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| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | 缺血性脑损伤机制的研究进展显示文摘在美国,中风是致死第三大因素,致残的首要因素。中风引起的脑损伤由有着复杂相互作用的多个通路引起,包括兴奋性神经毒性,酸中毒,电解质失衡,围梗死去极化,氧化和硝化应激,炎症反应和细胞凋亡。对于中风而言,现在有效的治疗途径很少。那么,探索新的治疗方法就需要对各种脑缺血损伤机制的全面了解。本文讨论基本的中风的病理生理过程,揭示治疗干预可靶向复杂通路。 | Doyle KP Simon RP Stenztl-Peore MP 王竞 杜俊蓉 | 2008 | 国际药学研究杂志2008，35，4： | 14 |
| 3 | 口服抗栓药物预防非瓣膜性房颤患者的卒中:美国心脏协会/美国卒中协会的科学建议显示文摘成年房颤患者的卒中发生率,依据合并症和既往脑血管事件史,为每年1%~20%不等(平均每年为4.5%)。对卒中风险的分层非常重要,因为用抗栓药降低房颤导致卒中的主要风险是出血。如华法令在减少缺血性事件风险的同时,每年有1%~12% | 戴若莲 糜建华 华驾略 董荃 苏爱萍 李焰生 Furie KL Goldstein LB Albers GW Khatri P Neyens R Turakhia MP Turan TN Wood KA | 2012 | 神经病学与神经康复学杂志2012，9，3： | 12 |
| 4 | 一种在表面形成Al_2O_3膜的新型耐热奥氏体不锈钢显示文摘一类以在材料表面形成Al2O3膜的奥氏体不锈钢(AFA)的开发正如火如荼地在全球展开。这类合金与传统的、在其表面形成Cr2O3膜的不锈钢相比,在不牺牲其成本、蠕变抗力和可焊性等其它性能的同时具有更高的使用温度和更好的耐环境侵蚀能力。作者简要介绍了该合金的开发方法和其抗氧化和蠕变抗力方面的数据。 | BRADY MP YAMAMOTO Y MAZIASZ PJ SANTELLA ML 韦习成 | 2008 | 自然杂志2008，30，4： | 10 |
| 5 | Tracing method study of bacterial translocation in vivo显示文摘INTRODUCTIONEndogenesis infection plays an important role innosocomial infection.By studying progress ofbacteria translocation from intestinal tract,theconcept of gut-origin infection has been acceptedgradually.Because of no ideal tracing method,there were some controversies.In order to solve theproblem,the PUC19 plasmid vector tracing | Fu WL Xiao GX Yue XL Hua C Lei MP | 2000 | World Journal of Gastroenterology2000，6，1： | 9 |
| 6 | 频闪法在带钢表面检查中的应用显示文摘 | Simo.,MP 余永桂 | 1994 | 世界钢铁1994，，4： | 8 |
| 7 | 新西兰的牧草种子生产显示文摘新西兰的牧草种子生产北京农业大学草地研究所韩建国[新西兰]M.P.Rolston新西兰牧草种子生产已有100多年的历史,近50年牧草种子平均年产量保持在2.2万t左右。近年来牧草种子的年收入平均为4000万新元(相当于2亿人民币)。牧草种子除满足本国... | 韩建国 Roln.,MP | 1994 | 世界农业1994，，11： | 8 |
| 8 | hsa-miR-29c and hsa-miR-135b differential expression aspotential biomarker of gastric carcinogenesis显示文摘AIM: To investigate the expression profiles of hsa-mi R-29 c and hsa-mi R-135 b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS: The expression levels of hsa-mi R-29 c and hsa-mi R-135 b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinaltype gastric adenocarcinoma were analysed using quantitative real-time PCR. The difference between hsa-mi R-29 c and hsa-mi R-135 b expression profiles in the grouped samples was evaluated by ANOVA and Student's t-test tests. The results were adjusted for multiple testing by using Bonferroni's correction. P values ≤ 0.05 were considered statistically significant. To evaluate hsa-mi R-29 c and hsa-mi R-135 b expressions as potential biomarkers of gastric carcinogenesis, we performed a receiver operating characteristic curve analysis and the derived area under the curve, and a Categorical Principal Components Analysis. In silico identification of the genetic targets of hsa-mi R-29 c and hsa-mi R-135 b was performed using different prediction tools, in order to identify possible genes involved in gastric carcinogenesis.RESULTS: The expression levels of hsa-mi R-29 c were higher in normal gastric mucosal samples, and decreased progressively in non-atrophic chronic gastritis samples, intestinal metaplasia