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| 1 | Crustal structure in Xiaojiang fault zone and its vicinity显示文摘Based on the integrative interpretation of travel-time data and amplitude information obtained from the deep seismic sounding experiment on the Chuxiong-Luoping profile,eastern Yunnan province,carried out in January of 2005,we present a 2-D P wave velocity structure along the profile. The crustal structure shows remarkable contrasts between the two sides of the Xiaojiang fault zone,although the whole profile is situated within the Yangtze platform. The average P wave velocities of the crust on the west and east sides of the fault zone are 6.21 km/s and 6.32 km/s,respectively,and the crustal thicknesses are 41 km and 45 km,respectively. These results imply that the crust to the east of the Xiaojiang fault zone presents characteristics of crustal structure in a stable platform,while the crust to the west is complicated with a lower velocity zone in middle of the upper crust. The average velocity of 6.21 km/s is lower than the global continental crustal average (6.30 km/s),indicating that the region is tectonically active. According to the lateral variation of velocity and depth of interfaces (including the Moho),it is inferred that the Xiaojiang fault zone has cut through the whole crust. It is also deduced that existence of low velocity zone in middle of the upper crust is conducive to the south-southeastern sliding of the SichuanYunnan (Chuan-Dian) rhombus block. | Chunyong Wang Hai Lou Xili Wang Jiazheng Qin Runhai Yang Jinming Zhao | 2009 | Earthquake Science2009，22，4： | 14 |
| 2 | Distributions of chlorophyll a and carbon fixed strength of phyto-plankton in autumn of the southern Huanghai Sea waters显示文摘Chlorophyll a (Chl a) concentration and primary productivity (PP), namely, carbon fixed strength of phytoplankton along four transects in the southern Huanghai Sea (SHS) were studied for their distribution features and controlling mechanisms based on the investigations from 17 October to 3 November 2005. The Chl a concentration in the study waters dynamically changed spatially. Surface Chl a concentrations ranged from 0.11 to 2.38 mg/m 3 with higher and lower values observed in the nutrient-laden inshore waters and central part of the SHS occupied by oligotrophic current, respectively. The vertical distribution of Chl a concentration showed a predominant pattern of subsurface concentration maximum profile. It followed the previous result of the deep dissolved oxygen concentration maximum profile, which was significantly correlated with phytoplankton and regional water mass. The primary productivity of carbon in autumn of the SHS, ranging from 95 to 1 634 mg/(m 2 ·d) mainly varied with nutrient condition, especially phosphate concentration in seawater and hydrological condition. Furthermore, associating the present study results together with previous studies, the annual value of carbon fixed production of phytoplankton in the entire marginal seas of East China (including the Bohai Sea, the Huanghai Sea and the East China Sea) was estimated to be 222 Mt, which accounted for 2% of that in the global margins. Besides, it was as 16.2 times as the annual value of apparent carbon sink strength (13.96 Mt) in the marginal seas of East China. This multiple was different in different sea areas (3.0 in the Bohai Sea, 6.7 in the Huanghai Sea and 81.6 in the East China Sea). | ZHENG Guoxia SONG Jinming DAI Jicui WANG Yiming | 2006 | Acta Oceanologica Sinica2006，25，3： | 13 |
| 3 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 4 | A novel colloidal gold immunochromatography assay strip for the diagnosis of schistosomiasis japonica in domestic animals显示文摘Background:Schistosomiasis remains a major public health concern in China and an epidemiological survey has revealed that schistosome-infected bovines and goats are the main transmission sources for the disease.Therefore,development of a sensitive technique for the diagnosis of schistosomiasis in domestic animals is necessary.Method:A novel colloidal gold immunochromatography assay(GICA)strip was developed for detecting Schistosoma japonicum in domestic animals.The colloidal