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| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | Effect of temperature and moisture on soil organic carbon mineralization of predominantly permafrost peatland in the Great Hing'an Mountains,Northeastern China显示文摘Boreal peatlands represent a large global carbon pool.The relationships between carbon mineralization,soil temperature and moisture in the permafrost peatlands of the Great Hing'an Mountains,China,were examined.The CO2 emissions were measured during laboratory incubations of samples from four sites under different temperatures(5,10,15,and 20°C) and moisture contents(0%,30%,60%,100% water holding capacity(WHC) and completely water saturated).Total carbon mineralization ranged from 15.51 to 112.92 mg C under the treatments for all sites.Carbon mineralization rates decreased with soil depth,increased with temperature,and reached the highest at 60% WHC at the same temperature.The calculated temperature coefficient(Q10) values ranged from 1.84 to 2.51 with the soil depths and moisture.However,the values were not significantly affected by soil moisture and depth for all sites due to the different peat properties(P > 0.05).We found that the carbon mineralization could be successfully predicted as a two-compartment function with temperature and moisture(R2 > 0.96) and total carbon mineralization was significantly affected by temperature and moisture(P < 0.05).Thus,temperature and moisture would play important roles in carbon mineralization of permafrost peatlands in the Great Hing'an Mountains,indicating that the permafrost peatlands would be sensitive to the environment change,and the permafrost peatlands would be potentially mineralized under future climate change. | Xianwei Wang Xiuzhen Li Yuanman Hu Jiujun Lv Ju Sun Zongmei Li Zhifeng Wu | 2010 | Journal of Environmental Sciences2010，22，7： | 26 |
| 3 | Geographical characteristics of China’s wetlands derived from remotely sensed data显示文摘In this paper, we report the first wetland mapping of the entire China using Landsat enhanced thematic mapper plus (ETM+) data. These data were obtained from the Global Land Cover Facility at the University of Maryland spanning from 1999 to 2002. A total of 597 scenes of Landsat images were georeferenced and mosaiced. Manual image interpretation of satellite images was aided with elevation data, soil data, land cover/land use data and Google Earth. The minimum mapping unit is 10 pixel × 10 pixel, equivalent to 9 ha. The aim of our first round of mapping was only targeted at the boundary delineation of any type of wetland except those wetlands that are under agricultural use (i.e., paddy fields), which has already been well mapped by others. Our interpretation results indicate that a total of 359478 km2 of wetlands are of non-agricultural use. Among our preliminarily mapped wetland, 339353 km2 are inland wetland, 2786 km2 are non-agricultural artificial wetland, and 17609 km2 are coastal wetland. Because low-tide is rarely captured in satellite images, an under-estimation of coastal wetland is inevitable. We conducted some statistics based on our mapped wetlands and compared them with those previously obtained from a number of sources including a land cover/land use map made with satellite images during the late 1990s and early 2000s, a marshland map developed in approximately the same period, survey data of coastal wetland in early 1980s, and area data for approximately 400 larger patches of marshland in China compiled in 1996. Because some inconsistencies exist in the guidelines of those different wetland surveys, difference in area is expected. Some further comparison indicates that the wetland distributions derived from the preliminary wetland map are reasonable and more objective than other sources. The mapping process also indicated that the method adopted by us was efficient and cost-effective. We also found that in order to ensure comparability of the wetland maps developed at different times, a set of standard guidelines on the wetland categories to be mapped, and the mapping methods to be used must be well conceived, developed and effectively employed. We carried out some initial geographical analysis on the distribution of wetlands. | NIU ZhenGuo GONG Peng CHENG Xiao GUO JianHong WANG Lin HUANG HuaBing SHEN ShaoQing WU YunZhao WANG XiaoFeng WANG XianWei YING Qing LIANG Lu ZHANG LiNa WANG Lei YAO Qian YANG ZhenZhong GUO ZiQi DAI YongJiu | 2009 | Science China Earth Sciences2009，52，6： | 15 |
