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| 1 | Cervical Cancer Screening Rates Among Chinese Women—China,2015显示文摘What is already known about this topic?Cervical cancer is the fourth most common cancer of women around the world.Age-adjusted incidence and mortality rates of cervical cancer were 11.78 and 3.29 per 100,000,respectively,in China in 2015.What is added by this report?Cervical cancer screening rates were 25.7%for women aged 20–64 years old and 31.4%for women aged 35–64 years old in China in 2015.Screening rates were lower in rural areas than in urban areas and varied across provinces.What are the implications for public health practice?Efforts should be made to continue to strengthen national and local policy initiatives,financial support,health education,and accessibility to women in rural areas for cervical cancer screening coverage. | Mei Zhang Yijing Zhong Zhenping Zhao Zhengjing Huang Xiao Zhang Chun Li Maigeng Zhou Jing Wu Limin Wang Xiaoying Zheng Linhong Wang | 2020 | China CDC weekly2020，2，26： | 17 |
| 2 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 3 | Interleukin-1β and tumor necrosis factor-a increase stiffness and impair contractile function of articular chondrocytes显示文摘 | Cheng Chen JingXie Ravikumar Rajappa Linhong Deng Jeffrey Fredberg Liu Yang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，2： | 13 |
| 4 | Cervical Cancer Screening Coverage — China, 2018–2019显示文摘What is already known about this topic?The World Health Organization set a 2030 target of 70%cervical cancer screening coverage for women aged 35–45 years.Coverage stood at 37%in China in 2015.What is added by this report?In 2018–2019,China’s cervical cancer screening coverage reached 43.4%in women aged 35–44 years and 36.8%in women aged 35–64 years.Screening coverage was still lower in rural areas as well as central and western regions;large variations existed across provincial-level administrative divisions.What are the implications for public health practice?National and local policy and financial support should be maintained for cervical cancer screening,along with more targeted health education and outreach efforts and strengthened accessibility of health services in the rural areas and central and western regions. | Mei Zhang Yijing Zhong Limin Wang Heling Bao Zhengjing Huang Zhenping Zhao Xiao Zhang Chun Li Kelly Liang Sun Jing Wu Xiaoying Zheng Linhong Wang | 2022 | China CDC weekly2022，4，48： | 11 |
| 5 | Resistance and fitness costs in diamondback moths after selection using broflanilide, a novel meta-diamide insecticide显示文摘The diamondback moth (DBM) Plutella xylostella (L.) (Lepidoptera: Plutellidae) is an insect pest found around the world that feeds on cruciferous crops. The DBM has become resistant to most insecticides in current use in the field. Broflanilide is a novel meta-diamide insecticide that binds to a new site on the γ-aminobutyric acid receptor and very efficiently protects against most pests in the order Lepidoptera, including DBM. In this study, the resistance of a laboratory-bred susceptible strain of DBM to broflanilide and the fitness costs posed by broflanilide to the DBM were evaluated. The DBM had no obvious resistance to broflanilide after 10 generations of selection. The realized heritability h2 was 0.033, suggesting a low risk of resistance developing in this strain. The F10 generation had no cross-resistance to the insecticides abamectin and endosulfan (which target the γ-aminobutyric acid receptor) and chlorantraniliprole (which targets a non-γ-aminobutyric acid receptor). The specific activities of important detoxification enzymes (cytochrome P450 monooxygenase, esterase, and glutathione S-transferase) were not obviously altered. However, the larval stage was prolonged and the adult stage was shortened significantly in F11 generation than the F0 generation. The total preoviposition period TPOP significantly prolonged 1.90 d in F11 generation. The fitness value Rf (0.93) was lower for the F11 generation than the F0 generation. The results indicated that long-term exposure to broflanilide exerts clear fitness costs in the DBM. This information will be useful in identifying reasonable broflanilide application guidelines for managing broflanilide resistance in the DBM. | Xi Sun Rui Wei Linhong Li Bin Zhu Pei Liang Xiwu Gao | 2022 | Insect Science2022，29，1： | 5 |
