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| 1 | Geochemical Characteristics and Sources of Ore-forming Fluids of the Mayuan Pb-Zn Deposit,Nanzheng,Shaanxi,China显示文摘The Mayuan stratabound Pb-Zn deposit in Nanzheng,Shaanxi Province,is located in the northern margin of the Yangtze Plate,in the southern margin of the Beiba Arch.The orebodies are stratiform and hosted in breciated dolostone of the Sinian Dengying Formation.The ore minerals are primarily sphalerite and galena,and the gangue minerals comprise of dolomite,quartz,barite,calcite and solid bitumen.Fluid inclusions from ore-stage quartz and calcite have homogenization tempreatures from 98 to 337℃ and salinities from 7.7 wt%to 22.2 wt%(NaCl equiv.).The vapor phase of the inclusions is mainly composed of CH_4 with minor CO_2 and H_2S.The δD_(fluid) values of fluid inclusions in quartz and calcite display a range from-68‰ to-113‰(SMOW),and the δ^(18)O_(fluid)values calculated from δ^(18)O_(quartz) and δ^(18)O_(calcite) values range from 4.5‰ to 16.7‰(SMOW).These data suggest that the ore-forming fluids may have been derived from evaporitic sea water that had reacted with organic matter.The δ^(13)C_(CH4) values of CH_4 in fluid inclusions range from-37.2‰ to-21.0‰(PDB),suggesting that the CH_4 in the ore-forming fluids was mainly derived from organic matter.This,together with the abundance of solid bitumen in the ores,suggest that organic matter played an important role in mineralization,and that the thermochemical sulfate reduction(TSR) was the main mechanism of sulfide precipitation.The Mayuan Pb-Zn deposit is a carbonate-hosted epigenetic deposit that may be classified as a Mississippi Valley type(MVT) deposit. | LIU Shuwen LI Ronxi CHI Guoxiang ZENG Rong LIU Lingfang SHI Shun | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 5 |
| 2 | Distinct Contributions of Replication and Transcription to Mutation Rate Variation of Human Genomes显示文摘Here, we evaluate the contribution of two major biological processes-DNA replication and transcription-to mutation rate variation in human genomes. Based on analysis of the public human tissue transcriptomics data, high-resolution replicating map of Hela cells and dbSNP data, we present significant correlations between expres-sion breadth, replication time in local regions and SNP density. SNP density of tissue-specific (TS) genes is sig-nificantly higher than that of housekeeping (HK) genes. TS genes tend to locate in late-replicating genomic re-gions and genes in such regions have a higher SNP density compared to those in early-replication regions. In addi-tion, SNP density is found to be positively correlated with expression level among HK genes. We conclude that the process of DNA replication generates stronger mutational pressure than transcription-associated biological processes do, resulting in an increase of mutation rate in TS genes while having weaker effects on HK genes. In contrast, transcription-associated processes are mainly responsible for the accumulation of mutations in highly-expressed HK genes. | Peng Cui Feng Ding Qiang Lin Lingfang Zhang Ang Li Zhang Zhang Songnian Hu Jun Yu | 2012 | Genomics, Proteomics & Bioinformatics2012，10，1： | 5 |
| 3 | Dielectric Properties of Bi_4Ti_3O_(12) Ceramics by Impedance Spectroscopic Method显示文摘Various lead-free ceramics have been investigated in search for new high-temperature dielectrics. In particular, Bi_4Ti_3O_(12) is a type of ferroelectric ceramics, which is supposed to replace leadcontaining ceramics for its outstanding dielectric properties in the near future. Ferroelectric ceramics of Bi_4Ti_3O_(12) made by conventional mixed oxide route have been studied by impedance spectroscopy in a wide range of temperature. X-ray diffraction patterns show that Bi_4Ti_3O_(12) ceramics are a single-phase of ferroelectric Bi-layered perovskite structure whether it is calcined at 800 ℃ or after sintering