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| 1 | Recent glacial retreat in High Asia in China and its impact on water resource in Northwest China显示文摘Under the impact of climatic warming, the glaciers in the High Asia in China have been retreating continuously with negative glacial mass balance in recent several decades. The retreat became more intensive in the past 10 years. The spatial pattern of the glacial retreat in the High Asia in China is that the smallest magnitude of retreat is in the inland of the Tibetan Plateau, the magnitude increases from the inland to the margin of the Tibetan Plateau, and the largest magnitude at the margin of the Tibetan Plateau. The glacial retreat in the High Asia in China has an important impact on the water resource of the arid regions in Northwest China. This study shows that the glacial retreat in the 1990s has caused an increase of 5.5% in river runoff in Northwest China. In the Tarim River basin, the increase of river runoff is higher than 5.5%. | YAO Tandong 1,2 ,WANG Youqing 2 ,LIU Shiying 2,1 ,PU Jianchen 2,1 ,SHEN Yongping 2 & LU Anxin 2,1 1.Institute of Tibetan Plateau Research,Chinese Academy of Sciences,Beijing 100029,China 2.Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,Lanzhou 730000,China | 2004 | Science China Earth Sciences2004，47，12： | 117 |
| 2 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 3 | MiR-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cells显示文摘MicroRNAs regulate self renewal and differentiation of cancer stem cells.There,we sought to identify the expression of miR-181b in glioma stem cells and investigate the biological effect of miR-181b on glioma stem cells in this study.MiR-181b expression was measured by real-time PCR in glioma stem cells isolated from U87 cells by FACS sorting.After miR-181b was overexpressed in U87 glioma stem cells by miR-181b lentiviral expression vector and/or treatment of temozolomide,secondary neurosphere assay,soft agar colony assay and MTT assay were performed.Compared with U87 cells,the expression of miR-181b was significantly decreased in U87 glioma stem cells.Overexpression of miR-181b decreased neurosphere formation by U87 glioma stem cells in vitro and suppressed colony formation in soft agar,and the cell growth inhibition rates increased in a time-dependent manner in U87 glioma stem cells infected with miR-181b lentivirus.Furthermore,miR-181b had a synergistic effect on temozolomide-induced inhibition of secondary neurosphere and soft agar colony,and on cell growth inhibition rates.MiR-181b functions as a tumor suppressor that suppresses proliferation and reduces chemoresistance to temozolomide in glioma stem cells. | Ping Li Xiaoming Lu Yingyi Wang Lihua Sun Chunfa Qian Wei Yan Ning Liu Yongping You Zhen Fu | 2010 | The Journal of Biomedical Research2010，24，6： | 14 |
| 4 | Simulation of hydrological processes of mountainous watersheds in inland river basins: taking the Heihe Mainstream River as an example显示文摘The hydrological processes of mountainous watersheds in inland river basins are complicated.It is absolutely significant to quantify mountainous runoff for social,economic and ecological purposes.This paper takes the mountainous watershed of the Heihe Mainstream River as a study area to simulate the hydrological processes of mountainous watersheds in inland river basins by using the soil and water assessment tool(SWAT)model.SWAT simulation results show that both the Nash–Sutcliffe efficiency and the determination coefficient values of the calibration period(January 1995 to December 2002)and validation period(January 2002 to December 2009)are higher than 0.90,and the percent bias is controlled within±5%,indicating that the simulation results are satisfactory.According to the SWAT performance,we discussed the yearly and monthly variation trends of the mountainous runoff and the runoff components.The results show that from 1996 to 2009,an indistinctive