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您的检索式：作者名="Liling Wen"
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| 1 | Tracking of time-evolving sound speed profiles with an auto-regressive state-space model显示文摘An approach for time-evolving sound speed profiles tracking in shallow water is discussed.The inversion of time-evolving sound speed profiles is modeled as a state-space estimation problem,which includes a state equation for predicting the time-evolving sound speed profile and a measurement equation for incorporating local acoustic measurements.In the paper,auto-regression(AR) method is introduced to obtain a high-order AR evolution model of the sound speed field time variations,and the ensemble Kalman filter is utilized to track the sound speed field.To validate the approach,the accuracy in sound speed estimation is analyzed via a numerical implementation using the ASIAEX experimental environment and the sound velocity measurement data.Compared with traditional approaches based on the state evolution represented as a random walk,simulation results show the proposed AR method can effectively reduce the tracking errors of sound speed,and still keep good tracking performance at low signal-to-noise ratios. | JIN Liling LI Jianlong XU Wen | 2017 | Chinese Journal of Acoustics2017，36，3： | 4 |
| 2 | TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2显示文摘Tripartite motif(TRIM)family proteins are important effectors of innate immunity against viral infections.Here we identified TRIM35 as a regulator of TRAF3 activation.Deficiency in or inhibition of TRIM35 suppressed the production of type I interferon(IFN)in response to viral infection.777m35-deficient mice were more susceptible to influenza A virus(IAV)infection than were wild-type mice.TRIM35 promoted the RIG-Imediated signaling by catalyzing Lys63-linked polyubiquitination of TRAF3 and the subsequent formation of a signaling complex with VISA and TBK1.IAV PB2 polymerase countered the innate antiviral immune response by impeding the Lys63-linked polyubiquitination and activation of TRAF3.TRIM35 mediated Lys48-linked polyubiquitination and proteasomal degradation of IAV PB2,thereby antagonizing its suppression of TRAF3 activation.Our in vitro and in vivo findings thus reveal novel roles of TRIM35,through catalyzing Lys63-or Lys48-linked polyubiquitination,in RIG-I antiviral immunity and mechanism of defense against IAV infection. | Nan Sun Li Jiang Miaomiao Ye Yihan Wang Guangwen Wang Xiaopeng Wan Yuhui Zhao Xia Wen Libin Liang Shujie Ma Liling Liu Zhigao Bu Hualan Chen Chengjun Li | 2020 | Protein & Cell2020，11，12： | 4 |
| 3 | A comprehensive profile of TCF1^(+)progenitor and TCF1−terminally exhausted PD-1^(+)CD8^(+)T cells in head and neck squamous cell carcinoma:implications for prognosis and immunotherapy显示文摘The heterogeneity of exhausted T cells(Tex)is a critical determinant of immune checkpoint blockade therapy efficacy.However,few studies have explored exhausted T cell subpopulations in human cancers.In the present study,we examined samples from two cohorts of 175 patients with head and neck squamous cell cancer(HNSCC)by multiplex immunohistochemistry(mIHC)to investigate two subsets of Tex,CD8+PD1+TCF1+progenitor exhausted T cells(TCF1+Texprog)and CD8+PD1+TCF1−terminally exhausted T cells(TCF1−Texterm).Moreover,fresh tumor samples from 34 patients with HNSCC were examined by flow cytometry and immunohistochemistry to further investigate their properties and cytotoxic capabilities and their correlation with regulatory T cells(Tregs)in the tumor immune microenvironment(TIME).mIHC and flow cytometry analysis showed that TCF1−Texterm represented a greater proportion of CD8+PD1+Tex than TCF1+Texprog in most patients.TCF1+Texprog produced abundant TNFα,while TCF1−Texterm expressed higher levels of CD103,TIM-3,CTLA-4,and TIGIT.TCF1−Texterm exhibited a polyfunctional TNFα+GZMB+IFNγ+phenotype;and were associated with better overall survival and recurrence-free survival.The results also indicated that larger proportions of TCF1−Texterm were accompanied by an increase in the proportion of Tregs.Therefore,it was concluded that TCF1−Texterm was the major CD8+PD1+Tex subset in the HNSCC TIME and that these cells favor patient survival.A high proportion of TCF1−Texterm was associated with greater Treg abundance. | Dikan Wang Juan Fang Shuqiong Wen Qunxing Li Jinming Wang Lisa Yang Wenxiao Dai Huanzi Lu Junyi Guo Zhongyan Shan Wenqiang Xie Xiangqi Liu Liling Wen Jie Shen Anxun Wang Qianming Chen Zhi Wang | 2022 | International Journal of Oral Science2022，14，1： | 0 |
| 4 | AF9YEATS结构域在分子层面偶联组蛋白巴豆酰化和活跃转录显示文摘染色质结合蛋白质模块(“阅读器”)识别组蛋白共价修饰构成表观遗传调控的主要方式之一,例如溴域识别乙酰化赖氨酸修饰。除乙酰化之外,近来研究发现组蛋白赖氨酸还能发生巴豆酰化、丁酰化、丙酰化等酰基化修饰.但能够偏好识别这些新型酰基化修饰的阅读器尚未见报道。 | Yuanyuan Li Benjamin R.Sabari Tatyana Panchenko Hong Wen Dan Zhao Haipeng Guan Liling Wan He Huang Zhanyun Tang Yingming Zhao Robert G.Roeder Xiaobing Shi C.David Allis 李海涛 | 2017 | 科学新闻2017，19，4： | 0 |
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