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| 1 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 2 | Structural comparison and chromosomal localization of the human and mouse IL-13 genes 显示文摘 | McKenzie AN Li X Largaespada DA | 1993 | J Immunol1993，150，12： | 1 |
| 3 | Identification of a novel GTPase,the inducibly expressed GTPase, that accumulates in response to interferongamma显示文摘 | Taylor GA Jeffers M Largaespada DA | 1996 | J Biol Chem1996，271，34： | 1 |
| 4 | structural comparion and chromosomal Localization of the human and the mouse IL-13 gene 显示文摘 | Mackenzie AN Li X Largaespada DA | 1993 | J Immunal1993，150，12： | 1 |
| 5 | Why men are at higher risk'for hepatocellular carci- noma? 显示文摘 | KENG V W LARGAESPADA D A VILLANUEVA A | 2012 | J Hepatol2012，57，： | 1 |
| 6 | Structural comparison and chromosomal localization of the human and mouse IL-13 genes 显示文摘 | McKenzie A N J Li X Largaespada D A | 1993 | J Immunol1993，150，12： | 1 |
| 7 | Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma 显示文摘 | Taylor G A Jeffers M Largaespada D A | 1996 | Biol Chem1996，271，20： | 1 |
| 8 | Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system 显示文摘 | Dupuy A J Akagi K Largaespada DA | 2005 | Nature2005，436，7048： | 1 |
| 9 | Pluripotency of mesenchymal stem cells derived from adult marrow显示文摘 | Jiang Y Jahagirdar BN Reinhardt RL Schwartz RE Keene CD Ortiz-Gonzalez XR Reyes M Lenvik T Lund T Blackstad M Du J Aldrich S Lisberg A Low WC Largaespada DA Verfaillie CM | | 0，，： | 1 |
| 10 | Structural comparison and chromosomal localization of human and mouse IL-13 genes显示文摘 | Mckenzie ANJ Li X Largaespada DA | 1993 | J Immunol1993，150，12： | 1 |
| 11 | Identification of a novel GTPase, the inducibly expressed GTPase, that accu- mulates in response to interferon γ显示文摘 | TAYLOR GA JEFFERS M LARGAESPADA DA | 1996 | J Biol Chem1996，271，20： | 1 |
| 12 | Evi27 encodes a novel membrane protein with homology to the ILl7 receptor显示文摘 | Tian E Sawyer JR Largaespada DA | 2000 | Oncogene2000，19，： | 1 |
| 13 | Explaining sex differences in dental caries prevalence:Saliva,hormones,and“life-history”etiologies显示文摘 | Lukacs JR Largaespada LL | 2006 | American Journal of Human Biology2006，18，4： | 1 |
| 14 | A transposon and transposase system for human application 显示文摘 | Hackett PB Largaespada DA Cooper LJ | 2010 | :Mol Ther2010，18，4： | 1 |
| 15 | Structural comparsion and chromasomal localization of the human and mouse IL-13 genes 显示文摘 | Mckenzie AN Li X Largaespada DA | 1993 | J Immunol1993，150，： | 1 |
| 16 | Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system 显示文摘 | Dupuy A J Akagi K Largaespada DA | 2005 | Nature2005，436，7048： | 1 |
| 17 | Structural comparison and chromosomal localization of the human and mouse IL-13 genes显示文摘 | McKenzie AN Li X Largaespada DA | 1993 | J Immunol1993，150，12： | 1 |
| 18 | Transforming science: cancer gene identification显示文摘 | Collier LS Largaespada DA | 2006 | Curr Opin Genet Dev2006，16，1： | 1 |
| 19 | Canonical Wnt/β-catenin signaling drives human schwann cell transformation,progression,and tumor maintenance显示文摘 | Watson AL Rahrmann EP Moriarity BS Choi K Conboy CB Greeley AD Halfond AL Anderson LK Wahl BR Keng VW Rizzardi AE Forster CL Collins MH Sarver A Wallace MR Schmechel SC Ratner N Largaespada DA | | 0，，06： | 1 |
| 20 | A retrovirus that expresses v-abl and c-myc oncogens rapidly induces plasmacytomas显示文摘 | Largaespada DA Kaehler DA Mishak H | 1992 | Oncogene1992，7，4： | 1 |
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