algorithms may lead to the occurrence of frequency limitation. | ZHU Ninghua WANG Youlin CHEN Zhenyu | 2004 | Science China(Technological Sciences)2004，47，2： | 4 |
| 14 | Economic evaluation of cervical cancer screening strategies in urban China显示文摘Objective:This study evaluated the feasibility of different cervical cancer screening strategies in urban China.Methods:A Markov model was constructed to simulate a hypothetical cohort of 100,000 females aged 30-59 years in a 20-year period.Screening strategies included liquid-based cytology(LBC)every three years,human papillomavirus(HPV)DNA testing every three and five years,respectively,and a combination of HPV DNA testing and LBC(HPV+LBC)every three and five years,respectively.Model outcomes included cumulative incidence over 20 years,cumulative risk of cervical cancer,costs,life year saved(LYS),quality-adjusted life years(QALYs)and benefits.The cost-effectiveness ratios(CERs),incremental cost-effectiveness ratios(ICERs),costutility ratios(CURs),and benefit-cost ratios(BCRs)were used as outcomes in the health economic evaluation analysis.Univariate sensitivity analyses were performed to examine the stability of the results.Results:The cumulative incidence of the five screening strategies ranged from 833.02 to 1,158.07 cases per100,000 females.HPV DNA testing was most effective in reducing the cumulative risk of cervical cancer,saving life years and QALYs and gaining benefits.The CERs of HPV DNA testing every three and five years,and LBC every three years were considered to be very cost-effective if they were below China's GDP per capita.The CERs of HPV+LBC were considered to be cost-effective if they were below three times GDP per capita.The incremental cost-effectiveness analysis showed that HPV DNA testing every three and five years,LBC every three years and HPV+LBC every five years were dominant strategies.Conclusions:The findings of this study indicated that HPV DNA testing every five years or LBC every three years should be recommended in urban China. | Li Ma Yuying Wang Xiaohong Gao Yi Dai Yu Zhang Zhaojing Wang Xiaoxia Wang Limin Wang Jing Jiang Xinhua Jing Chunxia Yang Fanghui Zhao Jinghe Lang Youlin Qiao | 2019 | Chinese Journal of Cancer Research2019，31，6： | 4 |
| 15 | A novel target detection approach based on adaptive radar waveform design显示文摘To resolve problems of complicated clutter, fast-varying scenes, and low signal-clutterratio (SCR) in application of target detection on sea for space-based radar (SBR), a target detection approach based on adaptive waveform design is proposed in this paper. Firstly, complicated sea clutter is modeled as compound Gaussian process, and a target is modeled as some scatterers with Gaussian reflectivity. Secondly, every dwell duration of radar is divided into several sub-dwells. Regular linear frequency modulated pulses are transmitted at Sub-dwell 1, and the received signal at this sub-dwell is used to estimate clutter covariance matrices and pre-detection. Estimated matrices are updated at every following sub-dwell by multiple particle filtering to cope with fast-varying clutter scenes of SBR. Furthermore, waveform of every following sub-dwell is designed adaptively according to mean square optimization technique. Finally, principal component analysis and generalized likelihood ratio test is used for mitigation of colored interference and property of constant false alarm rate, respectively. Simulation results show that, considering configuration of SBR and condition of complicated clutter, 9 dB is reduced for SCR which reliable detection requires by this target detection approach. Therefore, the work in this paper can markedly improve radar detection performance for weak targets. | Wang Haitao Shi Lei Wang Youlin Ben De | 2013 | Chinese Journal of Aeronautics2013，26，1： | 4 |
