|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2005年全国治超工作要点显示文摘 | Issued by Ministry of Communications of the People′s Republic of China,T he Ministry of Public Security of the People′s Republic of China,National Development and Reform Comm ission,the Ministry of Propaganda of the CPC Central Committee,General Administration of Qu ality Supervision Inspection and Quarantine of the PRC,State Administration of Work Safety,State Administration for Industry & Commerce,China Legislative | 2005 | 交通标准化2005，，5： | 34 |
| 2 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 3 | 1997年全国艾滋病哨点监测报告显示文摘1997年,全国HIV监测哨点共调整为60个,分布在27个省(自治区、直辖市)。性病门诊哨点和长卡哨点中只检出极少数HIV感染者。1997年,在3个暗娼哨点中的检出率约为1%~2%,而1996年同期仅为不到0.5%;在12个吸毒哨点中有7个哨点(包括2个新增哨点)报告了HIV感染者,而在1996年同期8个哨点中有3个哨点报告了感染者。新疆自治区报告了83例(20.8%)感染者,而在前几年同期同一哨点只有32例(8.0%)。在大部分吸毒监测哨点中的静注比例正不断增加或保持一个较高水平。暗娼人群中有60%从不使用避孕套。该监测结果表明,局部地区吸毒者中HIV感染率在不断上升,HIV波及的地区在不断地增多,HIV感染已开始向性乱人群扩散;可引起HIV流行的危险因素在不断增加。 | Department of Disease Control,Ministry of Health,People′s Republic of China 1 Center for AIDS Surveillance,Chinese Academy of Preventive Medicine 2 Group of National HIV Sentinel Surveillance Program (Written by Qu Shuquan 2,Sun Xinhua 1,Zheng X | 1998 | 中国性病艾滋病防治1998，4，4： | 15 |
| 4 | 1996年中国艾滋病哨点监测报告显示文摘我国自1995年开始在23个省(自治区、直辖市)的42个哨点中对性传播疾病(STDs)门诊就诊者、暗娼、吸毒者和长途卡车司机四类人群进行监测,当年监测结果显示,在监测哨点所在的城市中,被监测的STDs门诊就诊者、暗娼、吸毒者和长途卡车司机人群中HIV感染率均很低,但存在广泛传播的危险性。1996年第一轮共监测10085人,发现HIV感染者35例。其中在STDs门诊就诊者中发现HIV感染者1例,在吸毒者中发现HIV感染者34例(其中新疆32例);第二轮监测11909人,发现HIV感染者72例,其中在暗娼人群中发现1例,在吸毒人群中发现71例(其中新疆69例)。1996年监测结果表明,在哨点所在的城市中,尽管被监测的STDs门诊就诊者、暗娼和长途卡车司机人群中HIV感染率仍很低,但我国HIV流行形势已发生改变,HIV感染的流行已不仅仅局限于云南吸毒者中,在其它地区已开始在吸毒者中流行,个别地区该人群中HIV感染率上升很快。 | Department of Disease control.Ministry of Health,People′s Republic of China 1 Center for AIDS Surveillance,Chinese Academy of Preventive Medicine 2 Group of National HIV sentinel surveillance program (Written by Qu Shuquan 2,Sun Xinhua 1,Zheng Xiwen | 1997 | 中国性病艾滋病防治1997，3，5： | 12 |
| 5 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 6 | Monitoring early responses to irradiation with dual-tracer micro-PET in dual-tumor bearing mice显示文摘AIM: To monitor the early responses to irradiation in primary and metastatic colorectal cancer (CRC) with 18 Ffluorothymidine ( 18 F-FLT) and 18 F-fluorodeoxyglucose ( 18 F-FDG) small-animal position emission tomography (micro-PET). METHODS: The primary and metastatic CRC cell lines, SW480 and SW620, were irradiated with 5, 10 and 20, l l l , Gy. After 24 h, the cell cycle phases were analyzed. A dual-tumor-bearing mouse model of primary and metastatic cancer was established by injecting SW480 and SW620 cells into mice. micro-PET with 18 F-FLT and 18 F-FDG was performed before and 24 h after irradiation with 5, 10 and 20 Gy. The region of interest (ROI) was drawn over the tumor and background to calculate the ratio of tumor to non-tumor (T/NT) in tissues. Immunohistochemical assay and Western blotting were used to examine the levels of integrin β3, Ki-67, vascular endothelial growth factor receptor 2 (VEGFR2) and heat shock protein 27 (HSP27). RESULTS: The proportion of SW480 and SW620 cells in the G 2 -M phase was decreased with an increasing radiation dose. The proportion of SW480 cells in the G 0 -G 1 phase was increased from 48.33% ± 4.55% to 87.09% ± 7.43% (P < 0.001) and that of SW620 cells in the S-phase was elevated from 43.57% ± 2.65% to 66.59% ± 7.37% (P = 0.021). In micro-PET study, with increasing dose of radiation, 18 F-FLT uptake was significantly reduced from 3.65 ± 0.51 to 2.87 ± 0.47 (P = 0.008) in SW480 tumors and from 2.22 ± 0.42 to 1.76 ± 0.45 (P = 0.026) in SW620 tumors. 