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| 1 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 2 | Epstein-Barr virus-encoded RNAs as a survival predictor in nasopharyngeal carcinoma显示文摘 | Ke Kengjian Wang Haiyun Fu Sha Zhang Zichen Duan Liping Liu Dabo Ye Jin | 2014 | Chinese Medical Journal2014，，2： | 5 |
| 3 | Aberrant seed development in Litchi chinensis is associated with the impaired expression of cell wall invertase genes显示文摘Cell wall invertase(CWIN)are known to play important roles in seed development.However,most reports to date have focused on a single gene family member,and have mainly investigated CWIN functions during the filling stage of seed development.In this study,we found significant lower levels of CWIN protein and activity associated with seed abortion in the Litchi chinensis cultivar“Nuomici.”We identified five litchi CWIN genes and observed that the expression of LcCWIN5 was limited to the flower tissues and decreased sharply with fruit development.Silencing of LcCWIN5 expression before 28 DAA(cell division stage)resulted in perturbed liquid endosperm development,smaller seeds,and higher seed abortion rate,while silencing after 28 DAA(filling stage)had no effect on seed development.In contrast,LcCWIN2 was mostly expressed in the funicle and seed coat,and increased with fruit development.Decreased LcCWIN2 expression and CWIN activity during early seed filling coincided with smaller seeds in the cultivar“Feizixiao.”Silencing of LcCWIN2 caused a reduction in the seed size without inducing seed abortion.We propose that CWIN activity in seed maternal tissues during cell division stage is likely due to LcCWIN5 expression,which regulates early seed development.On the other hand,CWIN activity during the filling stage is due to the expression of LcCWIN2,which may promote carbon import by creating a sucrose gradient.Comparable LcCWIN5 expression,but much lower CWIN activity,detected in the funicle of“Nuomici”is consistent with post-translational regulation. | Jieqiong Zhang Zichen Wu Fuchu Hu Lian Liu Xuming Huang Jietang Zhao Huicong Wang | 2018 | Horticulture Research2018，5，1： | 4 |
| 4 | DESIGN OPTIMIZATION FOR TRUSS STRUCTURES UNDER ELASTO-PLASTIC LOADING CONDITION显示文摘在这篇论文,为设计优化的一个方法 elasto 塑料捆绑结构基于参量的变化原则(PVP ) 被建议。优化试图在许可的节点排水量的限制下面发现最小的重量 / 卷答案。Thedesign 优化是有平衡限制(MPEC ) 的数学编程的明确的表达。在优化克服互补限制的数字困难,重复进程,包括二次的编程(QP ) 和更新的进程,被采用著名计算机生产厂商他优化方法。而且, elasto 塑料的弄弯捆绑成员在设计优化被看作限制。combinational 优化策略为排水量限制和弄弯的限制被建议,它包括上面提及的方法和一个最佳的标准。三个数字例子被举证明方法的有效性求婚了。 | Liu Tao Deng Zichen | 2006 | Acta Mechanica Solida Sinica2006，19，3： | 4 |
| 5 | Molecular mechanism mediating enteric bacterial translocation after severe burn:the role of cystic fibrosis transmembrane conductance regulator显示文摘Background:Gut ischemia and hypoxia post severe burn leads to breakdown of intestinal epithelial barrier and enteric bacterial translocation(EBT),resulting in serious complications,such as systemic inflammatory response syndrome,sepsis and multiple organ failure.Cystic fibrosis transmembrane conductance regulator(CFTR)is known to be downregulated by hypoxia and modulate junctional complexes,which are crucial structures maintaining the intestinal barrier.This study aimed to investigate whether CFTR plays a role in both regulating the intestinal barrier and mediating EBT post severe burn,as well as the signaling pathways involved in these processes.Methods:An in vitro Caco-2 cell model subjected to hypoxic injury and an in vivo mouse model with a 30%total body surface area full-thickness dermal burn were established.DF 508 mice(mice with F508del CFTR gene mutation)were used as an in vivo model to further demonstrate the role of CFTR in maintaining normal intestinal barrier function.QRT-PCR,western blot,ELISA,TER assay and immunofluorescence staining were used to detect the expression and localization of CFTR and tight junction proteins,as well as the function of tight junctions.Results:Our data indicated that,in Caco-2 cells,the hypoxia condition significantly reduced CFTR expression;activated extracellular signal-regulated