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| 1 | Survival outcome of patients with spontaneously ruptured hepatocellular carcinoma treated surgically or by transarterial embolization显示文摘AIM: To evaluate clinical outcomes of patients that underwent surgery, transarterial embolization (TAE), or supportive care for spontaneously ruptured hepatocellular carcinoma (HCC). METHODS: A consecutive 54 patients who diagnosed as spontaneously ruptured HCC at our institution between 2003 and 2012 were retrospectively enrolled. HCC was diagnosed based on the diagnostic guidelines issued by the 2005 American Association for the Study of Liver Diseases. HCC rupture was defined as disruption of the peritumoral liver capsule with enhanced fluid collection in the perihepatic area adjacent to the HCC by dynamic liver computed tomography, and when abdominal paracentesis showed an ascitic red blood cell count of > 50000 mm 3 /mL in bloody fluid. RESULTS: Of the 54 patients, 6 (11.1%) underwent surgery, 25 (46.3%) TAE, and 23 (42.6%) supportive care. The 2-, 4and 6-mo cumulative survival rates at 2, 4 and 6 mo were significantly higher in the surgery (60%, 60% and 60%) or TAE (36%, 20% and 20%) groups than in the supportive care group (8.7%, 0% and 0%), respectively (each, P < 0.01), and tended to be higher in the surgical group than in the TAE group. Multivariate analysis showed that serum bilirubin (HR = 1.09, P < 0.01), creatinine (HR = 1.46, P = 0.04), and vasopressor requirement (HR = 2.37, P = 0.02) were significantly associated with post-treatment mortality, whereas surgery (HR = 0.41, P < 0.01), and TAE (HR = 0.13, P = 0.01) were inversely associated with posttreatment mortality. CONCLUSION: Post-treatment survival after surgery or TAE was found to be better than after supportive care, and surgery tended to provide better survival benefit than TAE. | Young-Joo Jin Jin-Woo Lee Seoung-Wook Park Jung Il Lee Don Haeng Lee Young Soo Kim Soon Gu Cho Yong Sun Jeon Kun Young Lee Seung-Ik Ahn | 2013 | World Journal of Gastroenterology2013，19，28： | 23 |
| 2 | Does the bile duct angulation affect recurrence of choledocholithiasis?显示文摘AIM:To investigate whether bile duct angulation and T-tube choledochostomy influence the recurrence of choledocholithiasis.METHODS:We conducted a retrospective study including 259 patients who underwent endoscopic sphincterotomy and cholecystectomy for choledocholithiasis between 2000 and 2007.The imaginary line was drawn along the center of the bile duct and each internal angle was measured at the two angulation sites ofthe bile duct respectively.The values of both angles were added together.We then tested our hypothesis by examining whether T-tube choledochostomy was performed and stone recurrence occurred by reviewing each subject's medical records.RESULTS:The overall recurrence rate was 9.3% (24 of 259 patients).The mean value of sums of angles in the recurrence group was 268.3°± 29.6°,while that in the non-recurrence group was 314.8°± 19.9° (P < 0.05).Recurrence rate of the T-tube group was 15.9% (17 of 107),while that of the non T-tube group was 4.6% (7 of 152) (P < 0.05).Mean value of sums of angles after T-tube drainage was 262.5°± 24.6° and that before T-tube drainage was 298.0°± 23.9° in 22 patients (P < 0.05).CONCLUSION:The bile duct angulation and T-tube choledochostomy may be risk factors of recurrence of bile duct stones. | Dong Beom Seo Byoung Wook Bang Seok Jeong Don Haeng Lee Shin Goo Park Yong Sun Jeon Jung Il Lee Jin-Woo Lee | 2011 | World Journal of Gastroenterology2011，17，36： | 15 |
