|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 3 | Heterogeneous lamellar-edged Fe-Ni(OH)_(2)/Ni_(3)S_(2)nanoarray for efficient and stable seawater oxidation显示文摘Development of efficient non-precious catalysts for seawater electrolysis is of great significance but challenging due to the sluggish kinetics of oxygen evolution reaction(OER)and the impairment of chlorine electrochemistry at anode.Herein,we report a heterostructure of Ni_(3)S_(2)nanoarray with secondary Fe-Ni(OH)_(2)lamellar edges that exposes abundant active sites towards seawater oxidation.The resultant Fe-Ni(OH)_(2)/Ni_(3)S_(2)nanoarray works directly as a free-standing anodic electrode in alkaline artificial seawater.It only requires an overpotential of 269 mV to afford a current density of 10 mA·cm^(-2)and the Tafel slope is as low as 46 m V·dec^(-1).The 27-hour chronopotentiometry operated at high current density of 100 mA·cm^(-2)shows negligible deterioration,suggesting good stability of the Fe-Ni(OH)_(2)/Ni_(3)S_(2)@NF electrode.Faraday efficiency for oxygen evolution is up to〜95%,revealing decent selectivity of the catalyst in saline water.Such desirable catalytic performance could be benefitted from the introduction of Fe activator and the heterostructure that offers massive active and selective sites.The density functional theory(DFT)calculations indicate that the OER has lower theoretical overpotential than Cl_(2) evolution reaction in Fe sites,which is contrary to that of Ni sites.The experimental and theoretical study provides a strong support for the rational design of high-performance Fe-based electrodes for industrial seawater electrolysis. | Baihua Cui Zheng Hu Chang Liu Siliang Liu Fangshuai Chen Shi Hu Jinfeng Zhang Wei Zhou Yida Deng Zhenbo Qin Zhong Wu Yanan Chen Lifeng Cui Wenbin Hu | 2021 | Nano Research2021，14，4： | 7 |
| 4 | Polygenetic Mineralization of the Early ProterozoicTongkuangyu Metaporphyry Copper Deposit inthe Zhongtiao Mountains,Shanxi Province显示文摘The Tongkuangyu metaporphyry copper deposit formed in the Early Proterozoic is tectonically located in the northern part of the Zhongtiao X -type palaeorift depression, on the southern margin of the North China platform. The genesis of the deposit has long been a hot subject of research of geologists working on mineral deposits. By means of the protolith reconstruction and fluid inclusion and isotope studies of host rocks of the deposits, the authors hold that this deposit is the product of combined exogenic, endogenic and metamorphic processes. Its formation mainly involved the following four stages: (1) the stage of formation of Mg- and Fe-rich tuffaceous variegated cupriferous sand-shale and K-rich biomodal volcanic rocks; (2) the early stage of formation of the metaporphyry copper deposit; (3) the stage of formation of the metaporphyry copper deposit; and (4) the stage of reworking of the metaporphyry copper deposit. | CHEN Wenming ZHANG Chengxin LU Jiren DANG Zefa LI Shuping CUI Wenbin NING Yuan | 1998 | Acta Geologica Sinica(English Edition)1998，72，2： | 7 |
| 5 | SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis显示文摘During embryo development, the vascular precursors and ground tissue stem cells divide to renew them-selves and produce the vascular tissue, endodermal cells, and cortical cells. However, the molecular mech-anisms regulating division of these stem cells have remained largely elusive. In this study, we show that loss of function of SOMATIC EMBRYOGENESIS RECEPTOR-UKE KINASE (SERK) genes results in aberrant em-bryo development. Fewer cortical, endodermal, and vascular cells are generated in the embryos of serk1 serk2bak1 triple mutants. WUSCHEL-RELATED HOMBOBOX5 (WOXS) is ectopically expressed in vascular cells of serkl serk2 bak1 embryos. The first transverse division of vascular precursors in mid-globular em-bryos and second asymmetric division of ground tissue stem cells in early-heart embryos are abnormally altered to a longitudinal division. The embryo defects can be partially rescued by constitutively activated mitogen-activated protein kinase (MAPK) kinase kinase YODA (YDA) and MAPK kinase MKK5. Taken together, our results reveal that SERK-mediated signals regulate division patterns of vascular precursors and ground tissue stem cells, likely via the YDA-MKK4/5 cascade, during embryo development. | Huiqiang Li Zeping Cai Xiaojuan Wang Meizhen Li Yanwei Cui Nan Cui Fei Yang Mingsong Zhu Junxiang Zhao Wenbin Du Kai He Jing Yi Frans E.Tax Suiwen Hou Jia Li Xiaoping Gou | 2019 | Molecular Plant2019，12，7： | 7 |