kinase and nuclear factor-κB signaling;elevated secretion of inflammatory factors(tumor necrosis factor-α,interleukin-1βand interleukin-8);downregulated zonula occludens-1,occludin and E-cadherin expression;decreased transepithelial electrical resistance values;and led to a cellular mislocation of ZO-1.More importantly,knockdown of CFTR caused similar alterations.The upregulation of inflammatory factors and downregulation of tight junction proteins(ZO-1 and occludin)induced by knockdown of CFTR could be reversed by specific extracellular signal-regulated kinase or nuclear factor-κB inhibition.In support of the in vitro data,exuberant secretion of pro-inflammatory mediators and EBT was observed in the intestine of severely burnt mice in vivo.EBT occurred in DF508 mice(mice with the F508del CFTR gene mutation),accompanied by augmented tumor necrosis factor-α,interleukin-1βand interleukin-8 levels in the ileum compared to wildtype mice.In addition,vitamin D3 was shown to protect the intestinal epithelial barrier from hypoxic injury.Conclusions:Collectively,the present study illustrated that CFTR and downstream signaling were critical in modulating the intestinal epithelial junction and EBT post severe burn. | Xinzhu Liu Yu Chen Bo You Yuan Peng Yajie Chen Zichen Yang Yixin Zhang Jing Chen | 2021 | Burns & Trauma2021，9，1： | 4 |
| 6 | High Quality Data Hiding in Halftone Image Based on Block Conjugate显示文摘This paper proposes a High quality data hiding in halftone image based on block conjugate(HQDHBC). We construct Least mean square filters(LMSF),and using LMSFs to evaluate the quality of halftone images. This paper proposes block conjugate property, and this property can be applied to hide a secret pattern.Therefore a data hiding method based on block conjugate can be proposed, and in this method two images should be divided into multiple blocks of M × N pixels, and in the corresponding block if the first M × N-1 pixels are conjugate or identical, the last pixel can implement normal halftone method instead of date hiding methods. Experimental results show that the proposed HQDHBC can be applied in gray-scale and color error diffused halftone images, and through implementing this method, not only the quality of halftone images can be improved, but also the Correct decoding rate(CDR) of revealed pattern can be guaranteed. | DING Haiyang LI Zichen YANG Yixian YOU Fucheng LIU Fuping | 2018 | Chinese Journal of Electronics2018，27，1： | 3 |
| 7 | High-Performance Photo-Modulated Thin-Film Transistor Based on Quantum dots/Reduced Graphene Oxide Fragment-Decorated ZnO Nanowires显示文摘In this paper, a photo-modulated transistor based on the thin-film transistor structure was fabricated on the flexible substrate by spin-coating and magnetron sputtering. A novel hybrid material that composed of Cd Se quantum dots and reduced graphene oxide(RGO) fragment-decorated ZnO nanowires was synthesized to overcome the narrow optical sensitive waveband and enhance the photo-responsivity. Due to the enrichment of the interface and heterostructure by RGO fragments being utilized, the photo-responsivity of the transistor was improved to 2000 AW^(-1) and the photo-sensitive wavelength was extended from ultraviolet to visible. In addition, a positive back-gate voltage was employed to reduce the Schottky barrier width of RGO fragments and ZnO nanowires. As a result, the amount of carriers was increased by 10 folds via the modulation of back-gate voltage. With these inherent properties, such as integrated circuit capability and wide optical sensitive waveband, the transistor will manifest great potential in the future applications in photodetectors. | Zhi Tao Yi-an Huang Xiang Liu Jing Chen Wei Lei Xiaofeng Wang Lingfeng Pan Jiangyong Pan Qianqian Huang Zichen Zhang | 2016 | Nano-Micro Letters2016，8，3： | 2 |
