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| 1 | Novel role of phosphodiesterase inhibitors in the management of end-stage heart failure显示文摘In advanced heart failure(HF), chronic inotropic therapy with intravenous milrinone, a phosphodiesterase Ⅲ inhibitor, is used as a bridge to advanced management that includes transplantation, ventricular assist device implantation, or palliation. This is especially true when repeated attempts to wean off inotropic support result in symptomatic hypotension, worsened symptoms, and/or progressive organ dysfunction. Unfortunately, patients in this clinical predicament are considered hemodynamically labile and may escape the benefits of guidelinedirected HF therapy. In this scenario, chronic milrinone infusion may be beneficial as a bridge to introduction of evidence based HF therapy. However, this strategy is not well studied, and in general, chronic inotropic infusion is discouraged due to potential cardiotoxicity that accelerates disease progression and proarrhythmic effects that increase sudden death. Alternatively, chronic inotropic support with milrinone infusion is a unique opportunity in advanced HF. This review discusses evidence that long-term intravenous milrinone support may allow introduction of beta blocker(BB) therapy. When used together, milrinone does not attenuate the clinical benefits of BB therapy while BB mitigates cardiotoxic effects of milrinone. In addition, BB therapy decreases the risk of adverse arrhythmias associated with milrinone. We propose that advanced HF patients who are intolerant to BB therapy may benefit from a trial of intravenous milrinone as a bridge to BB initiation. The discussed clinical scenarios demonstrate that concomitant treatment with milrinone infusion and BB therapy does not adversely impact standard HF therapy and may improve left ventricular function and morbidity associated with advanced HF. | Abhishek Jaiswal Vinh Q Nguyen Thierry H Le Jemtel Keith C Ferdinand | 2016 | World Journal of Cardiology2016，8，7： | 4 |
| 2 | 外耦合布拉格光栅 5μm量子级联激光器(英文)显示文摘窄带宽的 Al Ga As/ Ga As布拉格光栅耦合到 In P的半导体量子级联激光器从而产生稳定的激光频谱 ,其激光谱线宽度在 1纳米左右。如果不加光栅 ,非稳定的自由激射的激光器的谱线宽度有 3 0 nm左右。 | 彭川 LE H Q Sarangan A M Ishaug B Thompson L | 2003 | 重庆邮电学院学报(自然科学版)2003，15，3： | 4 |
| 3 | Improved local control with stereotactic radiosurgical boost in patients with nasopharyngeal carcinoma显示文摘 | Le Q T Tate D Koong A | 2003 | Int J Radiat Oncol Biol Phys2003，56，4： | 2 |
| 4 | Interface formation between NPB and processed indium tin oxide显示文摘 | LE Q T FORSYTHE E W NUESCH F | 2000 | Thin Solid Films2000，363，： | 1 |
| 5 | Nonsurgical therapy for stages Ⅰ and Ⅱ non-small cell lung cancer显示文摘 | Le Q T Petrik DW | 2005 | Hematol Oncol Clin North Am2005，19，2： | 1 |
| 6 | Primary radio- therapy for localized orbital MALT lymphoma 显示文摘 | Le Q T Eulau S M George T I | 2002 | hit J Radiat Oncol Biol Phys2002，52，3： | 1 |
| 7 | Development of thermo- stable Candidaantarctica lipase B through novel in silico design of disulfidebridge显示文摘 | LE Q A T JOO J C YOO Y J | 2012 | Biotechnology and Bioengineering2012，109，4： | 1 |
| 8 | Modeling and analysis of coupling performance between passive magnetic bearing and hybrid magnetic radial bearing for magnetically suspended flywheel显示文摘 | Han B C Zheng S Q Le Y | 2013 | IEEE Transactions on Magnetics2013，49，10： | 1 |
| 9 | Effect of lactic acid fermented soyabean meal on the growth performance,intestinal microflora and morphology of weaned piglets显示文摘 | Wang N F Chen Q Le G W | 2007 | Journal of Animal and Feed Sciences2007，16，1： | 1 |
| 10 | High-performance polypyrrole nanoparticles counter electrode for dye- sensitized solar cells 显示文摘 | WU J H LI Q H FAN LE Q | 2008 | Journal of Power Sources2008，181，72： | 1 |
| 11 | Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome显示文摘 | LE L Q KABAROWSKI J H WENG Z | 2001 | Immunity2001，14，5： | 1 |
| 12 | Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients显示文摘 | Le Q T Kovacs M S Dorie M J | 2003 | Int J Radiat Oncol Biol Phys2003，56，2： | 1 |
| 13 | Postoperative irradiation of minor salivary gland malignancies of the head and neck显示文摘 | Le Q T Birdwell S Terris D J | 1999 | Radiother Oncol1999，52，2： | 1 |
| 14 | Variational algorithms for analysis and assimilation of meteorology observations,Theoretical aspect 显示文摘 | Le Dimet F Talagrand Q | 1986 | Tellus1986，38，： | 1 |
| 15 | Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling 显示文摘 | Miller RA Chu Q Le Lay J | 2011 | J Clin Invest2011，121，： | 1 |
| 16 | A computational study on the instrumented sharp indentations with dual indenters显示文摘 | LE M Q | 2008 | International Journal of Solids and Structures2008，45，： | 1 |
| 17 | High diversity and abundance of putative polyphosphate-aeeumulating Testrasphaera-related bacteria in activated sludge sys- tems显示文摘 | Nguyen H T Le V Q Hansen A A | 2011 | FEMS Mierobiol Eeol2011，76，2： | 1 |
| 18 | Constitutive Spt activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma 显示文摘 | Shi Q Le X Abbruzzese JL | 2001 | Cancer Res2001，61，10： | 1 |
| 19 | Importance of indium tin oxide surf ace acido basicity for charge injection into organic materials based light emitting di odes显示文摘 | Nuesch F Forsythe E W Le Q T | 2000 | J Appl Phys2000，87，11： | 1 |
| 20 | Volatile components of dry-cured ham 显示文摘 | BERDAGUAE J L DENOYER C LE Q J L | 1991 | Journal of Agricultural and Food Chemistry1991，39，7： | 1 |
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