| 4 | Fine-Tuning of MiR528 Accumulation Modulates Flowering Time in Rice显示文摘In plants,microRNA (miRNA) functions in the post-transcriptional repression of target mRNAs have been well explored.However,the mechanisms regulating the accumulation of miRNAs remain poorly under.stood.Here,we report that distinct mechanisms regulate accumulation of a monocot-specific miRNA,rice (Oryza sativa) miR528.At the transcriptional level,miR528 accumulated to higher levels in older plants than in young seedlings and exhibited aging-modulated gradual accumulation and diurnal rhythms in leaves;at the post-transcriptional level,aging also modulated miR528 levels by enhancing pri-miR528 alter.native splicing.We found that miR528 promotes rice flowering under long-day conditions by targeting RED AND FAR-RED INSENSITIVE2 (OsRFI2).Moreover,natural variations in the MIR528 promoter region caused differences in miR528 expression among rice varieties,which are correlated with their different binding affinities with the transcription factor OsSPL9 that activates the expression of miR528.Taken together,our findings reveal rice plants have evolved sophisticated modes fine-tuning miR528 levels and provide insight into the mechanisms that regulate MIRNA expression in plants. | Rongxin Yang Pingchuan Li Hailiang Mei Dong Wang Jing Sun Chao Yang Lili Hao Shouyun Cao Chengcai Chu Songnian Hu Xianwei Song Xiaofeng Cao | 2019 | Molecular Plant2019，12，8： | 12 |
| 5 | Evolution of the East Asian monsoon and its response to uplift of the Tibetan Plateau since 1.8 Ma recorded by major elements in sediments of the South China Sea显示文摘东方亚洲季风和它的反应的进化在全球变化的学习被调查了西藏的高原高举。在 ODP Leg184 期间在华南海钻的核心沉积样品是为学习东方亚洲季风的长期的可变性的最好的材料。在好谷物大小的没有碳酸盐的沉积的主要元素的R模式因素分析(< 4 m )上面 185 mcd 地点 1146 在华南海表演在 Leg184 期间钻了的 ODP 拼接那 Ti , TFe2O3 , MgO , K2O , P , CaO ,并且 Al2O3 一个陆上的因素是代表性的。在陆上的因素分数的变化在来源区域服从于化学侵蚀并且因此显示东方亚洲夏天季风的进化。陆上的因素分数在 1.3 妈, 0.9 妈,和 0.6 妈有三逐步的减少,显示夏天季风与有关的东方亚洲人变弱分阶段执行完全逐步,自从 1.8 妈,快西藏的高原高举。自从 0.6 妈,陆上的因素分数的周期的变化显示冰川间冰期的周期是驾驶东方亚洲季风的进化的主要力量。作为在中国黄土的情况中,在华南海的沉积记录的东方亚洲季风的长期的进化反映冰川间冰期的周期的 a coupled 效果并且西藏的高原高举。 | MENG XianWei XIA Peng ZHENG Jun WANG XiangQin | 2011 | Chinese Science Bulletin2011，56，6： | 11 |
| 6 | TAOK1 negatively regulates IL-17-mediated signaling and inflammation显示文摘Interleukin 17(IL-17)is an important cytokine that can induce tissue inflammation and is involved in the pathogenesis of numerous autoimmune diseases.However,the regulation of its signaling transduction has not been well described.In this study,we report that thousand and one kinase 1(TAOK1)functions as a negative regulator of IL-17-mediated signal transduction and inflammation.TAOK1 knockdown promotes IL-17-induced cytokine and chemokine expression and the activation of mitogen-activated protein kinases and nuclear factor-κB.We further demonstrate that TAOK1 interacts with IL-17 receptor A(IL-17RA)independent of its kinase activity,and TAOK1 dose-dependently prevents the formation of the IL-17R-Act1(nuclear factor activator 1,also known as tumor necrosis factor receptor-associated factor 3 interacting protein 2)complex.Consistent with this,TAOK1 deficiency exacerbates colitis in the 2,4,6-trinitrobenzenesulfonic acid-induced experimental model of inflammatory bowel disease,likely by its promotion of the IL-17-mediated signaling pathway.TAOK1 expression is decreased in the colons of ulcerative colitis patients.In conclusion,these findings suggest that TAOK1 is involved in the development of IL-17-related autoimmune disorders. | Zhaoru Zhang Zhen Tang Xianwei Ma Kai Sun Liping Fan Jie Fang Jianping Pan Xiaojian Wang Huazhang An Jun Zhou | 2018 | Cellular & Molecular Immunology2018，15，8： | 10 |
