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| 1 | Cervical Cancer Screening Rates Among Chinese Women—China,2015显示文摘What is already known about this topic?Cervical cancer is the fourth most common cancer of women around the world.Age-adjusted incidence and mortality rates of cervical cancer were 11.78 and 3.29 per 100,000,respectively,in China in 2015.What is added by this report?Cervical cancer screening rates were 25.7%for women aged 20–64 years old and 31.4%for women aged 35–64 years old in China in 2015.Screening rates were lower in rural areas than in urban areas and varied across provinces.What are the implications for public health practice?Efforts should be made to continue to strengthen national and local policy initiatives,financial support,health education,and accessibility to women in rural areas for cervical cancer screening coverage. | Mei Zhang Yijing Zhong Zhenping Zhao Zhengjing Huang Xiao Zhang Chun Li Maigeng Zhou Jing Wu Limin Wang Xiaoying Zheng Linhong Wang | 2020 | China CDC weekly2020，2，26： | 17 |
| 2 | Cervical Cancer Screening Coverage — China, 2018–2019显示文摘What is already known about this topic?The World Health Organization set a 2030 target of 70%cervical cancer screening coverage for women aged 35–45 years.Coverage stood at 37%in China in 2015.What is added by this report?In 2018–2019,China’s cervical cancer screening coverage reached 43.4%in women aged 35–44 years and 36.8%in women aged 35–64 years.Screening coverage was still lower in rural areas as well as central and western regions;large variations existed across provincial-level administrative divisions.What are the implications for public health practice?National and local policy and financial support should be maintained for cervical cancer screening,along with more targeted health education and outreach efforts and strengthened accessibility of health services in the rural areas and central and western regions. | Mei Zhang Yijing Zhong Limin Wang Heling Bao Zhengjing Huang Zhenping Zhao Xiao Zhang Chun Li Kelly Liang Sun Jing Wu Xiaoying Zheng Linhong Wang | 2022 | China CDC weekly2022，4，48： | 11 |
| 3 | Resistance and fitness costs in diamondback moths after selection using broflanilide, a novel meta-diamide insecticide显示文摘The diamondback moth (DBM) Plutella xylostella (L.) (Lepidoptera: Plutellidae) is an insect pest found around the world that feeds on cruciferous crops. The DBM has become resistant to most insecticides in current use in the field. Broflanilide is a novel meta-diamide insecticide that binds to a new site on the γ-aminobutyric acid receptor and very efficiently protects against most pests in the order Lepidoptera, including DBM. In this study, the resistance of a laboratory-bred susceptible strain of DBM to broflanilide and the fitness costs posed by broflanilide to the DBM were evaluated. The DBM had no obvious resistance to broflanilide after 10 generations of selection. The realized heritability h2 was 0.033, suggesting a low risk of resistance developing in this strain. The F10 generation had no cross-resistance to the insecticides abamectin and endosulfan (which target the γ-aminobutyric acid receptor) and chlorantraniliprole (which targets a non-γ-aminobutyric acid receptor). The specific activities of important detoxification enzymes (cytochrome P450 monooxygenase, esterase, and glutathione S-transferase) were not obviously altered. However, the larval stage was prolonged and the adult stage was shortened significantly in F11 generation than the F0 generation. The total preoviposition period TPOP significantly prolonged 1.90 d in F11 generation. The fitness value Rf (0.93) was lower for the F11 generation than the F0 generation. The results indicated that long-term exposure to broflanilide exerts clear fitness costs in the DBM. This information will be useful in identifying reasonable broflanilide application guidelines for managing broflanilide resistance in the DBM. | Xi Sun Rui Wei Linhong Li Bin Zhu Pei Liang Xiwu Gao | 2022 | Insect Science2022，29，1： | 5 |
| 4 | Breast Cancer Screening Rates Among Women Aged 20 Years and Above—China,2015显示文摘What is already known about this topic?Breast cancer is the most common cancer in women in China and around the world.By 2019,121 countries have instituted a national screening program as a secondary prevention measure for breast cancer.What is added by this report?Breast cancer screening rates in China were 18.9%in women aged 20 years and above,and 25.7%in women aged 35-64 years in 2015.The screening rate for women aged 20 years and above was significantly higher in urban areas than in rural areas(24.6%vs.15.0%),and in the eastern region than in the central and western regions(24.0%vs.15.1%and 15.3%). | Mei Zhang Yijing Zhong Heling Bao Zhenping Zhao Zhengjing Huang Xiao Zhang Chun Li Maigeng Zhou Limin Wang Jing Wu Xiaoying Zheng Linhong Wang | 2021 | China CDC weekly2021，3，13： | 5 |