samples and intestinal-type gastric adenocarcinoma samples. The expression of hsa-mi R-29 c in the gastric lesions showed that non-atrophic gastritis have an intermediate profile to gastric normal mucosa and intestinal-type gastric adenocarcinoma, and that intestinal metaplasia samples presented an expression pattern similar to that in intestinal-type gastric adenocarcinoma. This micro RNA(mi RNA) has a good discriminatory accuracy between normal gastric samples and(1) intestinal-type gastric adenocarcinoma; and(2) intestinal metaplasia, and regulates the DMNT3 A oncogene. hsa-mi R-135 b is up-regulated in non-atrophic chronic gastritis and intestinal metaplasia samples and down-regulated in normal gastric mucosa and intestinal-type gastric adenocarcinoma samples. Non-atrophic chronic gastritis and intestinal metaplasia are significantly different from normal gastric mucosa samples. hsa-mi R-135 b expression presented a greater discriminatory accuracy between normal samples and gastric lesions. This mi RNA was associated with Helicobacter pylori presence in non-atrophic chronic gastritis samples and regulates the APC and KLF4 tumour suppressor genes.CONCLUSION: Our results provide evidence of epigenetic alterations in non-atrophic chronic gastritis and intestinal metaplasia and suggest that hsa-mi R-29 c and hsa-mi R-135 b are promising biomarkers of gastric carcinogenesis. | Amanda Ferreira Vidal Aline MP Cruz Leandro Magalhães Adenilson L Pereira Ana KM Anaissi Nélisson CF Alves Paulo JBS Albuquerque Rommel MR Burbano Samia Demachki Ândrea Ribeiro-dos-Santos | 2016 | World Journal of Gastroenterology2016，22，6： | 7 |
| 9 | Journal of Hepatology|血浆氨水平能够预测临床稳定的肝硬化门诊患者的肝脏相关并发症和病死率显示文摘高氨血症虽是肝性脑病发病机制的核心,但对其他器官系统也有多向毒害作用,影响免疫功能、能量代谢、门静脉高压及导致肌少症。该研究旨在验证临床稳定的门诊肝硬化患者中,高氨血症的严重程度是肝相关并发症的风险因素这一假设。研究收集了来自3个独立单位的754例临床稳定的肝硬化门诊患者的数据。将基准氨水平校正至参考实验室的正常值上限(AMM-ULN)。 | 董美丽 温晓玉 TRANAH TH BALLESTER MP CARBONELL-ASINS JA | 2022 | 临床肝胆病杂志2022，38，9： | 6 |
| 10 | Expression of inducible nitric oxide synthase in human gastric cancer显示文摘 | Jun Y Fei G Ebert MP Malfertheiner P | 1999 | World Journal of Gastroenterology1999，5，5： | 5 |
| 11 | 早发急性心肌梗死的长期结局和风险评估:10年随访研究显示文摘早发急性心肌梗死(acute myocardial infarction,AMI)是一种罕见的疾病,发病率和死亡率很高。该文在再灌注治疗广泛应用的大环境下,纳入前瞻性研究人群进行早发AMI的预后研究。方法:这项前瞻性多中心研究中连续纳入102例AMI存活者(≤40岁),临床预后通过奥地利死亡登记处和维也纳集中患者管理系统进行查询。 | 刘莉 叶鹏 Winter MP Blessberger H Alimohammadi A Pavo N Huber K Wojta J Lang IM Wiesbauer F Goliasch G | 2017 | 中华高血压杂志2017，25，4： | 5 |
| 12 | 早发性先兆子痫,迟发性先兆子痫和妊娠高血压后的心血管疾病危险因素显示文摘研究表明,有妊娠高血压病史的妇女心血管疾病(cardiovasculardisease,CVD)终生风险增加。这种风险与妊娠相关高血压疾病的严重程度及发病孕周有关。然而,cVD危险因素的差异是否在产后心血管筛查时就已经存在尚不清楚。研究人员将妊娠期高血压疾病患者分为3个亚组,分析CVD危险因素的产后差异。 | 刘莉 叶鹏 Veerbeek JH Hermes W Breimer AY van Rijn BB Koenen SV Mol BW Franx A de Groot CJ Koster MP | 2015 | 中华高血压杂志2015，23，2： | 5 |
| 13 | A NOTE ON A THEOREM OF TAS, TELCI AND FISHER显示文摘In this paper ,it has been shown that the condition of continuity in the fixed point theorem of Tas, Telci and Fishe[2] is not necessary. Also the completeness of (X, d)can be replaced by the completeness of T(X). | A. Banerjee B. Singh Thakur (Department of Mathematics, Govt. L. B. Girls P. G. College, Raipur (MP), 492001, India)(Govt. B. H. S. S., Gariaband, Dist. Raipur, 493889, India) | 1998 | Applied Mathematics and Mechanics(English Edition)1998，19，4： | 5 |