| 7 | Assessment of the Ecological Security in the Three Gorges Reservoir Area by Using the Ecological Footprint Method显示文摘The ecological footprint concept and its calculation models are useful for the measurement of the sustainable level of social and economic development.The ecological security situation of the Three Gorges Reservoir Area(TGRA) was evaluated using this concept in this study.The construction of the Three Gorges Reservoir has led to the change in the ecology and immigration status of TGRA.The ecological footprint method is an important means to study the regional ecological security.Our results suggested that,by excluding the areas for biodiversity conservation(12% of the total land),the ecological footprint per capita was 0.57895 ha,which exceeded the ecological carrying capacity in TGRA.The total ecological deficit was found to be 11,522,193.34 ha,accounting for 95.02% of the ecological carrying capacity.These findings suggested that the ecological security of TGRA was not good.In order to compensate for the ecological deficit,it was essential to introduce natural resources from other regions. | WANG Haiming WANG Hai'e SUN Hongyang WANG Xiaolan LIAO Xiaoyong CHEN Zhijian LI Xianwei | 2012 | Journal of Mountain Science2012，9，6： | 9 |
| 8 | The ignored emission of volatile organic compounds from iron ore sinter process显示文摘Iron ore sintering is a major source of gaseous and particulate pollutants emission in iron smelt plant. The aim of present study is to characterize the volatile organic compounds(VOCs) emission profiles from iron ore sintering process. Both sinter pot test and sinter simulation experiment were conducted and compared. Out results showed that sinter process produced large quantity of VOCs together with NOxand SO_2. VOCs and NO were produced simultaneously in sinter pot test from 3 to 24 min after ignition, flowed by SO_2 production from 15 min to the end of sintering. Total VOCs(TVOC) concentration in sinter flue gas was affected by the coal and coke ratio in sinter raw material. The maximum TVOC concentration was 34.5 ppm when using 100% coal as fuel. Sinter simulation experiments found that the number of VOCs species and their concentrations were found by sinter temperature. The largest VOCs species varieties were obtained at 500 °C. Benzene, toluene,xylene and ethylbenzene were major VOCs in sinter flue gas based on the results from both simulation test and sinter pot. It thus demonstrated that in addition to NO_x, SO_2 and metal oxide particles, sinter flue gas also contained significant amount of VOCs whose environmental impact cannot be ignored. Based on our work, it is timely needed to establish a new VOC emission standard for sinter flue gas and develop advanced techniques to simultaneously eliminate multi-pollutants in iron ore sinter process. | Juexiu Li Xiaoping He Bing Pei Xianwei Li Diwen Ying Yalin Wang Jinping Jia | 2019 | Journal of Environmental Sciences2019，31，3： | 7 |
| 9 | Development and Utilization of the World's and China's Bulk Mineral Resources and their Supply and Demand Situation in the Next Twenty Years显示文摘Bulk mineral resources of iron ores, copper ores, bauxite, lead ores, zinc ores and potassium salt play a pivotal role on the world's and China's economic development. This study analyzed and predicted their resources base and potential, development and utilization and their world's and China's supply and demand situation in the future 20 years. The supply and demand of these six bulk mineral products are generally balanced, with a slight surplus, which will guarantee the stability of the international mineral commodity market supply. The six mineral resources(especially iron ores and copper ores) are abundant and have a great potential, and their development and utilization scale will gradually increase. Till the end of 2014, the reserveproduction ratio of iron, copper, bauxite, lead, zinc ores and potassium salt was 95 years, 42 years, 100 years, 17 years, 37 years and 170 years, respectively. Except lead ores, the other five types all have reserve-production ratio exceeding 20 years, indicative of a high resources guarantee degree. If the utilization of recycled metals is counted in, the supply of the world's six mineral products will exceed the demand in the future twenty years. In 2015–2035, the supply of iron ores, refined copper, primary aluminum, refined lead, zinc and potassium salt will exceed their demand by 0.4–0.7 billion tons(Gt), 5.0–6.0 million tons(Mt), 1.1–8.9 