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| 1 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
| 2 | Achieving Ultra-Wideband and Elevated Temperature Electromagnetic Wave Absorption via Constructing Lightweight Porous Rigid Structure显示文摘Realizing ultra-wideband absorption,desirable attenuation capability at high temperature and mechanical requirements for real-life applications remains a great challenge for microwave absorbing materials.Herein,we have constructed a porous carbon fiber/polymethacrylimide(CP)structure for acquiring promising microwave absorption performance and withstanding both elevated temperature and high strength in a low density.Given the ability of porous structure to induce desirable impedance matching and multiple reflection,the absorption bandwidth of CP composite can reach ultra-wideband absorption of 14 GHz at room temperature and even cover the whole X-band at 473 K.Additionally,the presence of imide ring group in polymethacrylimide and hard bubble wall endows the composite with excellent heat and compressive behaviors.Besides,the lightweight of the CP composite with a density of only 110 mg cm^(−3) coupled with high compressive strength of 1.05 MPa even at 453 K also satisfies the requirements in engineering applica-tions.Compared with soft and compressible aerogel materials,we envision that the rigid porous foam absorbing material is particularly suitable for environmental extremes. | Zibao Jiao Wenjun Huyan Feng Yang Junru Yao Ruiyang Tan Ping Chen Xuewei Tao Zhengjun Yao Jintang Zhou Peijiang Liu | 2022 | Nano-Micro Letters2022，14，11： | 1 |
| 3 | Longitudinal connection effect on initial support steel frames in tunnels--Take the traffic tunnels as examples显示文摘Most tunnel projects are designed with cross-sectional loads,and the inhomogeneity of the longitudinal forces is ignored.In theory,such a support structure can resist large loads,but in practice,large deformation,concrete cracking,steel frame distortion,and other phenomena often occur in tunnels under poor surrounding rock conditions.Hence,the longitudinal stability of the tunnel must be considered.In this study,the mechanism of longitudinal connecting ribs(LCRs)of tunnels was investigated through element tests,theoretical analyses,and numerical simulations,and the effect of the LCRs was evaluated experimentally.The applicability of the constitutive relations and boundary conditions of the numerical model was verified.The instability mode of the steel frame reflecting the longitudinal stress gradient of the tunnel was analyzed,and the longitudinal surrounding rock pressure and the verified numerical model were applied to analyze the LCR using the load structure method.The results indicate the following:(1)LCRs can effectively improve the ultimate bearing capacity and stability of a structure and reduce the area and degree of damage;(2)Two types of instability modes occur in tunnel steel frames,and the main factor is bending failure caused by the axial force;(3)The distance sensitivity of the LCR in the tunnel is higher than the stiffness sensitivity.For large deformations of tunnels,double rows of rebars with a spacing of less than 1.5 m should be used as longitudinal connections. | Kaimeng Ma Jichun Zhang Junru Zhang Zhiyong Wang Jimeng Feng | 2022 | Underground Space2022，7，4： | 0 |
| 4 | Multi-functional and multi-scenario applications for MXene aerogels with synergistically enhanced asymmetric modules显示文摘The development of multifunctional materials and synergistic applications of various functions are important conditions for integrated and miniaturized equipment.Here,we developed asymmetric MXene/aramid nanofibers/polyimides(AMAP)aerogels with different modules using an integrated molding process.Cleverly asymmetric modules(layered MXene/aramid nanofibers section and porous MXene/aramid nanofibers/polyimides section)interactions are beneficial for enhanced performances,resulting in low reflection electromagnetic interference(EMI)shielding(specific shielding effectiveness of 2483(dB·cm^(3))/g and a low R-value of 0.0138),high-efficiency infrared radiation(IR)stealth(ultra-low thermal conductivity of 0.045 W/(m·K)and IR emissivity of 0.32 at 3–5μm and 0.28 at 8–14μm),and excellent thermal management performances of insulated Joule heating.Furthermore,these multifunctional AMAP aerogels are suitable for various application scenarios such as personal and building protection against electromagnetic pollution and cold,as well as military equipment protection against infrared detection and EMI. | Junru Yao Jintang Zhou Feng Yang Guiyu Peng Yijie Liu Zhengjun Yao Fan Wu Haibo Zeng | 2024 | Nano Research2024，17，4： | 0 |
| 5 | An Analysis of the Static and Dynamic Behavior of the Hydraulic Compensation System of a Multichannel Valve显示文摘Electro-hydraulic proportional valve is the core control valve in many hydraulic systems used in agricultural and engineering machinery.To address the problem related to the large throttling losses and poor stability typically associated with these valves,here,the beneficial effects of a triangular groove structure on the related hydraulic response are studied.A mathematical model of the pressure compensation system based on the power-bond graph method is introduced,and the AMESim software is used to simulate its response.The results show that the triangular groove structure increases the jet angle and effectively compensates for the hydrodynamic force.The steady-state differential pressure at the valve port of the new pressure compensation structure was 0.65 MPa.Furthermore,experimental results show that the pressure difference at the main valve port is 0.73 MPa,and that the response time is less than 0.2 s.It is concluded that the new compensation structure has good pressure compensation response characteristics. | Jikang Xu Ruichuan Li Yi Cheng Yanchao Li Junru Yang Chenyu Feng Xinkai Ding Huazhong Zhang | 2023 | Fluid Dynamics & Materials Processing2023，19，7： | 0 |
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