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| 1 | 中国老年心房颤动优化抗凝管理注册研究一年结果显示文摘目的研究旨在探讨合并多种疾病的老年心房颤动(房颤)患者的优化抗凝管理策略。方法中国老年房颤患者优化抗栓管理注册研究(ChiOTEAF研究)是一项前瞻性、多中心、真实世界的注册研究。2014年10月至2018年12月在全国44家中心招募老年房颤患者,随访1年的血栓栓塞、出血、急性冠状动脉综合征和全因死亡发生情况。使用Cox风险比例模型分析抗凝治疗对血栓、出血及全因死亡复合临床事件的影响。结果本研究共招募7073例房颤患者,其中6148例完成1年随访,年龄(74.3±10.5)岁,年龄范围65~92岁,其中女患者占39.4%(2422/6148)。非维生素K拮抗剂口服抗凝药(NOACs)、华法林和抗血小板药物的使用率分别为23.5%(1444/6148)、21.1%(1300/6148)和41.0%(2521/6148)。48.6%(2988/6148)患者同时存在CHA2DS2-VASc和HAS-BLED评分高危,49.6%(3052/6148)患者HAS-BLED评分≥3。42.3%(2601/6148)患者有跌倒风险,34.2%(2102/6148)患者合并心力衰竭,17.3%(1064/6148)患者年龄≥85岁,14.3%(878/6148)合并慢性肾脏病/肝病,9.0%(555/6148)合并恶性肿瘤。校正基线特征后,房颤合并CHA2DS2-VASc和HAS-BLED高危、HAS-BLED≥3、跌倒风险、慢性肾脏病/肝病、年龄≥85岁等患者,抗凝治疗较抗血小板治疗降低急性心肌梗死、缺血性脑卒中、脑出血和全因死亡的复合终点事件风险(均P<0.05)。结论权衡血栓及出血风险后,老年高危房颤患者抗凝治疗降低临床不良事件。 | 郭豫涛 王玉堂 单兆亮 时向民 奚国荣 王浩 Lip Gregory Y H | 2020 | 中华心律失常学杂志2020，24，4： | 13 |
| 2 | Study of HIV-1 Drug Resistance in Patients Receiving Free Antiretroviral Therapy in China显示文摘To investigate the prevalence of drug-resistance mutations,resistance to antiretroviral drugs,and the subsequent virological response to therapy in treatment-naive and antiretroviral-treated patients infected with HIV/AIDS in Henan,China,a total of 431 plasma samples were collected in Queshan county between 2003 and 2004,from patients undergoing the antiretroviral regimen Zidovudine + Didanosine + Nevirapine(Azt+Ddi+Nvp).Personal information was collected by face to face interview.Viral load and genotypic drug resistance were tested.Drug resistance mutation data were obtained by analyzing patient-derived sequences through the HIVdb Program(http://gffzz38c50ed9119344cfh90nucwxf6vqv6xkx.ffgz.tsg.suse.edu.cn).Overall,38.5% of treatment-naive patients had undetectable plasma viral load(VL),the rate significantly increased to 61.9% in 0 to 6 months treatment patients(mean 3 months)(P<0.005)but again significantly decrease to 38.6% in 6 to 12 months treatment patients(mean 9 months)(P<0.001)and 40.0% in patients receiving more than 12 months treatment(mean 16 months)(P<0.005).The prevalence of drug resistance in patients who had a detectable VL and available sequences were 7.0%,48.6%,70.8%,72.3% in treatment-na?ve,0 to 6 months treatment,6 to 12 months treatment,and treatment for greater than 12 months patients,respectively.No mutation associated with resistance to Protease inhibitor(PI)was detected in this study.Nucleoside RT inhibitor(NRTI)mutations always emerged after non-nucleoside RT inhibitor(NNRTI)mutations,and were only found in patients treated for more than 6 months,with a frequency less than 5%,with the exception of mutation T215Y(12.8%,6/47)which occurred in patients treated for more than 12 months.NNRTI mutations emerged quickly after therapy begun,and increased significantly in patients treated for more than 6 months(P<0.005),and the most frequent mutations were K103N,V106A,Y181C,G190A.There had been optimal viral suppression in patients undergoing treatment for less than 6 months in Queshan,Henan.The drug resistance strains were highly prevalent in antiretroviral-treated patients,and increased with the continuation of therapy,with many patients encountering virological failure after 6 months therapy. | Xin-ping LIP Hui XING Zhe WANG Xue-feng SI Lian-en WANG Hua CHENG Wei-guo CUI Shu-lin JIANG Ling-jie LIAO Hai-wei ZHOU Jiang-hong HUANG Hong PENG Peng-fei MA Yi-ming SHAO | 2007 | 中国病毒学2007，22，3： | 9 |
| 3 | 静脉血栓栓塞显示文摘静脉血栓栓塞,包括深静脉血栓形成与肺动脉栓塞,普通可见,在医院和院外均可进行治疗主要危险因素包括年龄、近期手术(特别是整形手术)、癌症及血栓形成倾向已确立的治疗有普通肝素、低分子量肝素。 | Andrew D Blann Gregory Y H Lip 刘仁斌(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 6 |