| 6 | Breast Cancer Screening Rates Among Women Aged 20 Years and Above—China,2015显示文摘What is already known about this topic?Breast cancer is the most common cancer in women in China and around the world.By 2019,121 countries have instituted a national screening program as a secondary prevention measure for breast cancer.What is added by this report?Breast cancer screening rates in China were 18.9%in women aged 20 years and above,and 25.7%in women aged 35-64 years in 2015.The screening rate for women aged 20 years and above was significantly higher in urban areas than in rural areas(24.6%vs.15.0%),and in the eastern region than in the central and western regions(24.0%vs.15.1%and 15.3%). | Mei Zhang Yijing Zhong Heling Bao Zhenping Zhao Zhengjing Huang Xiao Zhang Chun Li Maigeng Zhou Limin Wang Jing Wu Xiaoying Zheng Linhong Wang | 2021 | China CDC weekly2021，3，13： | 5 |
| 7 | Synthesis and antiviral bioactivities of novel chiral bis-thiourea-type derivatives containing α-aminophosphonate moiety显示文摘Starting from 1-((1R,2R)-2-aminocyclohexyl)-3-substituted thioureas (3a–c) and substituted isothiocyanates (9a–d),chiral bis-thiourea derivatives containing α-aminophosphonate moiety 10a–l were prepared and completely characterized by elemental analysis,physical and spectral (IR,1H NMR,13C NMR,31P NMR) data.The results of bioassay revealed that compounds 10a and 10e possessed appreciable curative bioactivities on cucumber mosaic virus (CMV) at 0.5 mg/mL in vivo (inhibitory rate = 60.3%,64.8% respectively) and tobacco mosaic virus (TMV) at 0.5 mg/mL in vivo (inhibitory rate = 50.3%,50.8% respectively),which were comparable to the values shown by standard reference (58.7%) and commercial product Ningnanmycin (56.3%),respectively.Chiral compound 10e displayed more potent antiviral activity (EC50 = 0.149 mg/mL) than Ningnanmycin (EC50 = 0.201mg/mL) against CMV. | YANG Xuan SONG BaoAn JIN LinHong WEI Xue BHADURY S Pinaki LI XiangYang YANG Song HU DeYu | 2011 | Science China Chemistry2011，54，1： | 5 |
| 8 | Sulfoalkyl ether β-cyclodextrin derivatives synthesized by a single step method as pharmaceutical biomaterials显示文摘We report a simple 'one pot' single step method to synthesize sulfoalkyl ether β-cyclodextrin (β-CD) derivatives in aqueous solution, which avoids the limitations associated with commonly used organic synthesis of such derivatives including multi-step reactions, use of expensive, toxic, and often environmentally hazardous organic solvents and/or reagents. Using this method, we obtained sulfopropyl and sulfobutyl ethyl β-CDs. We characterized these two derivatives and evaluated their ability to enhance solubility of fluconazole, a commonly used antifungal drug with poor water solubility. Experimental results indicate that these derivatives are structurally analogous to some of the commercially available β-CD derivatives. More importantly, when they formed supramolecular inclusion complexes with fluconazole, they demonstrated similar, if not better, capacity to enhance fluconazole solubility compared with commercially available β-CD derivatives, suggesting that the simple 'one pot' single step synthesis may provide an effective alternative approach to produce large quantity of β-CD derivatives as pharmaceutical biomaterials for medicinal applications. | SONG AiJing WANG JianHua LIU ChunDong DENG LinHong | 2009 | Chinese Science Bulletin2009，54，18： | 4 |
