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| 1 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 2 | Deposition and erosion in the fluctuating backwater reach of the Three Gorges Project after upstream reservoir adjustment显示文摘The construction of hydropower projects,such as Xiluodu and Xiangjiaba Reservoirs,in the upper Yangtze River will lead to variations of the incoming water and sediment conditions and in turn changes in the deposition and erosion processes in the fluctuating backwater reach of the Three Gorges Project(TGP).In this paper,based on the water and sediment characteristics,a 2D mathematical model in the boundary-fitting orthogonal curvilinear coordinate system has been employed to predict the space-time changes of sedimentation in the Chongqing reach,part of the fluctuating backwater reach of TGP,in a period of 100 years with repetition of the 1961-1970 hydrological series with and without the construction of upstream reservoirs.The results show that in the case of natural hydrological series(NHS) without upstream reservoirs,severe deposition occurs in bays with concave bank lines,recirculation flow areas and wide-shallow reaches.In the case with the adjustment of upstream reservoirs,only a little deposition exists in bays with concave bank lines,and the amounts of deposition in the Yangtze River and Jialing River reaches are about 10-20% of those in the case of NHS.Therefore,this is helpful to maintain the effective capacity of the TGP Reservoir and utilize the bank lines of the Chongqing reach. | Yongjun LU Liqin ZUO Rongyao JI Huaixiang LIU | 2010 | International Journal of Sediment Research2010，25，1： | 13 |
| 3 | 新疆东天山觉罗塔格地区自然铜矿化玄武岩的成岩年代及其地质意义显示文摘新疆觉罗塔格地区自然铜矿化玄武岩沿着阿齐库都克深大断裂北侧分布,前人对其成岩年代一直存在争议。本文测得玄武岩条带中部的黑尖山玄武岩同岩浆期锆石SHRIMPU-Pb年龄为306.2±4.0Ma;测得东部东尖峰玄武岩的同岩浆期锆石LA-ICPMSU-Pb年龄为308.9±5.8Ma,确定了玄武岩是晚石炭世的岩浆作用,且归属于晚石炭世马头滩组。与觉罗塔格地区著名的晚石炭世-早二叠世铜镍矿化基性-超基性岩成因对比表明,该晚石炭世玄武岩与之具有共同岩浆源区特征,它们都是觉罗塔格地区晚石炭世-早二叠世岩石圈地幔深部受热熔融而形成岩浆作用。马头滩组玄武岩层是自然铜矿化的重要矿源层。 | 张达玉 周涛发 袁峰 刘帅 LU YongJun 许超 宁福泉 | 2012 | 岩石学报2012，28，8： | 12 |
| 4 | A Fast Aerial Image Matching Method Using Airborne LiDAR Point Cloud and POS Data显示文摘A novel tie point matching algorithm of aerial images with the assistance of airborne LiDAR point clouds and POS data is proposed Firstly,the conjugate point searching strategy used in traditional correlation coefficient matching is improved and a fast algorithm is presented.Secondly,an automatic camera boresight misalignment calibration method based on virtual ground control points is proposed,and then the searching range of image matching is adaptively determined and applied to the image matching of the entire surveying area.Test results verified that the fast correlation coefficient matching algorithm proposed in this paper can reduce approximately 25% of the matching time without the loss of matching accuracy.The camera boresight misalignment calibration method can effectively increase the accuracy of exterior orientation elements of images calculated from POS data,and thus can significantly improve the predicted position of conjugate point for tie point matching.Our proposed image matching algorithm can achieve superior matching accuracy with multi-scale,multi-view,and cross-flight aerial images. | Yongjun ZHANG Xiaodong XIONG Mengqiu WANG Yihui LU | 2019 | Journal of Geodesy and Geoinformation Science2019，2，1： | 10 |
| 5 | Adaptive multiple subtraction using a constrained L1-norm method with lateral continuity显示文摘一次波L1范数最小化的多次波自适应相减方法,简称L1方法,是基于匹配滤波器设计的多次波自适应相减算法中的一种常用方法。当一次波和多次波混杂在一起时,L1方法有时会伤害一次波,导致一次波同相轴的连续性变差。本文利用预测误差滤波器度量一次波同相轴的连续性,在L1方法的基础上,提出一种能够在压制多次波的同时,尽量保持一次波同相轴连续性的多次波自适应相减算法,简称连续性约束L1方法。利用Pluto模型数据进行多次波相减的结果表明,连续性约束L1方法能够在有效压制多次波的同时,更好地保护一次波。 | Pang Tinghua Lu Wenkai Ma Yongjun | 2009 | Applied Geophysics2009，6，3： | 9 |
