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| 1 | Management of hilar cholangiocarcinoma in the North of England: Pathology, treatment, and outcome显示文摘AIM: To assess the management and outcome of hilar cholangiocarcinoma (Klatskin tumor) in a single tertiary referral center.METHODS: The notes of all patients with a diagnosis of hilar cholangiocarcinoma referred to our unit for over an 8-year period were identified and retrospectively reviewed. Presentation, management and outcome were assessed.RESULTS: Seventy-five patients were identified. The median age was 64 years (range 34-84 years). Male to female ratio was 1:1. Eighty-nine percent of patients presented with jaundice. Most patients referred were under Bismuth classification 3a, 3b or 4. Seventy patients required biliary drainage, 65 patients required 152percutaneous drainage procedures, and 25 had other complications. Forty-one patients had 51 endoscopic drainage procedures performed (15 failed). Of these,36 subsequently required percutaneous drainage. The median number of drainage procedures for all patients was three, 18 patients underwent resection (24%), nine had major complications and three died post-operatively.The 5-year survival rate was 4.2% for all patients, 21%for resected patients and 0% for those who did not undergo resection (P = 0.0021). The median number of admissions after diagnosis in resected patients was two and three in non-resected patients (P<0.05).Twelve patients had external-beam radiotherapy, seven brachytherapy, and eight chemotherapy. There was no significant benefit in terms of survival (P = 0.46) or hospital admissions.CONCLUSION: Resection increases survival but carries the risk of significant morbidity and mortality.Percutaneous biliary drainage is almost always necessary and endoscopic drainage should be avoided if possible. | SD Mansfield O Barakat RM Charnley BC Jaques CB O'Suilleabhain PJ Atherton D Manas | 2005 | World Journal of Gastroenterology2005，11，48： | 37 |
| 2 | 南海北部ODP1144站颜色反射率揭示的千年尺度气候波动显示文摘南海大洋钻探ODP1144站钻孔长517m,代表近100万年来的沉积记录,其颜色反射率是所有岩心物理性质测试中分辨率最高的,平均约60年一个测值,最高可达年级尺度,是研究千年尺度气候变化的理想材料。通过对颜色反射率、浮游有孔虫氧同位素的小波分析及其与地球轨道参数ETP的交叉频谱分析,表明两者在轨道周期上的变化极为相似,都反映出约70万年以来100ka的偏心率周期明显占优;与格棱兰冰心的对比亦揭示了颜色反射率同样记录了冰期中的类似D/O事件。对此站的颜色反射率短周期的小波分析,揭示出了约3ka、约1 5ka的变化周期,这些周期不仅仅出现在冰期(如MIS2—4、6、8期等),也出现在间冰期(如MIS15、17、19、25期等)和冰消期(如MIS11/12、15/16),且在70万年以来冰期信号强、间冰期信号弱,而在70万年之前正好相反,这不仅说明间冰期内部气候也存在不稳定性,而且进一步说明了中更新世的气候转型事件。 | 黄维 翦知湣 CBühring | 2003 | 海洋地质与第四纪地质2003，23，3： | 23 |
| 3 | 接受治疗的老年高血压患者的血压、抗高血压药物应用、衰弱指标与严重摔伤风险的关系显示文摘一些研究表明,降压药物、低收缩压和舒张压与跌倒风险增加相关。许多老年人表现出衰弱的指征,这可能会增加跌倒的风险。该研究纳入脑卒中地区和种族差异原因(the reasons for geographic and racial differences in stroke,REGARDS)研究中年龄≥65岁的受试者5236例,探索收缩压、舒张压、抗高血压药物类别数量以及衰弱指标与严重跌倒损伤风险的关系, | 刘莉 叶鹏 Bromfield SG Ngameni CA Colantonio LD Bowling CB Shimbo D Reynolds K Safford MM Banach M Toth PP Muntner P | 2017 | 中华高血压杂志2017，25，8： | 19 |
| 4 | Apoptosis in the pathogenesis and treatment of disease显示文摘 | Thompson CB | | 0，，： | 11 |
| 5 | Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai.显示文摘 | Zhang ZX Roman GC Hong Z Wu CB Qu QM Huang JB Zhou B Geng ZP Wu JX Wen HB Zhao H Zahner GE | 2006 | 中国生物学文摘2006，20，8： | 9 |
| 6 | SYNTHESIS OF TETRAMETHYL SALVIANOLIC ACID F AND TRIMETHYL PRZEWALSKINIC ACID A显示文摘SYNTHESISOFTETRAMETHYLSALVIANOLICACIDFANDTRIMETHYLPRZEWALSKINICACIDA￥ChunBoAIandLianNiangLi(InstituteofMateriaMedicaChineseAc... | Al, CB Li, LN | 1996 | Chinese Chemical Letters1996，7，5： | 9 |
