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| 1 | Bone Morphogenetic Protein (BMP) signaling in development and human diseases显示文摘Bone Morphogenetic Proteins(BMPs)are a group of signaling molecules that belongs to the Transforming Growth Factor-b(TGF-b)superfamily of proteins.Initially discovered for their ability to induce bone formation,BMPs are now known to play crucial roles in all organ systems.BMPs are important in embryogenesis and development,and also in maintenance of adult tissue homeostasis.Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects,highlighting the essential functions of BMPs.In this review,we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development.A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling. | Richard N.Wang Jordan Green Zhongliang Wang Youlin Deng Min Qiao Michael Peabody Qian Zhang Jixing Ye Zhengjian Yan Sahitya Denduluri Olumuyiwa Idowu Melissa Li Christine Shen Alan Hu Rex C.Haydon Richard Kang James Mok Michael J.Lee Hue L.Luu Lewis L.Shi | 2014 | Genes & Diseases2014，1，1： | 47 |
| 2 | The versatile functions of Sox9 in development,stem cells,and human diseases显示文摘The transcription factor Sox9 was first discovered in patients with campomelic dysplasia,a haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 expression during chondrogenesis.Since then,its role as a cell fate determiner during embryonic development has been well characterized;Sox9 expression differentiates cells derived from all three germ layers into a large variety of specialized tissues and organs.However,recent data has shown that ectoderm-and endoderm-derived tissues continue to express Sox9 in mature organs and stem cell pools,suggesting its role in cell maintenance and specification during adult life.The versatility of Sox9 may be explained by a combination of posttranscriptional modifications,binding partners,and the tissue type in which it is expressed.Considering its importance during both development and adult life,it follows that dysregulation of Sox9 has been implicated in various congenital and acquired diseases,including fibrosis and cancer.This review provides a summary of the various roles of Sox9 in cell fate specification,stem cell biology,and related human diseases.Ultimately,understanding the mechanisms that regulate Sox9 will be crucial for developing effective therapies to treat disease caused by stem cell dysregulation or even reverse organ damage. | Alice Jo Sahitya Denduluri Bosi Zhang Zhongliang Wang Liangjun Yin Zhengjian Yan Richard Kang Lewis L.Shi James Mok Michael J.Lee Rex C.Haydon | 2014 | Genes & Diseases2014，1，2： | 16 |
| 3 | Structural, densitometric and biomechanical evaluations of Chinese patients with long-term bisphosphonate treatment显示文摘 | LEUNG Kwok-sui TANG Ning James Griffith CHOY Tak-Kee HUNG Vivian Wing-Yin MOK Hoi-Wa SHI Lin LEUNG Ping-Chung CHEUNG Wing-Hoi | 2013 | Chinese Medical Journal2013，，1： | 4 |
| 4 | Strawberry fields forever? Urban agriculture in developed countries: a review显示文摘 | Hoi-Fei Mok Virginia G. Williamson James R. Grove Kristal Burry S. Fiona Barker Andrew J. Hamilton | 2014 | Agronomy for Sustainable Development2014，，1： | 1 |
| 5 | Use of C-Reactive Protein After Spinal Surgery: Comparison With Erythrocyte Sedimentation Rate as Predictor of Early Postoperative Infectious Complications显示文摘 | James M. Mok Murat Pekmezci Samantha L. Piper Erin Boyd Sigurd H. Berven Shane Burch Vedat Deviren Bobby Tay Serena S. Hu | 2008 | Spine2008，，4： | 1 |
| 6 | Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With EGFR Mutations显示文摘 | Lecia V. Sequist James Chih-Hsin Yang Nobuyuki Yamamoto Kenneth O’Byrne Vera Hirsh Tony Mok Sarayut Lucien Geater Sergey Orlov Chun-Ming Tsai Michael Boyer Wu-Chou Su Jaafar Bennouna Terufumi Kato Vera Gorbunova Ki Hyeong Lee Riyaz Shah Dan Massey Victori | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
| 7 | Partial portal vein arterialization using right gastroepiploic artery:A novel solution for portal hypoperfusion显示文摘To the Editor:Establishing dual arterial and portal inflow is essential for liver transplantation[1].Inadequate portal inflow compromises graft function and graft survival[2].Portal hypoperfusion is usually a consequence of spontaneous portosystemic shunt,ligation of which results in improvement of portal inflow[3].We encountered a patient with portal hypoperfusion,where no significant shunting could be identified.Portal inflow was boosted with incorporating arterial supply using right gastroepiploic artery.The early results were promising.A 39-year-old man with decompensated alcoholic cirrhosis underwent deceased-donor liver transplantation in June 2017. | Kin Pan Au Kenneth Siu Ho Chok Sui Ling Sin James Yan Yue Fung Chung Mau Lo Vivian Way Kay Mok | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，4： | 1 |
| 8 | Symptom Control and Quality of Life in LUX-Lung 3: A Phase III Study of Afatinib or Cisplatin/Pemetrexed in Patients With Advanced Lung Adenocarcinoma With EGFR Mutations显示文摘 | James Chih-Hsin Yang Vera Hirsh Martin Schuler Nobuyuki Yamamoto Kenneth J. O’Byrne Tony S.K. Mok Victoria Zazulina Mehdi Shahidi Juliane Lungershausen Dan Massey Michael Palmer Lecia V. Sequist | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
| 9 | Comparison of observer variation in conventional and three digital radiographic methods used in the evaluation of pa-tients with adolescent idiopathic scoliosis显示文摘 | James Mok MD Sigurd Berven MD Mohammad Diab MD | 2008 | Spine2008，6，： | 1 |
| 10 | Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With EGFR Mutations显示文摘 | Lecia V. Sequist James Chih-Hsin Yang Nobuyuki Yamamoto Kenneth O’Byrne Vera Hirsh Tony Mok Sarayut Lucien Geater Sergey Orlov Chun-Ming Tsai Michael Boyer Wu-Chou Su Jaafar Bennouna Terufumi Kato Vera Gorbunova Ki Hyeong Lee Riyaz Shah Dan Massey Victori | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
| 11 | Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With EGFR Mutations显示文摘 | Lecia V. Sequist James Chih-Hsin Yang Nobuyuki Yamamoto Kenneth O’Byrne Vera Hirsh Tony Mok Sarayut Lucien Geater Sergey Orlov Chun-Ming Tsai Michael Boyer Wu-Chou Su Jaafar Bennouna Terufumi Kato Vera Gorbunova Ki Hyeong Lee Riyaz Shah Dan Massey Victori | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
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