production. This study focused on the effect of the grain size on the electric properties of BIT ceramics. The BIT ceramics with different grain sizes were prepared at different sintering temperatures. Grain becomes coarser with the sintering temperature increasing by 50 ℃, relative permittivity and dielectric loss also change a lot. When sintered at 1 100 ℃, r values peak can reach 205.40 at a frequency of 100 k Hz, the minimum dielectric losses of four different frequencies make no difference, all close to 0.027. The values of Ea range from 0.52 to 0.68 e V. The dielectric properties of the sample sintered at 1 100 ℃ are relatively better than those of the other samples by analyzing the relationship of the grain, the internal stresses, the homogeneity and the dielectric properties. SEM can better explain the results of the dielectric spectrum at different sintering temperatures. The results show that Bi_4Ti_3O_(12) ceramics are a kind of dielectrics. Thus, Bi_4Ti_3O_(12) can be used in high-temperature capacitors and microwave ceramics. | 陈勇 SU Huyin XUE Simin LI Zhaozhi ZHANG Cancan CHEN Qi XU Lingfang 曹万强 黄兆祥 | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，5： | 3 |
| 4 | Reputation, Trust, and Rebates: How Online Auction Markets Can Improve Their Feedback Mechanisms显示文摘 | Lingfang (Ivy)Li | 2010 | Journal of Economics & Management Strategy2010，，2： | 1 |
| 5 | Nesiritide fails to reduce the mortality of patients with acute decompensated heart failure: An updated systematic review and cumulative meta-analysis显示文摘 | Bin Yan Liyuan Peng Xiaojing Zhao HsingChun Chung Lijun Li Lingfang Zeng HeanYee Ong Gang Wang | 2014 | International Journal of Cardiology2014，，： | 1 |
| 6 | Programmed death ligand-1 regulates angiogenesis and metastasis by participating in the c-JUN/VEGFR2 signaling axis in ovarian cancer显示文摘Background:Although programmed cell death-ligand 1(PD-L1)plays a wellknown function in immune checkpoint response by interacting with programmed cell death-1(PD-1),the cell-intrinsic role of PD-L1 in tumors is still unclear.Here,we explored the molecular regulatory mechanism of PD-L1 in the progression and metastasis of ovarian cancer.Methods:Immunohistochemistry of benign tissues and ovarian cancer samples was performed,followed by migration,invasion,and angiogenesis assays in PDL1-knockdown ovarian cancer cells.Immunoprecipitation,mass spectrometry,and chromatin immunoprecipitation were conducted along with zebrafish and mouse experiments to explore the specific functions and mechanisms of PD-L1 in ovarian cancer.Results:Our results showed that PD-L1 induced angiogenesis,which further promoted cell migration and invasion in vitro and in vivo of ovarian cancer.Mechanistically,PD-L1 was identified to directly interact with vascular endothelial growth factor receptor-2(VEGFR2)and then activated the FAK/AKT pathway,which further induced angiogenesis and tumor progression,leading to poor prognosis of ovarian cancer patients.Meanwhile,PD-L1 was found to be regulated by the oncogenic transcription factor c-JUN at the transcriptional level,which enhanced the expression of PD-L1 in ovarian cancer.Furthermore,we demonstrated that PD-L1 inhibitor durvalumab,combined with the antiangiogenic drug,apatinib,could enhance the effect of anti-angiogenesis and the inhibition of cell migration and invasion.Conclusion:Our results demonstrated that PD-L1 promoted the angiogenesis and metastasis of ovarian cancer by participating in the c-JUN/VEGFR2 signaling axis,suggesting that the combination of PD-L1 inhibitor and antiangiogenic drugs may be considered as a potential therapeutic approach for ovarian cancer patients. | Yufei Yang Lingfang Xia Yong Wu Hongyu Zhou Xin Chen Haoran Li Midie Xu Zihao Qi Ziliang Wang Huizhen Sun Xi Cheng | 2021 | Cancer Communications2021，41，6： | 1 |