| 4 | Unexpected complication of arteriovenous fistula of the left common carotid to internal jugular vein following central venous catheterization显示文摘Incidence of inadvertent arterial puncture secondary to central venous catheter insertion is not common with an arterial puncture rate of<1%.This is due to the advancements and wide availability of ultrasound to guide its insertion.Formation of arteriovenous fistula after arterial puncture is an unexpected complication.Till date,only five cases(including this case)of acquired arteriovenous fistula formation has been described due to inadvertent common carotid puncture.The present case is a 26-year-old man sustained traumatic brain injuries,chest injuries and multiple bony fractures.During resuscitative phase,attempts at left central venous catheter via left internal jugular vein under ultrasound guidance resulted in inadvertent puncture into the left common carotid artery.Surgical neck exploration revealed that the catheter had punctured through the left internal jugular vein into the common carotid artery with formation of arteriovenous fistula.The catheter was removed successfully and common carotid artery was repaired.Postoperatively,the patient recovered and clinic visits revealed no neurological deficits.From our literature review,the safest method for removal is via endovascular and open surgical removal.The pull/push technique(direct removal with compression)is not recommended due to the high risk for stroke,bleeding and hematoma formation. | Tan Chor Lip Henry Tan Jih Huei Mohamad Yuzaidi Lenny Suryani Safri K.Krishna Imran Alwi Rizal Md Idris Mohamad Azim Hanafiah Harunarashid | 2020 | Chinese Journal of Traumatology2020，23，1： | 5 |
| 5 | Survival analysis and mortality predictors of hospitalized severe burn victims in a Malaysian burns intensive care unit显示文摘Background:Prognostic measures to determine burn mortality are essential in evaluating the severity of individual burn victims.This is an important process of triaging patients with high risk of mortality that may be nursed in the acute care setting.Malaysian burn research is lacking with only one publication identified which describes the epidemiology of burn victims.Therefore,the objective of this study was to go one step further and identify the predictors of burn mortality from a Malaysian burns intensive care unit(BICU)which may be used to triage patients at higher risk of death.Methods:This is a retrospective cohort study of all admissions to Hospital Sultan Ismail’s BICU from January 2010 till October 2015.Admission criteria were in accordance with the American Burn Association guidelines,and risk factors of interest were recorded.Data was analyzed using simple logistic regression to determine significant predictors of mortality.Survival analysis with time to death event was performed using the Kaplan-Meier survival curve with log-rank test.Results:Through the 6-year period,393 patients were admitted with a male preponderance of 73.8%.The mean age and length of stay were 35.6(±15.72)years and 15.3(±18.91)days.There were 48 mortalities with an overall mortality rate of 12.2%.Significant risk factors identified on simple logistic regression were total body surface area(TBSA)>20%(p<0.001),inhalation injury(p<0.001)and presence of early systemic inflammatory response syndrome(SIRS)(p<0.001).Survival analysis using Kaplan-Meier survival curve showed similar results with TBSA>20%,presence of SIRS,mechanical ventilation and inhalation injury which were associated with poorer survival(p<0.001).Conclusion:The predictors of mortality identified in a Malaysian BICU were TBSA>20%,early SIRS,mechanical ventilation and inhalation injury which were associated with poorer survival outcome.The immunological response differs from individual patients and influenced by the severity of burn injury.Early SIRS on admission is an important predictor of death and may represent the severity of burn injury.Patients who required mechanical ventilation were associated with mortality and it is likely related to the severity of pulmonary insults sustained by individual patients.This data is important for outcome prognostication and mortality risk counselling in severely burned patients. | Henry Tan Chor Lip Jih Huei Tan Mathew Thomas Farrah-Hani Imran Tuan Nur’Azmah Tuan Mat | 2019 | Burns & Trauma2019，7，1： | 4 |
