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| 1 | Verification and fine-mapping of QTLs conferring days to flowering in soybean using residual heterozygous lines显示文摘The results of QTL mapping based on a primary mapping population should be further verified and refined for its real utilization in marker-assisted selection or map-based cloning.The primary mapping population contains 114 BC1F1 plants of the backcross between Essex (maturity group V,MG V) as the donor parent and ZDD2315 (MG II) as the recurrent parent.In this study,a genetic linkage map with 250 SSR markers spanning a total length of 2963.5 cM on 25 linkage groups (LG) was constructed using software MAPMAKER3.0.Six kinds of genetic statistical models of 4 softwares,i.e.WinQTL Cartographer Version 2.5,IciMapping Version 2.0,MapQTL Version 5.0 and QTLnetwork Version 2.0,were used to map QTLs conferring days to flowering of the BC1F3 lines.Nine QTLs were mapped on 6 different linkage groups (LG).Of those,6 QTLs were detected by at least two different genetic statistical models,while the other three were detected by only one procedure.Among the three QTLs,Flwdt7 was mapped between Sat_213 and Satt643 on LG C2 with only 11.0% contribution rate.For confirmation of Flwdt7,5 RHL populations were developed through selfing eight BC1F5 plants heterozygous at seven markers around the locus.The RHL populations with the same segregating loci were bulked and used to construct a secondary linkage map of the specific segment using software JoinMap 3.0.The genetic distances among the markers on the specific segment became shorter than those of the whole genome map.On the secondary map,Flwdt7 was mapped between Satt277 and Satt489,next to its primary interval Sat_213-Satt643,with distance 1.40 cM to Satt277 and 0.45 cM to Satt489,confidence interval narrowed to 2.7 cM,and contribution rate increased to 36.8%.The results were confirmed with significance analysis among marker genotypes on individual loci and comparison analysis of target marker intervals among near isogenic lines (plants).Thus the strategy by using residual heterozygous lines for QTL fine-mapping on target segments based on primary whole genome scanning with multiple mapping models was demonstrated to be effective. | SU ChengFu LU WeiGuo ZHAO TuanJie GAI JunYi | 2010 | Chinese Science Bulletin2010，55，6： | 6 |
| 2 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 3 | Exploration of presence/absence variation and corresponding polymorphic markers in soybean genome显示文摘This study was designed to reveal the genome‐wide distribution of presence/absence variation(PAV) and to establish a database of polymorphic PAV markers in soybean. The 33 soybean whole‐genome sequences were compared to each other with that of Williams 82 as a reference genome. A total of 33,127 PAVs were detected and 28,912 PAV markers with their primer sequences were designed as the database NJAUSoyPAV_1.0. The PAVs scattered on whole genome while only 518(1.8%) overlapped with simple sequence repeats(SSRs) in BARCSOYSSR_1.0database. In a random sample of 800 PAVs, 713(89.13%) showed polymorphism among the 12 differential genotypes. Using 126 PAVs and 108 SSRs to test a Chinese soybean germplasm collection composed of 828 Glycine soja Sieb. et Zucc. and Glycine max(L.) Merr. accessions, the per locus allele number and its variation appeared less in PAVs than in SSRs. The distinctness among alleles/bands of PCR(polymerase chain reaction) products showed better in PAVs than in SSRs, potential in accurate marker‐assisted allele selection. The association mapping results showed SSR t PAV was more powerful than any single marker systems.The NJAUSoyPAV_1.0 database has enriched the source of PCR markers, and may fit the materials with a range of per locus allele numbers, if jointly used with SSR markers. | Yufeng Wang Jiangjie Lu Shouyi Chen Liping Shu Reid G.Palmer Guangnan Xing Yan Li Shouping Yang Deyue Yu Tuanjie Zhao Junyi Gai | 2014 | Journal of Integrative Plant Biology2014，56，10： | 5 |