| 5 | Synthesis and antiviral bioactivities of novel chiral bis-thiourea-type derivatives containing α-aminophosphonate moiety显示文摘Starting from 1-((1R,2R)-2-aminocyclohexyl)-3-substituted thioureas (3a–c) and substituted isothiocyanates (9a–d),chiral bis-thiourea derivatives containing α-aminophosphonate moiety 10a–l were prepared and completely characterized by elemental analysis,physical and spectral (IR,1H NMR,13C NMR,31P NMR) data.The results of bioassay revealed that compounds 10a and 10e possessed appreciable curative bioactivities on cucumber mosaic virus (CMV) at 0.5 mg/mL in vivo (inhibitory rate = 60.3%,64.8% respectively) and tobacco mosaic virus (TMV) at 0.5 mg/mL in vivo (inhibitory rate = 50.3%,50.8% respectively),which were comparable to the values shown by standard reference (58.7%) and commercial product Ningnanmycin (56.3%),respectively.Chiral compound 10e displayed more potent antiviral activity (EC50 = 0.149 mg/mL) than Ningnanmycin (EC50 = 0.201mg/mL) against CMV. | YANG Xuan SONG BaoAn JIN LinHong WEI Xue BHADURY S Pinaki LI XiangYang YANG Song HU DeYu | 2011 | Science China Chemistry2011，54，1： | 5 |
| 6 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 7 | Associations Between Hypertension Status and Increased Heart Rate-China, 2015显示文摘Summary What is already known on this topic?Hypertension is a major public health concern in China,and hypertensive patients have elevated heart rates(HR),which can synergize with higher blood pressure to promote adverse health outcomes.What is added by this report?The risk of increased HR was statistically significant but relatively lower in subjects with treated and controlled hypertension.This lower impact might be modified by sex,marital status,smoking,and physical activity. | Xiao Zhang Mei Zhang Chun Li Linhong Wang Jing Wu Zhengjing Huang Limin Wang | 2020 | China CDC weekly2020，2，40： | 2 |
| 8 | The effect of the dosage of NT-3/chitosan carriers on the proliferation and differentiation of neural stem cells显示文摘 | Zhaoyang Yang Hongmei Duan Linhong Mo Hui Qiao Xiaoguang Li | 2010 | Biomaterials2010，，18： | 1 |
| 9 | APPLICATION AND DEVELOPMENT OF ‘GREEN’ PREVENTIVE AND CONTROL TECHNOLOGIES IN GUIZHOU TEA PLANTATIONS显示文摘The application and development of ‘green’ preventive technologies in teaplantations is an important means of ensuring tea quality and ecologicalsafety. Ecological, agronomic and biological controls are the main preventivemeasures used in Guizhou Province. This paper summarizes the ‘green’preventive technologies being applied in Guizhou tea plantations, including theuse of plant defense inducers to regulate tea plant responses to pathogens,natural enemies to control pest species causing damage to shoots andTrifolium repens to control the main weed species. In addition, it summarizesthe integrated ‘green’ preventive technologies being used in Guizhou andprovides a foundation for the ecological maintenance of tea plantations. | Xiangyang LI Linhong JIN Zhuo CHEN Baoan SONG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，1： | 1 |
| 10 | Experimental research on oxygen-enriched gasification of straw in an entrained-flow gasifier 显示文摘 | Yu Haimiao Li Zeshen Yang Xianyu Jiang Linhong Zhang Ze Chen Dezhen | 2013 | Journal of Renewable and Sustainable Energy2013，5，05： | 1 |
| 11 | Computer Aided Design Technology for Convex Faceted Gem Cuts Based on the Half-Edge Data Structure显示文摘Aiming to increase the efficiency of gem design and manufacturing, a new method in computer-aided-design (CAD) of convex faceted gem cuts (CFGC) based on Half-edge data structure (HDS), including the algorithms for the implementation is presented in this work. By using object-oriented methods, geometrical elements of CFGC are classified and responding geometrical feature classes are established. Each class is implemented and embedded based on the gem process. Matrix arithmetic and analytical geometry are used to derive the affine transformation and the cutting algorithm. Based on the demand for a diversity of gem cuts, CAD functions both for free-style faceted cuts and parametric designs of typical cuts and visualization and human-computer interactions of the CAD system including two-dimensional and three-dimensional interactions have been realized which enhances the flexibility and universality of the CAD system. Furthermore, data in this CAD system can also be used directly by the gem CAM module, which will promote the gem CAD/CAM integration. | Linhong Xu Xiangnan Li Jianhua Rao Yuan Han Zhipeng Li Jichun Li | 2019 | Journal of Beijing Institute of Technology2019，28，3： | 1 |
| 12 | Reduction of allergenic properties of shrimp (Penaeus vannamei) allergens by high intensity ultrasound显示文摘 | LI Zhenxing LINHONG Caolimin JAMIL K | 2006 | European Food Research and Technology2006，223，5： | 1 |
