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| 1 | The versatile functions of Sox9 in development,stem cells,and human diseases显示文摘The transcription factor Sox9 was first discovered in patients with campomelic dysplasia,a haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 expression during chondrogenesis.Since then,its role as a cell fate determiner during embryonic development has been well characterized;Sox9 expression differentiates cells derived from all three germ layers into a large variety of specialized tissues and organs.However,recent data has shown that ectoderm-and endoderm-derived tissues continue to express Sox9 in mature organs and stem cell pools,suggesting its role in cell maintenance and specification during adult life.The versatility of Sox9 may be explained by a combination of posttranscriptional modifications,binding partners,and the tissue type in which it is expressed.Considering its importance during both development and adult life,it follows that dysregulation of Sox9 has been implicated in various congenital and acquired diseases,including fibrosis and cancer.This review provides a summary of the various roles of Sox9 in cell fate specification,stem cell biology,and related human diseases.Ultimately,understanding the mechanisms that regulate Sox9 will be crucial for developing effective therapies to treat disease caused by stem cell dysregulation or even reverse organ damage. | Alice Jo Sahitya Denduluri Bosi Zhang Zhongliang Wang Liangjun Yin Zhengjian Yan Richard Kang Lewis L.Shi James Mok Michael J.Lee Rex C.Haydon | 2014 | Genes & Diseases2014，1，2： | 16 |
| 2 | Hydrogen sulfide suppresses transforming growth factor-β1-induced differentiation of human cardiac fibroblasts into myofibroblasts显示文摘In heart disease, transforming growth factor-β1(TGF-β1) converts fibroblasts into myofibroblasts, which synthesize and secrete fibrillar type I and III collagens. The purpose of the present study was to investigate how hydrogen sulfide(H2S) suppresses TGF-β1-induced differentiation of human cardiac fibroblasts to myofibroblasts. Human cardiac fibroblasts were serum-starved in fibroblast medium for 16 h before exposure to TGF-β1(10 ng m L-1) for 24 h with or without sodium hydrosulfide(Na HS, 100 μmol L-1, 30 min pretreatment) treatment. Na HS, an exogenous H2 S donor, potently inhibited the proliferation and migration of TGF-β1-induced human cardiac fibroblasts and regulated their cell cycle progression. Furthermore, Na HS treatment led to suppression of fibroblast differentiation into myofibroblasts, and reduced the levels of collagen, TGF-β1, and activated Smad3 in TGF-β1-induced human cardiac fibroblasts in vitro. We therefore conclude that H2 S suppresses TGF-β1-stimulated conversion of fibroblasts to myofibroblasts by inhibiting the TGF-β1/Smad3 signaling pathway, as well as by inhibiting the proliferation, migration, and cell cycle progression of human cardiac myofibroblasts. These effects of H2 S may play significant roles in cardiac remodeling associated with heart failure. | ZHANG YouEn WANG JiaNing LI Hua YUAN LiangJun WANG Lei WU Bing GE JunBo | 2015 | Science China(Life Sciences)2015，58，11： | 11 |
| 3 | Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia显示文摘Microglia 玩在由降级的 A 的清理的一个枢轴的角色他们在 lysosomes,在 Alzheimers 疾病(广告) 阻止淀粉的匾致病。最近的证据建议那个 lysosomal 机能障碍导致有毒的蛋白质总数的不够的消除。我们测试了是否与抄写因素 EB (TFEB ) 提高 lysosomal 功能,必要管理者 modulating lysosomal 小径,将在 microglia 支持一个清理。这里,我们证明 TFEB 的那 microglial 表情便于降级和还原剂扔了的纤丝状的 A (fA ) 淀粉的匾,它被 TFEB 的 deacetylation 进一步提高。用集体 spectrometry 分析,我们第一证实了是的 acetylation 一以前 TFEB 的 unreported 修正并且发现那 SIRT1 直接交往了与并且在离氨酸残余 116 点的 deacetylated TFEB。随后,当 TFEB 被击倒时, SIRT1 overexpression 由 TFEB 下游的目标的 upregulating transcriptional 层次提高了 lysosomal 功能和 fA 降级,它能被禁止。而且,在在 microglia 变异的 K116R 的 deacetylated TFEB 的 overexpression 由刺激 lysosomal 生物的续生说加速了细胞内部的 fA 降级并且极大地在 APP/PS1 转基因的老鼠的大脑片减少了扔的淀粉的匾。我们的调查结果表明 TFEB 的 deacetylation 能调整 lysosomal 生物的续生说和 fA 降级,为 attenuating 使 TFEB 的 microglial 激活成为可能的策略在广告的淀粉的匾免职。 | Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji | 2016 | Protein & Cell2016，7，6： | 10 |
| 4 | Soil hydraulic conductivity as affected by vegetation restoration age on the Loess Plateau,China显示文摘The Loess Plateau of China has experienced extensive vegetation restoration in the past several decades,which leads to great changes in soil properties such as soil bulk,porosity,and organic matter with the vegetation restoration age.And these soil properties have great effect on the soil infiltration and soil hydraulic conductivity.However,the potential changes in soil hydraulic conductivity caused by vegetation restoration age have not been well understood.This study was conducted to investigate the changes in soil hydraulic conductivity under five grasslands with different vegetation restoration ages(3,10,18,28 and 37 years)compared to a slope farmland,and further to identify the factors responsible for these