| 7 | The effect of citric acid to metal nitrates molar ratio on sol - gel combustion synthesis of nanocrystalline LaMnO3 powders显示文摘 | Li Yuanyuan Xue Lihong Fan Lingfang | 2009 | Journal of Alloys and Compounds2009，478，1： | 1 |
| 8 | GCRV 096 VP6 protein and its impacts on GCRV replication with different genotypes in CIK cells显示文摘Grass carp reovirus(GCRV)is the causative agent of grass carp hemorrhagic disease,which has detrimental effects on the grass carp aquaculture industry.There are four known genotypes of GCRV and strains of different GCRV genotypes differ greatly.In this study,the diversity of the protein VP6 from different GCRV stains and the effect of genotype GCRV 096 on replication was investigated in CIK cells.Our results showed that the VP6 protein of GCRV 096(genotypeІ)exhibited limited homology to that of GCRV GD108(genotypeШ),with few residues conserved in predicted protein-protein interaction domains.GCRV 096 VP6 protein was expressed and purified and an antiserum against it was characterized.Addition of purified VP6 protein or antiserum to culture media of CIK cells inhibited the replication of GCRV 096 in these cells.In contrast,replication of GCRV GD108(genotypeШ)was not affected in CIK cells under the same condition.Overall,our results indicated that the protein VP6 and VP6 antiserum did not provide cross-protection against GCRV strains and this can be attributed to differences among GCRV genotypes.It will be important to consider multiple GCRV genotypes in the development of effective GCRV vaccines and other therapies against grass carp hemorrhagic disease.In addition,bioinformatics analysis also suggested that the protein VP6 may have a role in the process of GCRV infection.This study lays the foundation for the prevention of grass carp hemorrhagic disease and further detailed studies on the pathogenesis of GCRV. | Xiuying Yan Lingfang Xiong Jie Li Ya Wang Zaohe Wu Jichang Jian Yu Ding | 2018 | Aquaculture and Fisheries2018，3，5： | 1 |
| 9 | Hard car- bon wrapped in graphene networks as lithum ion battery anode显示文摘 | Zhang Xiang Fan Changling Li Lingfang | 2014 | Electrochimica Acta2014，149，： | 1 |
| 10 | Fault Detection for Nonlinear Impulsive Switched Systems显示文摘 | Jian Li Qingyu Su Lingfang Sun Bo Li Xiaojie Su | 2013 | <journal-title>Mathematical Problems in Engineering2013，，： | 1 |
| 11 | Design of the nozzle of a yarn suction gun for fully drawn yarn 显示文摘 | LI Yonggui WEI Man ZHANG Lingfang | 2014 | Textile Research Journal2014，84，3： | 1 |
| 12 | Evaluating the effect of midpalatal corticotomy-assisted rapid maxillary expansion on the upper airway in young adults using computational fluid dynamics显示文摘Midpalatal corticotomy-assisted rapid maxillary expansion(MCRME)is a minimally invasive treatment of maxillary transverse deficiency(MTD)in young adults.However,the effect of MCRME on respiratory function still needs to be determined.In this study,we evaluated the changes in maxillary morphology and the upper airway following MCRME using computational fluid dynamics(CFD).Twenty patients with MTD(8 males,12 females;mean age 20.55 years)had cone-beam computed tomography(CBCT)images taken before and after MCRME.The CBCT data were used to construct a threedimensional(3 D)upper airway model.The upper airway flow characteristics were simulated using CFD,and measurements were made based on the CBCT images and CFD.The results showed that the widths of the palatal bone and nasal cavity,and the intermolar width were increased significantly after MCRME.The volume of the nasal cavity and nasopharynx increased significantly,while there were no obvious changes in the volumes of the oropharynx and hypopharynx.CFD simulation of the upper airway showed that the pressure drop and maximum velocity of the upper airway decreased significantly after treatment.Our results suggest that in these young adults with MTD,increasing the maxillary width,upper airway volume,and quantity of airflow by MCRME substantially improved upper airway ventilation. | Juan LI Lingfang SHI Xiayao ZHANG Luxi WENG Hong CHEN Jun LIN | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，2： | 1 |