| 7 | Cytomegalovirus frequency in neonatal intrahepatic cholestasis determined by serology, histology, immunohistochemistry and PCR显示文摘AIM: To determine cytomegalovirus (CMV) frequency in neonatal intrahepatic cholestasis by serology, histological revision (searching for cytomegalic cells), immunohistochemistry, and polymerase chain reaction (PCR), and to verify the relationships among these methods.METHODS: The study comprised 101 non-consecutive infants submitted for hepatic biopsy between March 1982 and December 2005. Serological results were obtained from the patient's f iles and the other methods were performed on paraffin-embedded liver samples from hepatic biopsies. The following statistical measures were calculated: frequency, sensibility, specif ic positive predictive value, negative predictive value, and accuracy.RESULTS: The frequencies of positive results were as follows: serology, 7/64 (11%); histological revision, 0/84; immunohistochemistry, 1/44 (2%), and PCR, 6/77 (8%). Only one patient had positive immunohistochemical fi ndings and a positive PCR. The following statistical measures were calculated between PCR and serology: sensitivity, 33.3%; specificity, 88.89%; positive predictive value, 28.57%; negative predictive value, 90.91%; and accuracy, 82.35%. CONCLUSION: The frequency of positive CMV varied among the tests. Serology presented the highest positive frequency. When compared to PCR, the sensitivity and positive predictive value of serology were low. | Maria Angela Bellomo-Brandao Paula D Andrade Sandra CB Costa Cecilia AF Escanhoela Jose Vassallo Gilda Porta Adriana MA De Tommaso Gabriel Hessel | 2009 | World Journal of Gastroenterology2009，15，27： | 8 |
| 8 | 端粒酶和癌症治疗显示文摘端粒酶是一个有吸引力的癌症靶标,它是所有癌症亚类细胞,包括癌干细胞,永生化所必需的成分。而且,在正常和肿瘤组织之间,端粒酶表达、端粒长度和细胞动力学存在明显的差异,提示靶向端粒酶可能相当安全。GRN163L,一种强而特异的端粒酶抑制剂,正与几种端粒酶治疗疫苗一起进行临床试验。基于端粒酶的新癌症候选药虽充满希望,但该治疗方法的局限性、优点以及哪种患者更适合等问题尚待探讨。 | 魏霞 黄世杰 Harley CB | 2008 | 国际药学研究杂志2008，35，5： | 7 |
| 9 | Generalized potential of adult neural stem cells显示文摘 | Clarke DL Johansson CB Wilbertz J | | 0，，： | 4 |
| 10 | 婴幼儿血管瘤的治疗与管理显示文摘婴幼儿血管瘤(IH)也称为婴幼儿毛细血管瘤、草莓状血管瘤或草莓痣,是儿童中常见的非恶性血管瘤。自然疾病过程通常包括长达1年的生长期,然后在几年内不经治疗而退化,不或少遗留美容或功能性后遗症。 | Satterfield KR Chambers CB 赵泽亮 | 2019 | 中国口腔颌面外科杂志2019，17，2： | 4 |
| 11 | DNA methylation, heterochromatin and epigenetic carcinogens显示文摘 | Klein CB Costa M | 1997 | Mutat Res1997，386，2： | 4 |
| 12 | 改善不安腿综合征的效果显示文摘不安腿综合征(RLS)是以不可控的双腿运动,常伴有蛇爬感、烧灼痛、抽搐、疼痛或坐卧不安等腿部不适感为特征的神经性失调。通常发生在患者不运动或坐着、躺下休息时,在伸展双腿或行走后症状减轻。该病在疾病发生和病情上变化多样,但有一个规律,85%~90%的患者在睡眠期间也出现周期性的肢体运动。该综合征可引起不适、疼痛、失眠、忧郁、白天困倦和过度疲劳感,诸多的痛苦严重影响了生活质量。该病临床比较常见,据估计在美国有5%~15%的人患病,但一直未被重视。 | Slack CB 房颖(摘) 潘洪涛(摘) 李海梅(校) 王鸿(校) | 2008 | 国际护理学杂志2008，27，6： | 3 |
| 13 | APOPTOSIS IN THE PATHOGENESIS AND TREATMENT OF DISEASE [Review]显示文摘 | Thompson CB | | 0，，： | 3 |
| 14 | Conserved seed pairing,often flanked by adenosines,indicates that thousands of human genes are microRNA targets显示文摘 | Lewis BP Burge CB Bartel DP | | Cell0，，： | 3 |
| 15 | Endoscopic management of polypoid early colon cancer显示文摘 | Williams CB Saunders BP Tallot IC | | World Journal of Surgery0，，： | 3 |
| 16 | Benificial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease显示文摘 | Treasure CB Klein JL | 1995 | N Engl J Med1995，332，8： | 2 |
| 17 | Apixaban versus warfarin in patients with atrial fibrillation显示文摘 | Granger CB Alexander JH McMurray JJ | | New England Journal of Medicine0，，： | 2 |
| 18 | Induction of wild-type p53,bax,and acidic endonuclease during somatostatin-signaled apoptosis in MCF-7 human breast cancer cells显示文摘 | Sharma K Srikant CB | 1998 | Iht J Cancer1998，76，： | 2 |
| 19 | Effects of transient cerebral ischmia on glial fibrillary acidic protein phosphorylation and immunocontent in rat hippocampus显示文摘 | Valentim LM Michalowski CB Gottardo SP | 1999 | Neurosci1999，91，： | 2 |
| 20 | Development of an asthma vaccine:research into BCG显示文摘 | Scanga CB Le Gros G | | 0，，： | 2 |
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