gold was conjugated with recombinant streptococcal protein G(rSPG).As the test and control lines,the schistosome soluble egg antigen and rSPG,respectively,were blotted on nitrocellulose membrane.Results:The lowest detectable serum dilution was 1∶640 for schistosome-infected buffaloes.The cross-reaction rate of GICA was 14.29%with Paramphistomum sp.in buffaloes,16.67%with Haemonchus sp.in goats,and 33.33%with Orientobilharzia sp.in goats.These results were slightly lower and similar to those obtained through ELISA.Moreover,the strips for detecting S.japonicum in mice,rabbits,buffaloes,and goats showed high sensitivity(100.00%,100.00%,100.00%,and 100.00%,respectively)and specificity(100.00%,100.00%,94.23%,and 88.64%,respectively).And the sensitivity or specificity of the GICA strips did not present any significant differences after storage for 12 months at room temperature.When compared with ELISA,the GICA strips exhibited similar sensitivity and specificity in the diagnosis of schistosomiasis in mice,rabbits,buffaloes,and goats.Besides,only 5μl of serum are required for the test and the detection can be completed within 5 min.Conclusion:This study is the first to develop a GICA strip using gold-rSPG conjugate for the diagnosing of schistosomiasis in domestic animals,and preliminary results showed that the developed strip may be suitable for large-scale screening of schistosomiasis in endemic areas. | Rui Xu Jintao Feng Yang Hong Chao Lv Dengyun Zhao Jiaojiao Lin Ke Lu Hao Li Jinming Liu Xiaodan Cao Tao Wang Jinli Zai Zhaozhe Wang Bingguang Jia Qian Han Chuangang Zhu | 2017 | Infectious Diseases of Poverty2017，6，1： | 12 |
| 5 | Impact of Anthropogenic Heat Release on Regional Climate in Three Vast Urban Agglomerations in China显示文摘We simulated the impact of anthropogenic heat release(AHR) on the regional climate in three vast city agglomerations in China using the Weather Research and Forecasting model with nested high-resolution modeling. Based on energy consumption and high-quality land use data, we designed two scenarios to represent no-AHR and current-AHR conditions. By comparing the results of the two numerical experiments, changes of surface air temperature and precipitation due to AHR were quantified and analyzed. We concluded that AHR increases the temperature in these urbanized areas by about 0.5℃– 1℃, and this increase is more pronounced in winter than in other seasons. The inclusion of AHR enhances the convergence of water vapor over urbanized areas. Together with the warming of the lower troposphere and the enhancement of ascending motions caused by AHR, the average convective available potential energy in urbanized areas is increased. Rainfall amounts in summer over urbanized areas are likely to increase and regional precipitation patterns to be altered to some extent. | FENG Jinming WANG Jun YAN Zhongwei | 2014 | Advances in Atmospheric Sciences2014，31，2： | 11 |
| 6 | Synthesis and Performance of Polyurethane Coated Urea as Slow/controlled Release Fertilizer显示文摘Polyurethane coated urea slow/controlled release fertilizer was prepared based on urea granules, isocyanate, polyols and paraffin. Isocyanate reacted with polyols to synthesize the polyurethane skin layer on urea granules surface. Paraffin serves as a lubricant during syntheses of polyurethane skin layers. The structure and nutrient release characteristics of the polyurethane skin layers were investigated by FTIR, SEM and TG. Urea nitrogen slow-release behavior of the polyurethane coated urea was tested. The experimental results indicated that compact and dense polyurethane skin layers with a thickness of 10-15 μm were formed on urea surface, the urea nitrogen slow-release time can reach 40-50 days. Paraffin proves to play a key role in inhibiting water to penetrate into urea, but excessive addition would decrease the polyurethane crosslinking density. | 李青山 WU Shu RU Tiejun 王利民 XING Guangzhong WANG Jinming | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，1： | 10 |