changes on the Loess Plateau of China.At each site,accumulative infiltration amount and soil hydraulic conductivity were determined using a disc permeameter with a water supply pressure of –20 mm.Soil properties were measured for analyzing their potential factors influencing soil hydraulic conductivity.The results showed that the soil bulk had no significant changes over the initial 20 years of restoration(P>0.05);the total porosity,capillary porosity and field capacity decreased significantly in the grass land with 28 and 37 restoration ages compared to the slope farmland;accumulative infiltration amount and soil hydraulic conductivity were significantly enhanced after 18 years of vegetation restoration.However,accumulative infiltration amount and soil hydraulic conductivity fluctuated over the initial 10 years of restoration.The increase in soil hydraulic conductivity with vegetation restoration was closely related to the changes in soil texture and structure.Soil sand and clay contents were the most influential factors on soil hydraulic conductivity,followed by bulk density,soil porosity,root density and crust thickness.The Pearson correlation coefficients indicated that the soil hydraulic conductivity was affected by multiply factors.These results are helpful to understand the changes in hydrological and erosion processes response to vegetation succession on the Loess Plateau. | REN Zongping ZHU Liangjun WANG Bing CHENG Shengdong | 2016 | Journal of Arid Land2016，8，4： | 9 |
| 5 | Land Use/Cover Changes and Environmental Consequences in Songnen Plain,Northeast China显示文摘The Songnen Plain in Northeast China,one of the key national bases of agricultural production,went through remarkable land use/cover changes in recent years.This study aimed to explore the long-term land use/cover changes and the effects of these changes on the environment.The Landsat-based analysis showed that,during 1986-2000,cropland,built-up land and barren land had increased,among which cropland had the largest increase of 9,198km2 with an increase rate of 7.5%.Woodland,grassland,water body and swampland had decreased correspondingly,among which grassland had the most dramatic decrease of 6,127km2 with a decrease rate of 25.6%.The transition matrix results revealed that grassland,woodland and swampland were the three main land use types converted to cropland.Climate warming created the potential environment for the conversion of grassland and swampland into cropland.Land resources policy made by central and provincial governments of China affected the pattern and intensity of land use.Land use/cover changes accompanied by climatic variation brought out a series of environmental consequences,such as sand desertification of land,land salinization and alkalinization,grassland degradation,and more frequent floods.Under this circumstance,optimized land use structure and restoration measures are needed. | LIU Dianwei WANG Zongming SONG Kaishan ZHANG Bai HU Liangjun HUANG Ni ZHANG Sumei LUO Ling ZHANG Chunhua JIANG Guangjia | 2009 | Chinese Geographical Science2009，19，4： | 8 |
| 6 | Valuation of the flexibility in decision-making for revamping installations―A case from fertilizer plants显示文摘This paper puts forward a valuation model for the flexibility of revamping urea plants based on the substitutability of switching between the internationally accepted fertilizer feedstock fuel oil and natural gas. The paper first builds a stochastic mean-reversion model for fuel oil prices and natural gas prices respectively, then estimates and tests the parameters using the fuel oil and natural gas prices data from the U.S. market. This paper also conducts a sensitivity analysis with important parameters. The results show that the real option method can be applied successfully to evaluate the flexibility in decision-making for revamping installations in fertilizer plants or other similar plants. | WANG Zhen LI Liangjun | 2010 | Petroleum Science2010，7，3： | 4 |
| 7 | Fenitized Wall Rock Geochemistry of the First Carbonatite Dyke at Bayan Obo, Inner Mongolia, China显示文摘The first carbonatite dyke at Bayan Obo is well exposed on the surface for a length and width of approximately 60 m and 1.1–1.5 m, respectively. Along its strike, the fenitized H1(Qs) and H2(Cs) quartzite is replaced by Na-amphiboles, aegirines, and alkali-feldspars, intermittently stretching as far away as 800 m in length. Based on petrographical characteristics, the dyke's fenitized wall rocks are divisible into different zones:(1) outer,(2) middle, and(3) inner. The outer zone is 5–17 m from the NW margin of the dyke. The middle zone is located at 3.5–5 m from the NW margin of the dyke. The inner contact zone is located between direct contact with the dyke and 3.5 m from the dyke. In the outer zone, upon visual examination, no evidence of outcrop fenitization was found and the major elemental rock composition is nearly identical to the unaltered