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| 1 | 在过去的十年和未来前景在中国关于城市农村的转变和农村开发的研究进行显示文摘城市农村的转变和农村开发是在关于地理,以及重要实际问题面对瓷器新都市化并且城市、农村的开发的全面计划的领域里的城市农村的关系的话题的研究的最前线的问题。地区性的农业、农村的开发的中心,在中国科学院下面的地理科学和自然资源研究的研究所的部分,在 2005 被建立。中心为在过去的十年在中国在农业地理和农村开发的区域集成研究打了稳固的基础。论文试图在过去的十年期间在中国在农村地理研究考察主要成就,在相关理论和方法分析创新开发,并且建议为支持城市农村的转变和农村地理的全面研究的前景和反措施。研究证明创新成就作为主要国家政策开发,结果的产量和决策支持在过去的十年在中国的农村地理研究被做了;新突破在象地理综合理论,陆地补习工程和技术示范工程,新都市化和城市农村的集成的如此的主要研究工程被完成了;重要进步在活跃地扩展农村地理的边疆并且在土地和资源工程推向前理论的革新被取得了;并且与在所有尊重造一个中等繁荣的社会并且在头脑完成现代化的瓷器发展目标,在农业、农村的地理的创新开发应该试图使研究更战略、系统、科学、面向安全的未来,与给在国际合作和全球农村地理上支持系统的科学研究的注意。 | LIU Yansui LONG Hualou CHEN Yufu WANG Jieyong LI Yurui LIYuheng YANG Yuanyuan ZHOU Yang | 2016 | Journal of Geographical Sciences2016，26，8： | 13 |
| 2 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 3 | Culturing adequate CAR-T cells from less peripheral blood to treat B-cell malignancies显示文摘Objective:Chimeric antigen receptor-modified T(CAR-T)cells have shown impressive results against relapsed/refractory B cell malignancies.However,the traditional manufacture of CAR-T cells requires leukapheresis to isolate large amounts of peripheral blood T cells,thus making some patients ineligible for the procedure.Methods:We developed a simple method for CAR-T cell preparation requiring small volumes of peripheral blood.First,CD3+T cells isolated from 50 mL peripheral blood from patients(B-cell malignancies)were stimulated with immobilized anti-CD3/RetroNectin in 6-well plates and then transduced with CAR-expressing lentiviral vector.After 4 d,the T cells were transferred to culture bags for large-scale CAR-T cell expansion.In vitro and animal experiments were performed to evaluate the activity of the manufactured CAR-T cells.Finally,29 patients with B-cell acute lymphoblastic leukemia(B-ALL)and 9 patients with B-cell lymphoma were treated with the CAR-T cells.Results:The CAR-T cells were expanded to 1–3×10^(8) cells in 8–10 d and successfully killed B cell-derived malignant tumor cells in vitro and in vivo.For patients with B-ALL,the complete remission rate was 93%1 month after CAR-T cell infusion;after 12 months,the overall survival(OS)and leukemia-free survival rates were 69%and 31%,respectively.For patients with lymphoma,the objective response rate(including complete and partial remission)was 78%2 months after CAR-T cell infusion,and after 12 months,the OS and progression-free survival rates were 71%and 43%,respectively.Cytokine-release syndrome(CRS)occurred in 65.51%and 55.56%of patients with B-ALL and B-cell lymphoma,respectively;severe CRS developed in 20.69%of patients with B-ALL and in no patients with lymphoma.Conclusions:Our novel method can generate sufficient numbers of CAR-T cells for clinical use from 50–100 mL peripheral blood,thus providing an alternative means of CAR-T cell generation for patients ineligible for leukapheresis. | Lu Han Jian Zhou Linlin Li Keshu Zhou Lingdi Zhao Xinghu Zhu Qingsong Yin Yufu Li Hongqin You Jishuai Zhang Yongping Song Quanli Gao | 2021 | Cancer Biology & Medicine2021，18，4： | 2 |
| 4 | Microinterface intensification in hydrogenation and air oxidation processes显示文摘Hydrogenations and air oxidations usually have low apparent reaction rate,generally controlled by mass transfer rate,and widely exist in the modern chemical manufacturing process.The key to increase the mass transfer rate is the reduction of the liquid film resistance 1/kLa.In this work,the original concept of microinterface intensification for mass transfer and then for these reactions has been proposed.We derived the regulation model and set up the mathematical calculation method of micron-scale gas-liquid interface structure on mass transfer and reaction,designed the mechanical energy exchange device that can produce gas-liquid microinterface system on a large scale,and established the OMIS system which is able on line to measure the diameter and distribution of millions of microbubbles,interface area a and mass transfer film thicknessδM,as well as developed a series of microinterface intensified reactor systems(MIRs)for the applications of hydrogenation and air oxidation processes.It is believed that this research will provide an up-to-date development for the intensification of hydrogenation and air oxidation reactions. | Hongliang Qian Hongzhou Tian Guoqiang Yang Gaodong Yang Lei Li Feng Zhang Zheng Zhou Weihua Huang Yufu Chen Zhibing Zhang | 2022 | Chinese Journal of Chemical Engineering2022，，10： | 2 |