| 13 | Effects of all-trans retinoic acid on proliferation of human aorta smooth muscle cells显示文摘The primary cultured human aorta smooth muscle cells(SMCs)were characterized and theeffects of all—trans retinoic acid(atRA)on these cells were analysed.It is found that atRA could slowdown the growth rate of SMCs,and decrease the expression Ievels of cyclinDl,CDK4,c-myc at39%。38%and 43.6%respectively,while atRA had no effects on the expression of c^-actin which isspecific for SMCs.Results demonstrated that atRA inhibited cell growth of SMCs but did not induce celIdifferentiation.These effects may be clue to the decreased translation Ievels of cyclinDl.CDK4 andtranscription Ievel of c-myc.The fact that ati tA inhibited SMCs proIiferation may become one of thetheoretic basis for the cIinicaI use of atRA in the trea㈣t of SMCs proliferative diseases such asatherosclerosis. | Guoxia Liu Cunxi Li Lingfang Zeng Yongchao Wang | 1999 | Chinese Science Bulletin1999，44，5： | 0 |
| 14 | YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths显示文摘N6-methyladenosine(m^(6)A)is a critical regulator in the fate of RNA,but whether and how m^(6)A executes its functions in different tissues remains largely obscure.Here we report downregulation of a crucial m^(6)A reader,YTHDF2,leading to tissue-specific programmed cell deaths(PCDs)upon fluorene-9-bisphenol(BHPF)exposure.Currently,Bisphenol A(BPA)substitutes are widely used in plastic manufacturing.Interrogating eight common BPA substitutes,we detected BHPF in 14%serum samples of pregnant participants.In a zebrafish model,BHPF caused tissue-specific PCDs triggering cardiac and vascular defects.Mechanistically,BHPF-mediated downregulation of YTHDF2 reduced YTHDF2-facilitated translation of m^(6)A-gch1 for cardiomyocyte ferroptosis,and decreased YTHDF2-mediated m^(6)A-sting1 decay for caudal vein plexus(CVP)apoptosis.The two distinct YTHDF2-mediated m^(6)A regulations and context-dependent co-expression patterns of gch1/ythdf2 and tnfrsf1a/ythdf2 contributed to YTHDF2-mediated tissue-specific PCDs,uncovering a new layer of PCD regulation.Since BHPF/YTHDF2-medaited PCD defects were also observed in mammals,BHPF exposure represents a potential health threat. | Jiebo Lin Guankai Zhan Jinfeng Liu Yasen Maimaitiyiming Zhiping Deng Baohua Li Kunhui Su Jiafeng Chen Siqi Sun Wanlin Zheng Xianghui Yu Feng He Xiaodong Cheng Lingfang Wang Bin Shen Ziqin Yao Xinquan Yang Jian Zhang Wentao He Hengyu Wu Hua Naranmandura Kao-Jung Chang Junxia Min Jun Ma Mikael Björklund Peng-Fei Xu Fudi Wang Chih-Hung Hsu | 2023 | National Science Review2023，10，12： | 0 |
| 15 | Fiber-specific increase of carotenoid content promotes cotton fiber elongation by increasing abscisic acid and ethylene biosynthesis显示文摘Cotton fiber is a raw material for the global textile industry and fiber quality is essential to its industrial application.Carotenoids are plant secondary metabolites that may serve as dietary components,regulate light harvesting,and scavenge reactive oxygen species.Although carotenoids accumulate predominantly in rapidly elongating cotton fibers,their roles in cotton fiber development remain poorly understood.In this study,a fiber-specific promoter proSCFP was applied to drive the expression of GhOR1Del,a positive regulator of carotenoid accumulation,to upregulate the carotenoid level in cotton fiber in planta.Fiber length,strength,and fineness were increased in proSCFP:GhOR1Del transgenic cotton and abscisic acid(ABA)and ethylene contents were increased in elongating fibers.The ABA downstream regulator GhbZIP27a stimulated the expression of the ethylene synthase gene GhACO3 by binding to its promoter,suggesting that ABA promoted fiber elongation by increasing ethylene production.These findings suggest the involvement of carotenoids and ABA signaling in promoting cotton fiber elongation and provide a strategy for improving cotton fiber quality. | Jianyan Zeng Dan Yao Ming Luo Lingli Ding Yi Wang Xingying Yan Shu’e Ye Chuannan Wang Yiping Wu Jingyi Zhang Yaohua Li Lingfang Ran Yonglu Dai Yang Chen Fanlong Wang Hanyan Lai Nian Liu Nianjuan Fang Yan Pei Yuehua Xiao | 2023 | The Crop Journal2023，11，3： | 0 |