18 F-FDG uptake in SW480 and SW620 tumors was reduced but not significantly (F = 0.582, P = 0.633 vs F = 0.273, P = 0.845). Dose of radiation was negatively correlated with 18 F-FLT uptake in both SW480 and SW620 tumors (r = -0.727, P = 0.004; and r = -0.664, P = 0.009). No significant correlation was found between 18 F-FDG uptake and radiation dose in SW480 or SW620 tumors. HSP27 and integrin β3 expression was higher in SW480 than in SW620 tumors. The T/NT ratio for 18 F-FLT uptake was positively correlated with HSP27 and integrin β3 expression (r = 0.924, P = 0.004; and r = 0.813, P = 0.025). CONCLUSION: 18 F-FLT is more suitable than 18 F-FDG in monitoring early responses to irradiation in both primary and metastatic lesions of colorectal cancer. | Hui Wang, Jia-He Tian, Bai-Xuan Xu, Zhi-Wei Guan, ChangBin Liu, Rui-Min Wang, Ying-Mao Chen, Jin-Ming Zhang, Nuclear Medicine Department, The General Hospital of the Chinese People’s Liberation Army and Military Medical Postgraduate College, Beijing 100853, China Bo Liu, Department of Hepatobiliary Surgery, The General Hospital of the Chinese People’s Liberation Army and Military Medical Postgraduate College, Beijing 100853, China Bao-Lin Qu, Department of Radiation Oncology, The General Hospital of the Chinese People’s Liberation Army and Military Medical Postgraduate College, Beijing 100853, China | 2010 | World Journal of Gastroenterology2010，16，43： | 10 |
| 7 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 8 | Taxol inhibits stretch-induced electrophysiological alterations in isolated rat hearts with acute myocardial infarction显示文摘Mechanosensitive channels have been determined to work as transducers of mechanoelectric feedback in the heart, which is associated with the generation of arrhythmias. Recent studies have investigated the role of the cytoskeleton in ion channels control. This study explored the ability of taxol to inhibit stretch-induced electrophysiological alterations in the ischemic myocardium. Thirty-two Wistar rats were randomly divided into four groups: normal control group (n=9), taxol group (n=7), myocardial infarction (MI) group (n=9), and MI+taxol group (n=7). After Langendorff perfusion, the isolated hearts were stretched for 5 s by balloon inflation to 0.2 or 0.3 mL. The effects of stretching on 90% monophasic action potential duration (MAPD90), premature ventricular beats (PVB), and ventricular tachycardia (VT) were observed for 30 s. Stretching increased MAPD90 in both the normal control and MI groups, but MAPD90 increased more in the MI group for the same degree of stretch. Taxol (5 μmol L?1) had no effect on MAPD90 under baseline, unstretched conditions, but MAPD90 in the taxol group was slightly increased after stretching compared with the normal control group (P>0.05). However, taxol reduced MAPD90 in infarcted myocardium (P<0.05 at V=0.3 mL). The incidences of PVB and VT in the MI group were higher than in the normal control group (both P<0.01). Taxol had no effect on the occurrence of arrhythmias in normal myocardium, but it inhibited PVB and VT in infarcted hearts (both P<0.01). Thus changes in MAPD and the occurrence of arrhythmias caused by mechanical stretching of the myocardium could be inhibited by taxol in isolated rat hearts during AMI, indicating the involvement of tubulin in mechanoelectric feedback in AMI. | CAO JunXian1, FU Lu1, SUN DianJun2, XIE RongSheng1, ZHOU Jue3 & QU Fan4 1Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China 2Chinese Research Center for Endemic Disease Control, Key Laboratory of Etiological Epidemiology, Ministry of Health (23618504), Harbin Medical University, Harbin 150081, China 3Pharmacy Department, King’s College London, Franklin-Wilkins Building, 150 Stamford Street, London, UK 4The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China | 2010 | Science China(Life Sciences)2010，53，8： | 2 |
| 9 | The patch test for mixed formulation显示文摘 | Zienkiewicz O C Qu S Taylor R L | 1986 | Int J for Numerical Methods in Engineering1986，23，： | 2 |
