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| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | Hemoglobin in- fusion augments the tumor necrosis factor response to bacterial endotoxin ( 1 ipopolysaccharide ) in mice 显示文摘 | Su Dong Hui Roth R I Levin J | 1999 | Crit Care Med1999，27，4： | 8 |
| 3 | 冠状动脉钙化的高血压患者左心室肥厚可预测心血管事件显示文摘冠状动脉钙化(coronary artery calcification,CAC)与心血管病风险增加有关。左心室肥厚(left ventricular hypertrophy,LVH)是心血管事件的独立危险因素。本研究目的是评估在CAC存在的情况下LVH的相对心血管病风险。 | Grossman C Levin M Koren-Morag N Bornstein G Lei-bowitz A Ben-Zvi I Shemesh J Grossman E 陈云 叶鹏 | 2019 | 中华高血压杂志2019，27，1： | 4 |
| 4 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 5 | Multitarget stool DNA for colorectal cancer screening:A review and commentary on the United States Preventive Services Draft Guidelines显示文摘Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an 'alternative' screening test that 'may be useful in select clinical circumstances',despite its very high sensitivity for early stage CRC.The evidence supporting mt-s DNA for routine screening use is robust.The clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing adherence.In a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence.This paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening. | Barry M Berger Bernard Levin Robert J Hilsden | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 3 |
| 6 | Development by Self-Digestion显示文摘 | Beth Levine Daniel J Klionsky | 2004 | Developmental Cell2004，，4： | 2 |
| 7 | p53, the Cellular Gatekeeper for Growth and Division显示文摘 | Arnold J Levine | 2002 | Cell2002，，3： | 2 |
| 8 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 9 | Elevated circulating levels of tumor necrosis factor in severe chronic heart failure显示文摘 | Levine B Kalman J Mayer L | 1990 | N Engl J Med1990，323，4： | 2 |
| 10 | Folate and vitamin B12 in idiopathic male infertility显示文摘尽管 methylenetetrahydrofolate reductase,叶酸的酶基因,与自发的男不孕被联系了,很少研究检验了另外的叶酸相关的代谢物和基因。我们调查了自发的男不孕是否与变体被联系在叶酸,维生素 B 12(B12 ) 和全部的 homocysteine (tHcy ) 联系了基因并且在血测量了这些代谢物。我们进行了与自发的不孕和在生育力中心和胎儿的照顾中心招募的 184 肥沃的男控制包括了 153 个人的盒子控制研究,大学医院, Malmö并且 Lund,瑞典。浆液叶酸的、红房间叶酸(RCF ) ,浆液 B12,血浆 tHcy 和精液质量被测量。题目是为在与 folate/B12/homocysteine 新陈代谢有关的 12 基因的 20 普通变体的 genotyped。代谢物集中和遗传型分布为 covariates 与调整用线性、逻辑的回归在案例和控制之间被作比较。phosphatidylethanolamine N-methyltransferase (PEMT ) M175V 和 TCblR rs173665 多型性显著地与不孕被联系(P=0.01 和 P=0.009,分别地) ,然而并非与精液质量。在补充的非用户之中,有的不肥沃的人降低浆液叶酸的集中比肥沃的人(12.89 对 14.73 nmol l −1 ;P=0.02 ) ,但是在 RCF, B12 或 tHcy 没有重要差别。叶酸, B12 和 tHcy 集中没与任何精液参数被相关。这研究几乎不提供小支持为低叶酸或在自发的男不孕的致病的 B12 地位。尽管另外的数据被需要证实这些起始的调查结果,我们的结果建议那 PEMT 和 TCblR,基因在胆碱和 B12 新陈代谢包含了,在自发的男不孕应得进一步的调查。 | Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 11 | Modern treatment strategies for penile prosthetics in Peyronie’s disease:a contemporary clinical review显示文摘Peyronie's disease is a common condition resulting in penile deformity,psychological bother,and sexual dysfunction.Erectile dysfunction is one common comorbid condition seen in men with Peyronie’s disease,and its presence significantly impacts treatment considerations.In a man with Peyronie's disease and significant erectile dysfunction who desires the most reliable treatment,penile prosthesis placement should be strongly considered.In some instances,such as those patients with relatively mild curvature,prosthesis placement alone may result in adequate straightening.However,many patients will require additional straightening maneuvers such as manual modeling,penile plication,and tunica albuginea incision with or without grafting.For patients with severe penile shortening,penile length restoration techniques may also be considered.Herein,we provide a comprehensive clinical review of penile prosthesis placement in men with Peyronie's disease.Specifically,we discuss preoperative indications,intraoperative considerations,adjunctive straightening maneuvers,and postoperative outcomes. | Matthew J Ziegelmann M Ryan Farrell Laurence A Levine | 2020 | Asian Journal of Andrology2020，22，1： | 2 |
| 12 | Predictors of progression in Barrett’s esophagus III: baseline flow cytometric variables显示文摘 | Peter S Rabinovitch Gary Longton Patricia L Blount Douglas S Levine Brian J Reid | 2001 | The American Journal of Gastroenterology2001，，11： | 2 |
| 13 | Predictors of progression in Barrett’s esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression显示文摘 | Brian J Reid Laura J Prevo Patricia C Galipeau Carissa A Sanchez Gary Longton Douglas S Levine Patricia L Blount Peter S Rabinovitch | 2001 | The American Journal of Gastroenterology2001，，10： | 2 |
| 14 | The effect of second phase volume fraction on the erosion resistance of metal-matrix composites 显示文摘 | Levin B F Dupont J N Marder A R | 2000 | Wear2000，238，5： | 2 |
| 15 | Folic acid and preconceptional care 显示文摘 | Levine NH Lyon Daniel K Mulinare J | 2001 | Prim Care Update Ob Gyns2001，8，2： | 1 |
| 16 | Colorectal cancer screening clinical p ractice guidelines显示文摘 | Levin B Barthel J S Burt R W | 2006 | J Natl Comp r Canc Netw2006，4，4： | 1 |
| 17 | Bacteriologic and clinical applications of a new extended-spectrum parental cephalosporin显示文摘 | Levin S | 1996 | Am J Med1996，100，6： | 1 |
| 18 | Low molecular weight heparin显示文摘 | Levine WN | 1992 | Blood1992，79，1： | 1 |
| 19 | Resonse to placebo among bipolar 1 disorder patients experiencing their first manic episode显示文摘 | Chengappa KN Tohen M Levine J | 2000 | Bipolar Disord2000，2，4： | 1 |
| 20 | Development by self-digestion:Molecular mechanisms and biological functions of autophagy显示文摘 | Levine B Klionsky D J | 2004 | Dev Cell2004，6，4： | 1 |
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