rising trend was observed for the yearly mountainous runoff,which is mainly recharged by lateral flow,and followed by shallow groundwater runoff and surface runoff.The monthly variation demonstrates that the mountainous runoff decreases slightly from May to July,contrary to other months.The mountainous runoff is mainly recharged by shallow groundwater runoff in January,February,and from October to December,by surface runoff in March and April,and by lateral flow from May to September. | ZhenLiang YIN HongLang XIAO SongBing ZOU Rui ZHU ZhiXiang LU YongChao LAN YongPing SHEN | 2014 | Journal of Arid Land2014，6，1： | 7 |
| 5 | Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated cases显示文摘Cryoablation 是为 hepatocellular 癌(HCC ) 的不太流行的经皮的夺格的治疗,并且关于它的实用性的当前的证据是有限的。我们在与经皮的 cryoablation 对待 1595 个 HCC 案例关于有效性,安全和这治疗的长期的结果给全面侧面报导我们的经验。从 2003 年 1 月到 2013 年 12 月,有 2313 个 HCC 小瘤的 1595 个病人在我们的中心与 2958 个 cryoablation 会议被切除。完全的脱离与 3.4 朠湥浯捩椠獮慴楢楬祴 ? 畢 ? 的一条吝啬的直径为 1893 个小瘤在 1294 个病人被完成 ?? 潣扭湩摥眠瑩 ??? 瑡整畮瑡摥琠敨攠瑸湥 ? 景朠湥浯捩椠獮慴楢楬祴椠 ? 牰浩牡 ? 塖′畴潭 ? 楴獳敵瑡吗?? | Guanghua Rong Wenlin Bai Zheng Dong Chunping Wang Yinying Lu Zhen Zeng Jianhui Qu Min Lou Hong Wang Xudong Gao Xiujuan Chang Linjing An Yan Chen Yongping Yang | 2015 | Frontiers of Medicine2015，9，1： | 7 |
| 6 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
| 7 | Ultrathin 2D Metal–Organic Framework Nanosheets In situ Interpenetrated by Functional CNTs for Hybrid Energy Storage Device显示文摘The controllable construction of two-dimensional(2D)metal–organic framework(MOF)nanosheets with favorable electrochemical performances is greatly challenging for energy storage.Here,we design an in situ induced growth strategy to construct the ultrathin carboxylated carbon nanotubes(C-CNTs)interpenetrated nickel MOF(Ni-MOF/C-CNTs)nanosheets.The deliberate thickness and specific surface area of novel 2D hybrid nanosheets can be effectively tuned via finely controlling C-CNTs involvement.Due to the unique microstructure,the integrated 2D hybrid nanosheets are endowed with plentiful electroactive sites to promote the electrochemical performances greatly.The prepared Ni-MOF/C-CNTs nanosheets exhibit superior specific capacity of 680 C g^−1 at 1 A g^−1 and good capacity retention.The assembled hybrid device demonstrated the maximum energy density of 44.4 Wh kg^−1 at a power density of 440 W kg^−1.Our novel strategy to construct ultrathin 2D MOF with unique properties can be extended to synthesize various MOF-based functional materials for diverse applications. | Feitian Ran Xueqing Xu Duo Pan Yuyan Liu Yongping Bai Lu Shao | 2020 | Nano-Micro Letters2020，12，4： | 5 |
| 8 | Pyrolysis mechanism of glucose and mannose: The formation of 5-hydroxymethyl furfural and furfural显示文摘Fast pyrolysis of biomass will produce various furan derivatives, among which 5-hydroxymethyl furfural(5-HMF) and furfural(FF) are usually the two most important compounds derived from holocellulose. In this study, density functional theory(DFT) calculations are utilized to reveal the formation mechanisms and pathways of 5-HMF and FF from two hexose units of holocellulose, i.e., glucose and mannose. In addition, fast pyrolysis experiments of glucose and mannose are conducted to substantiate the computational results, and the orientation of 5-HMF and FF is determined by ^(13)C-labeled glucoses. Experimental results indicate that C1 provides the aldehyde group in both 5-HMF and FF, and FF is mainly derived from C1 to C5 segment. According to the computational results, glucose and mannose have similar reaction pathways to form 5-HMF and FF with d-fructose(DF) and 3-deoxy-glucosone(3-DG) as the key intermediates. 5-HMF and FF are formed via competing pathways. The formation of 5-HMF is more competitive than that of FF, leading to higher yield of 5-HMF than FF from both hexoses. In addition, compared with glucose,mannose can form 5-HMF and FF via extra pathways because of the epimerization at C2 position. Therefore, mannose pyrolysis results in higher yields of 5-HMF and FF than glucose pyrolysis. | Bin Hu Qiang Lu Xiaoyan Jiang Xiaochen Dong Minshu Cui Changqing Dong Yongping Yang | 2018 | Journal of Energy Chemistry2018，27，2： | 4 |