| 6 | Guandishan Granitoids of the Paleoproterozoic Lüliang Metamorphic Complex in the Trans-North China Orogen:SHRIMP Zircon Ages,Petrogenesis and Tectonic Implications显示文摘The Paleoproterozoic L(u|¨)liang Metamorphic Complex(PLMC) is situated in the middle segment of the western margin of the Trans-North China Orogen(TNCO),North China Craton(NCC). As the most important lithological assemblages in the southern part of the PLMC,Guandishan granitoids consist of early gneissic tonalities,granodiorites and gneissic monzogranites,and younger gneissic to massive monzogranites.Petrochemical features reveal that the early gneissic tonalities and granodiorites belong to the medium-K calc-alkaline series;the early gneissic monzogranites are transitional from high-K calc-alkaline to the shoshonite series;the younger gneissic to massive monzogranites belong to the high-k calc-alkaline series,and all rocks are characterized by rightdeclined REE patterns and negative Nb,Ta,Sr,P,and Ti anomalies in the primitive mantle normalized spidergrams.SHRIMP zircon U-Pb isotopic dating reveals that the early gneissic tonalities and granodiorites formed at~2.17 Ga,the early gneissic monzogranites at~2.06 Ga,and the younger gneissic to massive monzogranites at~1.84 Ga.Sm-Nd isotopic data show that the early gneissic tonalities and granodiorites haveε_(Nd)(t) values of +0.48 to -3.19 with Nd-depleted mantle model ages (T_(DM)) of 2.76-2.47 Ga,and early gneissic monzogranites haveε_(Nd)(t) values of-0.53 to -2.51 with F_(DM)of 2.61-2.43 Ga,and the younger gneissic monzogranites haveε_(Nd)(t) values of -6.41 to -2.78 with a T_(DM)of 2.69-2.52 Ga.These geochemical and isotopic data indicate that the early gneissic tonalities, granodiorites,and monzogranites were derived from the partial melting of metamorphosed basaltic and pelitic rocks,respectively,in a continental arc setting.The younger gneissic to massive monzogranites were derived by partial melting of metamorphosed greywackes within the continental crust.Combined with previously regional data,we suggest that the Paleoproterozoic granitoid magmatism in the Guandishan granitoids of the PLMC may provide the best geological signature for the complete spectrum of Paleoproterozoic geodynamic processes in the Trans-North China Orogen from oceanic subduction,through collisional orogenesis,to post-orogenic extension and uplift. | LIU Shuwen LI Qiugen LIU Chaohui LU Yongjun ZHANG Fan | 2009 | Acta Geologica Sinica(English Edition)2009，83，3： | 9 |
| 7 | Polygenetic Mineralization of the Early ProterozoicTongkuangyu Metaporphyry Copper Deposit inthe Zhongtiao Mountains,Shanxi Province显示文摘The Tongkuangyu metaporphyry copper deposit formed in the Early Proterozoic is tectonically located in the northern part of the Zhongtiao X -type palaeorift depression, on the southern margin of the North China platform. The genesis of the deposit has long been a hot subject of research of geologists working on mineral deposits. By means of the protolith reconstruction and fluid inclusion and isotope studies of host rocks of the deposits, the authors hold that this deposit is the product of combined exogenic, endogenic and metamorphic processes. Its formation mainly involved the following four stages: (1) the stage of formation of Mg- and Fe-rich tuffaceous variegated cupriferous sand-shale and K-rich biomodal volcanic rocks; (2) the early stage of formation of the metaporphyry copper deposit; (3) the stage of formation of the metaporphyry copper deposit; and (4) the stage of reworking of the metaporphyry copper deposit. | CHEN Wenming ZHANG Chengxin LU Jiren DANG Zefa LI Shuping CUI Wenbin NING Yuan | 1998 | Acta Geologica Sinica(English Edition)1998，72，2： | 7 |
