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| 1 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 2 | Synthesis and antiviral bioactivities of novel chiral bis-thiourea-type derivatives containing α-aminophosphonate moiety显示文摘Starting from 1-((1R,2R)-2-aminocyclohexyl)-3-substituted thioureas (3a–c) and substituted isothiocyanates (9a–d),chiral bis-thiourea derivatives containing α-aminophosphonate moiety 10a–l were prepared and completely characterized by elemental analysis,physical and spectral (IR,1H NMR,13C NMR,31P NMR) data.The results of bioassay revealed that compounds 10a and 10e possessed appreciable curative bioactivities on cucumber mosaic virus (CMV) at 0.5 mg/mL in vivo (inhibitory rate = 60.3%,64.8% respectively) and tobacco mosaic virus (TMV) at 0.5 mg/mL in vivo (inhibitory rate = 50.3%,50.8% respectively),which were comparable to the values shown by standard reference (58.7%) and commercial product Ningnanmycin (56.3%),respectively.Chiral compound 10e displayed more potent antiviral activity (EC50 = 0.149 mg/mL) than Ningnanmycin (EC50 = 0.201mg/mL) against CMV. | YANG Xuan SONG BaoAn JIN LinHong WEI Xue BHADURY S Pinaki LI XiangYang YANG Song HU DeYu | 2011 | Science China Chemistry2011，54，1： | 5 |
| 3 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 4 | APPLICATION AND DEVELOPMENT OF ‘GREEN’ PREVENTIVE AND CONTROL TECHNOLOGIES IN GUIZHOU TEA PLANTATIONS显示文摘The application and development of ‘green’ preventive technologies in teaplantations is an important means of ensuring tea quality and ecologicalsafety. Ecological, agronomic and biological controls are the main preventivemeasures used in Guizhou Province. This paper summarizes the ‘green’preventive technologies being applied in Guizhou tea plantations, including theuse of plant defense inducers to regulate tea plant responses to pathogens,natural enemies to control pest species causing damage to shoots andTrifolium repens to control the main weed species. In addition, it summarizesthe integrated ‘green’ preventive technologies being used in Guizhou andprovides a foundation for the ecological maintenance of tea plantations. | Xiangyang LI Linhong JIN Zhuo CHEN Baoan SONG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，1： | 1 |
| 5 | Synthesis,X-ray crystallographic analysis,and antitumor activity of N-(benzothiazole-2-yl)-1-(fluorophenyl)-O,O-dialkyl-α-aminopbosphonates显示文摘 | Linhong Jin Baoan Song Guoping Zhang | 2006 | Bioorg Med Chem Lett2006，16，6： | 1 |
| 6 | Expression of hMOF, but not HDAC4, is responsible for the global histoneH4K16 acetylation in gastric carcinoma显示文摘 | Lin Zhu Jiaxing Yang Linhong Zhao Xue Yu Lingyao Wang Fei Wang Yong Cai Jingji Jin | 2015 | International Journal of Oncology2015，，6： | 1 |
| 7 | Synthesis,X-ray crystallographic analysis,and antitumor activity of N-(benzothiazole-2-yl)-1-(fluorophenyl)-O,O-dialkyl-alpha-aminophosphonates显示文摘 | JIN Linhong SONG Baoan ZHANG Guoping | 2006 | Bioorg Med Chem Lett2006，16，6： | 1 |
| 8 | Synthesis, X-ray crystallographic analysis and antiturmor activity of N-( benzothia- zole-2-yl)-l-(fluorophenyl) -O, O-dialkyl-α-aminophosphonates 显示文摘 | Jin Linhong Song Baoan Zhang Guoping | 2006 | Bioorganic & Medicinal Chemistry Letters2006，16，6： | 1 |
| 9 | A Study on Six-Bar Linkage Knee Prosthesis显示文摘 | Ruihong Zhang Linhong Ji Dewen Jin Jichuan Zhang Caiqin Bai(Department of Precision Instruments, Tsinghua University Beijing 100084, China) | 1999 | Chinese Journal of Biomedical Engineering(English Edition)1999，8，3： | 1 |
| 10 | A study on six-bar linkage knee prosthesis显示文摘 | Ji Linhong Jin Dewen | 1999 | Chinese J of Biomedical Engineering1999，8，3： | 1 |
| 11 | Synthesis and reaction of 16-electron Cp^tRh halfsandwich complexes containing 1,2- dichalcogenolate carborane ligands显示文摘The reactions of [CptRhCl(m-Cl)]2 (1) (Cpt = tBu2C5H3) with Li2E2C2B10H10 (E = S, Se) lead to the green 16-electron dichalcogenolate complexes CptRh(E2C2B10H10) [E = S(2a), Se(2b)]. The 16-electron complexes 2a and 2b can take up two-electron donor ligands such as tert-butyl isoni-trile and carbon monoxide to give the 18-electron dichalco-genolate derivatives Cpt(L)(E2C2B10H10) [L = tBuNC, E = S(3a), Se(3b); L = CO, E = S(4a), Se(4b)]. The molecular structures of complexes 2a and 3a were determined by X-ray crystal structure analysis. The molecular structure of 16- electron complex 2a shows the pseudoaromatic system in IrSe2C2 five numbered ring. | KONG Qingan, JIN Guoxin, CAI Shuyi & WENG Linhong Laboratory of Molecular Catalysis and Innovative Material, Chemistry Department, Fudan University, Shanghai 200433, China Correspondence should be addressed to Jin Guoxin (e-mail: gxjin@ fudan.edu.cn) | 2003 | Chinese Science Bulletin2003，48，16： | 1 |