Mt, 1.0–2.0 Mt, 1.2–2.0 Mt and 4.8–5.6 Mt, respectively. It is predicted that there is no problem with the supply side of bulk mineral products such as iron ores, but local or structural shortage may occur because of geopolitics, monopoly control, resources nationalism and trade friction. Affected by China's compressed industrialized development model, the demand of iron ores(crude steel), potassium salt, refined lead, refined copper, bauxite(primary aluminum) and zinc will gradually reach their peak in advance. The demand peak of iron ores(crude steel) will reach around 2015, 2016 for potassium salt, 2020 for refined lead, 2021 for bauxite(primary aluminum), 2022 for refined copper and 2023 for zinc. China's demand for iron ores(crude steel), bauxite(primary aluminum) and zinc in the future 20 years will decline among the world's demand, while that for refined copper, refined lead and potassium salt will slightly increase. The demand for bulk mineral products still remains high. In 2015–2035, China's accumulative demand for iron ores(crude steel) will be 20.313 Gt(13.429 Gt), 0.304 Gt for refined copper, 2.466 Gt(0.616 Gt) of bauxite(primary aluminum), 0.102 Gt of refined lead, 0.138 Gt of zinc and 0.157 Gt of potassium salt, and they account for the world's YOY(YOY) accumulative demand of 35.17%, 51.09%, 48.47%, 46.62%, 43.95% and 21.84%, respectively. This proportion is 49.40%, 102.52%, 87.44%, 105.65%, 93.62% and 106.49% of that in 2014, respectively. From the supply side of China's bulk mineral resources, it is forecasted that the accumulative supply of primary(mine) mineral products in 2015–2035 is 4.046 Gt of iron ores, 0.591 Gt of copper,1.129 Gt of bauxite, 63.661 Mt of(mine) lead, 0.109 Gt of(mine) zinc and 0.128 Gt of potassium salt, which accounts for 8.82%, 13.92%, 26.67%, 47.09%, 33.04% and 15.56% of the world's predicted YOY production, respectively. With the rapid increase in the smelting capacity of iron and steel and alumina, the rate of capacity utilization for crude steel, refined copper, alumina, primary aluminum and refined lead in 2014 was 72.13%, 83.63%, 74.45%, 70.76% and 72.22%, respectively. During 2000–2014, the rate of capacity utilization for China's crude steel and refined copper showed a generally fluctuating decrease, which leads to an insufficient supply of primary mineral products. It is forecasted that the supply insufficiency of iron ores in 2015–2035 is 17.44 Gt, 0.245 Gt of copper in copper concentrates, 1.337 Gt of bauxite, 38.44 Mt of lead in lead concentrates and 29.19 Mt of zinc in zinc concentrates. China has gradually raised the utilization of recycled metals, which has mitigated the insufficient supply of primary metal products to some extent. It is forecasted that in 2015–2035 the accumulative utilization amount of steel scrap(iron ores) is 3.27 Gt(5.08 Gt), 70.312 Mt of recycled copper, 0.2 Gt of recycled aluminum, 48 Mt of recycled lead and 7.7 Mt of recycled zinc. The analysis on the supply and demand situation of China's bulk mineral resources in 2015–2035 suggests that the supply-demand contradiction for these six types of mineral products will decrease, indicative of a generally declining external dependency. If the use of recycled metal amount is counted in, the external dependency of China's iron, copper, bauxite, lead, zinc and potassium salt will be 79%, 65%, 26%, 8%, 16% and 18% in 2014, respectively. It is predicted that this external dependency will decrease to 62%, 64%, 20%,-0.93%, 16% and 14% in 2020, respectively, showing an overall decreasing trend. We propose the following suggestions correspondingly.(1) The demand peak of China's crude steel and potassium salt will reach during 2015–2023 in succession. Mining transformation should be planned and deployed in advance to deal with the arrival of this demand peak.(2) The supply-demand contradiction of China's bulk mineral resources will mitigate in the future 20 years, and the external dependency will decrease accordingly. It is suggested to adjust the mineral resources management policies according to different minerals and regions, and regulate the exploration and development activities.