| 8 | Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy显示文摘Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE-1) are also overexpressing in the reticuloendothelial system(RES). Therefore,polyethylene glycol(PEG) modification of HA-based DDS is necessary to reduce RES capture.Unfortunately, pegylation remarkably inhibits tumor cellular uptake and endosomal escapement,significantly compromising the in vivo antitumor efficacy. Herein, we developed a Dox-loaded HA-based transformable supramolecular nanoplatform(Dox/HCVBP) to overcome this dilemma. Dox/HCVBP contains a tumor extracellular acidity-sensitive detachable PEG shell achieved by a benzoic imine linkage.The in vitro and in vivo investigations further demonstrated that Dox/HCVBP could be in a 'stealth' state at blood stream for a long circulation time due to the buried HA ligands and the minimized nonspecific interaction by PEG shell. However, it could transform into a 'recognition' state under the tumor acidic microenvironment for efficient tumor cellular uptake due to the direct exposure of active targeting ligand HA following PEG shell detachment. Such a transformative concept provides a promising strategy to resolve the dilemma of natural ligand-based DDS with conflicting two processes of tumor cellular uptake and in vivo nonspecific biodistribution. | Lu Zhong Lu Xu Yanying Liu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Yongjun Wang Jin Sun Zhonggui He | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 9 | Morphological responses in a meandering and island-braided reach of the Middle Yangtze River to the Three Gorges Reservoir impoundment显示文摘Literal migration is an important form of morphological changes on the Middle Yangtze River(MYR),particularly for the lower Jingjiang reach.The Three Gorges Reservoir(TGR) has substantially reduced sediment supply to the downstream river channels since its impoundment in June 2003.The scientific understanding of how decrease of sediment influences the processes of bank erosion and channel adjustments is complex and limited.In the present paper,the morphological responses in a typical meandering and island-braided river segment of the MYR to the filling of the TGR were investigated by a3-D morphodynamic model.The potential of the 3-D model has been demonstrated by the observed data.The morphological evolutions in the Shishou bend during the first 12 years of the TGR impoundment were predicted.The effects of the TGR operation on the planform evolutions in the study reach were analyzed based on the simulated results.Sediment load is decreased by 75%due to the early filling of the TGR.The magnitude of bed degradation with less sediment load due to the TGR operation is increased compared with the pre-dam situation.Qualitatively,the overall planform evolution trends in the Shishou bend after the TGR operation are similar to that without the TGR operation.The magnitude of lateral migration has been increased in some part of the channel bend,where the morphological response of the TGR operation exhibits more lateral migration rather than vertical degradation.Scouring at the bank toe enhances bank failure.Decrease of sediment load and weak bank anti-scour ability as well as the significant helical flow can be responsible for intensified bank erosion in the channel bend. | Dongdong Jia Xuejun Shao Xingnong Zhang Yongjun Lu Pengfei Hei | 2016 | International Journal of Sediment Research2016，31，2： | 6 |
| 10 | Cobalt phthalocyanine-graphene complex for electro-catalytic oxidation of dopamine显示文摘Cobalt phthalocyanine-graphene(CoPc-Gr) complex are fabricated through π-π interaction of each components,with CoPc adsorbed/inserted on/in the graphene sheets.The obtained complex could be used in the electro-chemical detection of various medicines.CoPc-Gr modified glassy electrode shows excellent response to the electro-oxidation of dopamine(DA) and ascorbic acid(AA),much better than those of CoPc,graphene oxide(GrO) or graphene(Gr) modified electrode.Significantly,the detection of dopamine is a diffusion-controlled process,highly selective,and has a low detection limit and broad linear range. | Jinghe Yang Di Mu Yongjun Gao Juan Tan Anhui Lu Ding Ma | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 6 |