| 9 | Development of DArT markers for a linkage map of flue-cured tobacco显示文摘Tobacco(Nicotiana tabacum) is one of the most economically important nonfood crops,and flue-cured tobacco accounts for approximately 80% of world tobacco production.An extremely narrow genetic diversity in the tobacco pool has led to a low efficiency of PCR-based molecular markers(such as AFLP and SSR).Diversity Arrays Technology(DArT) is a high-throughput hybridisation-based marker system that has been developed in many plants including wheat,which,like tobacco,has a complex genome.In this study,we developed a tobacco DArT chip that included 7680 representative sequence tags based on typical tobacco accessions.The 1076 DArT markers of flue-cured tobacco were identified and most(82.1%) of their polymorphism information contents(PICs) were greater than 0.4.An integrated linkage map that included 851 markers(238 DArT and 613 SSR),which is the highest density map of flue-cured tobacco to date,was constructed.This chip-based DArT system provides an alternative in high-throughput marker genotyping for tobacco. | LU XiuPing GUI YiJie XIAO BingGuang LI YongPing TONG ZhiJun LIU Yun BAI XueFei WU WeiRen XIA Ling HUTTNER Eric KILIAN Adrzej FAN LongJiang | 2013 | Chinese Science Bulletin2013，58，6： | 4 |
| 10 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 11 | Fracture Assessment for Electron Beam Welded Damage Tolerant Ti-6Al-4V Alloy by the FITNET Procedure显示文摘Fracture assessment of the cracked structures is essential to avoiding fracture failure.A number of fracture assessment procedures have been proposed for various steel structures.However,the studies about the application of available procedures for titanium alloy structures are scarcely reported.Fracture assessment for the electron beam(EB) welded thick-walled damage tolerant Ti-6Al-4V(TC4-DT) alloy is performed by the fitness-for-service(FFS) FITNET procedure.Uniaxial tensile tests and fracture assessment tests of the base metal and weld metal are carried out to obtain the input information of assessment.The standard options and advanced options of FITNET FFS procedure are used to the fracture assessment of the present material.Moreover,the predicted maximum loads of compact tensile specimen using FITNET FFS procedure are verified with the experimental data of fracture assessment tests.As a result,it is shown that the mechanical properties of weld metal are inhomogeneous along the weld depth.The mismatch ratio M is less than 10% at the weld top and middle,whereas more than 10% at the weld bottom.Failure assessment lines of standard options are close to that of advanced option,which means that the standard options are suitable for fracture assessment of the present welds.The accurate estimation of the maximum loads has been obtained by fracture assessment of standard options with error less than 6%.Furthermore,there are no potential advantages of applying higher options or mismatch options.Thus,the present welded joints can be treated as homogeneous material during the fracture assessment,and standard option 1 can be used to achieve accurate enough results.This research provides the engineering treatment methods for the fracture assessment of titanium alloy and its EB welds. | LU Wei SHI Yaowu LI Xiaoyan LEI Yongping | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 3 |