| 9 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 10 | Synthesis and Properties of Gemini Cationic Surfactants with Amide Spacers显示文摘Four gemini cationic surfactants {N,N'-di[2-(lauryldimethylamino)acetyl]polymethylenediamine dichloride, LAA-s-LAA, s=2,3,4,6} were synthesized by using four bis(α-chloroacetamide)s and N,N-dimethyllaurylamine, respectively. The molecular structures were characterized by means of IR, 1H NMR, 13C NMR and MS, and the behavior of their aqueous solutions was studied. The critical micell concentrations(CMC) of LAA-s-LAA were one order of magnitude lower than that of dodecyltrimethyl ammonium chloride(DTAC). With the change of the length of spacer chain(s), their CMC values change, and CMC reaches the top value at s=4. | DENGQi-gang YUHong-wei LINHong JIALi-hua GUOXiang-feng ZHOUDe-rui | 2005 | Chemical Research in Chinese Universities2005，21，3： | 3 |
| 11 | Effects of Dietary Protein Level on Growth and Utilization of Protein and Energy by Juvenile Mangrove Red Snapper(Lutjanus argentimaculatus)显示文摘A feeding trial was conducted in a recirculating water system to investigate the effects of dietary protein levels on growth, feed utilization, hepatosomatic index and liver lipid deposition of juvenile red snapper, Lutjanus argentimaculatus (average initial wet weight 8.0±0.39g and total length 3.14±0.3cm). In the experiment, six fishmeal-based diets were formulated to contain various protein levels (20% to 45% in 5% increments), with dietary energy ranging from 2210.7kJ 100g to 2 250.2 kJ 100 g dry matter. The protein to energy ratios of diets ranged from 8.58 mg protein kJ-1 to 20.03 mg protein kJ-1. Diets were fed for 90d to triplicate groups of fish stocked in 0.128 m3 seawater tanks, 25 individuals each. The daily ration of 2% wet body weight was offered to the fish thrice a day. The fish at the end of the study had more than ten-fold (77.0g) in- crease in weight compared to the initial (8.0g). Fish fed diets of 40% and 45% protein produced significantly (P<0.05) higher weight gain of 77.2g and 76.5 g, and specific growth rate (SGR) of 2.65% and 2.62% than those of 67.0 g and 68.3 g, and 2.49% and 2.51% of the other diets. The broken-line regression of SGR against dietary protein level yielded an optimum dietary protein requirement of 42.6% (Y = - 1.6295 + 0.1114 AT2, P<0.05). Survival remained 100% among groups. Feed conversion ratio decreased from 0.45 for fish fed 20% dietary protein to 0.35 for fish fed 45% dietary protein. Nitrogen in- take increased with an increase in dietary protein, which in turn resulted in an increase in nitrogen gain of fish whole body. Fish fed 40% and 45% protein diets showed higher (P<0.05) nitrogen gain (0.27g and 0.26g) than those (0.23g and 025g) fed all other diets. Gross energy intake (GEI) in fish fed 45% protein was lower (600.67kJ) than that (607.97kJ) of 40% protein diet, though the differences were not statistically significant (P>0.05); GEI ranging from 677.31 kJ to 663.20 kJ at remaining four diets (20% to 35% protein) did not appear to differ significantly (P>0.05). The highest energy gain of 518.33 kJ was obtained with fish fed 40% protein, resulting in the highest energy retention efficiency of 85.26%. The hep- atosomatic index of fish fed diets of 20%, 25%, 30% and 35% protein were significantly (P<0.05) higher (2.09% to 2.57%) than those (1.44% and 1.41%) of fish fed diets containing 40% and 45% protein. Liver lipid contents decreased from 8.72% to 7.0% in fish fed dietary protein of 20% to 45% in 5% increments. Results suggest that the diet containing 40% to 42.6% protein with a P/E ratio of 17.6mg protein kJ-1 is required for good growth of L. argentimaculatus weighing between 8.0 g and 85.2 g under the culture conditions of the present study. | GhulamAbbas KhalidJamil RukhsanaAkhtar LinHong | 2005 | Journal of Ocean University of China2005，4，1： | 3 |