(3) China should further establish and improve the forced mechanism of resolving the smelting overcapacity of steel, refined copper, primary aluminum, lead and zinc to really achieve the goal of 'reducing excess production capacity'.(4) In accordance with the national strategic deployment of 'One Belt One Road', China should encourage the excess capacity of steel, copper, alumina and primary aluminum enterprises to transfer to those countries or areas with abundant resources, high energy matching degree and relatively excellent infrastructure. Based on the national conditions, mining condition and geopolitics of the resources countries, we will gradually build steel, copper, aluminum and lead-zinc smelting bases, and potash processing and production bases, which will promote the excess capacity to transfer to the overseas orderly.(5) It is proposed to strengthen the planning and management of renewable resources recycling and to construct industrial base of renewable metal recycling.(6) China should promote the comprehensive development and utilization of paragenetic and associated mineral species to further improve the comprehensive utilization of bulk mineral resources. | ZHANG Zhaozhi JIANG Guangyu WANG Xianwei ZHANG Jianfeng | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 6 |
| 10 | Risk factors associated with 90-day recurrent stroke in patients on dual antiplatelet therapy for minor stroke or high-risk TIA:a subgroup analysis of the CHANCE trial显示文摘Objective Many patients receiving dual antiplatelet therapy still had recurrent strokes.We aimed to identify factors associated with recurrent stroke at 90 days in patients receiving dual antiplatelet therapy in Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events trial.Methods Patients with transient ischaemic attack or minor stroke receiving clopidogrel and aspirin in the trial were analysed in the study.The primary outcome was recurrent stroke within 90 days after the index event.Cox proportional hazard model with backward selection was used to identify factors associated with stroke.results Among 2584 patients,212(8.2%)had a recurrent stroke,216(8.4%)had a composite of stroke,myocardial infarction,or vascular death and 204(7.9%)had ischaemic stroke within 90 days.Multivariate analysis identified the following factors associated with stroke:history of hypertension with poor blood pressure control(HR,1.92;95%CI 1.22 to 3.03),the high baseline National Institute of Health Stroke Scale(NIHSS)score of 2 and 3(2.12(1.07 to 4.21)and 4.11(2.05 to 8.22),respectively),time from onset to randomisation of<12 hours(1.47(1.12 to 1.94)),the lipid-lowering therapy(0.61(0.47 to 0.83)),the open-label aspirin dose at day 1 of≥300 mg(1.98(1.45 to 2.69)).Intracranial arterial stenosis(ICAS)was significantly associated with stroke in the sensitivity analysis(2.17(1.16 to 4.04)).conclusions The high baseline NIHSS score,hypertension with poor blood pressure control,ICAS,time from onset to randomisation of less than 12 hours and no lipid-lowering therapy were associated with stroke,suggesting that patients with identified predictors still remain to be at high risk of recurrent stroke although being under the dual antiplatelet therapy. | Runqi Wangqin Xianwei Wang Yilong Wang Ying Xian Xingquan Zhao Liping Liu Hao Li Xia Meng Yongjun Wang | 2017 | Stroke & Vascular Neurology2017，2，4： | 6 |
| 11 | Innate lymphoid cell memory显示文摘Innate lymphoid cells(ILCs),including natural killer(NK)cells,ILC1s,ILC2s,ILC3s,and lymphoid tissue inducer(LTi)cells,comprise the first line of innate immune defense against pathogens and tumors.Over the past decade,accumulating evidence has demonstrated immunological memory in ILC subsets:for example,NK cells recall haptens,viruses,and cytokines;ILC1s recall haptens;and ILC2s recall cytokines.Although the development and functions of ILCs mirror those of T-cell subsets,ILC and T-cell memory exhibit both common characteristics and specific properties.Encouragingly,ILC memory has been found to confer benefits in long-term tumor control and vaccination,providing insight for novel memory ILC-based tumor immunotherapy and vaccine-development strategies.In this review,we discuss the evidence supporting ILC memory and present a comprehensive framework of the ILC memory system. | Xianwei Wang Hui Peng Zhigang Tian | 2019 | Cellular & Molecular Immunology2019，16，5： | 5 |