| 4 | Cytoplasmic and nuclear genome variations of rice hybrids and their parents inform the trajectory and strategy of hybrid rice breeding显示文摘The male sterility(MS)line is a prerequisite for efficient production of hybrid seeds in rice,a self-pollinating species.MS line breeding is pivotal for hybrid rice improvement.Understanding the historical breeding tra-jectory will help to improve hybrid rice breeding strategies.Maternally inherited cytoplasm is an appro-priate tool for phylogenetic reconstruction and pedigree tracing in rice hybrids.In this study,we analyzed the cytoplasmic genomes of 1495 elite hybrid rice varieties and identified five major types of cytoplasm,which correspond to different hybrid production systems.As the cytoplasm donors for hybrids,461 MS lines were also divided into five major types based on cytoplasmic and nuclear genomic architecture.Spe-cific core accessions cooperating with different fertility-associated genes drove the sequence divergence of MS lines.Dozens to hundreds of convergent and divergent selective sweeps spanning several agro-nomic trait-associated genes were identified among different types of MS lines.We further analyzed the cross patterns between different types of MS lines and their corresponding restorers.This study system-atically analyzed the cytoplasmic genomes of rice hybrids revealed their relationships with nuclear ge-nomes of MS lines,and illustrated the trajectory of hybrid rice breeding and the strategies for breeding different types of MS lines providing new insights for future improvement of hybrid rice. | Zhoulin Gu Zhou Zhu Zhen Li Qilin Zhan Qi Feng Congcong Zhou Qiang Zhao Yan Zhao Xiaojian Peng Bingxin Dai Rongrong Sun Yan Li Hengyun Lu Lei Zhang Tao Huang Junyi Gong Danfeng Lv Xuehui Huang Bin Han | 2021 | Molecular Plant2021，14，12： | 2 |
| 5 | Generation of human hepatocytes from extended pluripotent stem cells显示文摘Dear Editor,Human pluripotent stem cells have great potential for application in regenerative medicine,as they permit the generation of different lineages of functional cell types via directed differentiation.1 However,application of conventional human pluripotent stem cells is limited due to several factors,including heterogeneity in pluripotency,differentiation bias,relatively slow proliferation,and poor single-cell survival.2 Toovercome these problems. | Qiming Wang Da Sun Zhen Liang Junyi Wang Xinxing Zhong Yulin Lyu Junning Cao Zhongqing Lin Yuanyuan Du Zhenchuan Miao Shichun Lu Cheng Li Jun Xu Yan Shi Hongkui Deng | 2020 | Cell Research2020，30，9： | 1 |
| 6 | The draftgenome of a diploid cotton gossypium raimondii 显示文摘 | Kunbo Wang Zhiwen Wang Fuguang Li Wuwei Ye Junyi Wang Guoli Song Zhen Yue Lin Cong Haihong Shang Shilin Zhu Changsong Zou Qin Li Youlu Yuan Cairui Lu Hengling Wei Caiyun Gou Zequn Zheng Ye Yin Xueyan Zhang Kun Liu Bo Wang Chi Song Nan Shi Russell J Kohel Richard G Percy John Z Yu Yu-xian Zhu Jun Wang Shuxun Yu | 2012 | Nat Genet2012，，44： | 1 |
| 7 | The effect of temperature on gonad,embryonic development and survival rate of juvenile seahorses,Hippocampus kuda Bleeker显示文摘 | LIN Qiang LU Junyi GAO Yongli | 2006 | Aquaculture2006，254，： | 1 |
| 8 | Brilliant blue G attenuates lipopolysaccharide-mediated microglial activation and inflammation显示文摘Previous studies have confirmed that oxidized adenosine triphosphate, a P2X7 receptor antagonist, attenuates lipopolysaccharide-mediated microglial activation and inflammatory expression following neuronal damage in rat brain. NaCl and temperature may affect the potency of oxidized adenosine triphosphate. Brilliant blue G is a derivative of a widely used food additive and has little toxicity. This study explored the effects of brilliant blue G, a selective P2X7 receptor antagonist, on microglial activation and inflammation. Results demonstrated that brilliant blue G inhibited the release of cyclooxygenase-2 and interleukin-6 in BV2 cells. Immunofluorescence displayed that brilliant blue G could suppress lipopolysaccharide-induced microglial activation. This study used RNA interference to block P2X7 receptor expression and found that small interfering RNA also suppressed the release of cyclooxygenase-2 and interleukin-6 in BV2 cells. These results suggested that downregulation of the P2X7 receptor by brilliant blue G was involved in the inhibition of microglial activation and inflammation. | Kui Lu Jue Wang Bin Hu Xiaolei Shi Junyi Zhou Yamei Tang Ying Peng | 2013 | Neural Regeneration Research2013，8，7： | 1 |