| 12 | MOTION QUALITY EVALUATION OF TARGET-REACHING MOVEMENT OF INDEX FINGER显示文摘ms paper proposes a set of objective and quantitative human motion evaluation indices, among Which the index of difficulty and index of performance are introduced as the general indices for the quality measure of 2-D target-to-talget movement. As an example, the target-reaching movement of index finger, which is a basic functional action of index finger in the daily life of hUman beings, were experimentally investigated. In the experiment five healthy male subjects were asked to perform three target-reaching movement tasks Which have different indices of difficulty. All movements were recorded by a 3-D motion analysis system. Later, their motion qualities were measured with these evaluation metrics. The results showed that these indices are reasonable and have potential applications to biomedical engineering. | Huang Changhua Wang Jijun Wang Rencheng Ji Linhong Zhang Jichuan Jin Dewen(Department of Precision Instruments, Tsinghua University, Beiiing 100084, P.R.ChinaTel: +86-10-62785591, Fax:+86-10-62784691, Email: huangc5@asme.org) | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，4： | 0 |
| 13 | Sanguinarine Decreases Cell Stiffness and Traction Force and Inhibits the Reactivity of Airway Smooth Muscle Cells in Culture显示文摘Airway hyperresponsiveness(AHR)is the cardinal character of asthma,which involves the biomechanical properties such as cell stiffness and traction force of airway smooth muscle cells(ASMCs).Therefore,these biomechanical properties comprise logical targets of therapy.β2-adrenergic agonist is currently the mainstream drug to target ASMCs in clinical practice for treating asthma.However,this drug is known for side effects such as desensitization and non-responsiveness in some patients.Therefore,it is desirable to search for new drug agents to be alternative ofβ2-adrenergic agonist.In this context,sanguinarine,a natural product derived from plants such as bloodroots,that has been reported to relax gut smooth muscle emerges as a potential candidate.So far,it is unknown whether sanguinarine can regulate the biomechanical properties of ASMCs and reactivity of ASMCs to irritants.Thus,we tested the hypothesis that sanguinarine reduce the contractile potentials of ASMCs in culture.To do so,the primary cultured rat ASMCs were first treated with different concentration of sanguinarine.Then,cell stiffness,traction force,fiber distribution,and calcium signaling of the ASMCs were evaluated by optical magnetic twisting cytometry,Fourier transform traction microscopy,atomic force microscopy,and Fluo-4/AM based fluorescence confocal scanning microscopy,respectively.The results indicated that sanguinarine(0.05 and 0.5μmol/L)significantly decreased cell stiffness and traction force,inhibited reactivity of ASMCs to histamine,and disrupted the fiber structures in ASMCs in dose-dependent manner.These findings establish that sanguinarine can indeed change the biomechanical properties of ASMCs and may be used to treat AHR in asthma. | Mingzhi Luo Kai Ni Peili Yu Yang Jin Lei Liu Jingjing Li Yan Pan Linhong Deng | 2019 | Molecular & Cellular Biomechanics2019，16，2： | 0 |
