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| 1 | Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling显示文摘Bone remodeling is precisely coordinated by bone resorption and formation.Apoptotic osteoclasts generate large amounts of apoptotic bodies(ABs)marking the end of the bone resorption phase,whereas the functions of osteoclast-derived ABs remain largely unknown.Here,we identified the molecular profile of ABs derived from osteoclasts at distinct differentiation stages and investigated their corresponding functions.ABs were isolated from apoptotic bone marrow macrophages,preosteoclasts,and mature osteoclasts induced by staurosporine.Proteomic signature analysis with liquid chromatography-tandem mass spectrometry suggested marked protein cargo differences among the different ABs.Further bioinformatic analysis showed that the proteomic signatures of the ABs were highly similar to those of their parental cells.Functionally,pOC-ABs induced endothelial progenitor cell differentiation and increased CD31hiEmcnhi endothelial cell formation in a murine bone defect model via their PDGF-BB cargo.mOC-ABs induced osteogenic differentiation of mesenchymal stem cells and facilitated osteogenesis via RANKL reverse signaling.In summary,we mapped the detailed proteomic landscapes of ABs derived from osteoclasts and showed that their potential biological roles are important in coupling bone formation with resorption during bone remodeling. | Qinyu Ma Mengmeng Liang Yutong Wu Fei Luo Zaisong Ma Shiwu Dong Jianzhong Xu Ce Dou | 2021 | Bone Research2021，9，1： | 8 |
| 2 | Size,morphology,and composition of lunar samples returned by Chang'E-5 mission显示文摘This study focuses on the physical and chemical properties of surficial lunar regolith(LR)samples returned from the Moon by the Chang’E-5(CE-5)mission.Insights regarding the effect of a new sampling geological site on the surficial lunar sample CE5 C0400 were illustrated using nondestructive techniques such as laser diffractometry coupled with image analysis,X-ray computed tomography,and field emission scanning electron microscopy equipped with energy dispersive spectroscopy,and Xray diffraction combined with Rietveld refinement.From the characterization analyses,the CE-5 sampling site in the northeastern Oceanus Procellarum on the Moon yields a unique collection of relatively regular-shaped and fine basalt-dominated particles.The median grain size D_(50) is(55.24±0.96)μm,falling within the relatively low end of the range of the Apollo lunar returned samples.The coefficient of uniformity C_(u)of 15.1 and the coefficient of curvature C_(c)of 1.7 could classify CE5 C0400 to be well-graded.The minerals in CE5 C0400 comprise approximately 44.5%pyroxene,30.4%plagioclase,3.6%olivine,and6.0%ilmenite.There is a relatively low content of approximately 15.5%glass phase in the CE-5 lunar sample.From the results,we deduce that the CE-5 LR structure could have mainly resulted from micrometeoroid impacts to achieve such a high level of maturity. | Hui Zhang Xian Zhang Guang Zhang Keqi Dong Xiangjin Deng Xiaosong Gao Yaodong Yang Yuan Xiao Xiao Bai Kaixin Liang Yiwei Liu Wenbin Ma Shaofan Zhao Ce Zhang Xiaojing Zhang Jian Song Wei Yao Hong Chen Weihua Wang Zhigang Zou Mengfei Yang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 4 |
| 3 | Fenitized Wall Rock Geochemistry of the First Carbonatite Dyke at Bayan Obo, Inner Mongolia, China显示文摘The first carbonatite dyke at Bayan Obo is well exposed on the surface for a length and width of approximately 60 m and 1.1–1.5 m, respectively. Along its strike, the fenitized H1(Qs) and H2(Cs) quartzite is replaced by Na-amphiboles, aegirines, and alkali-feldspars, intermittently stretching as far away as 800 m in length. Based on petrographical characteristics, the dyke's fenitized wall rocks are divisible into different zones:(1) outer,(2) middle, and(3) inner. The outer zone is 5–17 m from the NW margin of the dyke. The middle zone is located at 3.5–5 m from the NW margin of the dyke. The inner contact zone is located between direct contact with the dyke and 3.5 m from the dyke. In the outer zone, upon visual examination, no evidence of outcrop fenitization was found and the major elemental rock composition is nearly identical to the unaltered H1 and H2 lithologies. In the thin sections, however, small amounts of Na-amphibole and phlogopite are present. Despite relatively poor development throughout the 5 m of fenitization, the wall rocks have retained at least a small geochemical signature comparable to the original sedimentary protolith. The fenites occurring in the inner zone exhibit distinct variations, not only for the sharp contact at the outcrop scale, but also for variations in major, rare earth elements(REE), and trace elements and Sm-Nd isotope composition. The wall rocks within 3.5 m have undergone strong