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| 1 | Melanoma of the rectum: A rare entity显示文摘A 41-year-old man presented with a 6-mo history of changed defecation and rectal bleeding. A 3-cm polypoid tumor of the lower rectum was found at rectosigmoidos- copy, which proved to be a leiomyosarcoma upon biopsy. Dissemination studies did not show any metastases. He was underwent to an abdomino-perineal resection (APR). Histopathology of the specimen showed a melanoma (S-100 stain positive). Two years after the resection, me- tastases in the abdomen and right lung were found. He died one and half years later. Primary anorectal melano- ma is a rare and very aggressive disorder. According to current data, one should always perform a S-100 stain when anorectal sarcoma is suspected. A positive S-100 stain suggests the tumour to be most likely a melanoma. Subsequently, thorough dissemination studies need to be performed. Depending on the outcome of the dissemina- tion studies, a surgical resection has to be performed. Nowadays, a sphincter-saving local excision combined with adjuvant loco-regional radiotherapy should be pre- ferred in case of small tumors. The same loco-regional control is achieved with less 'loss of function' compared to non-sphincter saving surgery. Only in the case of large and obstructing tumors an abdomino-perineal resection is the treatment of choice. | PM van Schaik MF Ernst HA Meijer K Bosscha | 2008 | World Journal of Gastroenterology2008，14，10： | 3 |
| 2 | Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: A population-based study in the Netherlands显示文摘 | A.E. Dassen V.E.P.P. Lemmens L.V. van de Poll-Franse G.J. Creemers S.J. Brenninkmeijer D.J. Lips A.A.M. vd Wurff K. Bosscha J.W.W. Coebergh | 2010 | European Journal of Cancer2010，，6： | 2 |
| 3 | Single-port laparoscopic cholecystectomy vs standard laparoscopic cholecystectomy:A non-randomized,agematched single center trial显示文摘AIM: To compare the safety of single-port laparoscopic cholecystectomies with standard four-port cholecystectomies.METHODS: Between January 2011 and December 2012 datas were gathered from 100 consecutive patients who received a single-port cholecystectomy. Patient baseline characteristics of all 100 single-port cholecystectomies were collected(body mass index, age, etc.) in a database. This group was compared with 100 age-matched patients who underwent a conventional laparoscopic cholecystectomy in the same period. Retrospectively, per- and postoperative data were added. The two groups were compared to each other using independent t-tests and χ2-tests, P values below 0.05 were considered significantly different.RESULTS: No differences were found between both groups regarding baseline characteristics. Operating time was significantly shorter in the total single-port group(42 min vs 62 min, P < 0.05); in procedures performed by surgeons the same trend was seen(45 min vs 59 min, P < 0.05). Peroperative complications between both groups were equal(3 in the single-port group vs 5 in the multiport group; P = 0.42). Although not significant less postoperative complications were seen in the single-port group compared with the multiport group(3 vs 9; P = 0.07). No statistically significant differences were found between both groupswith regard to length of hospital stay, readmissions and mortality. CONCLUSION: Single-port laparoscopic cholecystectomy has the potential to be a safe technique with a low complication rate, short in-hospital stay and comparable operating time. Single-port cholecystectomy provides the patient an almost non-visible scar while preserving optimal quality of surgery. Further prospective studies are needed to prove the safety of the single-port technique. | Yoen TK van der Linden Koop Bosscha Hubert A Prins Daniel J Lips | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 4 | FDG-PET has no definite role in preoperative imaging in gastric cancer显示文摘 | A.E. Dassen D.J. Lips C.J. Hoekstra J.F.M. Pruijt K. Bosscha | 2008 | European Journal of Surgical Oncology2008，，5： | 2 |
| 5 | Surgical management of severe secondary peritonitis显示文摘 | Bosscha K Vroonhoven TJ Werken CV | 1999 | Br J Surg1999，86，： | 1 |
| 6 | Prognostic scoring systems to predict outcome in peritonitis and intra-abdominal sepsis显示文摘 | Bosscha K Reijnders K Hulstaert Pf | 1997 | Br J Surg1997，84，11： | 1 |