H1 and H2 lithologies. In the thin sections, however, small amounts of Na-amphibole and phlogopite are present. Despite relatively poor development throughout the 5 m of fenitization, the wall rocks have retained at least a small geochemical signature comparable to the original sedimentary protolith. The fenites occurring in the inner zone exhibit distinct variations, not only for the sharp contact at the outcrop scale, but also for variations in major, rare earth elements(REE), and trace elements and Sm-Nd isotope composition. The wall rocks within 3.5 m have undergone strong fenitization, inheriting the geochemical signature derived from the carbonatite dyke. Fenitization in the middle zone was not as strong, at least compared to the inner zone, but was stronger than the outer zone. Compared to some trace elements and REEs, the major elements are relatively immobile during fenitization. The Sm-Nd isotope data for the carbonatite dyke and the adjacent fenitized wall rocks, where the Sm and Nd originate solely from the dyke, plots as a six-point isochron with an age of 1308±56 Ma. This age is identical to that of ore-bearing dolomite carbonatite and the related ore-forming events, indicating that there may be a petrogenetic link between the two. Based on Sr and Nd isotope compositional data, the first carbonatite dyke may be derived from an enriched mantle. | WANG Kaiyi ZHANG Jien YU Liangjun FANG Aimin DONG Ce HU Fuyou | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 3 |
| 8 | Novel detection method for DC series arc faults by using morphological filtering显示文摘It has been known that DC arc faults pose a hazard in power electronics systems. Due to the fault current is lower than normal current load, series arc is more difficult to be discovered than parallel arc. The traditional methods of DC series arc faults detection have some disadvantages, such as large computation, long delay and easier influence by interferences. In this paper, a novel method with multi-scale morphological filtering was utilized for the fault detection of DC series arc. Compared to the tradition method, the proposed method is more simple and efficient. It was verified that it was convenient for field application of on-line monitoring and diagnosis with a good ability to prevent misjudgments from the environment interference. | Chen Luping Wang Peng Xu Liangjun | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，5： | 2 |
| 9 | Sustainable Urban Development Evaluation of Shanghai:An Ecological Wellbeing Performance Perspective显示文摘Against the backdrop of aggravating resource and environment restriction,it is an inevitable choice to adopt the sustainable development pattern to maximize social well-being within the ecological threshold.From the perspective of ecological well-being performance,ecological footprint per capita and human development index were selected to construct the evaluation index system for sustainable urban development,and DEA applied to calculate the input-output efficiency,so as to analyze the sustainable development level of Shanghai from 1999 to 2012.The results showed that①human development index,ecological footprint per capita of Shanghai grew in step with economic development,but ecological footprint per capita level exceeded the ecological carrying capacity,thus the overall ecological conditions remained in the state of worsening 'deficit';②ecological well-being performance of Shanghai in most years remained in the DEA ineffective state,and the scale return had decreased gradually since 2005.In addition,the paper gave pertinent suggestions. | LONG Liangjun WANG Xia | 2016 | Journal of Landscape Research2016，8，4： | 2 |
| 10 | Nonvolatile waveguide transmission tuning with electrically-driven ultra-small GST phase-change material显示文摘Low-power reconfigurable optical circuits are highly demanded to satisfy a variety of different applications. Conventional electro-optic and thermo-optic refractive index tuning methods in silicon photonics are not suitable for reconfiguration of optical circuits due to their high static power consumption and volatility. We propose and demonstrate a nonvolatile tuning method by utilizing the reversible phase change property of GST integrated on top of the silicon waveguide. The phase change is enabled by applying electrical pulses to the lm-sized GST active region in a sandwich structure. The experimental results show that the optical transmission of the silicon waveguide can be tuned by controlling the phase state of GST. | Hanyu Zhang Linjie Zhou Jian Xu Ningning Wang Hao Hu Liangjun Lu B. M. A. Rahman Jianping Chen | 2019 | Science Bulletin2019，64，11： | 2 |