fenitization, inheriting the geochemical signature derived from the carbonatite dyke. Fenitization in the middle zone was not as strong, at least compared to the inner zone, but was stronger than the outer zone. Compared to some trace elements and REEs, the major elements are relatively immobile during fenitization. The Sm-Nd isotope data for the carbonatite dyke and the adjacent fenitized wall rocks, where the Sm and Nd originate solely from the dyke, plots as a six-point isochron with an age of 1308±56 Ma. This age is identical to that of ore-bearing dolomite carbonatite and the related ore-forming events, indicating that there may be a petrogenetic link between the two. Based on Sr and Nd isotope compositional data, the first carbonatite dyke may be derived from an enriched mantle. | WANG Kaiyi ZHANG Jien YU Liangjun FANG Aimin DONG Ce HU Fuyou | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 3 |
| 4 | Bone-targeted pH-responsive cerium nanoparticles for anabolic therapy in osteoporosis显示文摘Antiresorptive drugs are widely used for treatment of osteoporosis and cancer bone metastasis,which function mainly through an overall inhibition of osteoclast.However,not all osteoclasts are“bone eaters”;preosteoclasts(pOCs)play anabolic roles in bone formation and angiogenesis through coupling with osteoblasts and secreting platelet derived growth factor-BB(PDGF-BB).In this study,a bone-targeted pH-responsive nanomaterial was designed for selectively eliminating mature osteoclasts(mOCs)without affecting pOCs.Biocompatible cerium nano-system(CNS)was guided to the acidic extracellular microenvironment created by mOCs and gained oxidative enzymatic activity.Oxidative CNS decreased the viability of mOCs through accumulating intracellular reactive oxygen species and enhancing calcium oscillation.Non-acid secreting anabolic pOCs were thus preserved and kept producing PDGF-BB,which lead to mesenchymal stem cell osteogenesis and endothelial progenitor cell angiogenesis via PI3K-Akt activated focal adhesion kinase.In treating osteoporotic ovariectomized mice,CNS showed better protective effects compare with the current first line antiresorptive drug due to the better anabolic effects marked by higher level of bone formation and vascularization.We provided a novel anabolic therapeutic strategy in treating bone disorders with excessive bone resorption. | Ce Dou Jianmei Li Jian He Fei Luo Tao Yu Qijie Dai Yueqi Chen Jianzhong Xu Xiaochao Yang Shiwu Dong | 2021 | Bioactive Materials2021，6，12： | 3 |
| 5 | Mechanical properties of a novel, lightweight structure inspired by beetle's elytra显示文摘A new kind of bio-inspired, lightweight structure was designed and built from carbon fibre prepreg based on the cross-sectional microstructure of a beetle's elytra. The compression strength and failure process of the resulting structure was analysed using the finite element method; while at the same time, a quasi-static compression experiment was performed using an electronic universal testing machine to verify the effectiveness and accuracy of this finite element method. This bio-inspired structure was compared against a conventional honeycomb structure using FEM, revealing that for a given porosity and load parallel to the axis of the core tubes the respective compressive and specific compressive strengths of the bioinspired structure are much higher at 84.3 MPa and194.7 MPa/(g cm-3); thus demonstrating that this bioinspired structure has superior compressive capability. | Ce Guo Dong Li Zhenyu Lu Chunsheng Zhu Zhendong Da | 2014 | Chinese Science Bulletin2014，59，26： | 3 |
| 6 | Detrital Zircon U-Pb Geochronology: New Insight into the Provenance of Sanya Formation in the Yinggehai Basin显示文摘Objective The NNW-SSE trending Yinggehai Basin,located on the continental shelf at water depths of 50-200 m in the northwestern South China Sea,is a Cenozoic conversion extensional basin.Over the past decades,a number of hydrocarbon reservoirs have been discovered in the deepwater area of the basin,including the Lingtou Formation(Eocene),Yacheng and Lingshui | WANG Ce LIANG Xinquan FU Jiangang JIANG Ying DONG Chaoge | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 2 |