| 8 | Effect of sodium alginate on phosphorus recovery by vivianite precipitation显示文摘There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.In this study,as a representative of extracellular polymeric substance,the effect of sodium alginate(SA)on phosphorus recovery by vivianite precipitation under different initial SA concentrations(0–800 mg/L),p H values(6.5–9.0)and Fe/P molar ratios(1:1–2.4:1)was investigated using synthetic wastewater.The results showed that SA in low concentrations(≤400 mg/L)had little inhibitory effect on the phosphorus recovery rate.However,when the concentration of SA was larger than 400 mg/L,the phosphorus recovery rate decreased significantly with increasing SA concentrations.The inhibition rate of 800 mg/L SA was about 3 times as large as that of 400 mg/L SA.It was worth noting that the inhibitory effect of SA on vivianite precipitation decreased with increasing initial p H and Fe/P molar ratios.Additionally,SA has no obvious influence on the composition of products,but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes. | Cong Zhang Dexiu Hu Ruijie Yang Zichen Liu | 2020 | Journal of Environmental Sciences2020，32，7： | 2 |
| 9 | Bioresponsive nanotherapy for preventing dental caries by inhibiting multispecies cariogenic biofilms显示文摘Early childhood caries(ECC)is a public healthcare concern that greatly reduces the quality of life of young children.As a leading factor of ECC,cariogenic biofilms are composed of acidogenic/aciduric pathogens and extracellular polysaccharides(EPSs),creating an acidic and protected microenvironment.Antimicrobial photodynamic therapy(aPDT)is a noninvasive,painless,and efficient therapeutic approach that is suitable for treating ECC.However,due to the hyperfine structure of cariogenic biofilms,most photosensitizers(PSs)could not access and penetrate deeply in biofilms,which dramatically hamper their efficiency in the clinic.Herein,bioresponsive nanoparticle loaded with chlorin e6(MPP-Ce6)is developed,which largely increases the penetration depth(by over 75%)and retention(by over 100%)of PS in the biofilm compared with free Ce6.Furthermore,MPP-Ce6-mediated aPDT not only kills the bacteria in preformed biofilms but also inhibits multispecies biofilm formation.A rampant caries model is established to mimic ECC in vivo,where the population of cariogenic bacteria is decreased to 10%after MPP-Ce6-mediated aPDT.Importantly,the number and severity of carious lesions are efficiently reduced via Keyes’scoring and micro-CT analysis.This simple but effective strategy can serve as a promising approach for daily oral hygiene in preventing ECC. | Danfeng Liu Xianbin Ma Yaoting Ji Rourong Chen Shuhui Zhou Hantao Yao Zichen Zhang Mengjie Ye Zhigang Xu Minquan Du | 2022 | Bioactive Materials2022，7，8： | 2 |
| 10 | Bacteriophages in water pollution control:Advantages and limitations显示文摘Wastewater is a breeding ground for many pathogens,which may pose a threat to human health through various water transmission pathways.Therefore,a simple and effective method is urgently required to monitor and treat wastewater.As bacterial viruses,bacteriophages(phages)are the most widely distributed and abundant organisms in the biosphere.Owing to their capacity to specifically infect bacterial hosts,they have recently been used as novel tools in water pollution control.The purpose of this review is to summarize and evaluate the roles of phages in monitoring pathogens,tracking pollution sources,treating pathogenic bacteria,infecting bloom-forming cyanobacteria,and controlling bulking sludge and biofilm pollution in wastewater treatment systems.We also discuss the limitations of phage usage in water pollution control,including phage-mediated horizontal gene transfer,the evolution of bacterial resistance,and phage concentration decrease.This review provides an integrated outlook on the use of phages in water pollution control. | Mengzhi Ji Zichen Liu Kaili Sun Zhongfang Li Xiangyu Fan Qiang Li | 2021 | Frontiers of Environmental Science & Engineering2021，15，5： | 1 |
