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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Systematic Spatial Analysis of Gene Expression during Wheat Caryopsis Development显示文摘 | DREA S LEADER D J ARNOLD B C | 2005 | The Plant Cell2005，17，8： | 1 |
| 3 | Ala394Thr polymorphism in the clock gene NPAS2:a circadian modifier for the risk of nonHodgkin's lymphoma显示文摘 | Zhu Y Leaderer D Guss C | 2007 | Int J Cancer2007，120，2： | 1 |
| 4 | Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis显示文摘 | Yi CH Zheng T Leaderer D | | 0，，02： | 1 |
| 5 | Nero-synonymous polymor phisms in the circadian gene NPAS2 and breast cancer risk显示文摘 | Zhu Y Stevens RG Leaderer D | 2008 | Breast Cancer Res Treat2008，107，3： | 1 |
| 6 | Nonsynonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk显示文摘 | Zhu Y Stevens R G Leaderer D | 2008 | Breast Cancer Res Treat2008，107，3： | 1 |
| 7 | Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes 显示文摘 | Leader B Lim H Carabatsos M J Harrington A Ecsedy J Pellman D Maas R Leder P | 2002 | Nature Cell Biology2002，4，： | 1 |
| 8 | Ala394Thr polymorphism in the clock gene NPAS2:a circadian modifier for the risk of non-Hodg kin's lymphoma显示文摘 | Zhu Y Leaderer D Cuss C | 2007 | Int J Cancer2007，120，2： | 1 |
| 9 | Maternal trait anxiety, depression and life event stress in pregnancy: relation- ships with infant temperament显示文摘 | Austin M P Hadzi-Pavlovic D Leader L | 2005 | Early Hum Dev2005，81，2： | 1 |
| 10 | Topical application of a G-Quartet aptarner targeting nucleolin attenuates choroidal neovas?cularization in a model of age- related macular degeneration显示文摘 | Leaderer D Cashman SM Kumar-Singh R | 2015 | Exp Eye Res2015，140，： | 1 |
| 11 | Multiple snoRNA gene clusters from Arabidopsis 显示文摘 | Brown J W Clark G P Leader D J | 2001 | RNA2001，7，： | 1 |
| 12 | Maternal trait anxiety,depression and life event stress in pregnancy:relationships with infant temperament显示文摘 | Austin MP Hadzi-Pavlovic D Leader L | | 0，，02： | 1 |
| 13 | Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma显示文摘 | Zhu Y Leaderer D Guss C | 2007 | Int J Cancer2007，120，2： | 1 |
| 14 | Protein therapeutics: a summary and pharmacological classification显示文摘 | Leader B Baca Q J Golan D E | 2008 | Nat Rev Drug Discoy2008，7，1： | 1 |
| 15 | Multiple snoRNA gene clusters from Arabidopsis显示文摘 | BROWN J W CLARK G P LEADER D J | 2001 | RNA2001，7，： | 1 |
| 16 | Role of higher twist in polarized deep inelastic scattering 显示文摘 | LEADER E SIDOROV A V STAMENOV D B | 2003 | Physical Review D2003，67，074017： | 1 |
| 17 | High-throughput protein localization in Arabidopsis using Agrobacterium-mediated transient expression of GFP-ORF fusions显示文摘 | Koroleva O A Tomlinson M L Leader D | 2005 | The Plant Journal2005，41，1： | 1 |
| 18 | Genetic and epigenetic as- sociations of circadian gene TIMELESS and breast cancer risk 显示文摘 | Fu A Leaderer D Zheng T | 2012 | Mol Carcinog2012，51，12： | 1 |
| 19 | Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non Hodgkin' s lymphoma显示文摘 | Zhu Y Leaderer D Guss C | 2007 | Int J Cancer2007，120，： | 1 |
| 20 | Maternal trait anxiety, depression and life event stress in pregnancy: Relationships with infant temperament 显示文摘 | AUSTIN M P HADZI-PAVLOVIC D LEADER L | 2005 | Early Hum Dev2005，81，2： | 1 |
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