| 14 | 镍基单晶超合金中孔洞长大的试验和有限元分析(英文)显示文摘在高温状态下,镍基单晶超合金的变形、损伤及断裂分析中,孔洞的长大都起着主要的作用。本研究进行了系列的蠕变、疲劳及热机械疲劳(TMF)试验。对试件的断面进行的 SEM 观察表明,所有的断面都是有许多小断面构成,在断面的中心,至少有一个孔洞。孔洞的尺寸与加载的条件相关。使用晶体塑性有限元程序对单胞模型进行分析,模拟孔洞的长大规律。给出了蠕变和弹塑性两种条件下的模拟结果及不同的晶体取向对孔穴长大的影响结果。对孔洞长大的有限元分析有助于对实验结果的理解。 | 王毅 岳珠峰 Stein MP | 2006 | 稀有金属材料与工程2006，35，1： | 5 |
| 15 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C:a randomised trial显示文摘 | Manns MP McHutchison JG Gordon SC | | The Lancet0，，： | 4 |
| 16 | 基因重组人巨细胞病毒PPUL32蛋白在诊断中的应用显示文摘为组建可在诊断中应用的高纯度、高效价基因工程抗原,我们在同一克隆中同时表达了人巨细胞病毒(Human cytomegalovirus HCMV)PPUL32蛋白的两个抗原决定簇基因,在诊断中取得满意的结果。 材料和方法 1.克隆 A:表达HCMV PPUL32蛋白位于UL32区第1783~1842核苷酸的抗原决定簇基因。 2.克隆 B:表达HCMV PPUL32蛋白位于UL32区第3070~3144核苷酸的抗原决定族基因;克隆C和D分别表达此基因的二个和三个拷贝。 | 阮强 Ripalti A Landini MP | 1995 | 中华微生物学和免疫学杂志1995，15，2： | 4 |
| 17 | Diagnosis and management of autoimmune hepatitis显示文摘 | Manns MP Czaja AJ Gorham JD | | Hepatology0，，： | 4 |
| 18 | Umbilical hernia in patients with liver cirrhosis: A surgical challenge显示文摘Umbilical hernia occurs in 20% of the patients with liver cirrhosis complicated with ascites. Due to the enormous intraabdominal pressure secondary to the ascites, umbilical hernia in these patients has a tendency to enlarge rapidly and to complicate. The treatment of umbilical hernia in these patients is a surgical challenge. Ascites control is the mainstay to reduce hernia recurrence and postoperative complications, such as wound infection, evisceration, ascites drainage, and peritonitis. Intermittent paracentesis, temporary peritoneal dialysis catheter or transjugular intrahepatic portosystemic shunt may be necessary to control ascites. Hernia repair is indicated in patients in whom medical treatment is effective in controlling ascites. Patients who have a good perspective to be transplanted within 3-6 mo, herniorrhaphy should be performed during transplantation. Hernia repair with mesh is associated with lower recurrence rate, but with higher surgical site infection when compared to hernia correction with conventional fascial suture. There is no consensus on the best abdominal wall layer in which the mesh should be placed: Onlay, sublay, or underlay. Many studies have demonstrated several advantages of the laparoscopic umbilical herniorrhaphy in cirrhotic patients compared with open surgical treatment. | Julio CU Coelho Christiano MP Claus Antonio CL Campos Marco AR Costa Caroline Blum | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 4 |
| 19 | Smooth Muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat 显示文摘 | Bendeck MP Zempo N Clowes A | 1994 | Circ Res1994，75，3： | 3 |
| 20 | Highprevalence of sick building syndrome in a new air-conditioned building in Italy显示文摘 | Abbritti G Muzi G Accattoli MP | 1992 | Arch Environ Health1992，47，1： | 3 |
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