| 12 | Limit Load Solution for Electron Beam Welded Joints with Single Edge Weld Center Crack in Tension显示文摘Limit loads are widely studied and several limit load solutions are proposed to some typical geometry of weldments.However,there are no limit load solutions exist for the single edge crack weldments in tension(SEC(T)),which is also a typical geometry in fracture analysis.The mis-matching limit load for thick plate with SEC(T) are investigated and the special limit load solutions are proposed based on the available mis-matching limit load solutions and systematic finite element analyses.The real weld configurations are simplified as a strip,and different weld strength mis-matching ratio M,crack depth/width ratio a/W and weld width 2H are in consideration.As a result,it is found that there exists excellent agreement between the limit load solutions and the FE results for almost all the mis-matching ration M,a/W and ligament-to-weld width ratio(W-a)/H.Moreover,useful recommendations are given for evaluating the limit loads of the EBW structure with SEC(T).For the EBW joints with SEC(T),the mis-matching limit loads can be obtained assuming that the components are wholly made of base metal,when M changing from 1.6 to 0.6.When M decreasing to 0.4,the mis-matching limit loads can be obtained assuming that the components are wholly made of base metal only for large value of(W-a)/H.The recommendations may be useful for evaluating the limit loads of the EBW structures with SEC(T).The engineering simplifications are given for assessing the limit loads of electron beam welded structure with SEC(T). | LU Wei SHI Yaowu LI Xiaoyan LEI Yongping | 2012 | Chinese Journal of Mechanical Engineering2012，25，3： | 3 |
| 13 | Culturing adequate CAR-T cells from less peripheral blood to treat B-cell malignancies显示文摘Objective:Chimeric antigen receptor-modified T(CAR-T)cells have shown impressive results against relapsed/refractory B cell malignancies.However,the traditional manufacture of CAR-T cells requires leukapheresis to isolate large amounts of peripheral blood T cells,thus making some patients ineligible for the procedure.Methods:We developed a simple method for CAR-T cell preparation requiring small volumes of peripheral blood.First,CD3+T cells isolated from 50 mL peripheral blood from patients(B-cell malignancies)were stimulated with immobilized anti-CD3/RetroNectin in 6-well plates and then transduced with CAR-expressing lentiviral vector.After 4 d,the T cells were transferred to culture bags for large-scale CAR-T cell expansion.In vitro and animal experiments were performed to evaluate the activity of the manufactured CAR-T cells.Finally,29 patients with B-cell acute lymphoblastic leukemia(B-ALL)and 9 patients with B-cell lymphoma were treated with the CAR-T cells.Results:The CAR-T cells were expanded to 1–3×10^(8) cells in 8–10 d and successfully killed B cell-derived malignant tumor cells in vitro and in vivo.For patients with B-ALL,the complete remission rate was 93%1 month after CAR-T cell infusion;after 12 months,the overall survival(OS)and leukemia-free survival rates were 69%and 31%,respectively.For patients with lymphoma,the objective response rate(including complete and partial remission)was 78%2 months after CAR-T cell infusion,and after 12 months,the OS and progression-free survival rates were 71%and 43%,respectively.Cytokine-release syndrome(CRS)occurred in 65.51%and 55.56%of patients with B-ALL and B-cell lymphoma,respectively;severe CRS developed in 20.69%of patients with B-ALL and in no patients with lymphoma.Conclusions:Our novel method can generate sufficient numbers of CAR-T cells for clinical use from 50–100 mL peripheral blood,thus providing an alternative means of CAR-T cell generation for patients ineligible for leukapheresis. | Lu Han Jian Zhou Linlin Li Keshu Zhou Lingdi Zhao Xinghu Zhu Qingsong Yin Yufu Li Hongqin You Jishuai Zhang Yongping Song Quanli Gao | 2021 | Cancer Biology & Medicine2021，18，4： | 2 |