| 11 | Disease resistance conferred by components of essential chrysanthemum oil and the epigenetic regulation of OsTPS1显示文摘The sesquiterpene alpha-bisabolol is the predominant active ingredient in essential oils that are highly valued in the cosmetics industry due to its wound healing,anti-inflammatory,and skin-soothing properties.Alpha-bisabolol was thought to be restricted to Compositae plants.Here we reveal that alpha-bisabolol is also synthesized in rice,a non-Compositae plant,where it acts as a novel sesquiterpene phytoalexin.Overexpressing the gene responsible for the biosynthesis of alpha-bisabolol,Os TPS1,conferred bacterial blight resistance in rice.Phylogenomic analyses revealed that alpha-bisabolol-synthesizing enzymes in rice and Compositae evolved independently.Further experiments demonstrated that the natural variation in the disease resistance level was associated with differential transcription of Os TPS1 due to polymorphisms in its promoter.We demonstrated that Os TPS1 was regulated at the epigenetic level by JMJ705 through the methyl jasmonate pathway.These data reveal the cross-family accumulation and regulatory mechanisms of alpha-bisabolol production. | Chuansong Zhan Long Lei Hao Guo Shen Zhou Congping Xu Zixin Liu Zichen Wu Yuan Deng Yuanyuan Miao Yu Han Meng Zhang Hua Li Sishu Huang Chenkun Yang Feng Zhang Yufei Li Ling Liu Xianqing Liu Hafiz Muhammad Khalid Abbas Alisdair R.Fernie Meng Yuan Jie Luo | 2023 | Science China(Life Sciences)2023，66，5： | 1 |
| 12 | Analytical modeling and finite element simulation of the plasticcollapse of sandwich beams with pin-reinforced foam cores 显示文摘 | LIU Tao DENG Zichen LU Tianjian | 2008 | International Journal of Solids and Struc- tures2008，45，1819： | 1 |
| 13 | Silica nanoparticles encapsulated by polystyrene via surface grafting and in situ emulsion polymerization显示文摘 | Xuefeng Ding Jingzhe Zhao Yanhua Liu Hengbin Zhang Zichen Wang | 2004 | Materials Letters2004，，25： | 1 |
| 14 | Superconductivity in ThMo_2Si_2C with Mo_2C square net显示文摘We report the superconductivity of a new quaternary compound ThMo_(2)Si_(2)C, synthesized with the arc-melting technique. The compound crystallizes in a tetragonal CeCr_(2)Si_(2)C-type structure with cell parameters of a = 4.2296A and c = 5.3571 A. An interlayer Si–Si covalent bonding is suggested by the atomic distance. The electrical resistivity and magnetic susceptibility measurements indicate a Pauli-paramagnetic metal with dominant electron-electron scattering in the normal-state. Bulk superconductivity at 2.2 K is demonstrated with a dimensionless specific-heat jump of △C/γnT = 0.98. The superconducting parameters of the critical magnetic fields, coherence length, penetration depth, and superconducting energy gap are given. | ZiChen Liu BaiZhuo Li YuSen Xiao QingChen Duan YanWei Cui YuXue Mei Qian Tao ShuLi Wei ShuGang Tan Qiang Jing Qing Lu YuPing Sun YunYan Liu ShengGui Fu Hao Jiang Zhi Ren ZhuAn Xu Cao Wang GuangHan Cao | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，7： | 1 |
| 15 | Analytical modeling and finite element simulation of the plastic collapse of sandwich beams with pin-reinforced foam cores 显示文摘 | Liu Tao Deng Zichen Lu Tianjian | 2008 | International Journal of Solids and Structure2008，45，： | 1 |
| 16 | Laser tracking leader-follower automatic cooperative navigation system for UAVs显示文摘Currently,small payload and short endurance are the main problems of a single UAV in agricultural applications,especially in large-scale farmland.It is one of the important methods to solve the above problems of UAVs by improving operation efficiency through multi-UAV cooperative navigation.This study proposed a laser tracking leader-follower automatic cooperative navigation system for multi-UAVs.The leader in the cluster fires a laser beam to irradiate the follower,and the follower performs a visual tracking flight according to the light spot at the relative position of the laser tracking device.Based on the existing kernel correlation filter(KCF)tracking algorithm,an improved KCF real-time spot tracking method was proposed.Compared with the traditional KCF tracking algorithm,the recognition and tracking rate of the optimized algorithm was increased from 70%to 95%in indoor environment,and was increased from 20%to 90%in outdoor environment.The navigation control method was