| 9 | Enhancement of endocytic uptake of H IV-1 virions into CD4-negative epithelial cells by HIV-1 gp41 via its interaction with POB1显示文摘 | Yue Tan Junyi Wang Shan Su Qian Wang Shibo Jiang Lu Lu Ying-Hua Chen | 2017 | Cellular & Molecular Immunology2017，14，6： | 1 |
| 10 | Increasing Prevalence of Type 2 Diabetes in Chinese Adults in Shanghai显示文摘 | Li Rui Lu Wei Jiang Qing Wu Li Yan Yun Zhao Gen Ming Shi Liang Yang Qu Di Ruan Ye Jiang Junyi Zhang Sheng Nian Xu Wang Hong Zhong Wei Jian | 2012 | EN2012，，5： | 1 |
| 11 | Manipulating functional groups between polyvinylidene difluoride and nanoparticles for high-performance triboelectric nanogenerator显示文摘Interface functional groups play an essential role in regulating the electrical properties of bulk materials.In this work,we designed a novel strategy to explore a new way to enhance triboelectric performance by regulating the functional groups between nano-fillers and polymer matrix without obvious changes in the dielectric constant.The silica nanoparticles(SNPs)modified perfluoro-silane coupling agents(PFSCAs)with different chain lengths were added to the polyvinylidene difluoride to regulate the transferred charge density(TCD)of triboelectric nanogenerators(TENGs).When the doping concentration of perfluorodecyl modified SNPs is 2.25 wt.%,the nanocomposite film based TENG exhibits the maximum TCD of 166μC/m^(2)and power density of 3.12 W/m^(2)which are 6 times and 39 times as big as those of pure polyvinylidene difluoride(PVDF)film.The charge accumulation and decay process show that interface functional groups dominate the performance of TENGs.Then,a Fermi level model is proposed and why the TCD could be regulated by the concentration of nanoparticles in bulk materials is explained.This work provides a new concept for understanding the performance of TENG independent dielectric constant and points out a new direction for enhancing TENG’s performance,since wealthy functional groups with selectivity are applicable. | Zekun Li Lu Zhang Lihao Guo Wenwen Hu Aifang Yu Junyi Zhai | 2023 | Nano Research2023，16，9： | 1 |
| 12 | Genetic variants in the Hedgehog signaling pathway genes are associated with gastric cancer risk in a Chinese Han population显示文摘The Hedgehog signaling pathway participates in the occurrence and progression of cancers including gastric cancer.We conducted this study to evaluate whether genetic variants in the Hedgehog signaling pathway genes would affect gastric cancer risk.Multi-marker Analysis of GenoMic Annotation(MAGMA)was used to investigate the aggregated genetic effects of single nucleotide polymorphisms(SNPs)assigned to candidate genes.The relationship between SNPs and gastric cancer risk was estimated by multivariate logistic regression analyses.Gene expression was calculated using databases obtained from The Cancer Genome Atlas(TCGA)and The Gene Expression Omnibus(GEO).Kaplan‐Meier plotter was used to evaluate the association between gene expression with gastric cancer survival.Tumor Immune Estimation Resource 2.0(TIMER 2.0)was applied to determine the correlation between selected gene expression and the immune cell infiltration degree.We identified that the G allele of rs2990912 in KIF27 was associated with higher gastric cancer risk,especially in the young and male subgroups.The expression of KIF27 in gastric cancer tissues was higher than that in normal tissues,leading to poor survival in gastric cancer patients.Besides,KIF27 expression was related to immune cell infiltration and positively correlated with PD-L1 expression.Our findings highlight the key role of genetic variation in the Hedgehog signaling pathway genes in gastric cancer susceptibility,which may provide important insights into the diagnosis,prognosis,and treatment of gastric cancer. | Yujuan Zhang Kai Lu Xu Wu Hanting Liu Junyi Xin Xiaowei Wang Weida Gong Qinghong Zhao Meilin Wang Haiyan Chu Mulong Du Guoquan Tao Zhengdong Zhang | 2022 | The Journal of Biomedical Research2022，36，1： | 1 |
