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| 1 | High rate of Helicobacter pylori reinfection in Lithuanianpeptic ulcer patients显示文摘AIM: To evaluate the frequency of Helicobacter pylori(H. pylori) reinfection in peptic ulcer patients during 9 years after H. pylori eradication.METHODS: We invited 117 peptic ulcer patients in whom eradication of H. pylori was confirmed 1 year after eradication treatment both by histology and by rapid urease test. In total, 57 patients were available for the study procedures: 34(59.6%) male, 23(40.4%) female; mean age 52.3 ± 13.0 years. There were 45(78.9%) patients with duodenal ulcer and 12(21.1%) with gastric ulcer. H. pylori was diagnosed by a rapid urease test and histology if endoscopy was performed. If endoscopy was refused, H. pylori was diagnosed by the C14-urea breath test and serology. H. pylori was established if at least one of the tests was positive.RESULTS: The mean follow-up was 8.9 ± 1.0 years(range, 6-12). H. pylori was established in 15 patients. In 2 H. pylori-negative patients, H. pylori was established during the follow-up period and eradicated. Therefore, we consider that reinfection occurred in 17 patients. In the per protocol analysis, reinfection was established in 17 of 57(29.8%; 95%CI: 19.2-42.2) patients during the follow-up period. The annual rate of infection was 3.36%. If all non-responders were considered H. pylori-negative, reinfection would be 14.5%(17/117), the annual ratebeing 1.63%. The mean age of patients with reinfection was 51.8 ± 14.0 years, and without reinfection was 52.5 ± 13.0 years, P > 0.05; the mean body mass index of patients with reinfection was 27.2 ± 4.1 kg/m2, and without reinfection was 25.7 ± 4.2 kg/m2, P > 0.05. There were no differences in the reinfection rates according the location of the peptic ulcer, the eradication regimen used, and smoking status.CONCLUSION: The reinfection rate of H. pylori is relatively high in Lithuania and probably related to the high prevalence of H. pylori, what may reflect differences in the socioeconomic status between Western and Eastern European countries. | laimas jonaitis gediminas kiudelis paulius slepavicius limas kupcinskas | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 7 |
| 2 | Plexiform angiomyxoid myofibroblastic tumor of stomach:A rare case显示文摘Plexiform angiomyxoid myofibroblastic tumor(PAMT) is a rare benign mesenchymal tumor of stomach. Rarity of this kind of tumors and scarce review articles may cause underrecognition of this entity and pose a real diagnostic challenge to gastroenterologists, pathologists and surgeons when encountering such patients and differentiating PAMT from other gastric intramural tumors. We report a case of 28-year-old woman, who presented with epigastric pain after meals, iron-deficiency anaemia and weight loss. Upper gastrointestinal endoscopy revealed submucosal tumorlike elevated lesion in the anterior wall of the antrum with intact overlying mucosa. Endoscopic ultrasound showed a 3-cm hypoechoic homogenous mass, originating from the third layer of the gastric wall. Endoscopic ultrasound-guided fine needle aspiration was not informative. Endoscopic buttonhole biopsy was performed to obtain specimens. Following this, the unexpected prolapse of the tumor occurred into the lumen of the stomach, causing gastric outlet obstruction- the biopsy was obtained. Pathomorphological features suggested the diagnosis of PAMT. Gastric resection of the Billroth I type was performed. Diagnosis was confirmed by histological analysis of the surgical specimen. | Laimas Jonaitis Mindaugas Kiudelis Paulius Slepavicius Lina Poskiene Limas Kupcinskas | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，18： | 2 |