| 11 | Advances in sediment transport under combined action of waves and currents显示文摘沿海的地区连续地由于自然过程和人的活动变化。以便理解并且预言这些词法变化,对沉积运输的精确描述,由波浪和水流引起了(潮汐或导致波浪) ,是重要的。这份报纸在这域里论述最先进的知识的评论,包括沉积早期的运动,床表格,床粗糙,水流带来的碎石运输,推迟负担的运输,平衡沉积集中,和表流动。为未来学习的一些可能的研究领域和话题也被建议。 | Yongjun Lu Shouqian Li Liqin Zuo Huaixiang Liu J.A. Roelvink | 2015 | International Journal of Sediment Research2015，30，4： | 6 |
| 12 | Thrombolysis with alteplase 3-4.5 hours after acute ischaemic stroke:the first multicentre,phase III trial in China显示文摘background and purpose Data on the efficacy and safety of alteplase for acute ischaemic stroke(AIS)administered 3-4.5 hours after the onset of stroke symptoms in Chinese patients is limited.We sought to determine whether AIS patients would benefit from thrombolysis with alteplase between 3 and 4.5 hours after the onset of stroke symptoms in a prospective,multicentre,single-arm trial in China.Materials and methods Eligible AIS patients were given 0.9 mg/kg alteplase intravenously.The primary efficacy endpoint was a favourable outcome at 3 months,defined as a score of 0 or 1 on the modified Rankin Scale.Thresholds for the primary efficacy endpoint were determined to be 40%based on the literature review.The primary safety endpoint was symptomatic intracranial haemorrhage(sICH)according to the European Cooperative Acute Stroke Study III(ECASS III)trial definition.Post hoc analysis between this study and the ECASS III trial were compared using the propensity score matching(PSM)method.results A total of 120 eligible AIS patients from 11 sites in China received thrombolysis therapy in this study.The median time from onset of symptoms to needle was 3 hours 54 min.The percentage of patients with a favourable outcome was 63.3%(95%CI 54.4 to 71.4),significantly higher than the predefined threshold(p<0.0001).Three patients(2.5%,95%CI 0.5 to 7.1)had sICH,including two fatal sICH.Six patients died within 3 months after treatment.The post hoc PSM analysis showed a numerically higher rate of the primary efficacy endpoint in this study(63.3%)than the matched placebo arm(56.7%)in the ECASS III trial.Conclusions Intravenous alteplase with a standard dose administered between 3 and 4.5 hours after onset of symptoms is effective and safe for Chinese AIS patients. | Huaguang Zheng Yi Yang Huisheng Chen Chuanling Li Yangkun Chen Fu-Dong Shi Li Yang Xiaoping Cui Zuneng Lu Yanling Liang Songbiao Cui Anding Xu Yiqing Wu Yaqing Sun Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，3： | 4 |
| 13 | Efficacy of water fraction from Dioscorea cirrhosa on oxidative stress and apoptosis in H9c2 cardiomyocytes induced by H2O2显示文摘OBJECTIVE:To investigate the efficacy of water fraction from Dioscorea cirrhosa(WF)on oxidative damage and apoptosis of cardiomyocytes induced by H2O2,and to study its mechanism.METHODS:Cell viability was measured by the MST assay kit.The content of malondialdehyde(MDA),release of lactate dehydrogenase(LDH)and activity of catalase(CAT)and superoxide dismutase(SOD)were detected by biochemical kit.The content of reactive oxygen species(ROS)was assessed by nonfluorescent probe 2′,7′-dichlorofluorescin diacetate(DCFH-DA).JC-1 was used to analyze the mitochondrial membrane potential(mtΔΨ)and Annexin-V-FITC/PI staining was applied to assess apoptosis of H9c2 by flow cytometry.Moreover,the expression of B-cell lymphoma-2(Bcl-2),Bcl-2-associated X(Bax),caspase-3,caspase-9,cleaved-caspase-3 and cleaved-caspase-9 proteins was determined by western blot analysis.RESULTS:WF increased cell viability and decreased LDH leakage in H9c2 cells exposed to H2O2.WF treatment decreased ROS and MDA level,enhanced SOD and CAT activities,improved mtΔΨand inhibited apoptosis.Western blot analysis demonstrated that the ratio of Bcl-2/Bax was increased and the expression cleaved-caspase-3,caspase-3,cleaved-caspase-9 and caspase-9 were decreased in group treated with WF.CONCLUSION:WF protects H9c2 myocardial cells on H2O2-induced oxidative stress and apoptosis by scavenging ROS,improving antioxidant capacity,protecting mitochondrial and regulating the proteins expression related to apoptosis. | LIU Chunhua PAN Jie WANG Aimin LAN Yanyu LI Yongjun LU Yuan SUN Jia WANG Yonglin LIU Ting LU Dingyan YOU Jingrui | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 4 |