| 12 | Comparison of Taste Components between Triploid and Diploid Oyster显示文摘The main taste components of triploid and diploid oyster (Crassostrea gigas) were compared. Free amino acids, inosine monophosphate, succinate, trimethylamine oxide and betaine in fresh and boiled extractives were analyzed. The protein, lipids, glycogen, moisture and ash, which may affect the flavour, were evaluated. In boiled extractives, the amino acids were 394.1 mg(100 g) -1 in diploid and 183.5 mg(100 g) -1 in triploid. However, in fresh oyster extractives, they were 320.0 mg(100 g) -1 and 147.3 mg(100 g) -1 respectively. The inosine monophosphate in triploid was 44% more than that in diploid, and a little difference existed in the content of trimethylamine oxide between them. The contents of these taste components were the basis for taste flavour pattern determination. | LINHong WANGXiaoxue ZHANGBin TANGHaiqing XUEChanghu XUJiachao | 2002 | Journal of Ocean University of Qingdao2002，1，1： | 2 |
| 13 | Genistein antagonizes inflammatory damage induced by β-amyloid peptide in microglia through TLR4 and NF-κB显示文摘 | Xin Zhou Linhong Yuan Xia Zhao Chengcheng Hou Weiwei Ma Huanling Yu Rong Xiao | 2014 | Nutrition2014，，： | 2 |
| 14 | Incidence of persistent and high-risk human papillomavirus infection and associated factors among HIV-positive women in China, 2015-2016显示文摘Background:Persistent human papillomavirus(HPV)infection is the necessary factor for cervical cancer.Human immunodeficiency virus(HIV)-positive women are a high-risk population for cervical cancer,but little is known about persistent HPV infection among HIV-positive women in China.We aimed to investigate the persistence and incidence of infection with high-risk HPV(hrHPV)and associated factors among HIV-positive women in China.Method:Using a prospective observational study design,we collected data from 670 HIV-positive women in five counties of three provinces through interviews,medical record reviews,health examination,and laboratory tests at a baseline survey in 2015 and a follow-up survey in 2016.We tested HIVpositive women for hrHPV infection using the Cobas 4800 HPV test,and analyzed factors associated with persistence and new incidence of hrHPV infection using logistic regression.Results:After an average of 15 months at follow-up,the persistence and new incidence rates of hrHPV infection were 38.0%(46/121,95%CI:29.2%-46.8%)and 8.3%(35/420,95%CI:5.7%-11.1%),respectively.HIV-positive women in Yunnan and Guangxi were more likely to have persistent hrHPV infections than those in Xinjiang(aOR=3.18,95%CI:1.00-10.14,p=0.05;aOR=6.38,95%CI:2.29-17.77,p<0.001).Migrant women had a higher rate of new hrHPV incidence than local women(aOR=4.48,95%CI:1.65-12.15,p=0.003).HIV-positive women from Xinjiang were 6.5 times more likely to be newly infected with hrHPV than those from Yunnan(95%CI:2.40-17.60,p<0.001).HIV-positive women with HBV infection had a higher risk of being infected with hrHPV than those without HBV infection(aOR=3.48,95%CI:1.13-10.71,p=0.029).Conclusions:The persistence and new incidence rates of hrHPV infection among HIV-positive women were high and varied significantly between regions.HBV infection and being among the migrant population were associated with new hrHPV infection. | Yaping Qiao Ailing Wang Liwen Fang Linhong Wang | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，3： | 2 |
| 15 | Associations Between Hypertension Status and Increased Heart Rate-China, 2015显示文摘Summary What is already known on this topic?Hypertension is a major public health concern in China,and hypertensive patients have elevated heart rates(HR),which can synergize with higher blood pressure to promote adverse health outcomes.What is added by this report?The risk of increased HR was statistically significant but relatively lower in subjects with treated and controlled hypertension.This lower impact might be modified by sex,marital status,smoking,and physical activity. | Xiao Zhang Mei Zhang Chun Li Linhong Wang Jing Wu Zhengjing Huang Limin Wang | 2020 | China CDC weekly2020，2，40： | 2 |