| 7 | Dietary seaweed-derived polysaccharides improve growth performance of weaned pigs through maintaining intestinal barrier function and modulating gut microbial populations显示文摘Background:Seaweed-derived polysaccharides(SDP)represent an attractive source of prebiotic nutraceuticals for the food and animal husbandry industry.However,the mechanism by which SDP from Enteromorpha mediates pig growth are not fully understood.This study aimed to investigate how SDP supplementation influences the growth performance and intestinal health in weaned pigs.Results:In Exp.1,240 weaned pigs were randomly assigned to four dietary treatments and fed with a basal diet or a basal diet containing 200,400 or 800 mg/kg SDP,respectively,in a 21-day trial.Pigs on the 400 or 800 mg/kg SDP-supplemented group had greater ADG and lower F/G ratio than those on the control group(P<0.05).In Exp.2,20 male weaned pigs were randomly assigned to two treatments and fed with a basal diet(CON group)or a basal diet supplemented with 400 mg/kg SDP(the optimum does from Exp.1),in a 21-day trial.Pigs fed the SDP diet had greater ADG,the concentrations of serum IL-6 and TNF-αand the activities of glutathione peroxidase,superoxide dismutase and catalase(P<0.05),and lower F/G,diarrhea rate,as well as serum D-lactate concentrations and diamine oxidase activity(P<0.05).Moreover,dietary SDP supplementation enhanced secretory immunoglobulin A content,villus height and villous height:crypt depth ratio in small intestine,as well as the lactase and maltase activities in jejunum mucosa(P<0.05).SDP supplementation elevated the mRNA levels of inflammatory responserelated genes(IL-6,TNF-α,TLR4,TLR6 and MyD88),and the mRNA and protein levels of ZO-1,claudin-1 and occludin in jejunum mucosa(P<0.05).Importantly,SDP not only increased the Lactobacillus population but also reduced the Escherichia coli population in cecum(P<0.05).Furthermore,SDP increased acetic acid and butyric acid concentrations in cecum(P<0.05).Conclusions:These results not only suggest a beneficial effect of SDP on growth performance and intestinal barrier functions,but also offer potential mechanisms behind SDP-facilitated intestinal health in weaned pigs. | Tiande Zou Jin Yang Xiaobo Guo Qin He Zirui Wang Jinming You | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 10 |
| 8 | Effects of B on the Microstructure and Oxidation Resistance of Nb-Ti-Si-based Ultrahigh-temperature Alloy显示文摘采用电弧熔炼法制备了B含量为0到2at.%的Nb-Ti-Si基超高温合金。分析了B对Nb-Ti-Si基超高温合金的电弧熔炼态组织及氧化行为的影响。电弧熔炼态Nb-22Ti-16Si-6Cr-3Al-4Hf合金由(Nb,Ti)ss,β-(Nb,Ti)5Si3和γ-(Nb,Ti)5Si3组成,而Nb-22Ti-16Si-6Cr-3Al-4Hf-1B和Nb-22Ti-16Si-6Cr-3Al-4Hf-2B合金则由(Nb,Ti)ss,α-(Nb,Ti)5Si3和γ-(Nb,Ti)5Si3组成。Nb-Ti-Si基超高温合金主要是通过界面和(Nb,Ti)ss发生氧化的,在添加B的合金中,B明显降低了其在1200℃前50小时的氧化速率,但50小时后,B的添加反而降低了合金的抗氧化性。 | Wang Jun Guo Xiping Guo Jinming | 2009 | Chinese Journal of Aeronautics2009，22，5： | 8 |
| 9 | Multi-Stage Hydrocarbon Accumulation and Formation Pressure Evolution in Sinian Dengying FormationCambrian Longwangmiao Formation, Gaoshiti-Moxi Structure, Sichuan Basin显示文摘Sichuan Basin is a typical superimposed basin, which experienced multi-phase tectonic movements, meanwhile Sinian–Cambrian underwent complex hydrocarbon accumulation processes, causing exploration difficulties in the past 60 years. Based on the microscopic evidence of fluid inclusions, combined with basin-modelling, this paper determines stages and time of hydrocarbon accumulation, reconstructs evolution of formation pressure and dynamic processes of hydrocarbon accumulation in Sinian Dengying Formation-Cambrian Longwangmiao Formation of Gaoshiti-Moxi structure. Three stages of inclusions are detected, including a stage of yellow-yellowgreen fluorescent oil inclusions, a stage of blue fluorescent oil-gas inclusions and a stage of non-fluorescent gas inclusions, reflecting the study area has experienced a series of complex hydrocarbon accumulation processes, such as formation of paleo-oil reservoirs, cracking of crude oil, formation of paleo-gas reservoirs and adjustment to present gas reservoirs, which occurred during 219–188, 192–146 and 168–0 Ma respectively. During the period of crude oil cracking, Dengying Formation-Longwangmiao Formation showed weak overpressure to overpressure characteristics, then after adjustment of paleo-gas reservoirs to present gas reservoirs, the pressure in Dengying Formation changed into overpressure but finally reduced to normal pressure system. However, due to excellent preservation conditions, the overpressure strength in Longwangmiao Formation only slightly decreased and was still kept to this day. | Juan Wu Shugen Liu Guozhi Wang Yihua Zhao Wei Sun Jinming Song Yanhong Tian | 2016 | Journal of Earth Science2016，27，5： | 8 |