| 14 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 15 | Research on modeling of heat source for electron beam welding fusion-solidification zone显示文摘In this paper, the common heat source model of point and linear heat source in the numerical simulation of electron beam welding (EBW) were summarized and introduced. The combined point-linear heat source model was brought forward and to simulate the welding temperature fields of EBW and predicting the weld shape. The model parameters were put forward and regulated in the combined model, which included the ratio of point heat source to linear heat source Qpr and the distribution of linear heat source Lr. Based on the combined model, the welding temperature fields of EBW were investigated. The results show that the predicted weld shapes are conformable to those of the actual, the temperature fields are reasonable and correct by simulating with combined point-linear heat source model and the typical weld shapes are gained. | Wang Yajun Fu Pengfei Guan Yongjun Lu Zhijun Wei Yintao | 2013 | Chinese Journal of Aeronautics2013，26，1： | 3 |
| 16 | Geochemical and microbial characters of sediment from the gas hydrate area in the Taixinan Basin, South China Sea显示文摘The Taixinan Basin is one of the most potential gas hydrate bearing areas in the South China Sea and abundant gas hydrates have been discovered during expedition in 2013. In this study, geochemical and microbial methods are combinedly used to characterize the sediments from a shallow piston Core DH_CL_11(gas hydrate free) and a gas hydrate-bearing drilling Core GMGS2-16 in this basin. Geochemical analyses indicate that anaerobic oxidation of methane(AOM) which is speculated to be linked to the ongoing gas hydrate dissociation is taking place in Core DH_CL_11 at deep. For Core GMGS2-16, AOM related to past episodes of methane seepage are suggested to dominate during its diagenetic process; while the relatively enriched δ18O bulk-sediment values indicate that methane involved in AOM might be released from the 'episodic dissociation' of gas hydrate.Microbial analyses indicate that the predominant phyla in the bacterial communities are Firmicutes and Proteobacteria(Gammaproteobacteria and Epsilonproteobacteria), while the dominant taxa in the archaeal communities are Marine_Benthic_Group_B(MBGB), Halobacteria, Thermoplasmata, Methanobacteria,Methanomicrobia, Group C3 and MCG. Under parallel experimental operations, comparable dominant members(Firmicutes and MBGB) are found in the piston Core DH_CL_11 and the near surface layer of the long drilling Core GMGS2-16. Moreover, these members have been found predominant in other known gas hydrate bearing cores, and the dominant of MBGB has even been found significantly related to gas hydrate occurrence. Therefore,a high possibility for the existing of gas hydrate underlying Core DH_CL_11 is inferred, which is consistent with the geochemical analyses. In all, combined geochemical and microbiological analyses are more informative in characterizing sediments from gas hydrate-associated areas in the South China Sea. | GONG Junli SUN Xiaoming LIN Zhiyong LU Hongfeng LU Yongjun | 2017 | Acta Oceanologica Sinica2017，36，9： | 3 |