| 11 | Efficacy and safety of chemotherapy combined with bevacizumab in Chinese patients with metastatic colorectal cancer:A prospective,multicenter,observational,non-interventional phaseⅣtrial显示文摘Objective:Bevacizumab has an important and evolving role in improving outcomes in patients with metastatic colorectal cancer(mCRC)worldwide and was approved in China in 2010.However,there are limited real-world data on the efficacy and safety of chemotherapy regimens combined with bevacizumab in Chinese patients with mCRC.This observational,phase IV trial study aimed to obtain more experience on the efficacy and safety of bevacizumab combined with chemotherapy in Chinese mCRC patients.Methods:Between September 2013 and November 2016,patients with histologically confirmed mCRC were enrolled in a prospective,multicenter,observational,non-interventional phase IV trial at 26 centers across China.Eligible patients received different chemotherapeutic regimens combined with bevacizumab.The efficacy and safety data in the intention-to-treat study population were analyzed.Results:A total of 611 patients were included in the efficacy analysis.The median overall survival and median progression-free survival was 18.00 and 10.05 months,respectively.The objective response rate was 21.00%and disease control rate was 89.40%.In subgroup analyses,the survival differences were observed according to metastatic status,duration of treatment and elevation in blood pressure.A total of 613 patients were evaluable for safety assessments.And 569(92.82%)patients reported at least one adverse event(AE),and 151(24.63%)experienced grade 3 or higher AEs.The incidence of bevacizumab-associated AEs of special interest was reported in 31(5.06%)patients with hypertension(n=12),abscesses and fistulae(n=7),bleeding(n=6),proteinuria(n=3),gastrointestinal perforation(n=2)and venous thrombotic events(n=1).Conclusions:This observational phase IV trial broadens our experience and knowledge of bevacizumab in the Chinese population and provides a good indication of its overall efficacy and safety.Bevacizumab in combination with chemotherapy offers clinical benefits to Chinese patients with mCRC and has an acceptable and manageable safety profile. | Fenghua Wang Guanghai Dai Yanhong Deng Yong Tang Wei Wang Zuoxing Niu Feng Bi Liangjun Zhu Zengqing Guo Jin Yan Bing Hu Min Tao Shujun Yang Suzhan Zhang Lu Wen Ruihua Xu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 2 |
| 12 | Overview of recent progress in condition monitoring for insulated gate bipolar transistor modules:Detection,estimation,and prediction显示文摘The insulated gate bipolar transistor(IGBT)is one of the most fragile components in power electronics converters.In order to improve the reliability of IGBTs,various measurements are taken according to the condition monitoring(CM)technique.Traditional CM techniques include the measurement and estimation of the device operation conditions.Recently,emerging techniques have been developed,not only for the detection and estimation but also for the prognostics of IGBTs with the condition data.In this paper,a review is performed on the recent progress in the CM techniques for IGBTs.First,some emerging electrical and thermal measurements are reviewed.Based on the sensed data,the health indicator estimation techniques are summarised.Moreover,for the emerging prognostics and health management applications,some remaining using lifetime(RUL)prediction methods are reviewed.Finally,the research gaps and directions are discussed for the CM in IGBT applications. | Meng Huang Haoran Wang Liangjun Bai Kang Li Ju Bai Xiaoming Zha | 2021 | High Voltage2021，6，6： | 2 |
| 13 | MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-β1 Pathway显示文摘 | Zhenwei Pan Xuelin Sun Hongli Shan Ning Wang Jinghao Wang Jinshuai Ren Shuya Feng Liangjun Xie Chunying Lu Ye Yuan Yang Zhang Ying Wang Yanjie Lu Baofeng Yang | 2012 | Circulation2012，，7： | 2 |
| 14 | On the determination and simulation of seawater freezing point temperature under high pressure显示文摘At present,it is believed that the freezing point temperature of seawater is a function of salinity and pressure,and the freezing point is a key parameter in a coupled air-sea-ice system.Generally,empirical formulas or methods are used to calculate the freezing point of seawater.Especially in high-pressure situations,e.g.,under a thick ice sheet or ice shelf,the pressure term must be taken into account in the determination of seawater freezing point temperature.This study summarized various methods that have been used to calculate seawater freezing point with high pressure.The methods that were employed in two ocean-ice models were also assessed.We identified the disadvantages of these methods used in these two models and addressed the corresponding uncertainties of the freezing point temperature formulas.This study provides useful information on the calculation of the freezing point temperature in numerical modeling and indicates a need to investigate the sensitivity of numerical simulations to the uncertainties in the freezing point temperature in future. | YAN Liangjun WANG Zhaomin LIU Chengyan WU Yang | 2019 | Advances in Polar Science2019，30，4： | 2 |