| 7 | Remote sensing-based dynamic monitoring and environmental change of wetlands in southern Mongolian Plateau in 2000‒2018显示文摘The environmental change in the wetlands in the southern Mongolian Plateau has important impacts on the environment of North China and even the entire Northeast Asia,from which the global climate change can be understood on a large scale,especially the climate change in the Mongolian Plateau.This study extracted the information on the wetlands from three stages of remote sensing images(also referred to as RS images)of the study area,including Enhanced Thematic Mapper Plus(ETM+)images of 2000,TM images of 2010,and Landsat 8 Operational Land Imager(OLI)images of 2018.As indicated by the extraction results,the area of wetlands decreased from 796.90 km^(2) of 2000 to 666.24 km^(2) of 2018 at a rate of 7.26 km^(2)/a.The reduced area is 130.66 km^(2),which is about 16.4%reduction.And the patch number of wetlands decreased from 731 of 2000 to 316 of 2018 in the study area,approximately 56.8%reduction(415 patches),and the decrease in the area of the wetlands mainly occurred in the northwest endorheic region.In terms of wetland types,the change of the wetlands was dominated by the decrease of lacustrine wetlands,of which the area and patch number decreased by 106.2 km^(2) and 242,respectively.Furthermore,the area of the lacustrine wetlands decreased at the highest rate of 8.70 km^(2)/a in 2010‒2018.From the perspective of spatial distribution,the wetlands in the western part shrunk more notably than those in the eastern part as a whole in the study area.According to local meteorological data,the precipitation gently decreased and the temperature increased(about 1.7℃)from 1975-2018.Overall,the decrease in the area of the wetlands and the temperature rises in the study area were mainly driven by the Mongolian monsoon climate,reduction in precipitation,and human activities. | Wen-hui Jie Chun-lei Xiao Ce Zhang En Zhang Jing-yue Li Bing Wang Hai-wei Niu Shuang-fa Dong | 2021 | China Geology2021，4，2： | 2 |
| 8 | Detrital Zircon Provenance of Pliocene Yinggehai Formation in the Ledong Gas Field of the Yinggehai-Song Hong Basin显示文摘1 Introduction Over the past decades,a number of hydrocarbon reservoirs have been discovered in the deepwater area of the Yinggehai-Song Hong Basin,South China Sea.The NW-oriented Yinggehai-Song Hong Basin,located on the continental shelf at water depths of 50-200 m in the northwestern South China Sea,is one of the | WANG Ce LIANG Xinquan FU Jiangang ZHOU Yun JIANG Ying DONG Chaoge | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 2 |
| 9 | Bax and apoptosis in acute and chronic rejection of rat cardiac allografts 显示文摘 | Dong C Granville DJ Tuffnel CE | 1999 | Lab Invest1999，79，12： | 1 |
| 10 | Polystyreneacrylonitrile-CNTs nanocomposites preparations and tribological behavior research显示文摘 | WANG Ce XUE Tong DONG Bing | 2008 | Wear2008，265，1112： | 1 |
| 11 | Facile synthesis and dehydrogenation properties of Fe3 B nano-alloys显示文摘 | YU Lianqing DONG Kaituo YANG Ce | 2014 | Materials Letters2014，132，1： | 1 |
| 12 | Diffusion and Adsorption of Tetralin Hydrocracking Reaction on Different Zeolites by Molecular Simulation显示文摘Three different zeolite catalysts with different pore sizes(MFI-type,BEA-type,and FAU-type zeolites)have been prepared.The influence of different zeolite catalysts on reactivity and product shape selectivity of tetralin is investigated.Clear differences are observed in the reactivity of tetralin and distribution of products achieved by different catalysts.The diffusion and adsorption behavior of the reactant tetralin and its intermediates,n-butylbenzene and 1-methylindane under the reaction conditions are simulated using molecular simulation methods.Upon combining simulation results and experimental observations,it is shown that the difference in diffusion coefficient and competitive adsorption capacity can explain the reactivity of tetralin and the selectivity of products.The steric hindrance of the MFI-type zeolite mainly limits the key step of ring opening of tetralin,leading to lower selectivity of ring-opening products.n-Butylbenzene molecules can diffuse sufficiently fast in the large pores of FAU-type zeolite and the weak adsorption capacity of n-butylbenzene leads to its insufficient cracking.In addition,it also explains the reason that the BEA-type zeolite has the best BTX selectivity,because it can satisfy both good ring-opening activity and sufficient butylbenzene cracking depth. | Sun Lijie Fan Yaming Dong Songtao Xian Ce Long Xiangyun Li Dadong | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，1： | 1 |
| 13 | Adsorption and Vibration of O on the Pt Stepped Surfaces显示文摘The 5-parameter Morse potential (5-MP) of interaction between an adatom and metal surface cluster is put forward and performed on O-Pt stepped surface systems. We have primarily studied O/Pt(331), O/Pt(221) and O/Pt(553) systems and drawn some conclusions from the calculated results in good agreement with experimental and theoretical information. The O atom adsorbs stably near the step, so the step is the active place in the reaction. There are two types of atomic states, a1 and a2, in the adsorbed systems, corresponding to the three-fold states and four-fold long-bridged state behind the step respectively. Moreover, the length of (111) terrace affects weakly the properties of all critical points in these systems. | DONG Chen-Chu DIAO Zhao-Yu WANG Ze-Xin HAO Ce | 2005 | Chinese Journal of Structural Chemistry2005，24，8： | 1 |