| 14 | Triangulation of red sprites observed above a mesoscale convective system in North China显示文摘The triangulation of red sprites was obtained, based on concurrent observations over a mesoscale convective system(MCS) in North China from two stations separated by about 450 km. In addition, broadband sferics from the sprite-producing lightning were measured at five ground stations, making it possible to locate and identify the individual causative lightning discharges for different elements in this dancing sprite event. The results of our analyses indicate that the sprites were produced above the trailing stratiform region of the MCS, and their parent strokes were located mainly in the peripheral area of the stratiform. The lateral offset between sprites and causative strokes ranges from a few km to more than 50 km. In a particularly bright sprite, with a distinct halo feature and streamers descending down to an altitude of approximately 48 km, the sprite current signal identified in the electric sferic, measured at a range of about 1,110 km, peaked at approximately 1 ms after the return stroke. | YongPing Wang GaoPeng Lu Ming Ma HongBo Zhang YanFeng Fan GuoJin Liu ZheRun Wan Yu Wang Kang-Ming Peng ChangZhi Peng FeiFan Liu BaoYou Zhu BinBin Ni XuDong Gu Long Chen Juan Yi RuoXian Zhou | 2019 | Earth and Planetary Physics2019，3，2： | 2 |
| 15 | Possible change on the runoff in the upper Yellow River basin under global climate change显示文摘In this study,the characteristics and changing trends of temperature,precipitation,and runoff in the upper Yellow River basin up Tangnag station are analyzed by using hydrological and meteorological data in the past 50 years from observation stations in the basin.Further,in this study,the evolving trend of runoff in the future decades is forecasted in the basin based on the method of suppositional climate scenes combination.The results indicate temperature variation in the basin has an evident positive relation with global warming,and the precipitation variations are quite complicated in the basin because of differences of located geographic positions during the past 50 years.Runoff in the basin has been decreasing continually since the end of the 1980s because the mean temperature in the basin has been rising and precipitation in the main areas of runoff formation in the basin has been decreasing.Runoff will largely decrease if precipitation decreases and temperature rises continuously,whereas runoff will increase if temperature is invariable and precipitation increases largely;the increase magnitude of runoff may be more than that of precipitation because of the synchronously increasing supply of meltwater from snow,glacier,and frozen soils in future several decades. | YongChao Lan Jun Wen JunJie Chang YeXin Xu YongPing Shen XingLin Hu JinQi Lu | 2009 | Research in Cold and Arid Regions2009，1，2： | 2 |
| 16 | Prognostic factors and recurrence of hepatitis B-related hepatocellular carcinoma after argon-helium cryoablation: a prospective study显示文摘 | Chunping Wang Yinying Lu Yan Chen Yongyi Feng Linjing An Xinzhen Wang Shuhui Su Wenlin Bai Lin Zhou Yongping Yang Dongping Xu | 2009 | Clinical & Experimental Metastasis2009，，7： | 1 |
| 17 | Identification of NBS-Type Resistance Gene Homologs in Tobacco Genome显示文摘 | Xiaodong Leng Bingguang Xiao Sheng Wang Yijie Gui Yu Wang Xiuping Lu Jiahua Xie Yongping Li Longjiang Fan | 2010 | Plant Molecular Biology Reporter2010，，1： | 1 |
| 18 | Some equivalent definitions of high order Sobolev spaces on stratified groups and generalizations to metric spaces显示文摘 | Yongping Liu Guozhen Lu Richard L. Wheeden | 2002 | Mathematische Annalen2002，，1： | 1 |
| 19 | Some equivalent definitions of high order Sobolev spaces on stratified groups and generalizations to metric spaces显示文摘 | Yongping Liu Guozhen Lu Richard L. Wheeden | 2002 | Mathematische Annalen2002，，1： | 1 |
| 20 | Prognostic factors and recurrence of hepatitis B-related hepatocellular carcinoma after argon-helium cryoablation: a prospective study显示文摘 | Chunping Wang Yinying Lu Yan Chen Yongyi Feng Linjing An Xinzhen Wang Shuhui Su Wenlin Bai Lin Zhou Yongping Yang Dongping Xu | 2009 | Clinical & Experimental Metastasis2009，，7： | 1 |
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