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| 1 | Alpha-fetoprotein-targeted reporter gene expression imaging in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common cancers in Eastern Asia, and its incidence is increasing globally. Numerous experimental models have been developed to better our understanding of the pathogenic mechanism of HCC and to evaluate novel therapeutic approaches. Molecular imaging is a convenient and up-to-date biomedical tool that enables the visualization, characterization and quantification of biologic processes in a living subject. Molecular imaging based on reporter gene expression, in particular, can elucidate tumor-specific events or processes by acquiring images of a reporter gene's expression driven by tumor-specific enhancers/promoters. In this review, we discuss the advantages and disadvantages of various experimental HCC mouse models and we present in vivo images of tumorspecific reporter gene expression driven by an alphafetoprotein(AFP) enhancer/promoter system in a mouse model of HCC. The current mouse models of HCC development are established by xenograft, carcinogen induction and genetic engineering, representing the spectrum of tumor-inducing factors and tumor locations. The imaging analysis approach of reporter genes driven by AFP enhancer/promoter is presented for these different HCC mouse models. Such molecular imaging can provide longitudinal information about carcinogenesis and tumor progression. We expect that clinical application of AFP-targeted reporter gene expression imaging systems will be useful for the detection of AFP-expressing HCC tumors and screening of increased/decreased AFP levels due to disease or drug treatment. | Kwang Il Kim Hye Kyung Chung Ju Hui Park Yong Jin Lee Joo Hyun Kang | 2016 | World Journal of Gastroenterology2016，22，27： | 6 |
| 2 | Plasma Levels of Monocyte Chemotactic Protein 3 and Beta-Nerve Growth Factor Increase with Amnestic Mild Cognitive Impairment显示文摘A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (β-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI. | Kang Soo Lee Ji Hyung Chung Kyung Hye Lee Min-Jeong Shin Byoung Hoon Oh Soo Hyung Lee Chang Hyung Hong | 2009 | Cellular & Molecular Immunology2009，6，2： | 3 |
| 3 | Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice显示文摘 | Jae Hyun Park Jong Kwon Lee Hyung Soo Kim Seung Tae Chung Juno H. Eom Kyung A. Kim Se Jin Chung Soon Young Paik Hye Young Oh | 2004 | International Immunopharmacology2004，，3： | 2 |
| 4 | Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population显示文摘 | Hye‐Rim Song Hee Nam Kim Sun‐Seog Kweon Jin‐Su Choi Hyun Jeong Shim Sang Hee Cho Ik Joo Chung Young‐Kyu Park Soo Hyun Kim Yoo‐Duk Choi Kyung Woong Joo Min‐Ho Shin | 2013 | Mol Carcinog2013，，1： | 2 |
| 5 | New CT response criteria in non-small cell lung cancer: Proposal and application in EGFR tyrosine kinase inhibitor therapy显示文摘 | Ho Yun Lee Kyung Soo Lee Myung-Ju Ahn Hye Sun Hwang Ju Won Lee Keunchil Park Jin Seok Ahn Tae Sung Kim Chin A Yi Myung Jin Chung | 2010 | Lung Cancer2010，，： | 1 |
| 6 | Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells显示文摘 | Min Kyung Baek Jung Sun Park Ji Hye Park Mi Ha Kim Ho Dong Kim Woo Kyun Bae Ik Joo Chung Boo Ahn Shin Young Do Jung | 2009 | Cancer Letters2009，，1： | 1 |
| 7 | Randomized controlled trial of standardized education and telemonitoring for pain in outpatients with advanced solid tumors显示文摘 | Han Sang Kim Sang Joon Shin Sang Cheol Kim Surim An Sun Young Rha Joong Bae Ahn Byoung Chul Cho Hye Jin Choi Joo Hyuk Sohn Hyo Song Kim Hyun Cheol Chung Joo Hang Kim Jae Kyung Roh Soohyeon Lee | 2013 | Supportive Care in Cancer2013，，6： | 1 |
| 8 | Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate–activated protein kinase in human HepG2 cells and obese mice显示文摘 | Yong Pil Hwang Jae Ho Choi Eun Hee Han Hyung Gyun Kim Ji-Hyang Wee Kyung Ok Jung Kyung Hee Jung Kwang-il Kwon Tae Cheon Jeong Young Chul Chung Hye Gwang Jeong | 2011 | Nutrition Research2011，，12： | 1 |
| 9 | S-1 plus oxaliplatin versus capecitabine plus oxaliplatin for first-line treatment of patients with metastatic colorectal cancer: a randomised, non-inferiority phase 3 trial显示文摘 | Yong Sang Hong Young Suk Park Ho Yeong Lim Jeeyun Lee Tae Won Kim Kyu-pyo Kim Sun Young Kim Ji Yeon Baek Jee Hyun Kim Keun-Wook Lee Ik-Joo Chung Sang-Hee Cho Kyung Hee Lee Sang Joon Shin Hye Jin Kang Dong Bok Shin Sook Jung Jo Jae Won Lee | 2012 | Lancet Oncology2012，，11： | 1 |