| 14 | Research advance in sediment provenance of the Qiongdongnan Basin显示文摘1 Introduction Sediment provenance study,as an important part of basin analysis,is a key for source area definition,paleogeographic reconstruction,sediment transport route identification,and tectonic evolution(Haughton et al.,1991;Morton et al.,1999;Fontanelli et al.,2009;Cawood et al.,2012).The Qiongdongnan Basin(QDNB),lies in the northwestern passive continental margin of the | WANG Ce LIANG Xinquan LIANG Xirong DONG Chaoge XIE Hao | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 1 |
| 15 | Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p显示文摘Endochondral bone formation is an important route for bone repair.Although emerging evidence has revealed the functions of long non-coding RNAs(lncRNAs)in bone and cartilage development,the effect of lncRNAs in endochondral bone repair is still largely unknown.Here,we identified a lncRNA,named Hypertrophic Chondrocyte Angiogenesis-related lncRNA(HCAR),and proved it to promote the endochondral bone repair by upregulating the expression of matrix metallopeptidase 13(Mmp13)and vascular endothelial growth factorα(Vegfa)in hypertrophic chondrocytes.Lnc-HCAR knockdown in hypertrophic chondrocytes restrained the cartilage matrix remodeling and decrease the CD31hiEmcnhi vessels number in a bone repair model.Mechanistically,we proved that lnc-HCAR was mainly enriched in the cytoplasm using fluorescence in situ hybridization(FISH)assay,and it acted as a molecular sponge for miR-15b-5p.Further,in hypertrophic chondrocytes,lnc-HCAR competitively bound to miR-15b-5p to increase Vegfa and Mmp13 expression.Our results proved that lncRNA is deeply involved in endochondral bone repair,which will provide a new theoretical basis for future strategies for promoting fracture healing. | Yun Bai Xiaoshan Gong Rui Dong Zhen Cao Ce Dou Chuan Liu Jianmei Li Fei Kang Jingjin Dai Chunrong Zhao Zhansone Tian Jiulin Tan Qijie Dai Shiwu Dong | 2022 | Genes & Diseases2022，9，2： | 1 |
| 16 | Bax and apoptosis in acute and chronic rejection of rat cardiac allografts显示文摘 | Dong CM Granville DJ Tuffnel CE | 1999 | Lab Invest1999，79，12： | 1 |
| 17 | Prognostic Values of Serum Chloride and Sodium Levels in Patients with Three-vessel Disease显示文摘Objective Identification of new risk factors is needed to improve prediction of adverse outcomes in patients with three-vessel disease(TVD). The present study aimed to evaluate the prognostic values of serum chloride and sodium levels in patients with TVD. Methods We used data from a prospective cohort of consecutive patients with angiographically confirmed TVD. The primary endpoint was all-cause death. Cox proportional hazard regression was used to analyze the relationship of serum chloride and sodium levels with long-term outcomes of TVD patients. Results A total of 8,318 participants with available serum chloride and sodium data were included in this analysis. At baseline, patients in the low tertiles group of serum chloride level(≤ 102.0 mmol/L) or serum sodium level(≤ 139.0 mmol/L) had more severe disease conditions. During a median follow-up of 7.5-year, both low serum chloride level and low serum sodium level were found to be associated with an increased risk for mortality in univariate analysis. However, when both parameters were incorporated into a multivariate model, only low serum sodium level remained to be an independent predictor of all-cause death(hazard ratio: 1.16, 95% confidence interval: 1.01-1.34, P = 0.041). Modest but significant improvement of discrimination was observed after incorporating serum sodium level into the Synergy between percutaneous coronary intervention(PCI) with Taxus and Cardiac Surgery score. Conclusion Serum sodium level is more strongly associated with long-term outcomes of TVD patients compared with serum chloride level. Low serum sodium level is an independent risk factor for mortality, but only provides modest prognostic information beyond an established risk model. | ZHANG Ce WANG Dong HOU Bing Jie JIANG Lin XU Lian Jun TIAN Jian ZHAO Yan Yan ZHAO Xue Yan FENG Xin Xing ZHANG Yin SUN Kai XU Bo ZHAO Wei HUI Ru Tai GAO Run Lin LOU Hui Ling YUAN Jin Qing SONG Lei | 2019 | Biomedical and Environmental Sciences2019，32，4： | 1 |
| 18 | Bax and apoptosis in a- cute and chronic rejection of rat cardiac allografts显示文摘 | Dong CM Granville DJ Tuffnel CE | 1999 | Lab Invest1999，9，12： | 1 |
| 19 | Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients 显示文摘 | Sun G Luo T Yang C Dong X Li J Zhu Y Zheng H Tian W Wang S Barry CE 3rd Mei J Gao Q | 2012 | J Infect Dis2012，206，11： | 1 |
| 20 | Bax and apoptosis in acute and chronic rejection of root cardiac allografts 显示文摘 | DONG C GRANVILLE DJ TUFFNEI CE | 1999 | Lab Invest1999，79，12： | 1 |
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