| 10 | Association of H-FABP gene polymorphisms with intramuscular fat content in Threeyellow chickens and Hetian-black chickens显示文摘Background: To explore the relationship between the heart-type fatty acid binding protein(H-FABP) gene and intramuscular fat(IMF), a polymorphism of the second exon of the H-FABP gene was investigated in 60 Three-yellow chickens(TYCs) and 60 Hetian-black chickens(HTBCs).Results: The IMF contents of the cardiac, chest and leg muscles in HTBC were increased compared with TYC. Both TYC and HTBC populations exhibited Hardy-Weinberg Equilibrium(HWE) according to the χ2test. Three variations of the two birds were detected, namely, G939 A, G982 A and C1014 T. HTBCs with the TT genotypes exhibit increased IMF content in the chest muscles compared with the TC genotype. Thus, the G982 A site could be considered a genetic marker for selecting increased IMF content in the chest muscles of HTBC. The correlation coefficients revealed that H-FABP m RNA expression was negatively correlated with the IMF content in the cardiac, chest and leg muscles of HTBC and in the cardiac and chest muscles of TYC. The relative m RNA expression of H-FABP was reduced in the cardiac and leg muscles of HTBC compared with TYC, but this difference was not observed at the protein level, as assessed by Western blot analysis.Conclusions: These findings offer essential data that can be useful in the breeding program of HTBC and future research exploring the role of H-FABP in IMF deposition and regulation in chickens. | Yong Wang Xiaohong Hui Huie Wang Tursunjan Kurban Chao Hang Ying Chen Jinming Xing Jiufeng Wang | 2016 | Journal of Animal Science and Biotechnology2016，7，3： | 8 |
| 11 | Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles for enhanced delivery and antitumor efficacy of paclitaxel显示文摘结合的指向的药交货在细胞质的快速的药版本是强大的策略提高反癌症药的功效和还原剂离开目标效果。此处,我们描述由 pH 应答的共聚物 D 组成的一个双功能的混合 micellar 系统 -- tocopheryl 聚乙烯乙二醇 1000-blockpoly-( 氨基的酉旨)(TPGS-b-PBAE, TP ) 并且 AS1411 aptamer (恰当) 装饰了 TPGS 聚合物(Apt-TPGS ) ,它在癌症房间的血浆膜上认出过去表示的 nucleolin。反癌症药 paclitaxel (PTX ) 在恰当混合的微粒被包含,并且这些装载药的微粒有一种合适的粒子尺寸和 116.3 nm eir single-crystalline-like 的希腊语的第六个字母潜力远程的电子连接, VN MCNS 交付 1.44 的电的传导性 ??? 汰獵瀭畬 ?? ￣吗? | Jinming Zhang Rule Chen Xiefan Fang Fengqian Chen Yitao Wang Meiwan Chen | 2015 | Nano Research2015，0，1： | 6 |
| 12 | Anti-PD-L1/TGF-BR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer显示文摘Background:Second-generation programmed cell death-protein 1/pro-grammed death-ligand 1(PD-1/PD-L1)inhibitors,such as bintrafusp alfa(M7824),SHR-1701,and YM101,have been developed to simultaneously block PD-1/PD-L1 and transforming growth factor-beta/transforming growth factor-beta receptor(TGF-P/TGF-βR).Consequently,it is necessary to identify predictive factors of lung cancer patients who are not only resistant to PD-1/PD-LI inhibitors but also sensitive to bifunctional drugs.The purpose of this study was to search for such predictors.Methods:Multivariable Cox regression was used to study the association between the clinical outcome of treatment with PD-1/PD-L1 inhibitors and lym-phocyte recovery after lymphopenia in lung cancer patients.Murine CMT167 lung cancer cells were engineered to express the firefly luciferase gene and implanted orthotopically in the lung of syngeneic mice.Bioluminescence imag-ing,flow cytometry,and immunohistochemistry were employed to detrmine response to immunotherapy and function of tumor-infiltrating immune cells.Results:For lung cancer patients treated with anti-PD-1/PD-LI antibodies,poor lymphocyte recovery was associated with a shorter progression-free survival(PFS;P<0.001),an accumulation of regulatory T cells(Tregs),and an elimi-nation of CD8+T cells in the peripheral blood.Levels of CD8+T cells and Treg cells were also imbalanced in the tumors and peripheral immune organs of mice with poor lymphocyte