| 5 | Building new countryside in China: A geographical perspective显示文摘 | Hualou Long Yansui Liu Xiubin Li Yufu Chen | 2009 | Land Use Policy2009，，2： | 1 |
| 6 | Fabrication and characterization of Ba Ce_(0.8)Y_(0.2)O_(2.9)-Ce_(0.85)Sm_(0.15)O_(1.925) composite electrolytes for IT-SOFCs显示文摘The Ba Ce0.8Y0.2O2.9-Ce0.85Sm0.15O1.925 composite electrolytes were prepared with Ba Ce0.8Y0.2O2.9(BCY) and Ce0.85Sm0.15O1.925(SDC). The SDC and BCY powders were mixed in the weight ratio of 95:5, 85:15, and 75:25, respectively(named as BS95, BS85, and BS75). Because of the composite effect between the SDC and BCY phases, the BS95 and BS85 exhibit improved conductivity compared with the pure SDC and BCY. The conductivity of BS95 is higher than that of BS85, indicating that the composite effect of BS95 is greater than that of BS85. Nevertheless, the composite effect in BS75 does not exist. Hence, we conclude that the composite effect in the BCY-SDC composites will decrease with the increase of the amount of BCY and even disappear when the amount of BCY exceeds a certain value. In our case, the optimum composition of the composite electrolyte is 95 wt% SDC and 5 wt% BCY. The BS95 has the highest conductivity(σ1t=0.07808 S cm-1, at 800 °C) and the fuel cell based on the BS95 shows the best performance(the maximum power density reaches as high as 526 mw cm-2 at 750 °C). The encouraging results suggest that the BCY-SDC composites are the very promising electrolyte materials for IT-SOFCs. | Ji Yu Ning Tian Yufu Deng Guannan Li Ling Liu Liying Cheng Peng Gao Qingchao Pan Yuancheng Wang Xiuyan Chen Kezhen Qi | 2015 | Science China Chemistry2015，58，3： | 1 |
| 7 | Building new countryside in China: A geographical perspective 显示文摘 | Long Hualou Liu Yansui Li Xiubin Chen Yufu | 2010 | Land Use Policy2010，，2： | 1 |
| 8 | Non-conjugated polymers as thickness-insensitive electron transport materials in high-performance inverted organic solar cells显示文摘Two non-conjugated polymers PEIE-DBO and PEIE-DCO, prepared by quaternization of polyethyleneimine ethoxylate by 1,8-dibromooctane and 1,8-dichlorooctane respectively, are developed as electron transport layer(ETL) in high-performance inverted organic solar cells(OSCs), and the effects of halide ions on polymeric photoelectric performance are fully investigated. PEIE-DBO possesses higher electron mobility(3.68×10-4 cm2 V-1s-1), higher conductivity and more efficient exciton dissociation and electron extraction, attributed to its lower work function(3.94 eV) than that of PEIE-DCO, which results in better photovoltaic performance in OSCs. The inverted OSCs with PTB7-Th: PC71BM as photoactive layer and PEIE-DBO as ETL exhibit higher PCE of 10.52%, 9.45% and 9.09% at the thickness of 9, 35 and 50 nm,respectively. To our knowledge, PEIE-DBO possesses the best thickness-insensitive performance in polymeric ETLs of inverted fullerene-based OSCs. Furthermore, PEIE-DBO was used to fabricate the inverted non-fullerene OSCs(PM6:Y6) and obtained a high PCE of 15.74%, which indicates that PEIE-DBO is effective both in fullerene-based OSCs and fullerene-free OSCs. | Zhiquan Zhang Zheling Zhang Yufu Yu Bin Zhao Sheng Li Jian Zhang Songting Tan | 2020 | Journal of Energy Chemistry2020，29，8： | 1 |
| 9 | Vulcanizing kinetics of silicone rubber显示文摘 | Yuan Qiang Li Yufu Li Guangliang | 1988 | Chinese Journal of Polymer Science1988，6，4： | 1 |
| 10 | Characterization of the lubricity of bio-oil/diesel fuel blends by high frequency reciprocating test rig显示文摘 | Yufu Xu Qiongjie Wang Xianguo Hu Chuan Li Xifeng Zhu | 2009 | Energy2009，，1： | 1 |