| 13 | A comprehensive profile of TCF1^(+)progenitor and TCF1−terminally exhausted PD-1^(+)CD8^(+)T cells in head and neck squamous cell carcinoma:implications for prognosis and immunotherapy显示文摘The heterogeneity of exhausted T cells(Tex)is a critical determinant of immune checkpoint blockade therapy efficacy.However,few studies have explored exhausted T cell subpopulations in human cancers.In the present study,we examined samples from two cohorts of 175 patients with head and neck squamous cell cancer(HNSCC)by multiplex immunohistochemistry(mIHC)to investigate two subsets of Tex,CD8+PD1+TCF1+progenitor exhausted T cells(TCF1+Texprog)and CD8+PD1+TCF1−terminally exhausted T cells(TCF1−Texterm).Moreover,fresh tumor samples from 34 patients with HNSCC were examined by flow cytometry and immunohistochemistry to further investigate their properties and cytotoxic capabilities and their correlation with regulatory T cells(Tregs)in the tumor immune microenvironment(TIME).mIHC and flow cytometry analysis showed that TCF1−Texterm represented a greater proportion of CD8+PD1+Tex than TCF1+Texprog in most patients.TCF1+Texprog produced abundant TNFα,while TCF1−Texterm expressed higher levels of CD103,TIM-3,CTLA-4,and TIGIT.TCF1−Texterm exhibited a polyfunctional TNFα+GZMB+IFNγ+phenotype;and were associated with better overall survival and recurrence-free survival.The results also indicated that larger proportions of TCF1−Texterm were accompanied by an increase in the proportion of Tregs.Therefore,it was concluded that TCF1−Texterm was the major CD8+PD1+Tex subset in the HNSCC TIME and that these cells favor patient survival.A high proportion of TCF1−Texterm was associated with greater Treg abundance. | Dikan Wang Juan Fang Shuqiong Wen Qunxing Li Jinming Wang Lisa Yang Wenxiao Dai Huanzi Lu Junyi Guo Zhongyan Shan Wenqiang Xie Xiangqi Liu Liling Wen Jie Shen Anxun Wang Qianming Chen Zhi Wang | 2022 | International Journal of Oral Science2022，14，1： | 0 |
| 14 | Country-level land carbon sink and its causing components by the middle of the twenty-first century显示文摘Background:Countries have long been making efforts by reducing greenhouse-gas emissions to mitigate climate change.In the agreements of the United Nations Framework Convention on Climate Change,involved countries have committed to reduction targets.However,carbon(C)sink and its involving processes by natural ecosystems remain difficult to quantify.Methods:Using a transient traceability framework,we estimated country-level land C sink and its causing components by 2050 simulated by 12 Earth System Models involved in the Coupled Model Intercomparison Project Phase 5(CMIP5)under RCP8.5.Results:The top 20 countries with highest C sink have the potential to sequester 62 Pg C in total,among which,Russia,Canada,USA,China,and Brazil sequester the most.This C sink consists of four components:productiondriven change,turnover-driven change,change in instantaneous C storage potential,and interaction between production-driven change and turnover-driven change.The four components account for 49.5%,28.1%,14.5%,and 7.9%of the land C sink,respectively.Conclusion:The model-based estimates highlight that land C sink potentially offsets a substantial proportion of greenhouse-gas emissions,especially for countries where net primary production(NPP)likely increases substantially and inherent residence time elongates. | Lifen Jiang Junyi Liang Xingjie Lu Enqing Hou Forrest MHoffman Yiqi Luo | 2021 | Ecological Processes2021，10，1： | 0 |