| 3 | Sequential transcatheter arterial chemoembolization and portal vein embolization before right hemihepatectomy in patients with hepatocellular carcinoma显示文摘Background:Recent studies showed that sequential selective transcatheter arterial chemoembolization(TACE)and portal vein embolization(PVE)provided better future liver remnant(FLR)regeneration rate and disease-free survival following surgery compared with PVE alone.The present study aimed to clarify whether preoperative sequential TACE and PVE before right hemihepatectomy can reduce postoperative hepatocellular carcinoma(HCC)recurrence and improve long-term disease-free and overall survival.Methods:Recurrence and survival outcomes were retrospectively evaluated in 205 patients with HCC who underwent right hemihepatectomy by a single surgeon from November 1993 to November 2017.Patients were divided into four groups according to the procedure performed before the surgery:sequential TACE and PVE(TACE-PVE),PVE-only,TACE-only,or na?ve control groups.The baseline patient and tumor characteristics,postoperative outcomes,recurrence-free survival and overall survival were analyzed.Results:Baseline patient and tumor characteristics upon diagnosis were similar in all four groups,while sequential TACE and PVE were well tolerated.The TACE-PVE group had a higher mean increase in percentage FLR volume compared with that of the PVE-only group(17.46%±6.63%vs.12.14%±5.93%;P=0.001).The TACE-PVE group had significantly better overall and disease-free survival rates compared with the other groups(both P<0.001).Conclusions:Sequential TACE and PVE prior to surgery can be an effective therapeutic strategy for patients with HCC scheduled for major hepatic resection.The active application of preoperative sequential TACE and PVE for HCC would allow more patients with marginal FLR volume to become candidates for major hepatic resection by promoting compensatory FLR hypertrophy without the deterioration of basal hepatic functional reserve or tumor progression. | Gil Chun Park Sung Gyu Lee Young In Yoon Kyu Bo Sung Gi Young Ko Dong Il Gwon Dong Hwan Jung Yong Kyu Jung | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 9 |
| 4 | Giant choledocholithiasis treated by mechanical lithotripsy using a gastric bezoar basket显示文摘Mechanical lithotripsy(ML) is usually considered as a standard treatment option for large bile duct stones.However,it is impossible to retrieve oversized stones because the conventional lithotripsy basket may not be able to grasp the stone.However,there is no established endoscopic extraction method for such giant stone removal.We describe a case of successful extraction of a 4-cm large stone using a gastric bezoar basket.A 78-year-old woman had suffered from upper abdominal pain for 20 d.Contrast-enhanced computed tomogram revealed a 4-cm single stone in the distal common bile duct(CBD).Endoscopic stone retraction was decided upon and endoscopic papillary balloon dilation was performed using a large balloon.An attempt to capture the stone using a standard lithotripsy basket failed due to the large stone size.Subsequently,we used a gastric bezoar basket to successfully capturethe stone.The stone was fragmented into small pieces and extracted.The stone was completely removed after two sessions of