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| 1 | Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts显示文摘Bone is a dynamic tissue that is constantly renewed by the coordinated action of two cell types, i.e., the bone-resorbing osteoclasts and the bone-forming osteoblasts. However, in some circumstances, bone regeneration exceeds bone self repair capacities. This is notably often the case after bone fractures, osteolytic bone tumor surgery, or osteonecrosis. In this regard,bone tissue engineering with autologous or allogenic mesenchymal stem cells(MSCs) is been widely developed. MSCs can be isolated from bone marrow or other tissues such as adipose tissue or umbilical cord, and can be implanted in bone defects with or without prior amplification and stimulation. However, the outcome of most pre-clinical studies remains relatively disappointing. A better understanding of the successive steps and molecular mechanisms involved in MSC-osteoblastic differentiation appears to be crucial to optimize MSC-bone therapy. In this review, we first present the important growth factors that stimulate osteoblastogenesis. Then we review the main transcription factors that modulate osteoblast differentiation, and the microRNAs(miRs)that inhibit their expression. Finally, we also discuss articles dealing with the use of these factors and miRs in the development of new bone MSC therapy strategies. We particularly focus on the studies using human MSCs, since significant differences exist between osteoblast differentiation mechanisms in humans and mice for instance. | Maya Fakhry René Buchet David Magne Eva Hamade Bassam Badran | 2013 | World Journal of Stem Cells2013，5，4： | 32 |
| 2 | 中国环境镉接触人群低骨密度及肾功能不全的研究显示文摘25年前,Ambio曾载文提出应警惕环境镉污染引起的健康效应。1998年在中国进行了这方面的研究,评价了因食用大米而接触镉人群的前臂骨密度(BMD)和肾功能,发现尿镉(CdU) 或血镉(CdB)高的绝经后妇女及血镉(CdB)高的男性,BMD均有所下降。在CdB或CdU与肾功能不全(视黄醇结合蛋白排泄增加)之间也发现了明显的、有统计学意义的剂量-效应关系及剂量-反应关系。第一次报道了日本以外的亚洲地区镉接触人群中存在骨不良效应。本文的意义在于阐明了亚洲的环境镉接触人群中仍存在着与肾和骨(镉的比较严重的有害效应)的联合效应,也讨论了一些欧洲镉接触人群的骨效应。 | Gunnar Nordberg 金泰廙 Alfred Bernard Sebastien Fierens Jean Pierre Buchet 叶葶葶 孔庆瑚 王洪复 | 2002 | AMBIO-人类环境杂志2002，31，6： | 19 |
| 3 | Effects of vanadium complexes with organic ligands on glucose metabolism: a comparison study in diabetic rats显示文摘 | Reul B A Amin S S Buchet J P | 1999 | Br J Pharmacol1999，126，2： | 2 |
| 4 | Arsenic uptake, cytoxocity and detoxification studied in mammalian cells in culture 显示文摘 | Fisher A B Buchet J P Lauwerys RR | 1985 | Arch Toxicol1985，57，3： | 1 |
| 5 | Epidemiological survey of workers exposed to cobalt oxides,cobalt salts,and cobalt metal显示文摘 | Swennen B Buchet JP Stanescu D | 1993 | Br J Ind Med1993，50，9： | 1 |
| 6 | Renal and neurologic effects of cadmium,lead,mercury,and arsenic in children:evidence of early effects and multiple interactions at environmental exposure levels显示文摘 | de Burbure C Buchet JP Leroyer A | 2006 | Environ Health Perspect2006，114，4： | 1 |
| 7 | Effects of vanadium complexes with organic ligands on glucose metabolism : a comparison study in diabetic rats 显示文摘 | REUL B A AMIN S S BUCHET J P | 1999 | Br J Pharmacol1999，126，2： | 1 |
| 8 | The feasibility of vaginal hysterectomy显示文摘 | Michel Cosson Denis Querleu Damien Subtil Isabelle Switala Benedicte Buchet Gilles Crepin | 1996 | European Journal of Obstetrics and Gynecology1996，，1： | 1 |
| 9 | The relationship between cadmium exposure or body burden and the concentration of cadmium in blood and urine in man显示文摘 | LAUWERYS R R BUCHET J P ROELS H | 1976 | International archives of occupational and environmental health1976，36，4： | 1 |
| 10 | Relation between airborne arsenic trioxide and urinary excretion of inorganic arsenic and its methylated metabolites显示文摘 | Offergdt JA Reels H Buchet JP | 1992 | Br J Ind Med1992，49，： | 1 |
| 11 | Are genetic polymorphisms in OGG1,XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations?显示文摘 | AKA P MATEUCA R BUCHET J P | 2004 | Mutat Res2004，556，12： | 1 |
| 12 | Fructose Concentration in Seminal Plasma from Men with Nonobstructive Azoospermia显示文摘 | Buchet W M Lewis Jones D I | 2002 | Arch Androl2002，48，1： | 1 |
| 13 | Long-term expression of beta-glucoronidase by genetically modefied human neural progenitor cells grafted into the mouse central nervous system 显示文摘 | Buchet D Serguera C Zennon V | 2002 | Mol Cell Neurosci2002，19，3： | 1 |
| 14 | Effects of temperature on the growth of pollack ( Pollachius pollachius ) juveniles显示文摘 | J. Person-Le Ruyet V. Buchet B. Vincent H. Le Delliou L. Quéméner | 2005 | Aquaculture2005，，2： | 1 |
| 15 | Effect of lipid level in a compound diet on the development of red drum Sciaenops ocellatus显示文摘 | Larvae V Buchet A Zambonino J L | 2000 | Aquaculture2000，，184： | 1 |
| 16 | The feasibility of vaginal hysterectomy显示文摘 | Michel Cosson Denis Querleu Damien Subtil Isabelle Switala Benedicte Buchet Gilles Crepin | 1996 | European Journal of Obstetrics and Gynecology1996，，1： | 1 |
| 17 | Peroxidase activity of annexin 1 from Arabidopsis thaliana显示文摘 | Karolina M. Gorecka Dorota Konopka-Postupolska Jacek Hennig Rene Buchet Slawomir Pikula | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 1 |
| 18 | Urinary excretion of nomovanillic acid in workers exposed to mangenese显示文摘 | Roels H Buchet JP Msgos C | 1993 | Int Arch Occup Environ Health1993，65，2： | 1 |
| 19 | Determinants of benzo (a) pyrene diol epoxide adducts to albumin in workers exposed to polycyclic aromatic hydrocarbons显示文摘 | TAS S BUCHET J P LAUWERYS R | 1994 | Int Arch Occup Environ Health1994，66，： | 1 |
| 20 | Inorganic arsenic methylation by rat tissue slices 显示文摘 | Georis B Cardenas A Buchet JP | 1990 | Toxicology1990，63，： | 1 |
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