| 15 | Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice显示文摘The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease(DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate(EP) and annulus fibrosus(AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligase Vhl in EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of the Hif1α gene delayed DDD pathogenesis in Vhl-deficient mice. Administration of 2-methoxyestradiol(2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD. | Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang Siru Zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie | 2022 | Bone Research2022，10，1： | 1 |
| 16 | Experimental study on water use efficiency of winter wheat in different irrigation methods显示文摘 | Wang Shunsheng Fei Liangjun Gao Chuanchang | | 0，，01： | 1 |
| 17 | Emergence of photoluminescence on bulk MoS2 by laser thinning and gold particle decoration显示文摘 | Lili Gong Qi Zhang Liangjun Wang Jianfeng Wu Cheng Han Bo Lei Wei Chen Goki Eda Kuan Eng Johnson Goh Chorng Haur Sow | 2018 | Nano Research2018，11，9： | 1 |
| 18 | Exploring a particle-size-reduction strategy of YAG:Ce phosphor via a chemical breakdown method显示文摘Particle size reduction of Y_(3)Al_(5)O_(12):Ce(YAG:Ce) phosphor is highly needed for micro-LED display applications.In this work,size control of YAG:Ce phosphor particles is achieved via carbon coating and further heat treatment.A thin layer of carbon is deposited on the surface of YAG:Ce by chemical vapor deposition.During the heat treatment,carbon reacts with oxygen element in the phosphor and escapes from phosphor particles.The reaction results in the phosphor breaking into smaller particles.The phosphors were characterized by laser light scattering for particle size distribution,scanning electron microscopy(SEM),transmission electron microscopy for morphologies,X-ray diffraction refinements for crystal structure and electron energy-loss spectroscopy for elemental analysis.It is demonstrated that the median diameter(D_(50)) of the phosphor particle size is significantly reduced from 19.1 to 0.96 μm yet the photoluminescent properties have little changes.The carbon coating and further heat treatment method show potential application in size control of phosphors. | Hongren Chen Licheng Ju Li Zhang Xin Wang Linbo Zhang Xin Xu Lin Gao Kehui Qiu Liangjun Yin | 2021 | Journal of Rare Earths2021，39，8： | 1 |
| 19 | MXene and MXene-based materials for lithium-sulfur batteries显示文摘Lithium-sulfur(Li–S)batteries are regarded as potential alternatives to lithium-ion batteries due to their extremely high theoretical energy density.Nevertheless,Li–S batteries still suffer from low coulombic efficiency,low sulfur utilization,and poor cycling life,which hinder their further applications.To obtain ideal Li–S cells,intensive work has been dedicated to improve the conductivity of the electrode,inhibiting the shuttle of lithium polysulfides,and promoting the redox of sulfur.Two-dimensional transition metal carbides,nitrides or carbonitrides,also known as MXenes,attracting significant research interest in Li–S batteries due to their high conductivity,abundant active sites,layered structure and adjustable surface chemistry.In this review,we summarize the partial etching methods of MXenes with different surface terminations,the role of MXenes in Li–S batteries and MXene-based composites designed for Li–S batteries based on interfacial chemistry and interlayer structure.In the end,we also propose the perspectives of MXenes for Li–S batteries. | Youquan Zhang Cheng Ma Weitao He Chunxiao Zhang Liangjun Zhou Gao Wang Weifeng Wei | 2021 | Progress in Natural Science:Materials International2021，31，4： | 1 |
| 20 | Synthesis of AgInS_2 QDs in droplet microreactors:Online fluorescence regulating through temperature control显示文摘For the synthesis of AgInS_2 quantum dots(QDs), a suitable temperature is extremely important for control of the size, shape and fluorescence properties of QDs. Most of synthesis methods for AgInS_2 QDs are based on batch reactors, which bring uneven distribution of temperature, affecting their fluorescence properties and size uniformity. Here we designed a droplet microreactor with a temperature-controllable region, and successfully synthesized water-soluble AgInS_2 QDs. By accurately controlling temperature,we also studied how the reaction temperature affected the fluorescence properties of AgInS_2 QDs. The results showed that with the increasing of reaction temperature, the QDs size increased and the fluorescence peak constantly red-shifted along with enhanced fluorescence intensity. Based on the droplet microreactor, we could achieve more appropriate reaction condition to synthesize AgInS_2 QDs with higher fluorescence quantum yield(QY) and intensity. | Haotian Ma Liangjun Pan Ji Wang Li Zhang Zhiling Zhang | 2019 | Chinese Chemical Letters2019，30，1： | 1 |
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