| 12 | Existence of Al2F-7^- in molten MF–AlF3(M = K, Cs) systems as determined by Raman spectroscopy and structural simulation显示文摘The molten mixtures of alkali metal fluorides and aluminum fluoride are applied as aluminum electrolytes or brazing fluxes.However,the presence of Al2F-7^-in such molten systems is disputed.In the present study,MF-AlF3(M=K,Cs)systems with molar ratios<1 were studied by in-situ Raman spectroscopy and molecular simulation.The results show that,in addition to AlF6^(3-),AlF5^(2-),and AlF4^-,the systems also contained Al2F-7^-.The characteristic bands in the Raman spectra belonging to Al2F-7^-were located at about 225 cm^-1,315 cm^-1,479 cm^-1,and 720 cm^-1.There are two possible structures of Al2F-7^-,which belong to the D3d and D3hpoint groups.Both of these structures are linear,and their single-point energies were found to differ by only 0.31 kcal/mol. | Ming Lin Xianwei Hu Zhongning Shi Bingliang Gao Jiangyu Yu Zhaowen Wang | 2020 | Journal of Energy Chemistry2020，29，5： | 5 |
| 13 | The efficacy and safety of nimodipine in acute ischemic stroke patients with mild cognitive impairment: a double-blind, randomized,placebo-controlled trial显示文摘Nimodipine might be effective in subcortical vascular dementia(VaD). Its benefit in preventing further cognitive decline in patients with acute ischemic stroke(AIS) and vascular mild cognitive impairment(VaMCI) remains to be established. In this multicenter, double-blind trial, we randomly assigned 654 eligible patients to nimodipine 30 mg three times a day or placebo. The primary outcome was any cognitive decline defined by the changes on the Mini-Mental State Examination(DMMSE à3) or vascular AD assessment scale cognitive subscale(DADAS-cog ! 4) at 6 months. Secondary outcomes included any distribution shift of DADAS-cog, DMMSE or cognitive improvement defined by DADAS-cog à2, or DMMSE ! 0. The primary outcome in the nimodipine group and placebo group were similar for DMMSE à3(4.18% and 7.22%, respectively, P = 0.15) and DADAS-cog ! 4(8.36% and 8.93% respectively,P = 0.88). The distribution shift of DADAS-cog and DMMSE differed significantly between the two groups(P = 0.03 and P = 0.05 respectively). Cognitive improvement occurred in 55.4% in the nimodipine group and 43.6% in the placebo group measured by DADAS-cog à2(Odds Ratio, 1.54; 95% confidence interval[CI] 1.10–2.14, P < 0.01) or 84.0% and 74.6% respectively by DMMSE ! 0(Odds Ratio, 1.79; 95% CI 1.18–2.70, P < 0.01). Nimodipine was associated with better cognitive function in the memory domain. The adverse events rate was similar in two groups. This study is registered with ClinicalTrials.gov,NCT01220622. Nimodipine did not show benefit to prevent cognitive decline in AIS patients with VaMCI, but improved cognition moderately, especially measured in the memory domain. | Huaguang Zheng Yilong Wang Anxin Wang Hao Li David Wang Xingquan Zhao Penglian Wang Haipeng Shen Lijun Zuo Yuesong Pan Zixiao Li Xia Meng Xianwei Wang Weixiong Shi Yi Ju Liping Liu Kehui Dong Chunxue Wang Rubo Sui Rong Xue Xiaoping Pan Xiaoyua Niu Benyan Luo Yi Sui Huali Wang Tao Feng Yongjun Wang | 2019 | Science Bulletin2019，64，2： | 5 |
| 14 | High-yield preparation of robust gold nanoshells on silica nanorattles with good biocompatiblity显示文摘Although gold nanoshells are widely considered as one of the promising photothermal nanomaterials used for biomedicine, the high cost, low yield and poor stability severely limit their potential application in clinical trials.Herein, robust gold nanoshells on silica nanorattles(GSNs)were easily prepared in a high yield by an improved seedmediated method employing polyvinylpyrrolidone(PVP) as a stabilizing and capping agent. The present method is very simple, effective and reproducible and can well control the growth process of gold nanoshells. The as-prepared GSNs have a narrow size distribution(<10 % in standard deviation). Furthermore, the utilization rate of Au in the solution used for the growth of gold nanoshells increases by 70 %than that in previous method. The resultant GSNs have a good structural stability after placing over 6 months due to the protection of PVP. More importantly, in vivo and in vitro toxic studies indicate that the GSNs have good biocompatibility. We believe that our preparation method will remarkably promote the use of gold nanoshells for biomedicine. | Changhui Fu Chaofeng He Longfei Tan Shunhao Wang Lu Shang Linlin Li Xianwei Meng Huiyu Liu | 2016 | Science Bulletin2016，61，4： | 5 |