| 15 | Unraveling energy and charge transfer in type-II van der Waals heterostructures显示文摘Recent experiments observed significant energy transfer in type-II van der Waals(vdW)heterostructures,such as WS_(2)/MoSe_(2),which is surprising due to their staggered band alignment and weak spectral overlap.In this work,we carry out first-principles calculations to shed light on energy and charge transfer in WS_(2)/MoSe_(2) heterostructure.Incorporating excitonic effect in nonadiabatic electronic dynamics,our first-principles calculations uncover a two-step process in competing energy and charge transfer,unravel their relative efficiencies and explore the means to control their competition.While both Dexter and Förster mechanisms can be responsible for energy transfer,they are shown to operate at different conditions.The excitonic effect is revealed to drive ultrafast energy and charge transfer in type-II WS_(2)/MoSe_(2) heterostructure.Our work provides a comprehensive picture of exciton dynamics in vdW heterostructures and paves the way for rational design of novel vdW heterostructures for optoelectronic and photovoltaic applications. | Junyi Liu Zi Li Xu Zhang Gang Lu | 2021 | npj Computational Materials2021，，1： | 0 |
| 16 | A dynamic speed guidance method at on-ramp merging areas of urban expressway considering driving styles显示文摘Dynamic speed guidance for vehicles in on-ramp merging zones is instrumental in alleviating traffic congestion on urban expressways.To enhance compliance with recommended speeds,the development of a dynamic speed-guidance mechanism that accounts for heterogeneity in human driving styles is pivotal.Utilizing intelligent connected technologies that provide real-time vehicular data in these merging locales,this study proposes such a guidance system.Initially,we integrate a multi-agent consensus algorithm into a multi-vehicle framework operating on both the mainline and the ramp,thereby facilitating harmonized speed and spacing strategies.Subsequently,we conduct an analysis of the behavioral traits inherent to drivers of varied styles to refine speed planning in a more efficient and reliable manner.Lastly,we investigate a closed-loop feedback approach for speed guidance that incorporates the driver’s execution rate,thereby enabling dynamic recalibration of advised speeds and ensuring fluid vehicular integration into the mainline.Empirical results substantiate that a dynamic speed guidance system incorporating driving styles offers effective support for human drivers in seamless mainline merging. | Haoran LI Yunpeng LU Yaqiu LI Junyi ZHANG | 2024 | Frontiers of Engineering Management2024，11，1： | 0 |
| 17 | A novel nine gene signature integrates stemness characteristics associated with prognosis in hepatocellular carcinoma显示文摘Cancer stem cells(CSCs)are heterogeneous with self-renewal and differentiation ability.The mRNA expression-based stemness index(mRNAsi)described the similarity between tumor cells and CSCs,which is positively associated with the poor prognosis of cancer patients.However,the key prognostic genes related to mRNAsi in hepatocellular carcinoma(HCC)remains unclear.A 9-gene signature related to mRNAsi and HCC prognosis including PSMG3,SNRPD1,DTYMK,PIGU,NME1,TXNL4A,IPO4,PES1,and REXO4 was obtained.High expression of this signature indicates poor prognosis of HCC.PIGU was an independent prognostic factor of HCC,which was significantly associated with progression of HCC.Among them,DTYMK and NME1 enriched in pyrimidine metabolism,SNRPD1 and TXNL4A enriched in spliceosome and PIGU enriched in glycosyl phosphatidylinositol(GPI)-anchor biosynthesis pathways.High levels of IPO4,NME1,PES1,PIGU and SNRPD1 were closely associated with metastasis of HCC,and low levels of IPO4,PIGU and REOX4 were significantly associated with sorafenib resistance of HCC.High expression of the 9-gene signature was negatively correlated with the stromal cell infiltration,and positively correlated with specific immune subtypes-related to angiogenesis,M1/M2 macrophage polarization,and M2 response.The 9-gene signature was