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| 1 | Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia显示文摘Microglia 玩在由降级的 A 的清理的一个枢轴的角色他们在 lysosomes,在 Alzheimers 疾病(广告) 阻止淀粉的匾致病。最近的证据建议那个 lysosomal 机能障碍导致有毒的蛋白质总数的不够的消除。我们测试了是否与抄写因素 EB (TFEB ) 提高 lysosomal 功能,必要管理者 modulating lysosomal 小径,将在 microglia 支持一个清理。这里,我们证明 TFEB 的那 microglial 表情便于降级和还原剂扔了的纤丝状的 A (fA ) 淀粉的匾,它被 TFEB 的 deacetylation 进一步提高。用集体 spectrometry 分析,我们第一证实了是的 acetylation 一以前 TFEB 的 unreported 修正并且发现那 SIRT1 直接交往了与并且在离氨酸残余 116 点的 deacetylated TFEB。随后,当 TFEB 被击倒时, SIRT1 overexpression 由 TFEB 下游的目标的 upregulating transcriptional 层次提高了 lysosomal 功能和 fA 降级,它能被禁止。而且,在在 microglia 变异的 K116R 的 deacetylated TFEB 的 overexpression 由刺激 lysosomal 生物的续生说加速了细胞内部的 fA 降级并且极大地在 APP/PS1 转基因的老鼠的大脑片减少了扔的淀粉的匾。我们的调查结果表明 TFEB 的 deacetylation 能调整 lysosomal 生物的续生说和 fA 降级,为 attenuating 使 TFEB 的 microglial 激活成为可能的策略在广告的淀粉的匾免职。 | Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji | 2016 | Protein & Cell2016，7，6： | 10 |
| 2 | Land Use/Cover Changes and Environmental Consequences in Songnen Plain,Northeast China显示文摘The Songnen Plain in Northeast China,one of the key national bases of agricultural production,went through remarkable land use/cover changes in recent years.This study aimed to explore the long-term land use/cover changes and the effects of these changes on the environment.The Landsat-based analysis showed that,during 1986-2000,cropland,built-up land and barren land had increased,among which cropland had the largest increase of 9,198km2 with an increase rate of 7.5%.Woodland,grassland,water body and swampland had decreased correspondingly,among which grassland had the most dramatic decrease of 6,127km2 with a decrease rate of 25.6%.The transition matrix results revealed that grassland,woodland and swampland were the three main land use types converted to cropland.Climate warming created the potential environment for the conversion of grassland and swampland into cropland.Land resources policy made by central and provincial governments of China affected the pattern and intensity of land use.Land use/cover changes accompanied by climatic variation brought out a series of environmental consequences,such as sand desertification of land,land salinization and alkalinization,grassland degradation,and more frequent floods.Under this circumstance,optimized land use structure and restoration measures are needed. | LIU Dianwei WANG Zongming SONG Kaishan ZHANG Bai HU Liangjun HUANG Ni ZHANG Sumei LUO Ling ZHANG Chunhua JIANG Guangjia | 2009 | Chinese Geographical Science2009，19，4： | 8 |
| 3 | Overview of recent progress in condition monitoring for insulated gate bipolar transistor modules:Detection,estimation,and prediction显示文摘The insulated gate bipolar transistor(IGBT)is one of the most fragile components in power electronics converters.In order to improve the reliability of IGBTs,various measurements are taken according to the condition monitoring(CM)technique.Traditional CM techniques include the measurement and estimation of the device operation conditions.Recently,emerging techniques have been developed,not only for the detection and estimation but also for the prognostics of IGBTs with the condition data.In this paper,a review is performed on the recent progress in the CM techniques for IGBTs.First,some emerging electrical and thermal measurements are reviewed.Based on the sensed data,the health indicator estimation techniques are summarised.Moreover,for the emerging prognostics and health management applications,some remaining using lifetime(RUL)prediction methods are reviewed.Finally,the research gaps and directions are discussed for the CM in IGBT applications. | Meng Huang Haoran Wang Liangjun Bai Kang Li Ju Bai Xiaoming Zha | 2021 | High Voltage2021，6，6： | 2 |
| 4 | Shrinkage and fragmentation of grasslands in the West Songnen Plain, China显示文摘 | Zongming Wang Kaishan Song Bai Zhang Dianwei Liu Chunying Ren Ling Luo Ting Yang Ni Huang Liangjun Hu Haijun Yang Zhiming Liu | 2008 | Agriculture, Ecosystems and Environment2008，，1： | 1 |
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