| 15 | Targeted DNA demethylation produces heritable epialleles in rice显示文摘Dear Editor,DNA methylation is an important epigenetic mark that is associated with the silencing of genes and transposable elements(TEs)(Law and Jacobsen,2010).Changes in DNA methylation can be transgenerationally inherited to generate stable epialleles in plants.Epialleles broaden genetic and phenotypic diversity。 | Shanjie Tang Chao Yang Dong Wang Xian Deng Xiaofeng Cao Xianwei Song | 2022 | Science China(Life Sciences)2022，65，4： | 4 |
| 16 | An improved Landsat Image Mosaic of Antarctica显示文摘A revised Landsat Image Mosaic of Antarctica (LIMA) is presented, using the 1073 multi-band scenes of the original Landsat-7 ETM+ LIMA image collection available at the United States Geological Survey (USGS: http://gffzza64998f73d704ee0h9oxkuxw5o9vv6okw.ffgz.tsg.suse.edu.cn/). Three improvements have been applied during the data processing: (1) DN saturation is adjusted by adopting a linear regression, which has a lower root mean square error than the ratio regression used by LIMA; (2) solar elevation angle is calculated using pixel-level latitude/longitude and the acquisition time and date of the central pixel of the scene, improving slightly upon the bilinear interpolation of the solar elevation angles of scene corners applied in LIMA; and (3) two additional image bands, Band 5 and Band 7, are sharpened using the panchromatic band (Band 8) and a Gram-Schmidt Spectral Sharpening algorithm to more easily distinguish snow, cloud and exposed rocks. The final planetary reflectance product is stored in 16-bit bands to preserve the full radiometric content of the scenes. A comparative statistical analysis among 12 sample regions indicates that the new mosaic has enhanced visual qualities, information entropy, and information content for land cover classification relative to LIMA. | HUI FengMing CHENG Xiao LIU Yan ZHANG YanMei YE YuFang WANG XianWei LI Zhan WANG Kun ZHAN ZhiFei GUO JianHong HUANG HuaBing LI XiuHong GUO ZiQi GONG Peng | 2013 | Science China Earth Sciences2013，56，1： | 4 |
| 17 | Non-Cooperative Differential Game Based Energy Consumption Control for Dynamic Demand Response in Smart Grid显示文摘In this paper, we conduct research on the dynamic demand response problem in smart grid to control the energy consumption. The objective of the energy consumption control is constructed based on differential game, as the dynamic of each users’ energy state in smart gird can be described based on a differential equation. Concept of electricity sharing is introduced to achieve load shift of main users from the high price hours to the low price hours. Nash equilibrium is given based on the Hamilton equation and the effectiveness of the proposed model is verified based on the numerical simulation results. | Manxi Wang Haitao Xu Shengsong Yang Lifeng Yang Ruifeng Duan Xianwei Zhou | 2019 | China Communications2019，16，8： | 4 |
| 18 | Late Holocene mangrove development and response to sea level change in the northwestern South China Sea显示文摘Mangroves,widely distributed along the coasts of tropical China,are influenced by Asia monsoon,relative sea level change and enhanced human activity.To predict the impacts of future climate change on mangrove ecosystems,it can be understood by reconstructing past mangrove dynamics using proxies preserved in coastal sediments.In this study,we quantitatively partitioned buried organic matter(OM)sources,collected from a vulnerable mangrove swamp in the Qinzhou Bay of northwestern South China Sea,using a ternary end-member mixing model of δ^13C and C:N values.Mangrove-derived OM(MOM)contribution was used as a tracer for mangrove development since 2.34 cal ka BP.This information,together with paleoclimate records(i.e.,speleothem δ^18O values,sea level change,grain size parameters)and human activity,was used to divide