| 6 | Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with, firsthand examples显示文摘纳米技术在药交货广泛地被使用了改进各种各样的疾病的治疗学的结果。巨大的努力在与他们的生物命运和函数的关系集中于 nanoparticles 的物理化学的性质的新奇 nanoparticles 和描述的开发。然而在这些基于纳米技术的药交货系统的设计和评估,交付的药的药理学并且(patho-) 主人的生理学收到了更少的注意。在这评论,我们讨论集成于使纳米技术能的药交货系统和治疗的设计的重要药理学机制,生理的特征,和病理学的因素。第一手的例子被举由利用 1 为癌症治疗说明如此的综合设计策略的原则和优点)到克服的multidrug抵抗的癌症的药药和 drug-nanomaterial 联合的细胞内部的 synergistic 相互作用, 2 )循环系统到的血流动方向为肺转移最大化药交货到肿瘤 neovasculature 和房间 overexpressing integrin 受体, 3 )装饰 nanocarriers 和 t 的内长的脂蛋白关于在糖尿病管理的申请,一个使纳米技术能的靠近环的胰岛素交货系统被设计在生理地相关的时间规模和葡萄糖层次提供动态胰岛素版本。和另外的研究结果,这些例子建议药理学的相互影响的那利用,(patho-) 生理学和纳米技术是一条灵巧的途径与高效率和翻译潜力开发创新的药交货系统和治疗。 | Rui Xue ZHANG Jason LI Tian ZHANG Mohammad A AMINI Chunsheng HE Brian LU Taksim AHMED HoYin LIP Andrew M RAUTH Xiao Yu WU | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 7 | Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: A population-based study in the Netherlands显示文摘 | A.E. Dassen V.E.P.P. Lemmens L.V. van de Poll-Franse G.J. Creemers S.J. Brenninkmeijer D.J. Lips A.A.M. vd Wurff K. Bosscha J.W.W. Coebergh | 2010 | European Journal of Cancer2010，，6： | 2 |
| 8 | Single-port laparoscopic cholecystectomy vs standard laparoscopic cholecystectomy:A non-randomized,agematched single center trial显示文摘AIM: To compare the safety of single-port laparoscopic cholecystectomies with standard four-port cholecystectomies.METHODS: Between January 2011 and December 2012 datas were gathered from 100 consecutive patients who received a single-port cholecystectomy. Patient baseline characteristics of all 100 single-port cholecystectomies were collected(body mass index, age, etc.) in a database. This group was compared with 100 age-matched patients who underwent a conventional laparoscopic cholecystectomy in the same period. Retrospectively, per- and postoperative data were added. The two groups were compared to each other using independent t-tests and χ2-tests, P values below 0.05 were considered significantly different.RESULTS: No differences were found between both groups regarding baseline characteristics. Operating time was significantly shorter in the total single-port group(42 min vs 62 min, P < 0.05); in procedures performed by surgeons the same trend was seen(45 min vs 59 min, P < 0.05). Peroperative complications between both groups were equal(3 in the single-port group vs 5 in the multiport group; P = 0.42). Although not significant less postoperative complications were seen in the single-port group compared with the multiport group(3 vs 9; P = 0.07). No statistically significant differences were found between both groupswith regard to length of hospital stay, readmissions and mortality. CONCLUSION: Single-port laparoscopic cholecystectomy has the potential to be a safe technique with a low complication rate, short in-hospital stay and comparable operating time. Single-port cholecystectomy provides the patient an almost non-visible scar while preserving optimal quality of surgery. Further prospective studies are needed to prove the safety of the single-port technique. | Yoen TK van der Linden Koop Bosscha Hubert A Prins Daniel J Lips | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 9 | Intraoperative blood transfusion requirement is the main determinant of early surgical re-intervention after orthotopic liver transplantation显示文摘 | H. G. D. Hendriks J. Meer J. T. M. Wolf P. M. J. G. Peeters R. J. Porte K. Jong H. Lip W. J. Post M. J. H. Slooff | 2005 | Transplant International2005，，11： | 2 |