endoscopic retrograde cholangiopancreatography;each of which took 30 min.No complications occurred during or after the procedure.The patient was fully recovered and discharged on day 11 of hospitalization.ML using a gastric bezoar basket is a safe and effective retrieval method in select cases,and is considered as an alternative nonoperative option for the management of difficult CBD stones. | Hyun Jung Chung Seok Jeong Don Haeng Lee Jung Il Lee Jin-Woo Lee Byoung Wook Bang Kye Sook Kwon Hyung Kil Kim Yong Woon Shin Young Soo Kim | 2012 | World Journal of Gastroenterology2012，18，25： | 7 |
| 5 | Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer显示文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers. | Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 6 |
| 6 | Alpha-fetoprotein-targeted reporter gene expression imaging in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common cancers in Eastern Asia, and its incidence is increasing globally. Numerous experimental models have been developed to better our understanding of the pathogenic mechanism of HCC and to evaluate novel therapeutic approaches. Molecular imaging is a convenient and up-to-date biomedical tool that enables the visualization, characterization and quantification of biologic processes in a living subject. Molecular imaging based on reporter gene expression, in particular, can elucidate tumor-specific events or processes by acquiring images of a reporter gene's expression driven by tumor-specific enhancers/promoters. In this review, we discuss the advantages and disadvantages of various experimental HCC mouse models and we present in vivo images of tumorspecific reporter gene expression driven by an alphafetoprotein(AFP) enhancer/promoter system in a mouse model of HCC. The current mouse models of HCC development are established by xenograft, carcinogen induction and genetic engineering, representing the spectrum of tumor-inducing factors and tumor locations. The imaging analysis approach of reporter genes driven by AFP enhancer/promoter is presented for these different HCC mouse models. Such molecular imaging can provide longitudinal information about carcinogenesis and tumor progression. We expect that clinical application of AFP-targeted reporter gene expression imaging systems will be useful for the detection of AFP-expressing HCC tumors and screening of increased/decreased AFP levels due to disease or drug treatment. | Kwang Il Kim Hye Kyung Chung Ju Hui Park Yong Jin Lee Joo Hyun Kang | 2016 | World Journal of Gastroenterology2016，22，27： | 6 |
| 7 | 海相页岩气储层特征研究进展与发展动态显示文摘富有机质泥页岩复杂的沉积成岩过程、细粒特征,以及远小于常规储层的以微米—纳米级为主的孔隙空间,给海相页岩气储层特征研究带来了极大的挑战。近年来借助多项先进技术方法的推广运用,在海相页岩气储层的多个方面形成了重要认识,页岩有机质与其成熟度关系密切,岩石矿物组分判定方法向定量化发展,岩相预测与建模技术得以应用,但成岩作用对储层的影响尚有待进一步探知,物性变化趋势的认识尚存在不同见解,孔隙结构实现了从定性到定量表征的跨越,页岩力学性质的解析能够有效指导压裂改造。通过进一步分析海相页岩气储层研究的发展动态,就页岩气储层孔隙结构系统表征、区域尺度上成岩与岩相变化的时空配置关系、成岩演化—岩相—孔隙系统—有机质丰度潜在的多元关系等研究方向作出了展望,以期推进储层特征研究在深度和广度上向前发展。 | 张鹏辉 梁杰 陈建文 Lee Yong Il 袁勇 龚建明 董刚 王文娟 张玉玺 姜鹍鹏 黄晓伟 | 2017 | 海相油气地质2017，22，4： | 6 |
| 8 | 砂岩储集层粒间孔隙保存机制显示文摘关于深埋藏、高温度条件下的砂岩储层孔隙保存研究在保存机理、适用条件、实验模拟等方面都存在着不少的争议。为了更好地剖析砂岩储层粒间孔隙保存的机理,在系统总结国内外学者近年来在砂岩粒间孔隙保存方面研究成果的基础上,阐述了颗粒包膜发育、孔隙流体超压、与外来盐体有关的热流扰动以及烃类充注等4种因素对储层质量的影响,并指出了孔隙保存机制未来的研究趋势与方向。研究结果表明:①颗粒包膜发育能够通过抑制石英增生而保存粒间孔隙,其中绿泥石膜主要集中发育在三角洲和河流相沉积环境中,砂岩粒度较粗且绿泥石膜粒表覆盖率较高的储集层易形成优质储层,其抑制石英胶结的效果优于伊利石膜,微晶石英膜则通过无定形硅与玉髓共生的纳米薄层以及微晶石英的集合来共同抑制石英增生;②孔隙流体超压主要通过抑制压实和压溶作用而成为浅层砂岩中一种主要的孔隙保存机制;③外来盐体的存在可以实现对地温的抑制,以减少砂岩储层的石英增生量,并且盐体较厚、侵位时间较早的砂岩更易保存较多的粒间孔隙;④油气充注对孔隙保存的影响程度尚难以定量评价。结论认为:目前对于影响深层砂岩粒间孔隙保存因素的分析预测仍停留在微观观测和实验模拟阶段,区域上的预测识别技术亟待进一步探索;基于孔隙保存机制认识下的砂岩储层孔隙度演化模拟是未来研究攻关的难点和重点。 | 张鹏辉 Lee Yong Il 张金亮 梁杰 武英利 袁勇 王晋晨 刘璐晨 王正云 付俊杰 | 2019 | 天然气工业2019，39，7： | 5 |