mangrove development into three stages during the late Holocene:relative flourish(2.34-1.13 cal ka BP),relative degradation(1.13-0.15 cal ka BP)and further degradation(0.15-0 cal ka BP).Before 1.13 cal ka BP,mangroves flourished with a high MOM contribution((88.9±10.6)%),corresponding to stable and high sea level under a warm and humid climate.After 1.13 cal ka BP,rapid fall in relative sea level coupled with the strengthening of the Asian winter monsoon,resulted in mangrove degradation and MOM reduction((62.4±18.9)%).Compared with air temperature and precipitation,the relative sea level fall was the main controlling factor in mangrove development before entering the Anthropocene(the time of the Industrial Revolution).After^150 cal a BP,reclamation of mangrove swamps to shrimp ponds is the main factor causing mangrove degradation and MOM reduction. | Peng Xia Xianwei Meng Zhen Li Pengyao Zhi Mengwei Zhao Enkang Wang | 2019 | Acta Oceanologica Sinica2019，38，11： | 4 |
| 19 | Aboveground biomass and its spatial distribution pattern of herbaceous marsh vegetation in China显示文摘Herbaceous marsh is the most widely distributed type of marsh wetland ecosystem,and has important ecological functions such as water conservation,climate regulation,carbon storage and fixation,and sheltering rare species.The carbon sequestration function of herbaceous marsh plays a key role in slowing climate warming and maintaining regional environmental stability.Vegetation biomass is an important index reflecting the carbon sequestration capacity of wetlands.Investigating the biomass of marsh vegetation can provide a scientific basis for estimating the carbon storage and carbon sequestration capacity of marshes.Based on field survey data of aboveground biomass of herbaceous marsh vegetation and the distribution data set of marsh in China,we analyzed the aboveground biomass and its spatial distribution pattern of herbaceous marsh on a national scale for the first time.The results showed that in China the total area of herbaceous marsh was 9.7×10^(4) km^(2),the average density of aboveground biomass of herbaceous marsh vegetation was 227.5±23.0 g C m-2(95%confidence interval,the same below),and the total aboveground biomass was 22.2±2.2 Tg C(1 Tg=1012 g).The aboveground biomass density of herbaceous marsh vegetation is generally low in Northeast China and the Tibetan Plateau,and high in central North China and coastal regions in China.In different marsh distribution regions of China,the average biomass density of herbaceous marsh vegetation from small to large was as follows:temperate humid and semi-humid marsh region(182.3±49.3 g C m^(-2)) | Xiangjin SHEN Ming JIANG Xianguo LU Xingtu LIU Bo LIU Jiaqi ZHANG Xianwei WANG Shouzheng TONG Guangchun LEI Shengzhong WANG Chuan TONG Hangqing FAN Kun TIAN Xiaolong WANG Yuanman HU Yonghong XIE Muyuan MA Shuwen ZHANG Chunxiang CAO Zhichen WANG | 2021 | Science China Earth Sciences2021，64，7： | 4 |
| 20 | Law of gas production during coal heating oxidation显示文摘Coal spontaneous combustion is a great threat to mine safety,and gas is the key index to describe coal spontaneous combustion.Taking the coal samples of different kinds of coal as research object,the temperature programmed oxidation experiment was carried out,and the gases produced by coal samples at different temperatures were collected and analyzed by gas chromatography.This research studied the variation characteristics of gas species and gas concentrations in different coal samples during heating oxidation.The experimental results show that different coal samples produce different kinds of gases in the process of heating and oxidation.The order of gas production is CO,C2H6,C2H4,C3H8,and the relationship between gas production and temperature is approximately exponential.With the increase of coal metamorphic degree,the turning point temperature of sharp rise in coal sample gas production rate become higher,the oxidation ability of coal sample decreases,and the quantity of gas production decreases during the same time period. | Xianwei Dong Zhichao Wen Fusheng Wang Yaning Meng | 2019 | International Journal of Mining Science and Technology2019，29，4： | 4 |
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