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| 1 | Correlation analysis of dual-energy CT iodine maps with quantitative pulmonary perfusion MRI显示文摘AIM:To correlate dual-energy computed tomography(DECT) pulmonary angiography derived iodine maps with parameter maps of quantitative pulmonary perfusion magnetic resonance imaging(MRI).METHODS:Eighteen patients with pulmonary perfusion defects detected on DECT derived iodine maps were included in this prospective study and additionally underwent time-resolved contrast-enhanced pulmonary MRI [dynamic contrast enhanced(DCE)-MRI].DCE-MRI data were quantitatively analyzed using a pixel-by-pixel deconvolution analysis calculating regional pulmonary blood flow(PBF),pulmonary blood volume(PBV) and mean transit time(MTT) in visually normal lung parenchyma and perfusion defects.Perfusion parameterswere correlated to mean attenuation values of normal lung and perfusion defects on DECT iodine maps.Two readers rated the concordance of perfusion defects in a visual analysis using a 5-point Likert-scale(1 = no correlation,5 = excellent correlation).RESULTS:In visually normal pulmonary tissue mean DECT and MRI values were:22.6 ± 8.3 Hounsfield units(HU);PBF:58.8 ± 36.0 mL/100 mL per minute;PBV:16.6 ± 8.5 mL;MTT:17.1 ± 10.3 s.In areas with restricted perfusion mean DECT and MRI values were:4.0 ± 3.9 HU;PBF:10.3 ± 5.5 mL/100 mL per minute,PBV:5 ± 4 mL,MTT:21.6 ± 14.0 s.The differences between visually normal parenchyma and areas of restricted perfusion were statistically significant for PBF,PBV and DECT(P < 0.0001).No linear correlation was found between MRI perfusion parameters and attenuation values of DECT iodine maps(PBF:r = 0.35,P = 0.15;PBV:r = 0.34,P = 0.16;MTT:r = 0.41,P = 0.08).Visual analysis revealed a moderate correlation between perfusion defects on DECT iodine maps and the parameter maps of DCE-MRI(mean score 3.6,k 0.45).CONCLUSION:There is a moderate visual but not statistically significant correlation between DECT iodine maps and perfusion parameter maps of DCE-MRI. | Jan Hansmann Paul Apfaltrer Frank G Zoellner Thomas Henzler Mathias Meyer Gerald Weisser Stefan O Schoenberg Ulrike I Attenberger | 2013 | World Journal of Radiology2013，5，5： | 6 |
| 2 | Neural invasion in pancreatic cancer: A mutual tropism between neurons and cancer cells显示文摘 | Güralp O. Ceyhan Ihsan Ekin Demir Burak Altintas Ulrich Rauch Gerald Thiel Michael W. Müller Nathalia A. Giese Helmut Friess Karl-Herbert Sch?fer | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 2 |
| 3 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 4 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 5 | Self-assembly and photophysical properties of lamthanide dinuclear triple-helical complexes显示文摘 | Claude Piguet Jean-Claude G Bunzli Gerald Bernardinell | 1993 | J Am Chem Soc1993，115，18： | 2 |
| 6 | Laser gated-ranging for underwater robot vision in turbid waters 显示文摘 | HE Duo-min GERALD G L S | 2002 | SPIE2002，4546，： | 1 |
| 7 | Cardiac amyloidoma with IgM-κ gammopathy显示文摘 | Kathleen JW Gerald G Guillermo AH | 1994 | Arch Pathol Lab Med1994，118，： | 1 |
| 8 | Electricity market dynamics: Oligopolistic competition显示文摘 | Gutierrez-Alcaraz G Gerald B S | 2006 | Electric Power Systems Research2006，76，： | 1 |
| 9 | Roles of interleuckin-13 and interferon-γ in lung inflammation 显示文摘 | Gabriele G Gerald J Dale T | 2000 | Chest2000，121，2： | 1 |
| 10 | Oxidative stress promotes myofibroblast differentiation and tumour spreading 显示文摘 | TOULLEC A GERALD D DESPOUY G | 2010 | EMBO Mol Med2010，2，6： | 1 |
| 11 | Ultra-Wideband wireless systems显示文摘 | ROBERTO AIELLO G ROGERSON GERALD D | 2003 | IEEE Microwave Magazine2003，4，2： | 1 |
| 12 | Influence of QI on Mesophase St ructure显示文摘 | TAYLOR G H PENNOCK G M FITZ Gerald J D | 1993 | Carbon1993，31，2： | 1 |
| 13 | Feign versus fight : influences of temperature, body size and Locomotor abilities on death feigning in neonate snakes 显示文摘 | GERALD W G | 2008 | Animal Behaviour2008，75，： | 1 |
| 14 | Roles of interleuckin13 and interferon-γ in lung inflammation显示文摘 | Gabriele G Gerald J Dale T | 2000 | Chest2000，121，2： | 1 |
| 15 | Chemopreventive agents:selenium 显示文摘 | GERALD F C WILLIAM P G | 1998 | Pharmacology and Therapeutics1998，79，3： | 1 |
| 16 | Engineering design database for plastics显示文摘 | Trantina Gerald G Ysseldyke | 1987 | Materials Engineering1987，104，10： | 1 |
| 17 | Natural languages and context-free languages显示文摘 | Pullum G K Gerald G | 1982 | Linguistics and Philosophy1982，4，4： | 1 |
| 18 | Mechanisms forcing abrupt fluctuations of the Indian Ocean summer monsoon during the last deglaciation 显示文摘 | Karin A F Gerald G Simon G | 1997 | Quaternary Science Reviews1997，16，： | 1 |
| 19 | Beneficial effect of epilepsy surgery in a case of childhood non-paraneoplastic limbic encephalitis显示文摘 | Angelika M Gudrun G Gerald P | 2010 | Epilepsy Research2010，90，3： | 1 |
| 20 | Atmospheric Corrosion of Copper and the Colour,Structure and Composition of Natural Patinas on Copper显示文摘 | Fitz Gerald K P Nairn J Skennerton G | 2006 | Corrision Science2006，48，： | 1 |
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