| 17 | Inhibition of Axinl in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation显示文摘Axinl is a negative regulator of β-catenin signaling and its role in osteoblast precursor cells remains undefined.In the present studies,we determined changes in postnatal bone growth by deletion of Axinl in osteoblast precursor cells and analyzed bone growth in newborn and postnatal Axin1 O5X mice and found that hypertrophic cartilage area was largely expanded in AxinlOSX KO mice.A larger number of chondrocytes and unabsorbed cartilage matrix were found in the bone marrow cavity of Axin1OSX KO mice.Osteoclast formation in metaphyseal and subchondral bone areas was significantly decreased,demonstrated by decreased TRAPpositive cell numbers,associated with reduction of MMP9-and cathepsin K-positive cell numbers in Axin1 O5X KO mice.OPG expression and the ratio of O p g to Rankl were significantly increased in osteoblasts of Axinl O5X KO mice.Osteoclast formation in primary bone marrow derived microphage(BMM)cells was significantly decreased when BMM cells were cultured with conditioned media(CM)collected from osteoblasts derived from Axin1OSX mice compared with BMM cells cultured with CM derived from WT mice.Thus,the loss of Axinl in osteoblast precursor cells caused increased OPG and the decrease in osteoclast formation,leading to delayed bone growth in postnatal Axin1°sx KO mice. | Bing Shu Yongjian Zhao Shitian Zhao Haobo Pan Rong Xie Dan Yi Ke Lu Junjie Yang Chunchun Xue Jian Huang Jing Wang Dongfeng Zhao Guozhi Xiao Yongjun Wang Di Chen | 2020 | Bone Research2020，8，3： | 3 |
| 18 | Impact of COVID-2019 on stroke services in China: survey from the Chinese Stroke Association显示文摘Background The COVID-19 pandemic and physical distancing guidelines have compelled stroke practices worldwide to reshape their delivery of care significantly.We aimed to illustrate how the stroke services were interrupted during the pandemic in China.Methods A 61-item questionnaire designed on Wenjuanxing Form was completed by doctors or nurses who were involved in treating patients with stroke from 1 February to 31 March 2020.Results A total of 415 respondents completed the online survey after informed consent was obtained.Of the respondents,37.8%,35.2%and 27.0%were from mild,moderate and severe epidemic areas,respectively.Overall,the proportion of severe impact(reduction>50%)on the admission of transient ischaemic stroke,acute ischaemic stroke(AIS)and intracerebral haemorrhage(ICH)was 45.0%,32.0%and 27.5%,respectively.Those numbers were 36.9%,27.9%and 22.3%;36.5%,22.1%and 22.6%;and 66.4%,47.5%and 41.1%in mild,moderate and severe epidemic areas,respectively(all p<0.0001).For AIS,thrombolysis was moderate(20%-50%reduction)or severely impacted(>50%),as reported by 54.4%of the respondents,while thrombectomy was 39.3%.These were 44.4%,26.3%;44.2%,39.4%;and 78.2%,56.5%,in mild,moderate and severe epidemic areas,respectively(all p<0.0001).For patients with acute ICH,39.8%reported the impact was severe or moderate for those eligible for surgery who had surgery.Those numbers were 27.4%,39.0%and 58.1%in mild,moderate and severe epidemic areas,respectively.For staff resources,about 20%(overall)to 55%(severe epidemic)of the respondents reported moderate or severe impact on the on-duty doctors and nurses.Conclusion We found a significant reduction of admission for all types of patients with stroke during the pandemic.Patients were less likely to receive appropriate care,for example,thrombolysis/thrombectomy,after being admitted to the hospital.Stroke service in severe COVID-19 epidemic areas,for example,Wuhan,was much more severely impacted compared with other regions in China. | Xia Wang Menglu Ouyang Cheryl Carcel Chen Chen Lingli Sun Jie Yang Yao Zhang Guofang Chen Shoujiang You Yongjun Cao Lu Ma Xin Hu Yi Sui Craig Anderson Lili Song Yongjun Wang David Wang | 2020 | Stroke & Vascular Neurology2020，5，4： | 2 |