| 14 | Heterogeneous Growth of ZnO Crystal on GaN/Al_(2)O_(3) Substrate显示文摘Hydrothermal(HT)ZnO substrates were usually used as seeds for the vapor growth of ZnO crystals.In this work,ZnO bulk crystals were grown using the relatively low-cost GaN/AlOsubstrates as seeds by chemical vapor transport(CVT).With the increase of growth time,the dislocation densities in the crystal decreased from about 1×10^(6) to 6×10^(3) cm^(-2).The carrier concentration decreased from 1.24×10^(19) to 1.57×10^(17)cm^(-3),while the carrier mobility increased from 63.8 to 179 cm^(2)/(V·s).The optical transmittance in the VIS-NIR wavelength increased significantly in combination with the decreasing dislocation densities and impurity concentrations.The dislocation lines and related fast diffusion paths gradually decreased and disappeared in the late growth stage,and the crystal qualities were consequently improved.The experimental results show that the properties of as-grown ZnO crystals are comparable with bulk ZnO grown on the HT substrates to some extent.The GaN/Al_(2)O_(3) seeds may have a potential application value in the industrial production of ZnO single crystals. | 樊龙 ZHONG Changjie WANG Xuemin CAO Linhong WANG Jin PENG Liping ZHAN Zhiqiang 熊政伟 吴卫东 | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，4： | 0 |
| 15 | Sensing Traction Strain Induces Cell-Cell Distant Communications显示文摘Mechanobiology has been a highly recognized field in studying the importance of physical forces in physiologies at the molecular,cellular,tissue,organ and body-levels.Beside the intensive work focusing on the fine local biomechanical forces,the long-range force which can propagate through a relatively distant scale(in hundreds of micrometers and beyond)has been an intriguing topic with increasing attentions in recent years.The collective functions at cell population level often rely on cell-cell communications with or without direct contacts.Recent progresses including our own work indicate that the long-range biomechanical force propagating across scales far beyond single cell size may reserve the capability to trigger coordinative biological responses within cell population.Whether and how cells communicate mechanically in a distant manner remains largely to be explored.In respiratory system,the mechanical property of airway smooth muscle(ASM)is associated with asthma attack with prolonged contraction during airway hyper-responsiveness.In this work,we found that ASM cells rapidly self-assembled into a well-constructed network on 3D matrigel containing type I collagen(COL I),which required the collective functions and coordination of thousands of cells completed within 12-16 hours.Cells were assembled with aligned actin stress fibers and elongated nuclei.The assembling process relied on the long-range mechanical forces across the matrix to direct cell-cell distant interactions.We further found that single ASM cells could rapidly initiate multiple buds precisely pointing to neighboring cells in distance,which relied on cell traction force and force strain on the matrix.Beads tracking assay demonstrated the long-range transmission of cellular traction force to distant locations,and modeling of maximum strain distribution on matrix by finite element method predicted the consistency with cell directional protrusions and movements in experiments.Cells could sense each other in distance to move directionally on both non-fibrous matrigel and in much more efficient way when containing COL I.Cells recruited COL I from the hydrogel to build nearly identical COL I fibrous network to mechanically stabilize the cell network.Our results revealed that ASM cells can sense the traction strain transmitted through matrix to initiate distant communications and rapidly coordinate the network assembly at the population level through active cell-matrix interactions.As an interesting phenomenon,cells sound able to’make phone call’via the role of long-range mechanical force.In summary,this work demonstrated that long-range biomechanical force facilitates the collective functions of ASM cell population for network assembly.The cells reacted to traction strain on the matrix for distant communications,which resulted in directional budding and movement.Fibrous COL I had important roles in facilitating the efficiency of force transmission to induce the assembly and stabilizing the cell network.This work has helped advance the understanding of the feature andfunction of long-range biomechanical force at the cell population level.The observed high mechano-sensitivity of ASM cells might suggest a re-enforced feedback of enhanced contraction by excessive ASM under asthmatic condition. | Zhili Qian Yang Jin Bing Bu Yan Pan Linhong Deng Mingxing Ouyang | 2019 | 医用生物力学2019，34，A01： | 0 |
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