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| 1 | Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy显示文摘Chemotherapy outcomes for the treatment of glioma remains unsatisfactory due to the inefficient drug transport across the blood–brain barrier(BBB) and insufficient drug accumulation in the tumor region. Although many approaches, including various nanosystems, have been developed to promote the distribution of chemotherapeutics in the brain tumor, the delivery efficiency and the possible damage to the normal brain function still greatly restrict the clinical application of the nanocarriers.Therefore, it is urgent and necessary to discover more safe and effective BBB penetration and gliomatargeting strategies. In the present study, menthol, one of the strongest BBB penetration enhancers screened from traditional Chinese medicine, was conjugated to casein, a natural food protein with brain targeting capability. Then the conjugate self-assembled into the nanoparticles to load anti-cancer drugs.The nanoparticles were characterized to have appropriate size, spheroid shape and high loading drug capacity. Tumor spheroid penetration experiments demonstrated that penetration ability of mentholmodified casein nanoparticles(M-CA-NP) into the tumor were much deeper than that of unmodified nanoparticles. In vivo imaging further verified that M-CA-NPs exhibited higher brain tumor distribution than unmodified nanoparticles. The median survival time of glioma-bearing mice treated with HCPT-MCA-NPs was significantly prolonged than those treated with free HCPT or HCPT-CA-NPs. HE staining ofthe organs indicated the safety of the nanoparticles. Therefore, the study combined the advantages of traditional Chinese medicine strategy with modern delivery technology for brain targeting, and provide a safe and effective approach for glioma therapy. | Caifang Gao Jianming Liang Ying Zhu Chengli Ling Zhekang Cheng Ruixiang Li Jing Qin Weigen Lu Jianxin Wang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 12 |
| 2 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 3 | Efficient Scheduling Mapping Algorithm for Row Parallel Coarse-Grained Reconfigurable Architecture显示文摘Row Parallel Coarse-Grained Reconfigurable Architecture(RPCGRA)has the advantages of maximum parallelism and programmable flexibility.Designing an efficient algorithm to map the diverse applications onto RPCGRA is difficult due to a number of RPCGRA hardware constraints.To solve this problem,the nodes of the data flow graph must be partitioned and scheduled onto the RPCGRA.In this paper,we present a Depth-First Greedy Mapping(DFGM)algorithm that simultaneously considers the communication costs and the use times of the Reconfigurable Cell Array(RCA).Compared with level breadth mapping,the performance of DFGM is better.The percentage of maximum improvement in the use times of RCA is 33%and the percentage of maximum improvement in non-original input and output times is 64.4%(Given Discrete Cosine Transfor 8(DCT8),and the area of reconfigurable processing unit is 56).Compared with level-based depth mapping,DFGM also obtains the lowest averages of use times of RCA,non-original input and output times,and the reconfigurable time. | Naijin Chen Zhen Wang Ruixiang He Jianhui Jiang Fei Cheng Chenghao Han | 2021 | Tsinghua Science and Technology2021，26，5： | 4 |
| 4 | Maiden Flight of Long March 7--The New Generation Medium Launch Vehicle in China显示文摘On June 25, 2016, the Long March 7(LM-7) launch vehicle completed its maiden flight successfully. LM-7, as a new generation of medium and basic launch vehicle based on the design concepts of non-toxic and nonpolluting, was developed for the purpose of launching a cargo spacecraft to the Chinese space station. Based on the experience on launching cargo spacecraft and satellites, LM-7 can be adapted for mainstream satellite launch missions in the future with its characteristics of serialization and continuous optimization. LM-7 is expected to be used to launch manned spacecraft in the future. This paper presents a general review of LM-7 with regard to the general scheme and provides references for the development prospects of a medium launch vehicle series in China. | WANG Xiaojun FAN Ruixiang CHENG Tangming XU Lijie YANG Haoliang | 2016 | Aerospace China2016，17，3： | 2 |
| 5 | A Novel Harmonics Currents Detection Method Based on Rotating d-p Reference Frame for Active Power Filter Electronics Specialist Conference显示文摘 | HAO Ruixiang CHENG Zhiguang YOU Xiaojie | 2004 | Aachen2004，，： | 1 |
| 6 | Improvement of softening treatment technology of bamboo 显示文摘 | CHENG Ruixiang ZHANG Qishenng SUI Shujuan | 2006 | Wood Sci Technol2006，40，4： | 1 |
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