| 9 | The feasibility of combined transcatheter arterial chemoembolization and radiotherapy for advanced hepatocellular carcinoma显示文摘 | Ju‐Yeon Cho Yong‐Han Paik Hee Chul Park Jeong Il Yu Won Sohn Geum‐Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2014 | Liver Int2014，，5： | 5 |
| 10 | Expression of Ki-67,p53,and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma显示文摘AIM: To examine surgical specimens of pancreas with either chronic pancreatitis or pancreatic cancer in order to study whether ductal hyperplasia and dysplasia in pancreas represent precursor lesions for pancreatic cancer.METHODS: We examined expression of Ki-67, CEA,p53, and K-ras, in the surgical specimens of pancreas with adenocarcinomas (n = 11) and chronic pancreatitis (n = 12). Cellular proliferation was assessed by Ki-67proliferation index using the proliferation marker Ki-67.In specimens with pancreas cancer, we divided pancreas epithelium into normal (n=7), ductal hyperplasia (n=3), dysplasia (n=4), and cancerous lesion (n=11) after hematoxylin and eosin staining, Ki-67, and CEA immunohistochemical staining. In cases with chronic pancreatitis, the specimen was pathologically examined as in cases with pancreas cancer, and they were also determined as normal (n=10), ductal hyperplasia (n=4), or dysplasia (n= 5). p53 and K-ras expression were also studied by immunohistochemical staining.RESULTS: In pancreatic cancer, the Ki-67 index was 3.73±3.58 in normal site, 6.62±4.39 in ductalhyperplasia, 13.47±4.02 in dysplasia and 37.03±10.05in cancer tissue, respectively. Overall, p53 was positive in normal ducts, ductal hyperplasia, dysplasia, and carcinoma cells in 0 of 14 (0%), 0 of 7 (0%), 7 of 9 (78%),and 10 of 11 (91%), respectively, and K-ras was positive in 0 of 8 (0%), 1 of 3 (33%), 4 of 6 (67%), 4 of 5 (80%),respectively.CONCLUSION: Our results favorably support the hypothesis that ductal hyperplasia and dysplasia of the pancreas might be precursor lesions for pancreas cancer.Further evaluation of oncogenes by the molecular study is needed. | Seok Jeong Don Haeng Lee Jung Il Lee Jin-Woo Lee Kye Sook Kwon Pum-Soo Kim Hyung Gil Kim Yong Woon Shin Young Soo Kim Young Bae Kim | 2005 | World Journal of Gastroenterology2005，11，43： | 4 |
| 11 | Crustal growth history of the Korean Peninsula: Constraints from detrital zircon ages in modern river sediments显示文摘U-Pb analyses were carried out on detrital zircon grains from major river-mouth sediments draining South Korea to infer provenance characteristics and the crustal growth history of the southern Korean Peninsula, using a laser ablation inductively coupled plasma mass spectrometer(LA-ICP-MS). The Korean Peninsula is located in the East Asian continental margin and mainly comprises three Precambrian massifs and two metamorphic belts in between them. We obtained 515 concordant to slightly discordant zircon ages ranging from ca. 3566 to ca. 48 Ma. Regardless of river-mouth location, predominance of Mesozoic(249e79 Ma) and Paleoproterozoic(2491e1691 Ma) ages with subordinate Archean ages indicates that the zircon ages reflect present exposures of plutonic/metamorphic rocks in the drainage basins of the South Korean rivers and the