| 16 | Copper-catalyzed Meerwein carboarylation of alkenes with anilines to form 3-benzyl-3-alkyloxindole显示文摘A simple and direct route for double C–C bond formation by copper-catalyzed Meerwein carboarylation process has been developed. In the presence of Cu I(5 mol%), tert-butyl nitrite and anilines, a wide variety of N-arylacrylamides underwent tandem Meerwein arylation/C–H cyclization to produce pharmaceutically important 3-benzyl-3-alkyloxindole in moderate to good yield. | Shi Tang Dong Zhou Youlin Deng Zhihao Li You Yang Jianguang He Yingchun Wang | 2015 | Science China Chemistry2015，58，4： | 3 |
| 17 | The Zα domain of fish PKZ facilitates the B-Z conformational transition of oligonucleotide DNAs with d(GC), inserts显示文摘PKZ (象 PKR 一样) 在鱼作为 elF2 kinase 家庭的一个成员被发现,它在 C 终端并且也拥有 eIF2 kinase 的一个保存催化领域在 N 终端的二个 Z-DNA-binding 领域(Z1 和 Z2 ) 。PKZ 能通过 Z 的绑定被激活到 Z-DNA。然而, PKZ Z 的规章的功能仍然保持不清楚。调查 PKZ Z 怎么与 Z-DNA 交往的分子的机制,我们在 Escherichia coli 罗塞达碑紧张表示了 Z 多肽 Z12 并且在 Ni-NTA 上由亲密关系层析净化了树脂。oligonucleotide DNA 与的不同长度各种各样插入,也就是 d (GC ) n (n = 6, 8, 10, 13 ) , d (TA ) n (n = 6, 10 ) , non-d (GC ) ,和 non-d (TA ) ,被设计并且综合。圆形的二色性光谱和胶化活动性移动试金被用来在不同 oligonucleotide DNA 的 conformational 转变上调查 Z12 的效果。结果证明 oligonucleotide DNA 当 Z12 不在时保留了常规 B-DNA 符合构造。与 Z12 滴定的增加的数量, d (GC ) n 被认出并且在某种程度上把符合构造变换成 Z-DNA。与增加重复数字(从 n = 6 到 n = 13 ) , conformational 转变的趋势变得更明显。然而,有 n 插入的 d (TA ) 的 oligonucleotides 的符合构造面对 Z12 有点变化了,并且 Z12 没在有 non-d (GC ) 或 non-d (TA ) 的 oligonucleotides 的转变插入的 conformational 上有效果。胶化活动性移动试金进一步证明 Z12 能与 d (GC ) 绑在 oligonucleotide 10。换句话说, Z12 能与 n 插入到 Z-DNA 符合构造的 d (GC ) 转 oligonucleotides 并且与高亲密关系绑在它。 | Puzhong Lu Shoulong Deng Youlin Zhu Yongbin Yan Yong Liu Chengyu Hu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，11： | 3 |
| 18 | A novel coated-particle design and fluidized-bed chemical vapor deposition preparation method for fuel-element identification in a nuclear reactor显示文摘 | Rongzheng Liu Malin Liu Youlin Shao Xiaotong Chen Jingtao Ma Bing Liu | 2017 | Particuology2017，15，2： | 3 |
| 19 | A single nucleotide substitution at 5'-UTR of GSN1 represses its translation and leads to an increase of grain length in rice显示文摘Rice grain size is an important trait that affects rice yield and quality, and thus the identification of genes related to grain size is of great significance for improving rice yield and quality. Many genes related to grain size, such as DEP1(Huang et al., 2009),GW5(Liu et al., 2017). | Xia Zhang Peng Qin Youlin Peng Bo Ma Jiangbo Hu Shijun Fan Binhua Hu Guohua Zhang Hua Yuan Wei Yan Weilan Chen Bin Tu Hang He Bingtian Ma Yuping Wang Shigui Li | 2019 | Journal of Genetics and Genomics2019，46，2： | 2 |
| 20 | The Zα domain of fish PKZ converts DNA hairpin with d(GC)n inserts to Z-conformation显示文摘PKZ,蛋白质 kinase 包含 Z-DNA 领域,是脊椎动物 eIF2 kinase 家庭的一个新奇成员。在 N 终点在 C 终点和二个 Z-DNA 有约束力的领域(Z1 和 Z2 ) 包含一个催化领域, PKZ 能通过 Z 的绑定被激活到 Z-DNA。然而, PKZ Z 的规章的功能尚待被证实。这里,蛋白质被表示在 DNA conformational 转变,野类型的 Z1Z2 和 11 异种上理解 PKZ Z 的影响并且净化。同时, DNA hairpinsd (GC ) 的几不同长度 nT4 (GC ) n (n = 26 ) 并且 RNA hairpinr (GC ) 6T4 (GC ) 6 被综合。这些合成 DNA 或 RNA 发卡的符合构造上的 Z1Z2 和变异的蛋白质的效果被使用圆形的二色性光谱和胶化活动性移动试金调查。结果证明 DNA 发卡当 Z1Z2 不在时保留了常规 B-DNA 符合构造,当一些 DNA 发卡(n3 ) 在 Z1Z2 正式就职下面被变换成 Z 符合构造时。趋势按比例与 GC 重复的增加的数量被联系。与 Z1Z2 比较, Z1Z1 而非 Z2Z2 在变换 d (GC ) 显示了一个更高的能力 6T4 (GC ) 6 从 B- 到 Z-DNA。这些结果证明那 Z1 子域比 Z2 子域在 BZ conformational 转变的过程起了一个更必要的作用。变异的蛋白质(K34A, N38A, R39A, Y42A, P57A, P58A,和 W60A ) 不能变换 d (GC ) 6T4 (GC ) 6 进 Z-DNA,而 S35A 或 K56A 保留了一些部分活动。有趣地, Z1Z2 也能导致 r (GC ) 6T4 (GC ) 从 A 符合构造的 6 RNA 到在适当条件下面的 Z 符合构造。 | Puzhong Lu Shoulong Deng Chuxin Wu Youlin Zhu Yong Liu Gang Lin Yongbin Yan Chengyu Hu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 2 |
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