| 11 | Driving mechanisms of desertification process in the Horqin Sandy Land—a case study in Zhalute Banner,Inner Mongolia of China显示文摘Both natural and human factors contributing to desertification were examined to understand the driving mechanisms of the desertification process in Zhalute Banner,Inner Mongolia of China.The coefficient of variation(CV)and climate departure index(Z)were calculated to examine the fluctuations and trends of interannual variations of temperature and precipitation;TM remote sensing data was extracted to obtain the sandy land area;linear regression analysis was used to analyze climate changes and the socio-economic evolution over the years,and it was also used to standardize the variables,which included annual temperature,annual precipitation,human population,and livestock number,in order to measure the difference in the rate of change between climate and anthropogenic factors.The results showed that there was a rise of about 1.6uC in temperature but no significant change in precipitation from 1961 to 2000,which indicated a short-term climatic trend toward aridity in this area,a condition necessary for desertification.The fraction of precipitation in spring tended to increase whilst the fraction in autumn and winter decreased.Both the human population and livestock population had tripled and the cultivated area had doubled from 1961 to 2000,suggesting that socio-economic factors might have contributed more significantly to the desertification.Between 1988 and 1997,the sandy land area increased by 12.5%,nearly 2.4 times in the farming section.It could be concluded that the driving mechanisms of the desertification processes in Zhalute banner are mainly the policy of cropland expansion and the rising populations of humans and their livestock,which has affected the land use pattern in the past decades. | Haiping TANG Yufu CHEN Xinyu LI | 2008 | Frontiers of Environmental Science & Engineering2008，2，4： | 1 |
| 12 | Overexpression of a maize WRKY58 gene enhances drought and salt tolerance in transgenic rice显示文摘 | Ronghao Cai Yang Zhao Yufu Wang Yongxiang Lin Xiaojian Peng Qian Li Yuwei Chang Haiyang Jiang Yan Xiang Beijiu Cheng | 2014 | Plant Cell, Tissue and Organ Culture (PCTOC)2014，，3： | 1 |
| 13 | Development and characterization of polymorphic microsatellite markers in Linum usitatissimum显示文摘 | Xin Deng Songhua Long Dongfeng He Xiang Li Yufu Wang Jia Liu Xinbo Chen | 2010 | Journal of Plant Research2010，，1： | 1 |
| 14 | On the thermal oxidation stability of pyrolysis biomass oil 显示文摘 | HU Xianguo LI Chuan XU Yufu | 2011 | International Journal of Renewable Energy Technology2011，2，2： | 1 |
| 15 | Density Map Guided Region Localization for End-to-End Small Object Detection显示文摘With the advancement of society and science and technology, the demand for detecting small objects in practical scenarios becomes stronger. Such objects are only represented by relatively small coverage of pixels, and the features are degraded severely after being extracted by a deep convolutional neural network, which is detrimental to the detection performance for small objects. Therefore, an intuitive solution is to increase the resolution of small objects by cropping the original image. In this paper, we propose a simple but effective object density map guided region localization module (DMGRL) to locate and crop the regions of interest where small objects may exist. Firstly, the density map of the objects is estimated by object density map estimation network, and then the coordinates of the small object regions are calculated;Secondly, the continuous differentiable affine transformation is utilized to crop these regions so that the detector with DMGRL can be trained end-to-end instead of two-stage training. Finally, the all prediction results of input image and cropped region images are merged together to output the final detection results by non maximum suppression (NMS). Extensive experiments demonstrate the superior performance of the detector incorporated DMGRL. | Bo LI Kai HUANG Junhui LI Yufu LIAO | 2023 | Journal of Systems Science and Information2023，11，6： | 0 |
| 16 | Discussion on the Treatment of Palmoplantar Keratosis by TCM Soaking and Washing显示文摘By combing the mechanism and advantages of traditional Chinese medicine(TCM)soaking and washing and combining TCM syndrome differentiation with western medicine differentiation of diseases,guided by the view that'the principle of external treatment is that of internal treatment',this article discusses the differentiation and treatment ideas of palmoplantar keratosis by TCM soaking and washing,which will provide a reference for clinical treatment. | Yufu FANG Yanshen HU Juntao XU Li WANG Wenyu ZHAO | 2023 | Medicinal Plant2023，14，3： | 0 |