| 16 | In vitro assay of cytoskeleton nanomechanics as a tool for screening potential anticancer effects of natural plant extract, tubeimoside I on human hepatoma (HepG2) cells显示文摘Cytoskeleton nanomechanics characterizes cancer cell's physical behaviors such as how it spread and invade. For anticancer drug, cytoskeleton nanomechanics may be a target to inhibit invasiveness and metastasis of cancer cells. Therefore, in vitro assay of cytoskeleton nanomechanics may be used to evaluate the effects of potential anticancer drug on various cancer types. Here, we investigated the effects of tubeimoside I (TBMS I) on human hepatoma (HepG2) cells by using optical magnetic twisting cytometry, a well-established technique for measuring nanomechanics of the Factin cytoskeleton. TBMS I is a natural compound extracted from a traditional Chinese herbal medicine, and is reported with antitumor effect. In this study, we demonstrated that the cytoskeleton stiffness (G) of HepG2 cells was affected by TBMS I. G′ exhibited a typical power law with respect to the loading frequency (f), i.e. G^f . The magnitude of G′ and the value of exponent (α) of the HepG2 cells decreased consistently with the increase of concentration for TBMS I exposure. In addition, the HepG2 cells responded to TBMS I much faster than the normal liver (L-02) cells. Such alteration of cytoskeleton nanomechanics induced by TBMS I was reported for the first time, which was further corroborated by assays of Factin cytoskeleton structure and cell migration. Taken together, these results suggest that in vitro assay of cytoskeleton nanomechanics may have a great potential as an additional tool in screening of anticancer drug candidates. | ZHAO HongBo WANG YaShu JIANG XueMei SHI XiaoHao ZHONG HongZhe WANG YaJie CHEN Jun DENG LinHong | 2013 | Chinese Science Bulletin2013，58，21： | 2 |
| 17 | Filterbank-based fingerprint matching 显示文摘 | ANIL K JAIN SALIL PRABHAKAR LINHONG SHARATH PANKANTI | 2000 | IEEE Trans On Image Processing2000，9，5： | 1 |
| 18 | The effect of the dosage of NT-3/chitosan carriers on the proliferation and differentiation of neural stem cells显示文摘 | Zhaoyang Yang Hongmei Duan Linhong Mo Hui Qiao Xiaoguang Li | 2010 | Biomaterials2010，，18： | 1 |
| 19 | Knowledge of Cervical Cancer and HPV,and Willingness to Receive HPV Vaccination Among 20–45-Year-Old Women—Six Provinces,China,2018显示文摘Summary What is already known about this topic?Cervical cancer is a significant public health problem with approximately 570,000 cases and 311,000 deaths occurring in 2018 globally.It is imperative to raise awareness of cervical cancer and human papillomavirus(HPV).What is added by this report?Compared to previous studies,this is one of the largest cross-sectional studies of cervical cancer and HPV in Chinese adult females in recent years.We found that knowledge level of cervical cancer and HPV vaccine was still inadequate among women aged 20–45 years old,and the willingness to receive HPV vaccination was highly associated with knowledge level.What are the implications for public health practice?Intervention programs should aim to improve awareness and knowledge about cervical cancer and HPV vaccines,primarily focusing on women of lower socio-economic status. | Di Gao Gengli Zhao Jiangli Di Xiaosong Zhang Linhong Wang | 2023 | China CDC weekly2023，5，9： | 1 |
| 20 | Long-term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice显示文摘 | Huanling Yu Yanxia Bi Weiwei Ma Lingling He Linhong Yuan Jinfang Feng Rong Xiao | 2009 | International Journal of Developmental Neuroscience2009，，3： | 1 |
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