| 6 | Effect of Interlayers on Microstructure and Properties of 2205/Q235B Duplex Stainless Steel Clad Plate显示文摘In this research,2205/Q235 B clad plates were prepared by a vacuum hot rolling composite process.The effects of adding Fe,Ni,and Nb interlayers on the bonding interface structures and the shear strengths of the clad steel plates were studied.The results showed that 2205 duplex stainless steel and the three interlayers produced a large amount of plastic deformation and low-angle boundaries,and the main structures were the recrystallized and deformed grains.There were many recrystallized grains in the microstructure of the Q235 B low-carbon steel due to the low deformation in the rolling process.The Fe interlayer had better wettability with the two kinds of steel,but the lower strength led to the reduction of shear strength by about14 MPa compared with the original clad steel plate.The C element in the Q235 B low-carbon steel easily diffused into the Fe interlayer,and the clad steel plate attained a poor corrosion resistance because a large decarburization area was formed.The Nb interlayer reacted with the Mo element in the 2205 duplex stainless steel to form an Nb-Mo binary alloy,which generated long-banded ferrite.The decarburization area was also produced because the Nb reacted with the C element in the Q235 B to form hard and brittle NbCx.As a result,the shear strength was significantly reduced by about 282 MPa,and the corrosion resistance of the bonding surface was deteriorated.The Ni interlayer did not react with the alloy elements in both sides,and therefore effectively prevented element diffusion and improved the corrosion resistance of the bonding surface.Due to the low strength of the Ni interlayer and the increased number of bonding surfaces of the clad steel plates,the shear strength was reduced to some extent(about 40 MPa),but it still met the engineering application standards. | Fengqiang Xiao Dongpo Wang Wenbin Hu Lei Cui Zhiming Gao Lanju Zhou | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，5： | 2 |
| 7 | Proof for Part of the Strla Flow Experimental Conclusion and the Improvement of Flugel Formula 显示文摘 | Zhang Chunfa Cui Yinghong Yang Wenbin Zhang Decheng Song Zhiping | 2002 | Science in china (Series E)2002，45，1： | 1 |
| 8 | Proof for part of the St la flow experimental conclusion and the improvement of Flügel formula显示文摘 | Chunfa Zhang Yinghong Cui Wenbin Yang Decheng Zhang Zhiping Song | | 0，，： | 1 |
| 9 | D-Galactose-caused life shortening in Drosophila melanogaster and Musca domestica is associated with oxidative stress显示文摘 | Xu Cui Luning Wang Pingping Zuo Zhitao Han Zhengyu Fang Wenbin Li Jiankang Liu | 2004 | Biogerontology2004，，5： | 1 |
| 10 | Development and characterizations of super-fine wool powder 显示文摘 | Xu Weilin Cui Weigang Li Wenbin | 2004 | Powder Technology2004，140，12： | 1 |
| 11 | Comparison between steam-injection pressing and conventional hot pressing in producing poplar particleboards 显示文摘 | WANG Jiezing LIU Zhengtian CUI Wenbin | 1997 | Journal of Beijing Forestry University (English Ed:)1997，6，1： | 1 |
| 12 | D-Galactose-caused life shortening in Drosophila melanogaster and Musca domestica is associated with oxidative stress显示文摘 | Xu Cui Luning Wang Pingping Zuo Zhitao Han Zhengyu Fang Wenbin Li Jiankang Liu | 2004 | Biogerontology2004，，5： | 1 |
| 13 | Proof for part of the sttla flow experimental conclusion and the improvement of flugel formula显示文摘 | Zhang Chunfa Cui Yinghong Yang Wenbin Zhang Decheng Song Zhiping | 2002 | Science in china(Series E)2002，45，1： | 1 |
| 14 | Proof for part of the sttla flow experimental conclusion and the improvement of flugel formula显示文摘 | Zhang Chunfa Cui Yinghong Yang Wenbin | 2002 | Science in China(Series E)2002，45，1： | 1 |
| 15 | Development and characterizations of super-fine wool powder显示文摘 | Xu Weilin Cui Weigang Li Wenbin | 2004 | Powder Technology2004，140，： | 1 |
| 16 | Linking corporate social responsibility to firm default risk显示文摘 | Wenbin Sun Kexiu Cui | 2014 | European Management Journal2014，32，： | 1 |
| 17 | Snippet counting for cotton length distribution measurement using image analysis 显示文摘 | Xu Weilin Xu Bugao LI Wenbin CUI Weigan | 2008 | Textile Research Journal2008，78，： | 1 |
| 18 | Proof for part of the stria flow experimental conclusion and the improvement of flugel formula 显示文摘 | Zhang Chunfa Cui Yinghong Yang Wenbin | 2002 | Science in China (Series E)2002，45，1： | 1 |
| 19 | Proof for part of the sttla flow experimental conclu-sion and the improvement of flugel formula 显示文摘 | Zhang Chunfa Cui Yinghong Yang Wenbin Zhang Decheng Song Zhiping | 2002 | Science in china( series E)2002，，： | 1 |
| 20 | Proof for Part of the Sttla Flow Experimental Conclusion and the Improvement of Flugel Formula显示文摘 | Zhang Chunfa Cui Yinghong Yang Wenbin | 2002 | Science in China( Series E)2002，45，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员