studied from two aspects:the distance coordinate transformation model based on micro-gyroscope and navigation control strategy.The error of spot position was reduced from the maximum(3.12,−3.66)cm to(0.14,0.12)cm by correcting the deviation distance of the spot at different angles through a coordinate correction algorithm.An image coordinate conversion model was established for a complementary metal-oxide-semiconductor(CMOS)camera and laser receiving device at different mounting distances.The laser receiving device was divided into four regions,S0-S3,and the speed of the four regions is calculated using an uncontrollable discrete Kalman filter.The outdoor flight experiments of two UAVs were carried out outdoors using this system.The experiment results show that the average flight error of the two UAVs on the X-axis is 5.2 cm,and the coefficient of variation is 0.0181.The average flight error on the Z-axis is 7.3 cm,and the coefficient of variation is 0.0414.This study demonstrated the possibility and adaptability of the developed system to achieve multi-UAVs cooperative navigation. | Rui Ming Zhiyan Zhou Zichen Lyu Xiwen Luo Le Zi Cancan Song Yu Zang Wei Liu Rui Jiang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，2： | 0 |
| 17 | Near-infrared fluorophores with absolute aggregation-caused quenching and negligible fluorescence re-illumination for in vivo bioimaging of nanocarriers显示文摘Environment-responsive fluorophores with aggregation-caused quenching(ACQ)properties have been applied to track nanocarriers with reduced artefacts caused by unbound or free fluorophores but suffer from incomplete fluorescence quenching and significant re-illumination,which undermine bioimaging accuracy.Herein,through structural modifications to reinforce the hydrophobicity,planarity and rigidity of fluorophores with an aza-BODIPY framework,probes featuring absolute ACQ(aACQ)and negligible re-illumination are developed and evaluated in various nanocarriers.aACQ probes,FD-B21 and FD-C7,exhibit near-infrared emission,high quantum yield,photostability,water sensitivity,and negligible re-illumination in blood,plasma and 1%Tween-80 in contrast to ACQ probe P2 and conventional probe DiR.All nanocarriers can be labeled efficiently by the tested fluorophores.Polymeric micelles(PMs)labeled by different aACQ probes manifest similar biodistribution patterns,which however differ from that of DiR-labeled PMs and could be ascribed to the appreciable re-illumination of DiR.Significantly lower re-illumination is also found in aACQ probes(2%-3%)than DiR(20%-40%)in Caco-2,Hela,and Raw264.7 cells.Molecular dynamics simulations unravel the molecular mechanisms behind aggregation and re-illumination,supporting the hypothesis of planarity dependency.It is concluded that aACQ fluorophores demonstrate excellent water sensitivity and negligible fluorescence re-illumination,making themselves useful tools for more accurate bioimaging of nanocarriers. | Yifan Cai Xin Ji Yunsen Zhang Chang Liu Zichen Zhang Yongjiu Lv Xiaochun Dong Haisheng He Jianping Qi Yi Lu Defang Ouyang Weili Zhao Wei Wu | 2023 | Aggregate2023，4，2： | 0 |
| 18 | Grinding-assisted heterogeneous nucleation of BiOAc on MoS_(2) nanoflowers to heterojunction with good visible-light photocatalytic performance显示文摘Bismuth oxide subacetate(CH3COO(BiO);BiOAc)with a large band gap energy(Eg)was first applied as an ultraviolet-light-driven photocatalyst in our group.MoS_(2)nanoflowers have been used to improve the visible-light photocatalytic activity of bismuth-based semiconductors with wide Eg because of their good visible-light response.Herein,the grinding-assisted solid-state reaction method was used to prepare a MoS_(2)/BiOAc composite to improve the visible-light photoreactivity of BiOAc.As compared with commonly used wet chemical and hydrothermal routes,the grinding-assisted synthesis facilitated heterogeneous nucleation,which was beneficial to achieving close contact and subsequent charge transfer and separation at the interfaces,resulting in enhanced photocatalytic activity for malachite green,methylene blue,and antibiotic tetracycline degradation under visible-light irradiation.Notably,the dispersion in the mixing solution of ethanol and water(v/v=1)of MoS_(2)nanosheets induced self-assembly into flower-like nanostructures,thus enhancing the photocatalytic activity of MoS_(2)/BiOAc.A possible mechanism for visible-light photocatalysis of MoS_(2)/BiOAc was proposed. | Huanzhen Liu Qiaofeng Han Xuemei Jia Zichen Shen | 2021 | Particuology2021，19，3： | 0 |