crustal growth of the southern Korean Peninsula was focused in these two periods. Comparison of detrital zircon-age data between the North and South Korean river sediments reveals that the Paleoproterozoic zircon age distributions of both regions are nearly identical,while the Neoproterozoice Paleozoic ages exist and the Mesozoic ages are dominant in southern Korean Peninsula. This result suggests that Precambrian terrains in Korea record the similar pre-Mesozoic magmatic history and that the influence of Mesozoic magmatism was mainly focused in South Korea. | Taejin Choi Yong Il Lee Yuji Orihashi | 2016 | Geoscience Frontiers2016，7，5： | 3 |
| 12 | Clinical usefulness of 18F-FDG PET-CT for patients with gallbladder cancer and cholangiocarcinoma显示文摘 | Seung Won Lee Hong Joo Kim Jung Ho Park Dong Il Park Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim | 2010 | Journal of Gastroenterology2010，，5： | 2 |
| 13 | Endoscopic large-balloon sphincteroplasty without preceding sphincterotomy for the removal of large bile duct stones: a preliminary study显示文摘 | Seok Jeong Sung-Ho Ki Don Haeng Lee Jung Il Lee Jin-Woo Lee Kye Sook Kwon Hyung Gil Kim Yong Woon Shin Young Soo Kim | 2009 | Gastrointestinal Endoscopy2009，，5： | 2 |
| 14 | Phase 3 Trial of Postoperative Chemotherapy Alone Versus Chemoradiation Therapy in Stage III-IV Gastric Cancer Treated With R0 Gastrectomy and D2 Lymph Node Dissection显示文摘 | Tae Hyun Kim Sook Ryun Park Keun Won Ryu Young-Woo Kim Jae-Moon Bae Jun Ho Lee Il Ju Choi Yeon-Joo Kim Dae Yong Kim | 2012 | International Journal of Radiation Oncology Biology Physics2012，，5： | 2 |
| 15 | Saccular damage in patients with idiopathic sudden sensorineural hearing loss without vertigo显示文摘 | Seok Min Hong Jae Yong Byun Chan Hum Park Jun Ho Lee Moon Suh Park Chang Il Cha | 2008 | Otolaryngology - Head and Neck Surgery2008，，4： | 1 |
| 16 | Phase 3 Trial of Postoperative Chemotherapy Alone Versus Chemoradiation Therapy in Stage III-IV Gastric Cancer Treated With R0 Gastrectomy and D2 Lymph Node Dissection显示文摘 | Tae Hyun Kim Sook Ryun Park Keun Won Ryu Young-Woo Kim Jae-Moon Bae Jun Ho Lee Il Ju Choi Yeon-Joo Kim Dae Yong Kim | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，5： | 1 |
| 17 | An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach显示文摘 | Sung Kim Do Hoon Lim Jeeyun Lee Won Ki Kang John S. MacDonald Chan Hyung Park Se Hoon Park Se-Hoon Lee Kihyun Kim Joon Oh Park Won Seog Kim Chul Won Jung Young Suk Park Young-Hyuck Im Tae Sung Sohn Jae Hyung Noh Jin Seok Heo Yong Il Kim Chul Keun Park Keu | 2005 | International Journal of Radiation Oncology Biology Physics2005，，5： | 1 |
| 18 | Variable phenotype of Pierson syndrome显示文摘 | Hyun Jin Choi Beom Hee Lee Ju Hyung Kang Hyoen Joo Jeong Kyung Chul Moon Il Soo Ha Young Suk Yu Verena Matejas Martin Zenker Yong Choi Hae Il Cheong | 2008 | Pediatric Nephrology2008，，6： | 1 |
| 19 | Microscopic observations of the ablation behaviours of carbon fibre/phenolic composites显示文摘 | Donghwan Cho Jin Yong Lee Byling Il Yoon | 1993 | Journal of Materials Science Letters1993，，24： | 1 |
| 20 | Incidence and Etiology of Overt Gastrointestinal Bleeding in Adult Patients with Aplastic Anemia显示文摘 | Yong Bum Park Jong-Wook Lee Byung Sik Cho Woo-Sung Min Dae Young Cheung Jin Il Kim Se Hyun Cho Soo-Heon Park Jae Kwang Kim Sok Won Han | 2010 | Digestive Diseases and Sciences2010，，1： | 1 |
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