| 17 | Morphology-Tunable Fluorescent Nanoparticles: Synthesis, Photophysical Properties and Two-Photon Cell Imaging显示文摘一篇小说水溶性荧光灯 amphiphile 基于氨基的聚乙烯乙二醇(PEG-NH 2) 代替了 oligo (p-phenyleneethynylene )( 打开) 成功地被设计并且综合。拿阴离子打开是的 amphiphile 比较, photophysical 特征通过紫外吸收被调查(紫外) 并且光致发光(PL ) 分析。由于 OPE 的恐水病吸水的性质结合了分子,有从“谷物”与形态学的变化一起从 19.6 ~ 93.5 nm 到“草莓”的尺寸的自我装配的 nanoparticles 方便地经由调整集中被准备打开水的答案。在为时间的一个时期的老化以后,有趣地,同类的空 nanospheres 自发地与大约 200 nm 的一条直径被构造。Cytotoxicity 测试和 nanoparticles 的细胞的举起行为进一步被调查评估他们的潜在的生物医学的应用。随后,二光子的房间成像的有希望的应用用人的胰腺的癌症房间(PANC-1 房间) 被探索,它显示 nanoparticles 主要位于房间细胞质以内。 | Xiaoming Hu Chao Yin Wenbo Hu Zhen Yang Jie Li Xiang Li Xiaomei Lu Hui Zhao Yufu Tang Quli Fan Wei Huang | 2015 | Chinese Journal of Chemistry2015，33，8： | 0 |
| 18 | Trees as hotspots:Using forests,trees,and agroforestry to foster diverse sustainable landscapes显示文摘Forests,trees,and agroforestry(FTA)are ecosystem hotspots.They exemplify the contributions of biodiversity to sustainable and resilient landscapes,green circular economy and to sustainable agriculture and food systems for healthy diets.However,most research on these topics have been performed separately and lack comparison.The International FTA-Kunming Conference'Forests,trees and agroforestry for diverse sustainable landscapes'22nd–24th June 2021,focused on these contributions,brought together scientists NGOs,and policy makers to further the understanding of tree diversity;provided a communication platform for scientists to share their research results;evaluated the role of tree diversity in agroecology and circular agriculture;assessed benefits of landscape restoration;and explored applied research in mountain ecosystems and food security.The goals were to gather evidence that ground the design of solutions that can contribute to the implementation of the post 2020 Global Biodiversity Framework and towards the UN Food Systems Summit,and the overall implementation of the SDGs.This paper summarizes the outcomes of the international FTA Conference in Kunming 2021 and points out the highlights of research involved in six major themes. | Vincent Gitz Jianchu Xu Yuanchang Lu Elaine Springgay Illias Animon Razan Khalifa Al Mubarak Robert Nasi Tony Simons Ranjit Barthakur Ren Wang Jianrong Su Fergus Sinclair Eduardo Somarriba Dossa G.O.Gbadamassi Ramni Jamnadass Christopher JKettle Dengpan Bu Anja Gassner Yves Laumonier Mi Zhou Himlal Baral Fangyuan Hua Peter AMinang Yufu Guo Michael Allen Brady Yanxia Li Peter Mortimer Bin Yang Heng Gui Fiona Worthy Deli Zhai Huafang Chen Huili Li Yufang Su Alexandre Meybeck Fabio Ricci | 2022 | Circular Agricultural Systems2022，2，1： | 0 |
| 19 | Negative correlation between acetyl-CoA acyltransferase 2 and cetuximab resistance in colorectal cancer显示文摘The emergence of anti-EGFR therapy has revolutionized the treatment of colorectal cancer(CRC).However,not all patients respond consistently well.Therefore,it is imperative to conduct further research to identify the molecular mechanisms underlying the development of cetuximab resistance in CRC.In this study,we find that the expressions of many metabolism-related genes are downregulated in cetuximab-resistant CRC cells compared to their sensitive counterparts.Specifically,acetyl-CoA acyltransferase 2(ACAA2),a key enzyme in fatty acid metabolism,is downregulated during the development of cetuximab resistance.Silencing of ACAA2 promotes proliferation and increases cetuximab tolerance in CRC cells,while overexpression of ACAA2 exerts the opposite effect.RTK-Kras signaling might contribute to the downregulation of ACAA2 expression in CRC,and ACAA2 predicts CRC prognosis in patients with Kras mutations.Collectively,our data suggest that modulating ACAA2 expression contributes to secondary cetuximab resistance in Kras wild-type CRC patients.ACAA2 expression is related to Kras mutation and demonstrates a prognostic role in CRC patients with Kras mutation.Thus,ACAA2 is a potential target in CRC with Kras mutation. | Yitao Yuan Xun Sun Mengling Liu Suyao Li Yu Dong Keshu Hu Jiayu Zhang Bei Xu Sining Ma Hesheng Jiang Pengcong Hou Yufu Lin Lu Gan Tianshu Liu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，9： | 0 |
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