| 10 | Long-term prognosis of an endoscopically treated rectal neuroendocrine tumor: 10-year experience in a single institution显示文摘 | Hye Young Sung Sang Woo Kim Won Kyung Kang Su Young Kim Chan-Kwon Jung Yu Kyung Cho Jae Myung Park In Seok Lee Myung-Gyu Choi In-Sik Chung | 2012 | European Journal of Gastroenterology & Hepatology2012，，8： | 1 |
| 11 | Protective effect of caffeic acid phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice显示文摘 | Kyung Jin Lee Jae Ho Choi Tilak Khanal Yong Pil Hwang Young Chul Chung Hye Gwang Jeong | 2008 | Toxicology2008，，1： | 1 |
| 12 | Measuring the economic value of special libraries显示文摘 | Hye Kyung Chung | 2007 | The Bottom Line:Managing Library Finances2007，20，1： | 1 |
| 13 | An oligosaccharide fraction from Korean mugwort herb suppresses death of the mouse thymocytes in culture by down-regulating the Fas death receptor gene显示文摘 | Hye Kyung Chung Eun Kyong Bae Hee Jung Ji Jung Suk Hwang Dong Woon Park Jung Eun Kim Hwa Jin Jung Hyun Ju Choi Dong Seok Lee Hyun Joo Youn | 2003 | Biotechnology Letters2003，，18： | 1 |
| 14 | Measuring the economic value of special libraries 显示文摘 | Hye Kyung Chung | 2007 | The Bottom Line: Managing Li- brary Finances2007，，1： | 1 |
| 15 | Importance of Patients’ Knowledge of Their Prescribed Medication in Improving Treatment Adherence in Inflammatory Bowel Disease显示文摘 | Chung Hyun Tae Sung-Ae Jung Hye Sung Moon Jung-A Seo Hye Kyung Song Chang Mo Moon Seong-Eun Kim Ki-Nam Shim Hye-Kyung Jung | 2016 | Journal of Clinical Gastroenterology2016，，2： | 1 |
| 16 | Suppressive effects ofPlatycodon grandiflorum on the progress of carbon tetrachloride-lnduced hepatic fibrosis显示文摘 | Kyung Jin Lee Ji Young Kim Kyung Sik Jung Chul Yung Choi Young Chul Chung Dong Hee Kim Hye Gwang Jeong | 2004 | Archives of Pharmacal Research2004，，12： | 1 |
| 17 | Serum high mobility group box‐1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma显示文摘 | Hye Won Chung Jong‐Baeck Lim Sunphil Jang Kyong Joo Lee Kyung Hwa Park Si Young Song | 2012 | Cancer Sci2012，，9： | 1 |
| 18 | A prospective phase II trial of S-1 and cisplatin-based chemoradiotherapy for locoregionally advanced esophageal cancer显示文摘 | Hyun Chang Sung Kwan Shin Byoung Chul Cho Chang-Geol Lee Choong Bai Kim Dae Joon Kim Jin Gu Lee Jin Hur Chang Young Lee Mi Kyung Bae Hye Ryun Kim Sang Kil Lee Jun Chul Park Hyuk Lee Hyoung-Il Kim Hyunsoo Chung Jihye Cha Yong Chan Lee Joo-Hang Kim | 2014 | Cancer Chemotherapy and Pharmacology2014，，： | 1 |
| 19 | Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice显示文摘 | Kyung Jin Lee Jae Ho Choi Hyung Gyun Kim Eun Hee Han Yong Pil Hwang Young Chun Lee Young Chul Chung Hye Gwang Jeong | 2008 | Food and Chemical Toxicology2008，，5： | 1 |
| 20 | Comparison of double pants with single pants on satisfaction with colonoscopy显示文摘AIM: To increase satisfaction and diminish anxiety and shame during colonoscopy, we developed novel double pants (NDP) which consist of doubled fabrics with an inner hole. The aim of study was to compare satisfaction, anxiety and shame between NDP and conventional single pants (CSP). METHODS: Total 160 consecutive examinees were randomly divided into NDP and CSP group. Before colonoscopy, questionnaires identifying state and trait anxiety were completed. After colonoscopy, questionnaires for overall satisfaction (Group Health Association of America 9) and pants-specific satisfaction (5-20), state anxiety (20-80), and shame (6-24) were interviewed. RESULTS: Pants-specific satisfaction scores regarding willingness to repeat colonoscopy using same pants (3.3 ± 0.8 vs 2.1 ± 0.9, P < 0.001) and recommendation of same pants to other people (3.3 ± 0.7 vs 2.0 ± 1.0, P < 0.001) were significantly higher in NDP than CSP groups. State anxiety (33.0 ± 7.0 vs 35.4 ± 6.9, P = 0.028) and shame (6.6 ± 1.5 vs 8.1 ± 3.2, P = 0.001) after colonoscopy was lower in NDP group compared with CSP group. CONCLUSION: The NDP contribute to increase satisfaction and decrease anxiety and shame after colonoscopy. | Sook Hee Chung Soo Jung Park Jong Suk Hong Jee Young Hwang Sin Ae Lee Kyung Ran Kim Hye Sun Lee Sung Pil Hong Jae Hee Cheon Tae Il Kim Won Ho Kim | 2013 | World Journal of Gastroenterology2013，19，26： | 0 |
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