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| 1 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 2 | STRAIN INDUCED STRUCTURAL TRANSITION OF INTERFACES AND TWINS IN A HOT-DEFORMED DUAL-PHASE TIAL ALLOY显示文摘STRAININDUCEDSTRUCTURALTRANSITIONOFINTERFACESANDTWINSINAHOT-DEFORMEDDUAL-PHASETIALALLOYCHENGuoFiang;WANGJinguo;ZHANGLichunand... | CHEN GuoFiang WANG Jinguo ZHANG Lichun and YE Hengqiang(State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing, 100083, P. R. China Laboratory of Atomic Imaging of Solids, Institute of Metal Researc | 1995 | Acta Metallurgica Sinica(English Letters)1995，8，Z1： | 2 |
| 3 | Evolution of TCP Phase During Long Term Thermal Exposure in Several Re-Containing Single Crystal Superalloys显示文摘The application and component designs of single crystal superalloys are restricted by the precipitation of topologically closed packed(TCP)phases,which can deteriorate the microstructural stability of the alloys severely.Limited researches concerning the type and morphology evolution of TCP phases under elevated temperature conditions have been reported previously.In the present work,three Re-containing single crystal alloys were designed to investigate TCP phase evolution via long term isothermal exposure tests at 1120℃while the effects of Re on the microstructural characteristic and elements segregation were also clarified.The results showed that the addition of Re increased the instability of the alloys and the volume fraction of the TCP phases exceeded 5 vol%when the Re content reached 3 wt%.The increasing Re content had also raised the precipitation temperature of TCP phases but it did not change the type of them after long term aging;all the TCP particles were identified asμphase in this study.Moreover,the elements segregation became considerably serious as Re addition increased constantly,which brought about various morphologies of theμphase in the experimental alloys.In particular,the rod-like and needle-likeμphases demonstrated the typical orientation withinγmatrix while the blockyμphase was dispersedly distributed in the space.No specific orientation relationship could be observed in theμphase when the addition of Re exceeded certain threshold value. | Zihao Tan Lin Yang Xinguang Wang Yunling Du Lihua Ye Guichen Hou Yanhong Yang Jinlai Liu Jide Liu Jinguo Li Yizhou Zhou Xiaofeng Sun | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，5： | 1 |
| 4 | Deformation-induced α_2/γ Interfaces in a Hot-deformed Ti-45Al-10Nb Alloy显示文摘The structure change of α2/γ interface in a Ti-45Al-10Nb alloy induced by hot deformation was investigated by conventional and high-resolution transmission eIectron microscopy. Two types of hot deformation induced special α2/γ intedeces, coherent intedeces with high density of ledges and semi-coherent α2/γ intedeces were found to be due to the absorption of mobile dislocations into the α2/γ inteface. For the misoriented semi-coherent α2/γ interfaces, the densities of dislocation ledges increase with the misoriented angle between (111)γ and (0001)α2 planes, and 1/3[111] Frank partial dislocations were involved in the dislocation ledges. Formation mechanism of these deformation-induced α2/γ interfaces was discussed to be related to the role of α2/γ interface5 adjusting the deformation as a dislocation sink absorbing the slipping dislocations in the γ | Jinguo WANG Lichun ZHANG and Guoliang CHEN (State Key Lab. for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083, China )Henqiang YE(Lab. of Atomic Imaging of Solids, Institute of Metal Research, Chinese Academy | 1998 | Journal of Materials Science & Technology1998，14，2： | 0 |
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