| 10 | Endothelial Dysfunction and Damage in Congestive Heart Failure: Relation of Flow-Mediated Dilation to Circulating Endothelial Cells, Plasma Indexes of Endothelial Damage, and Brain Natriuretic Peptide显示文摘 | Aun Yeong Chong Andrew D. Blann Jeetesh Patel Bethan Freestone Elizabeth Hughes Gregory Y.H. Lip | 2004 | Circulation2004，，13： | 2 |
| 11 | Aspects of multiple infeed of HVDC inverter station into a common AC system 显示文摘 | Lips H P | 1973 | IEEE Transactions on Power Apparatus Systems1973，92，2： | 2 |
| 12 | Relationship of homocysteine to markers of platelet and endothelial activation in ‘high risk’ hypertensives: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial显示文摘 | Charles G.C. Spencer Steven C. Martin Dirk C. Felmeden Andrew D. Blann Gareth D. Beevers Gregory Y.H. Lip | 2004 | International Journal of Cardiology2004，，2： | 2 |
| 13 | Is soluble P-selectin a new marker of platelet activation显示文摘 | Blann AD Lip GYH | 1997 | Atherosclerosis1997，128，： | 2 |
| 14 | 高血压和心房颤动:流行病学、病理生理学与临床结局的关系显示文摘心房颤动是临床实践中最常见的持续性心律失常。单纯的心房颤动并不多见,更多的是作为心血管病临床表现的一部分,与左心房结构和电信号重构有关。由于在心房颤动人群的患病率高,动脉性高血压在心房颤动及其并发症的发病机制中起重要作用。 | Dzeshka MS Shahid F Shantsila A Lip GYH 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，4： | 2 |
| 15 | 应用多重连接探针扩增法简便高效检测Prader-Willi综合征的基因缺失(英文)显示文摘Objective: Prader-Willi syndrome (PWS) is characterized by severe hypotonia and feeding difficulties in early infancy, followed by excessive eating and gradual development of morbid obesity in later infancy or early childhood. Patients with PWS are often too young to manifest sufficient features or have atypical findings, making genetic testing important to confirm the diagnosis of PWS. Approximately 99% of patients with PWS have a diagnostic abnormality in the parent-specific methylation imprint within the Prader-Willi critical region (PWCR) at chromosome 15q11.2-q12. Of them, 70% have a paternal deletion; 25% have a maternal uniparental disomy (UPD); and <5% have a mutation in the imprinting center. Methods: Current techniques can identify a diagnostic abnormality, such as paternal deletion or maternal UPD for most of patients with PWS, but they are labor-intensive and cost-expensive. Multiplex ligation-dependent probe amplification (MLPA) is a novel, simple, and cost-effective technique for analysis of relative quantification in a single assay, which has recently been applied for the detection of genomic deletions, duplications, and amplifications in a variety of genes. Results: Six out of 20 patients referred for genetic diagnosis of PWS were found to have a deletion by MLPA, confirmed by FISH and DNA methylation analysis with 100% concordance. Conclusion: MLPA’s high sensitivity and specificity for deletion detection is the same as FISH or Southern blot based analysis. Additional collaborative effort for developing and validating the complete MLPA-PWS assay, for not only detecting deletion but also identifying methylation abnormality, is on going. | Va LIP | 2005 | 北京大学学报(医学版)2005，37，1： | 2 |
| 16 | FDG-PET has no definite role in preoperative imaging in gastric cancer显示文摘 | A.E. Dassen D.J. Lips C.J. Hoekstra J.F.M. Pruijt K. Bosscha | 2008 | European Journal of Surgical Oncology2008，，5： | 2 |
| 17 | Atrial fibrillation显示文摘 | Gregory YH Lip Hung Fat Tse Deirdre A Lane | 2012 | The Lancet . 2012 (9816)2012，，： | 2 |
| 18 | Estimates of optimal vitamin D status显示文摘 | Bess Dawson-Hughes Robert P. Heaney Michael F. Holick Paul Lips Pierre J. Meunier Reinhold Vieth | 2005 | Osteoporosis International2005，，7： | 2 |
| 19 | The Role of Aspirin in Cardiovascular Prevention显示文摘 | Armen Yuri Gasparyan Timothy Watson Gregory Y.H. Lip | 2008 | Journal of the American College of Cardiology2008，，19： | 2 |
| 20 | Soluble P-selectin in atherosclerosis: a comparison with endothelial cell and platelet markers 显示文摘 | Blann AD Lip GY Beevers DG | 1997 | Thromb Haemost1997，77，6： | 1 |
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