| 10 | Hepatology|过氧化物酶体增殖物激活受体α通过YAP-TEAD信号通路促进肝脏增大和肝脏再生显示文摘过氧化物酶体增殖物激活受体α(PPARα)是内/外源物质代谢调控的关键核受体之一。Yes相关蛋白(YAP)是Hippo信号通路的核心调节元件,YAP激活后入核与转录因子TEAD结合,启动下游基因表达,对肝脏大小起到重要调控作用。PPARα激动可致肝增大并在肝再生过程中发挥关键作用,但具体机制仍不清楚。该研究旨在揭示PPARα通过YAP-TEAD信号通路促进肝增大和肝再生的分子调节机制。 | 毕惠嫦 范仕成 高悦 FAN S GAO Y QU A | 2022 | 临床肝胆病杂志2022，38，2： | 2 |
| 11 | Relative frequency and survival of primary cutaneous lymphomas: a retrospective analysis of 98 patients显示文摘 | Liu J Liu YH Jin HZ Ma DL Qu T Wang T S un QN Yu X | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 12 | Development of FBMINC model for particle diffusion in fluids显示文摘An accurate particle tracking method using FBMINC (new fractional Brownian motion) is outlined. It generates non-Fickian diffusion rather than Fickian diffusion as traditional particle tracking model does. The FBMINC model is based on fractional Brownian motion (fBm) which is generalization of regular Brownian motion. The two models of fBms (FBM model and FBMINC model) were explored and the differences of the two models are compared from the three aspects: the standard deviation of each step, the small memory and the effect of the number of particles in the cloud. The results show the FBMINC model is a better model as it produces more accurate statistics. The effect of simple shear dispersion for both Brownian and fBm was investigated. The power law scaling of fBm shear dispersion was correctly identified. In addition, a scaling coefficient was found numerically. The FBMINC model is then used for producing both superdiffusive and subdiffusive particle paths, therefore, the non-Fickian diffusion of soil particle clouds can be modelled. The particle clouds represent soil contaminant are released in an idealised coastal bay and the fBm particle tracking method is used for simulation the particle cloud spreading in the bay. There is a noticeable increase in the spreading rate of the cloud. In addition, owning to the spreading rate of the cloud, a noticeable part of it has escaped the bay area and transported downstream. The variation of the Hurst exponent can lead to an area of the flow being affected by a contaminant cloud which is not picked up by the regular Brownian motion models. The purpose of this paper is to bring soil transport engineers a new angle on soil particle transport research in fluids. Using FBMINC particle tracking model allows more flexibility in simulation of diffusion in soil contaminant spread in coastal bay or ocean surface. | Bo QU Paul S ADDISION | 2009 | International Journal of Sediment Research2009，24，4： | 2 |
| 13 | Pulse electrodeposition of nanocrystalline nickel using ultra narrow pulse width and high peak current density显示文摘 | QU N S ZHU D CHAN K C | 2003 | Surface and Coatings Technology2003，1，68： | 1 |
| 14 | Characterization of a humanized IgG4 anti-HLA-DR monoclonal antibody that lacks effeetor cell functions but retains direct antilymphoma activity and increases the potency of rituximab 显示文摘 | Stein R Qu Z Chen S | 2006 | Blood2006，108，8： | 1 |
| 15 | A conventional theory of mechanism-based strain gradient plasticity 显示文摘 | Huang Y Qu S Hwang K C | 2004 | International Journal of Plasticity2004，20，1： | 1 |
| 16 | Investigation of composition and microstructure effect on fracture behaviour of tungsten heavy alloys显示文摘 | Islam S H Qu X He X | 2007 | Powder Metallurgy2007，50，1： | 1 |
| 17 | Interconnecting bilayer networks显示文摘 | Xu X L Qu Y Q Guan S | 2011 | Europhy Lett2011，93，68： | 1 |
| 18 | Quality- of- protection (QoP)-an online monitoring and self- protection mechanism 显示文摘 | Hariri S Qu G Modukuri R | 2005 | IEEE Journal on Selected Areas in Communications2005，10，23： | 1 |
| 19 | A lower prevalence of asthma among patients with chronic rhinosinusitis in southern China显示文摘 | Fan Y Chen S Qu X | 2011 | J Allergy Clin Immunol2011，127，2： | 1 |
| 20 | Preparation and flammability properties of polyethylene/clay nanocomposites by melt intercalation显示文摘 | S F Wang Y Hu Qu Z K | 2003 | Materials Letters2003，57，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员