negatively correlated with the stroma,and SNRPD1 and TXNL4 were positively correlated with immune infiltrate.NME1 was negatively correlated with tumor purity.Therefore,a 9-gene signature related to mRNAsi and poor prognosis in HCC were identified,which can be used as biomarkers for the diagnosis of HCC and functional mechanism exploration of CSCs in HCC.These genes such as IPO4 and PIGU might drive the transition of tumor cells into CSCs which possibly controls the balance between metastasis and drug resistance in HCC.The challenge on balance between metastasis and drug resistance for tumor therapy was firstly reported by the present study. | XINGHONG YAO CHENGQUAN LU JUNYI SHEN WENLI JIANG YAN QIU YE ZENG LIANG LI | 2021 | BIOCELL2021，45，6： | 0 |
| 18 | Fabrication of highly luminescent TiO_(2):Eu^(3+) thin film with low annealing temperature requirement by co-doping with Sn^(4+) ions显示文摘Rare earth(RE)-doped TiO_(2)thin films possess important applications in modern optoelectronic devices.However,the high annealing temperature requirement remains a critical restriction in device fabrications.In this work,TiO_(2)thin films doped with trivalent europium(Eu^(3+))ions were fabricated by a convenient sol-gel approach and subsequent annealing treatment.Interestingly,it is found that the optimal post-annealing temperature of TiO_(2):Eu^(3+)thin film is dramatically reduced from 800 to 300℃by incorporating 10 at%Sn^(4+)into the sol precursor.The Sn-incorporated film annealed at 300℃shows a 4-fold enhancement in photoluminescence(PL)intensity related to Eu^(3+)ions to the optimized Sn-free film.Systematic analysis reveals that this enhancement is attributed to Sn element promoting the crystallization of both anatase TiO_(2)and rutile SnO_(2)clusters at 300℃,which provides sufficient SnO_(2)/TiO_(2)crystal boundary facilitating Eu^(3+)to occupy and sensitized by SnO_(2)crystals.These results provide valuable insights into fabricating highly luminescent RE-doped TiO_(2)thin films with low annealing temperature requirement,which is essential for designing optoelectronic devices based on RE materials more freely in the future. | Lu Zhang Bolin Zheng Junyi Zhai Tao Lin | 2023 | Journal of Rare Earths2023，41，10： | 0 |
| 19 | The ternary combination of polymer gel, microsphere and surfactant for conformance control and oil displacement to improve oil recovery in strong heterogeneous reservoir显示文摘The reservoir heterogeneity of Suizhong 36-1 oilfield is very obvious,the average permeability reaches 2000mD.Long-term water injection development leads to serious water channeling in high permeability layers,resulting in ineffective circulation of injected water and reduction of oil recovery.It is urgent to form an effective EOR method.In this paper,the oil displacement effect of different combination slugs including polymer gel,polymer microsphere and surfactant is evaluated by means of conformance control and chemical flooding.Three-layer heterogeneous 3-D plate model is used for oil displacement experiment.The experimental results show that the combination slug sequentially composed of polymer gel,polymer microspheres and surfactant have the best oil displacement effect with the oil recovery increment by 21.2% after the first water flooding.In addition,using the best slug combination for two rounds flooding,the recovery factor increased by 28.2% compared with the first water flooding.This paper provides some new insights for enhanced oil recovery in strong heterogeneity reservoir. | Siqi Liu Hu Jia Hongshen Wang Yanbin Liang Duansheng Shi Zhichong Lu Junyi Wu | 2023 | Petroleum Research2023，8，2： | 0 |
| 20 | Activated mouse CD4+Foxp3- T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity显示文摘 | Xiaojuan Wang Yanyan Cui Gaoxmg Luo Qinghong Wang Jie Hu Weifeng He Jun Yuan Junyi Zhou Yan Wu Xiaofeng Sun Simon C Robson Xianchang Li Jiangling Tan Yanmeng Peng Gang Xue Linrong Lu Wenda Gao Jun Wu | 2012 | Cell Research2012，22，12： | 0 |
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