recovery after chemotherapy.Moreover,these mice failed to respond to anti-PD-1 antibodies but remained sensitive to the anti-PD-LI/TGF-βR fusion protein(SHR-1701).Consistently,SHR-1701 but not anti-PD-1 antibod-ies,markedly enhanced IFN-γproduction and Ki-67 expression in peripheral CD8+T cells from patients with impaired lymphocyte recovery.Conclusions:Lung cancer patients with poor lymphocyte recovery and suffer-ing from persistent lymphopenia after previous chemotherapy are resistant to anti-PD-1/PD-L1 antibodies but might be sensitive to second-generation agents such as SHR-1701. | Bo Cheng Kaikai Ding Pengxiang Chen Jianxiong Ji Tao Luo Xiaofan Guo Wei Qiu Chunhong Ma Xue Meng Jian Wang Jinming Yu Yuan Liu | 2022 | Cancer Communications2022，42，1： | 5 |
| 13 | A new mechanism of atmospheric CO2 absorption promoted by iron-nitrogen coupling in low-latitude oceans during ice age显示文摘It has been confirmed by a large number of studies that iron can significantly improve the carbon fixation level in the high-latitude oceans (Martinez-Garcia et al., 2014). Although there are many studies on the mechanism of ironcarbon coupling in the modem ocean, the research on ironnitrogen-carbon coupling is rare (Tagliabue et al., 2014;Song, 2010). It is of great significance for the prediction of future ocean changes to identify the key processes of modem ocean and analyze the past ocean changes. | Jinming SONG Qidong WANG | 2020 | Science China Earth Sciences2020，63，1： | 5 |
| 14 | Detecting Droughts in Southwest China from GPS Vertical Position Displacements显示文摘The solid Earth responds elastically to terrestrial water storage(TWS)changes.Here global positioning system(GPS)vertical position data at 31 stations from the crustal movement observation network of China(CMONOC)from August 2010 to December 2016 are used to detect droughts in Southwest China.Monthly GPS vertical position displacements respond negatively to precipitation changes and TWS changes observed by gravity recovery and climate experiments(GRACE)as well as river water level variations.GPS vertical position anomalies(the non-seasonal term)are well correlated negatively(correlations of about-0.70)with the commonly used meteorological composite index(CI)in China and the GRACE drought severity index(GRACE-DSI),but less correlated with the standardized precipitation evapotranspiration index(SPEI).Compared to CI,GPS vertical position anomalies have the advantage of detecting droughts caused by abrupt precipitation deficits in a short time.GRACE-DSI is less accurate in drought monitoring for some periods due to the missing data,while the severity of abrupt precipitation absent in some cases can be overestimated from SPEI with big variability.This study shows the reliability and advantages of GPS data in drought monitoring. | Chaolong YAO Zhicai LUO Yueming HU Changwei WANG Rui ZHANG Jinming LI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，3： | 5 |
| 15 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 16 | Synthesis, Characterization, and Catalytic Application of Highly Ordered Mesoporous Alumina-Carbon Nanocomposites显示文摘高度订的 mesoporous 碳氧化铝 nanocomposites (OMCA ) 被热分解在高温度跟随的一个多部件合作集会方法第一次综合了。在这合成, resol 酚甲醛树脂(PF 树脂) 和氧化铝大音阶的第五音分别地作为模板被用作碳和氧化铝先锋和 triblock 共聚物 Pluronic F127。N2 吸附大小, X 光检查衍射,和传播电子显微镜学揭示了那,随在从 11 ~ 48 wt.% 的 nanocomposite 的氧化铝内容的增加,当订的 mesoporous 结构被保留时,毛孔尺寸从 2.9 ~ 5.0 nm 增加了。进一步增加氧化铝内容到 53 wt.% 导致了像虫孔的结构,尽管毛孔尺寸分发仍然是狭窄的。nanocomposite 墙由连续的碳和非结晶的氧化铝组成,它允许订的 mesostructure 被 HF 在空中由锻烧蚀刻或碳的移动很好甚至在氧化铝的移动以后保存。OMCA nanocomposites 低于 1000 展出了好 | Jinming Xu Aiqin Wang Xiaodong Wang Dangsheng Su Tao Zhang | 2011 | Nano Research2011，4，1： | 5 |