| 19 | Awareness intervention for Beijing neurologists regarding secondary prevention of cerebral infarction/transient ischemia Cross-sectional investigation显示文摘BACKGROUND: Stroke prevention guidelines should be made available to neurologists for clinical application to aid in uniformity, timing, preciseness, and acceptance of disease. OBJECTIVE: To investigate the awareness of neurologists in some Beijing hospitals of intervention in secondary prevention of cerebral infarction/transient ischemia. DESIGN: Cross-sectional study. SETTING: Beijing Tiantan Hospital, Beijing Anzhen Hospital, General Hospital of Beijing Military Area, Command of Chinese PLA, Beijing Chuiyangliu Hospital, Beijing 6th Hospital, Beijing Hepingli Hospital, and Beijing Daxing District Hospital. PARTICIPANTS: A total of 28 (associate) chief physicians, 58 attending physicians, and 54 resident physicians who engaged in clinical treatment of cerebrovascular diseases were selected from 8 hospitals in Beijing from March to April 2007. All physicians provided informed consent. METHODS: Self-made closed questionnaires were provided for data collection, consisting of 16 questions that were single choice or multiple choice. Specifically, questions 1-7 focused on awareness of blood pressure regulation in different patients and first choice of decompression drug; questions 8-12 focused on awareness of lipid regulation; and questions 13-16 focused on awareness of anti-blood platelet drugs applied in secondary prevention. The scores ranged from 0-100 points, and each question was worth 6.25 points. The scores positively correlated with the awareness rate. To test leveling real-time, the survey lasted for a maximum of 20 minutes. One questionnaire was independently finished by each subject in the survey. MAIN OUTCOME MEASURES: Awareness intervention among neurologists during secondary prevention of cerebral infarction/transient ischemia and questionnaire scores. RESULTS: 140 subjects were included in the final analysis. ① The awareness rate among neurologists for intervention during secondary prevention of cerebral infarction/transient ischemia ranged from 0.7-57.9%, the scores ranged between 0-56 points, and the mean score was 26 points. ② Scores of resident physicians were 0-56 points with a mean score of 26 points; attending physicians scored 6-50 points, with a mean score of 26 points; and chief physicians scored 6-50 points, with a mean score of 23 points. There were no significant differences among the various physicians (F = 0.771, t = 0.465, P > 0.05). CONCLUSION: Awareness among neurologists of intervention during secondary prevention of cerebral infarction/transient ischemia is not ideal. However, there was no significant difference between professional titles. | Ruihua Ma Chunxue Wang Xianwei Wang Yuhui Zhang Yongjun Wang Yilong Wang Xingquan Zhao Jingjing Li Ying Lu Mingjie Xu Zhuo Zhang Li Wang Weiwei Zhang Lang Lin Jiping Tan Yao Li Ming Wei Hongtao Li | 2008 | Neural Regeneration Research2008，3，3： | 2 |
| 20 | Impact of hydroelectric projects on river environment: Analysis of water quality changes in Ningxia Reach of Yellow River显示文摘In this paper, the relationship between hydroelectric projects and the river environment is analyzed. Recently, the large-scale regulation of runoff by large hydroelectric projects in the Ningxia Reach of the Yellow River has altered natural runoff processes, causing an increase in the probability of low discharge and an overall adjustment of riverbed evolution and river characteristics. During low-flow years, the combined effects of these two changes can weaken the self-purification capacity and reduce the water environmental capacity of the river. This is one of the main reasons for the recent decrease of water quality in the Ningxia Reach. This research shows that it is necessary to implement river training projects to maintain stable flow paths, not only for adjusting river regimes and for flood control, but also for increasing the self-purification capacity and the water environmental capacity of the river. Methods and proposals for coordinating the operation of hydroelectric projects with the protection of the river environment are presented in the interest of promoting sustainable development. | Sun Dongpo Lu Ruili Song Yongjun Yan Jun | 2008 | Water Science and Engineering2008，1，2： | 2 |
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