| 13 | Key-Recovery Attacks on LED-Like Block Ciphers显示文摘Asymmetric cryptographic schemes, represe nted by RSA, have bee n show n to be in secure un der quantum computing conditions. Correspondingly, there is a need to study whether the symmetric cryptosystem can still guarantee high security with the advent of quantum computers. In this paper, based on the basic principles of classical slide attacks and Simon's algorithm, we take LED-like lightweight block ciphers as research objects to present a security analysis under both classical and quantum attacks, fully considering the influence on the security of the ciphers of adding the round constants. By analyzing the information leakage of round constants, we can introduce the differential of the round constants to propose a classical slide attack on full-round LED-64 with a probability of 1. The analysis result shows that LED-64 is unable to resist this kind of classical slide attack, but that attack method is not applicable to LED-128. As for quantum attacks, by improving on existing quantum attack methods we dem on strate a qua ntum single-key slide attack on LED-64 and a quantum related-key attack on LED- 128, and indicators of the two attack algorithms are analyzed in detail. The attack results show that adding round consta nts does not completely improve the security of the ciphers, and quantum attacks can provide an exp on ential speed-up over the same attacks in the classical model. It further illustrates that the block cipher that is proved to be safe under classical settings is not necessarily secure under quantum conditions. | Linhong Xu Jiansheng Guo Jingyi Cui Mingming Li | 2019 | Tsinghua Science and Technology2019，24，5： | 1 |
| 14 | Hypertension Prevalence,Awareness,Treatment,Control,and Associated Factors in the Labor Force Population--China,2015显示文摘What is already known about this topic?Hypertension has become a major public health problem worldwide because of its high prevalence and various complications,and it ranks the most important risk factor for cardiovascular diseases(CVDs).What is added by this report?The prevalence,awareness,treatment,and control of hypertension in the labor force population in 2015 in China were 21.4%,26.1%,19.6%,and 6.3%,respectively.Hypertension prevalence in the labor force population remains high and the control of hypertension is still very low.What are the implications for public health practice?Effective public health strategies targeting the labor force population,especially older adults,males,and overweight and obese participants are needed for hypertension prevention and control. | Yunqi Guan Mei Zhang Xiao Zhang Zhenping Zhao Zhengjing Huang Chun Li Maigeng Zhou Youfa Wang Limin Wang Jing Wu Linhong Wang | 2020 | China CDC weekly2020，2，10： | 1 |
| 15 | Breast Cancer Screening Coverage—China,2018-2019显示文摘Summary What is already known about this topic?In 2015,only 18.9%of adult women underwent breast cancer screening in China.What is added by this report?Breast cancer screening coverage for women aged 20 years and above in China reached 22.3%during 2018-2019.Women with lower socioeconomic status had lower screening coverage.There were significant variations across the provincial-level administrative divisions. | Mei Zhang Heling Bao Xiao Zhang Zhengjing Huang Zhenping Zhao Chun Li Maigeng Zhou Jing Wu Limin Wang Linhong Wang | 2023 | China CDC weekly2023，5，15： | 0 |
| 16 | Variations in the Prevalence of Anemia of Varying Severity Among Urban Non-Pregnant Women—China,2021显示文摘Summary What is already known about this topic?Anemia is a significant public health issue affecting women globally.Prior studies in China predominantly concentrated on anemia in pregnant or reproductiveage women,leaving a gap in available data concerning anemia in non-pregnant women of all age groups in China. | Xiaoxi Liu Bo Wang Sailimai Man Heling Bao Yuanyuan Huang Canqing Yu Jun Lyu Linhong Wang Liming Li Hui Liu | 2024 | China CDC weekly2024，6，10： | 0 |
| 17 | Prevalence of Reproductive Tract Infections and Association with Human Papillomavirus Infection Among Reproductive-Age Women—Six Tertiary Hospitals,China,June 2021-December 2022显示文摘Summary What is already known about this topic?Previous studies have indicated a possible association between reproductive tract infections(RTIs)and highrisk human papillomavirus(HPV)infection,but the evidence is still inconclusive.What is added by this report?This multicenter study found significantly higher positive rates of HPV,including general HPV,highrisk HPV. | Di Gao Jiayue Li Gengli Zhao Zhaohui Liu Hui Bi Dai Zhang Fengxia Xue Chen Liu Hongtao Ma Bei Lin Xu Wang Xiaosong Zhang Linhong Wang | 2024 | China CDC weekly2024，6，10： | 0 |