| 17 | CMIP5/AMIP GCM Simulations of East Asian Summer Monsoon显示文摘The East Asian summer monsoon(EASM) is a distinctive component of the Asian climate system and critically influences the economy and society of the region. To understand the ability of AGCMs in capturing the major features of EASM, 10 models that participated in Coupled Model Intercomparison Project/Atmospheric Model Intercomparison Project(CMIP5/AMIP), which used observational SST and sea ice to drive AGCMs during the period 1979–2008, were evaluated by comparing with observations and AMIP II simulations. The results indicated that the multi-model ensemble(MME) of CMIP5/AMIP captures the main characteristics of precipitation and monsoon circulation, and shows the best skill in EASM simulation, better than the AMIP II MME. As for the Meiyu/Changma/Baiyu rainbelt, the intensity of rainfall is underestimated in all the models. The biases are caused by a weak western Pacific subtropical high(WPSH) and accompanying eastward southwesterly winds in group I models, and by a too strong and west-extended WPSH as well as westerly winds in group II models. Considerable systematic errors exist in the simulated seasonal migration of rainfall, and the notable northward jumps and rainfall persistence remain a challenge for all the models. However, the CMIP5/AMIP MME is skillful in simulating the western North Pacific monsoon index(WNPMI). | FENG Jinming WEI Ting DONG Wenjie WU Qizhong WANG Yongli | 2014 | Advances in Atmospheric Sciences2014，31，4： | 4 |
| 18 | Real-time crash prediction on freeways using data mining and emerging techniques显示文摘Recent advances in intelligent transportation system allow traffic safety studies to extend from historic data-based analyses to real-time applications. The study presents a new method to predict crash likelihood with traffic data collected by discrete loop detectors as well as the web-crawl weather data. Matched case–control method and support vector machines(SVMs) technique were employed to identify the risk status. The adaptive synthetic over-sampling technique was applied to solve the imbalanced dataset issues. Random forest technique was applied to select the contributing factors and avoid the over-fitting issues. The results indicate that the SVMs classifier could successfully classify 76.32% of the crashes on the test dataset and 87.52% of the crashes on the overall dataset,which were relatively satisfactory compared with the results of the previous studies. Compared with the SVMs classifier without the data, the SVMs classifier with the web-crawl weather data increased the crash prediction1.72%, showing the potential value of the massive web weather data. Mean impact value method was employed to evaluate the variable effects, and the results are identical with the results of most of previous studies.are identical with the results of most of previous studies.The emerging technique based on the discrete traffic data and web weather data proves to be more applicable on realtime safety management on freeways. | Jinming You Junhua Wang Jingqiu Guo | 2017 | Journal of Modern Transportation2017，25，2： | 3 |
| 19 | Nitrogen-doped hierarchically porous carbon spheres for low concentration CO_(2) capture显示文摘Synthesis of spherical carbon beads with effective CO_2 capture capability is highly desirable for large scale application of CO2 sorption, but remains challenging. Herein, a facile and efficient strategy to prepare nitrogen-doped hierarchically porous carbon spheres was developed via co-pyrolyzation of poly(vinylidene chloride) and melamine in alginate gel beads. In this approach, melamine not only serves as the nitrogen precursor, but also acts as a template for the macropores structures. The nitrogen contents in the hierarchically porous carbon spheres reach a high level, ranging from 11.8 wt% to 14.7 wt%, as the melamine amount increases. Owing to the enriched nitrogen functionalities and the special hierarchical porous structure, the carbon spheres exhibit an outstanding CO_2 capture performance, with the dynamic capacity of as much as about 7 wt% and a separation factor about 49 at 25 °C in a gas mixture of CO_2/N_2(0.5:99.5, v/v). | Yang Li Jing Wang Sisi Fan Fanan Wang Zheng Shen Hongmin Duan Jinming Xu Yanqiang Huang | 2021 | Journal of Energy Chemistry2021，30，2： | 3 |
| 20 | Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway显示文摘Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases. | Bo Huang Yufeng Qian Shujun Xie Xianhua Ye Hanwen Chen Zhifeng Chen Lihuan Zhang Jinming Xu Hu Hu Shenglin Ma Paul Héroux Di Wang Han-Ming Shen Yihua Wu Dajing Xia | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
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