| 3 | X-linked juvenile retinoschisis: phenotypic and genetic characterization显示文摘Juvenile X-linked retinoschisis(XLRS, MIM#312700) belongs to a group of the vitreoretinal dystrophies. We aimed to describe the phenotype-genotype correlation of three XLRS cases in juveniles with different novel mutations from the Lithuanian population. The patients demonstrated macular retinoschisis and typical cyst-like cavities on spectral-domain optical coherence tomography(SD-OCT) images. The mean central foveal thickness was 569.7 μm. Two patients presented with peripheral retinoschisis. Flash electroretinogram demonstrated a reduced b/a ratio(<1.0) in all patients. RS1(NM_000330.3) gene coding exons Sanger sequencing was performed. RS1 c.599 G>T(p.R200 L) mutation was detected in one case, showing to be pathogenic in silico analysis. c.(92_97) ins C(p.W33 fs) mutation was identified for another patient, indicating the variant is possibly damaging in silico analysis. The third case was identified with a pathogenic mutation c.422 C>G(p.R141 H), HGMD CM981753. These are the first cases of XLRS in the Lithuanian population confirmed by molecular genotyping. Presented patients had a different genotype but similar phenotypic traits. | Rasa Strupaite Laima Ambrozaityte Loreta Cimbalistiene Rimvydas Asoklis Algirdas Utkus | 2018 | International Journal of Ophthalmology(English edition)2018，11，11： | 2 |
| 4 | Polymorphisms of micro RNA target genes IL12B, INSR, CCND1 and IL10 in gastric cancer显示文摘AIM To evaluate associations between mi RNA target genes IL12B,INSR,CCND1 and IL10 polymorphisms and gastric cancer(GC)in European population.METHODS Gene polymorphisms were analyzed in 508 controls and474 GC patients from 3 tertiary centers in Germany,Lithuania and Latvia.Controls were patients from the out-patient departments,who were referred for upper endoscopy because of dyspeptic symptoms and had no history of previous malignancy.Gastric cancer(GC)patients had histopathological verification of gastric adenocarcinoma.Genomic DNA was extracted using salting out method from peripheral blood mononuclear cells.IL12B T>G(rs1368439),INSR T>C(rs1051690),CCND1 A>C(rs7177)and IL10 T>C(rs3024498)SNPs were genotyped by the real-time polymerase chain reaction.Associations between gene polymorphism and GC were evaluated using multiple logistic regression analysis with adjustment for sex,age and country of birth.RESULTS We observed similar distribution of genotypes and allelic frequencies of all polymorphisms between GC patients and controls except of INSR rs1051690.The frequency of the T allele of INSR gene was significantly higher in GC patients than in controls(23.26%and 19.19%respectively,P=0.028).CT genotype was also more prevalent in patients compared to control group(38.48%and 30.12%respectively,P<0.021).Logistic regression analysis revealed that only one polymorphism(rs1051690 in INSR gene)was associated with increased risk of GC.Carriers of CT genotype had higher odds of GC when compared to CC genotype(OR=1.45,95%PI:1.08-1.95,P=0.01).Similar association was observed in a dominant model for INSR gene,where comparison of TT+CT vs CC genotypes showed an increased risk of GC(OR=1.44,95%PI:1.08-1.90,P=0.01).Other analyzed SNPs were not associated with the presence of GC.CONCLUSION INSR rs1051690 SNP is associated with increased risk of GC,while polymorphisms in IL12B,CCND1 and IL10genes are not linked with the presence of GC. | Vytenis Petkevicius Violeta Salteniene Simonas Juzenas Thomas Wex Alexander Link Marcis Leja Ruta Steponaitiene Jurgita Skieceviciene Limas Kupcinskas Laimas Jonaitis Gediminas Kiudelis Peter Malfertheiner Juozas Kupcinskas | 2017 | World Journal of Gastroenterology2017，23，19： | 2 |
| 5 | Supermodulus effect by grain-boundary wetting in nanostructured multilayers显示文摘The effect of thermal treatments on mechanical properties was systematically investigated in Ni/Mo multilayers with a constant modulation period(160 nm)prepared by magnetron sputtering deposition.A supermodulus effect was found in the annealed multilayers as compared to the as-deposited state.A large tensile stress development was observed in the multilayers.The evolution of grain-boundary(GB)wetting was observed at the interfaces of the multilayers,which results in an enhanced modulus based on the mechanism of GB-wetting-induced interfacial stress/strain.The GB wetting phenomenon was further supported by a thermodynamic calculation.The results not only bring clear evidence of the important role of interfacial structures in governing the elastic behavior of metallic multilayers,but also allow designing the multilayers with special properties through atomic diffusion and wetting at the interfaces based on the thermodynamic calculation. | Jing Wang Lu Han Xiaohu Li Dongguang Liu Laima Luo Yuan Huang Yongchang Liu Zumin Wang | 2021 | Journal of Materials Science & Technology2021，，6： | 1 |