| 18 | Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons显示文摘The expression of linear DNA sequence is precisely regulated by the three-dimensional(3D)architecture of chromatin.Morphine-induced aberrant gene networks of neurons have been extensively investigated;however,how morphine impacts the 3D genomic architecture of neurons is still unknown.Here,we applied digestion-ligation-only high-throughput chromosome conformation capture(DLO Hi-C)technology to investigate the effects of morphine on the 3D chromatin architecture of primate cortical neurons.After receiving continuous morphine administration for 90 days on rhesus monkeys,we discovered that morphine re-arranged chromosome territories,with a total of 391 segmented compartments being switched.Morphine altered over half of the detected topologically associated domains(TADs),most of which exhibited a variety of shifts,followed by separating and fusing types.Analysis of the looping events at kilobase-scale resolution revealed that morphine increased not only the number but also the length of differential loops.Moreover,all identified differentially expressed genes from the RNA sequencing data were mapped to the specific TAD boundaries or differential loops,and were further validated for changed expression.Collectively,an altered 3D genomic architecture of cortical neurons may regulate the gene networks associated with morphine effects.Our finding provides critical hubs connecting chromosome spatial organization and gene networks associated with the morphine effects in humans. | Liang Wang Xiaojie Wang Chunqi Liu Wei Xu Weihong Kuang Qian Bu Hongchun Li Ying Zhao Linhong Jiang Yaxing Chen Feng Qin Shu Li Qinfan Wei Xiaocong Liu Bin Liu Yuanyuan Chen Yanping Dai Hongbo Wang Jingwei Tian Gang Cao Yinglan Zhao Xiaobo Cen | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 19 | Genetically Encoded FRET Biosensor Detects the Enzymatic Activity of Prostate-Specific Antigen显示文摘Prostate cancer is the most common cancer among men beyond 50 years old,and ranked the second in mortality.The level of Prostate-specific antigen(PSA)in serum has been a routine biomarker for clinical assessment of the cancer development,which is detected mostly by antibody-based immunoassays.The proteolytic activity of PSA also has important functions.Here a genetically encoded biosensor based on fluorescence resonance energy transfer(FRET)technology was developed to measure PSA activity.In vitro assay showed that the biosensor containing a substrate peptide‘RLSSYYSGAG’had 400%FRET change in response to 1µg/ml PSA within 90 min,and could detect PSA activity at 25 ng/ml.PSA didn’t show enzymatic activity toward the biosensor in serum solution,likely reflecting the existence of other inhibitory factors besides Zn^(2+).By expressing the biosensor on cell plasma membrane,the FRET responses were significant,but couldn’t distinguish well the cultured prostate cancer cells from non-prostate cancer cells under microscopy imaging,indicating insufficient speci-ficity to PSA.The biosensor with the previously known‘HSSKLQ’substrate showed little response to PSA in solution.In summary,we developed a genetically encoded FRET biosensor to detect PSA activity,which may serve as a useful tool for relevant applications,such as screening PSA activation substrates or inhibitors;the purified biosensor protein can also be an alternative choice for measuring PSA activity besides currently commercialized Mu-HSSKLQ-AMC substrate from chemical synthesis. | Hui Yao Liqun Wang Jia Guo Weimin Liu Jingjing Li Yingxiao Wang Linhong Deng Mingxing Ouyang | 2020 | Molecular & Cellular Biomechanics2020，17，3： | 0 |
| 20 | Simvastatin Blocks Reinstatement of Cocaine-induced Conditioned Place Preference in Male Mice with Brain Lipidome Remodeling显示文摘Drug-associated reward memories are conducive to intense craving and often trigger relapse.Simvastatin has been shown to regulate lipids that are involved in memory formation but its influence on other cognitive processes is elusive.Here,we used a mass spectrometry-based lipidomic method to evaluate the impact of simvastatin on the mouse brain in a cocaine-induced reinstatement paradigm.We found that simvastatin blocked the reinstatement of cocaine-induced conditioned place preference(CPP)without affecting CPP acquisition.Specifically,only simvastatin administered during extinction prevented cocaine-primed reinstatement.Global lipidome analysis showed that the nucleus accumbens was the region with the greatest degree of change caused by simvastatin.The metabolism of fatty-acids,phospholipids,and triacylglycerol was profoundly affected.Simvastatin reversed most of the effects on phospholipids induced by cocaine.The correlation matrix showed that cocaine and simvastatin significantly reshaped the lipid metabolic pathways in specific brain regions.Furthermore,simvastatin almost reversed all changes in the fatty acyl profile and unsaturation caused by cocaine.In summary,pre-extinction treatment with simvastatin facilitates cocaine extinction and prevents cocaine relapse with brain lipidome remodeling. | Wei Xu Yuman He Jiamei Zhang Hongchun Li Xuemei Wan Menglu Li Yonghai Wang Rui Xu Haoluo Zhang Yanping Dai Haxiaoyu Liu Linhong Jiang Ying Zhao Xiaobo Cen | 2021 | Neuroscience Bulletin2021，37，12： | 0 |
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