| 16 | H3‑T6SS of Pseudomonas aeruginosa PA14 contributes to environmental adaptation via secretion of a biofilm‑promoting effector显示文摘Microbial species often occur in complex communities and exhibit intricate synergistic and antagonistic interactions.To avoid predation and compete for favorable niches,bacteria have evolved specialized protein secretion systems.The type VI secretion system(T6SS)is a versatile secretion system widely distributed among Gram-negative bacteria that translocates effectors into target cells or the extracellular milieu via various physiological processes.Pseudomonas aeruginosa is an opportunistic pathogen responsible for many diseases,and it has three independent T6SSs(H1-,H2-,and H3-T6SS).In this study,we found that the H3-T6SS of highly virulent P.aeruginosa PA14 is negatively regulated by OxyR and OmpR,which are global regulatory proteins of bacterial oxidative and acid stress.In addition,we identified a H3-T6SS effector PA14_33970,which is located upstream of VgrG3.PA14_33970 interacted directly with VgrG3 and translocated into host cells.Moreover,we found that H3-T6SS and PA14_33970 play crucial roles in oxidative,acid,and osmotic stress resistance,as well as in motility and biofilm formation.PA14_33970 was identified as a new T6SS effec-tor promoting biofilm formation and thus named TepB.Furthermore,we found that TepB contributes to the virulence of P.aeruginosa PA14 toward Caenorhabditis elegans.Overall,our study indicates that H3-T6SS and its biofilm-promot-ing effector TepB are regulated by OxyR and OmpR,both of which are important for adaptation of P.aeruginosa PA14 to multiple stressors,providing insights into the regulatory mechanisms and roles of T6SSs in P.aeruginosa. | Yantao Yang Damin Pan Yanan Tang Jiali Li Kaixiang Zhu Zonglan Yu Lingfang Zhu Yao Wang Peng Chen Changfu Li | 2022 | Stress Biology2022，2，1： | 0 |
| 17 | The influence of Bi content on dielectric properties of Bi_(4-x)Ti_(3)O_(12-1.5x) ceramics显示文摘A kind of lead-free dielectric materials,such as the bismuth layered perovskite-type structure of Bi4-xTi3O12-1.5x(x=0.04,0.02,0,-0.02,-0.04),was prepared by the conventional solid-state method at 800C and sintered at 1100C.The variation of structure and electrical properties with different Bi concentration was studied.All the Bi4-xTi3O12-1.5x(x=0.04,0.02,0,-0.02,-0.04)samples exhibited a single structured phase.SEM could be a better approach to present the microstructure of Bi4-xTi3O12-1.5x(x=0.04,0.02,0,-0.02,-0.04)ceramics.It could be found that the grain size of Bi4.02Ti3O12.03 sintered at 1100C was smaller than that of others among the five samples through grain size mechanics.Through impedance spectra analysis,we knew,when the Bi content was fixed,that the dielectric constant and the loss values increased with the decrease of frequency.The Curie temperature of the five samples was about 670C.In particular,while at the frequency of 100 kHz,the lowest loss was 0.001 when Bi content was 3.98.The Bi4.02Ti3O12.03 ceramics with the minimum grain size had highest dielectric constant and the relatively low loss.Due to its high Curie temperature,high permittivity and low loss,the Bi_(4)Ti_(3)O_(12)(BIT)ceramics have a broad application prospect in high density memory,generator,sensor,ferroelectric tunnel junctions and so on. | Hui Gong Xiying Ke Shuqin Yang Zhaozhi Li Huyin Su Cancan Zhang Qian Luo Qi Chen Lingfang Xu Yong Chen Wei Wang | 2017 | Journal of Advanced Dielectrics2017，7，3： | 0 |
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