| 19 | Assessment of Atmospheric Reanalysis Data Based on Buoy Observations over the Tropical Western Indian Ocean in 2019显示文摘Atmospheric reanalysis data are an important data source for studying weather and climate systems.The sea surface wind and sea level pressure observations measured from a real-time buoy system deployed in Kenya’s offshore area in 2019 conducted jointly by Chinese and Kenyan scientists were used to evaluate the performance of the major high-frequency atmospheric reanalysis products in the western Indian Ocean region.Compared with observations,the sea level pressure field could be accurately simulated using the atmospheric reanalysis data.However,significant discrepancies existed between the surface wind reanalysis data,especially between meridional wind and the observational data.Most of the data provide a complete understanding of sea level pressure,except for the Japanese 55-year Reanalysis data,which hold a significant system bias.The Modern-Era Reanalysis for Research and Applications,Version-2,provides an improved description of all datasets.All the reanalysis datasets for zonal wind underestimate the strength during the study period.Among reanalysis data,NCEP-DOE Atmospheric Model Intercomparison Project reanalysis data presents an inaccurate description due to the worst correlation with the observations.For meridional wind,most reanalysis datasets underestimate the variance,while the European Centre for Medium-Range Weather Forecasts Atmospheric Composition Reanalysis 4 has a larger variance than the observations.In addition to the original data comparison,the diurnal variability of sea level pressure and surface wind are also assessed,and the result indicates that the diurnal variations have a significant gap between observation and reanalysis data.This study indicates that the current high-frequency reanalysis data still have disadvantages when describing the atmospheric parameters in the Western Indian Ocean region. | LUO Yulan LIU Lin PAUL Oloo PHILIP Sagero LI Kuiping YANG Yang SU Qinglei LI Qiuchi MIAO Zichen | 2023 | Journal of Ocean University of China2023，22，4： | 0 |
| 20 | Progresses of mycobacteriophage-based Mycobacterium tuberculosis detection显示文摘Tuberculosis(TB)remains a major cause of morbidity and mortality worldwide,particularly in developing countries.A rapid and efficient method for TB diagnosis is indispensable to check the trend of tuberculosis expansion.The emergence of drug-resistant bacteria has increased the challenge of rapid drug resistance tests.Due to its high specificity and sensitivity,bacteriophage-based diagnosis is intensively pursued.In this review,we mainly described mycobacteriophage-based diagnosis in TB detection,especially two prevalent approaches:fluorescent reporter phage and phage amplified biologically assay(PhaB).The rationale of reporter phage is that phage carrying fluorescent genes can infect host bacteria specifically.Phage amplified biological assay based on the principle that phages can infect the live Mycobacterium tuberculosis in the specimen under suitable conditions and produce plaques.Other phage-based diagnostic methods,such as a combination of the amplified biologically assay and nucleic acid amplification or lateral flow assays,are also actively explored.This review will help us improve the understanding of mycobacteriophages in TB detection and better promote the development of the rapid diagnosis of M.tuberculosis. | ZICHEN LIU SIYAO GUO MENGZHI JI KAILI SUN ZHONGFANG LI XIANGYU FAN | 2020 | BIOCELL2020，44，4： | 0 |
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