| 7 | Fulminant acute pancreatitis and infected necrosis results of open management of the abdomen and 'planned' reoperation显示文摘 | Bosscha K Hulsteart PA Hennipman A | 1998 | J Am Coll Surg1998，187，： | 1 |
| 8 | Accuraey of transrectal ultra- sonography in staging rectal tumors that are clinically eligible for transanal endoscopic microsurgery 显示文摘 | Koebrugge B Bosscha K Jager G | 2010 | J Clin Ultrasound2010，38，5： | 1 |
| 9 | Relationship of cellu2 lar glutathione to the cytotixicity and resistance of seven platinumcompounds显示文摘 | Meijer C Mulder NH Bosscha H | 1992 | Cancer Res1992，52，24： | 1 |
| 10 | Interdigestive small bowel motility and duodenal bacterial over - growth in experimental acute pancreatitis 显示文摘 | Van Felius ID Akkermans LM Bosscha K | 2003 | Neumgastroenteml Motil2003，15，3： | 1 |
| 11 | Fulminant acute pancreatitis and infected necrosis: results of open management of the abdomen and ''planned'' reoperations 显示文摘 | Bosscha K Hulstaert PF Hennipman A | 1998 | J Am Coll Surg1998，187，3： | 1 |
| 12 | prognostic scoring systems to predict outcome in peritonitis and intraabdominal sepsis显示文摘 | Bosscha K Reijnders k Hulstaert PF | 1997 | Br J Surg1997，84，11： | 1 |
| 13 | Fulm inant acute pancreatits and infected necrosis results of management of the abdomen and 'Planned' reparations显示文摘 | Bosscha K Halstaett PF Hennipinan A | 1998 | Coll Jam Surg1998，187，3： | 1 |
| 14 | Fulminant acute pancreatitis and infected necrosis:results of open management of abdomen and 'pained' reoperations显示文摘 | Bosscha K Hulastart PF Hennipman A | 1998 | Am Coll Sug1998，187，3： | 1 |
| 15 | Internal Fixation of metacarpal and phalangeal Fractures with AO mini Fragthent screws and plates: a prospective study显示文摘 | Bosscha K | 1993 | Injury1993，24，3： | 1 |
| 16 | Interdigestive small bowel motility and duodenal bacterial overgrowth in experiment acute pancreatitis显示文摘 | Van Felius ID Akkermans LM Bosscha M | 2003 | Neuro Gastroenterol Motil2003，15，： | 1 |
| 17 | Fulminant acute pancreatitis and infected necrosis result of open management of the abdomen and 'Planned' reoperation显示文摘 | Bosscha K Hulstaert PT Hennimpman A | 1998 | J Am Coll Surg1998，187，3： | 1 |
| 18 | Gastrointestinal motility and gastric tube feeding in mechanically ventilated patients显示文摘 | Bosscha K Nieuwenhuijs VB Vos A | | 0，，9： | 1 |
| 19 | Phase Ⅱ study of docetaxel,cisplatin and capecitabine as preoperative chemotherapy in resectable gastric cancer显示文摘AIM To investigate the feasibility of preoperative docetaxel,cisplatin and capecitabine(DCC) in patients with resectable gastric cancer.METHODS Patients with resectable gastric cancer fulfilling the inclusion criteria,were treated with 4 cycles of docetaxel(60 mg/m2),cisplatin(60 mg/m2) and capecitabine(1.875 mg/m2 orally on day 1-14,two daily doses) repeated every three weeks,followed by surgery.Primary end point was the feasibility and toxicity/safety profile of DCC,secondary endpoints were pathological complete resection rate and pathological complete response(p CR) rate.RESULTS All of the patients(51) were assessable for the feasibility and safety of the regimen.The entire preoperative regimen was completed by 68.6% of the patients.Grade Ⅲ/Ⅳ febrile neutropenia occurred in 10% of all courses.Three patients died due to treatment related toxicity(5.9%),one of them(also) because of refusing further treatment for toxicity.Of the 45 patients who were evaluable for secondary endpoints,four developed metastatic disease and 76.5% received a curative resection.In 3 patients a p CR was seen(5.9%),two patients underwent a R1 resection(3.9%).CONCLUSION Four courses of DCC as a preoperative regimen for patients with primarily resectable gastric cancer is highly demanding.The high occurrence of febrile neutropenia is of concern.To decrease the occurrence of febrile neutropenia the prophylactic use of granulocyte colonystimulating factor(G-CSF) should be explored.A curative resection rate of 76.5% is acceptable.The use of DCC without G-CSF support as preoperative regimen in resectable gastric cancer is debatable. | Anneriet E Dassen Nienke Bernards Valery EPP Lemmens Yes AJ van de Wouw Koop Bosscha Geert-Jan Creemers Hans JFM Pruijt | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 1 |
| 20 | Interdigestive small bowel motility and duodenal bacterial overgrowth in experiment acute pancreatitis 显示文摘 | Van Felius ID Akkermans LM Bosscha M | 2003 | Neuro Gastroenterol Motil2003，15，3： | 1 |
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