| 6 | The influence of long emersion on biota,ammonium fluxes and nitrification in intertidal sediments of Marennes-Ol Ron Bay,France显示文摘 | LAIMA M BROSSARD D SAURIAU P G | 2002 | Marine Environmental Research2002，53，4： | 1 |
| 7 | Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: a combined haplotype analysis显示文摘 | Limas Kupcinskas Thomas Wex Juozas Kupcinskas Marcis Leja Audrius Ivanauskas Laimas Virgilijus Jonaitis Dainius Janciauskas Gediminas Kiudelis Konrads Funka Agnese Sudraba Han-Mo Chiu Jaw-Town Lin Peter Malfertheiner | 2010 | European Journal of Gastroenterology & Hepatology2010，，10： | 1 |
| 8 | Preparation and characterization of Ni-coated Cr3C2 powder by room temperature ultrasonic-assisted electroless plating显示文摘 | Luo Laima Yu Jia Luo Juan | | 0，，06： | 1 |
| 9 | Evolution of H elicobacter pylori susceptibility to antibiotics during a 10‐year period in L ithuania显示文摘 | Limas Kupcinskas Lone Rasmussen Laimas Jonaitis Gediminas Kiudelis Marianne J?rgensen Neringa Urbonaviciene Vytas Tamosiunas Juozas Kupcinskas Jolanta Miciuleviciene Edmundas Kadusevicius Douglas Berg Leif P. Andersen | 2012 | APMIS2012，，5： | 1 |
| 10 | Preparation and characterization of Ni-coated Cr 3 C 2 powder by room temperature ultrasonic-assisted electroless plating显示文摘 | Laima Luo Jia Yu Juan Luo Jian Li | 2010 | Ceramics International2010，，6： | 1 |
| 11 | Investigation and control of vortex-induced vibration of twin box girders显示文摘 | Shujin Laima Hui Li Wenli Chen Fengchen Li | 2013 | Journal of Fluids and Structures2013，，： | 1 |
| 12 | Plasminogen activator inhibitor-1 activity in type 2 diabtetes: a different relationship with coronary heart disease and diabetic retinopathy显示文摘 | Laima B Kevin R Alicia J | 2008 | Arterioscler Thromb Vasc Biol2008，28，4： | 1 |
| 13 | 显示文摘 | Luo Laima Liu Shaoguang Yu jia | 2010 | Real MetalMaterials and Engineering2010，39，2： | 1 |
| 14 | Intake patterns of food nutrients and other substances associated with chronic pancreatitis显示文摘 | Richard C. Turner Laima B. Brazionis Robyn McDermott | 2013 | Pancreatology2013，，1： | 1 |
| 15 | Investigation of vortex-induced vibration of a suspension bridge with two separated steel box girders based on field measurements 显示文摘 | Li Hui Shujin Laima Ou Jin-ping | 2011 | Engineering Structures2011，，33： | 1 |
| 16 | Smooth muscle cells of the media in the dilatative pathology of ascending thoracic aorta: Morphology, immunoreactivity for osteopontin, matrix metalloproteinases, and their inhibitors显示文摘 | Vaiva Lesauskaite Piero Tanganelli Carlo Sassi Eugenio Neri Francesco Diciolla Laima Ivanoviene Maria Carmela Epistolato Anna Vittoria Lalinga Carlo Alessandrini Donatella Spina | 2001 | Human Pathology2001，，9： | 1 |
| 17 | Investigation and control of vortex-induced vibration of twin box girders 显示文摘 | Laima Shujin Li hui Chen Wen-li | 2013 | Journal of Fluids and Structures2013，39，： | 1 |
| 18 | Preparation and characterization of Ni-coated Cr 3 C 2 powder by room temperature ultrasonic-assisted electroless plating显示文摘 | Laima Luo Jia Yu Juan Luo Jian Li | 2010 | Ceramics International2010，，6： | 1 |
| 19 | Interfem α-2bin combination with ribavirin for the treatment of chonic hepatitis C:assessment of virological,biochemical and histological treatment response显示文摘 | Vitalija Petrenkiene Inga Gudinaviciene Laimas Jonaitis | 2004 | Medicina (Kaunas)2004，40，6： | 1 |
| 20 | Investigation of vortex-induced vibration of a suspension bridge with two separated steel box girders based on field measurements显示文摘 | Hui Li Shujin Laima Jinping Ou Xuefeng Zhao Wensong Zhou Yan Yu Na Li Zhiqiang Liu | 2011 | Engineering Structures2011，，6： | 1 |
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