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| 1 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 2 | High-security-level multi-dimensional optical storage medium:nanostructured glass embedded with LiGa_(5)O_(8):Mn^(2+) with photostimulated luminescence显示文摘The launch of the big data era puts forward challenges for information preservation technology,both in storage capacity and security.Herein,a brand new optical storage medium,transparent glass ceramic(TGC)embedded with photostimulated LiGa5O8:Mn2+nanocrystals,capable of achieving bit-by-bit optical data write-in and read-out in a photon trapping/detrapping mode,is developed.The highly ordered nanostructure enables light–matter interaction with high encoding/decoding resolution and low bit error rate.Importantly,going beyond traditional 2D optical storage,the high transparency of the studied bulk medium makes 3D volumetric optical data storage(ODS)possible,which brings about the merits of expanded storage capacity and improved information security.Demonstration application confirmed the erasable-rewritable 3D storage of binary data and display items in TGC with intensity/wavelength multiplexing.The present work highlights a great leap in photostimulated material for ODS application and hopefully stimulates the development of new multi-dimensional ODS media. | Shisheng Lin Hang Lin Chonggeng Ma Yao Cheng Sizhe Ye Fulin Lin Renfu Li Ju Xu Yuansheng Wang | 2020 | Light(Science & Applications)2020，9，1： | 12 |
| 3 | A comparative study on source apportionment of polycyclic aromatic hydrocarbons in sediments of the Daliao River,China:Positive matrix factorization and factor analysis with non-negative constraints显示文摘Two receptor models,positive matrix factorization (PMF) and factor analysis with non-negative constraints (FA-NNC),were applied for source apportionment of polycyclic aromatic hydrocarbons (PAHs) in sediments of the Daliao River,China.The source profiles and source contributions derived from the two receptor models were comparable.For PMF,PAHs mainly came from coal combustion (43.3%),followed by biomass burning (24.3%),traffic emissions (16.7%) and coke oven (15.7%).As for FA-NNC,coal combustion (50.4%) was dominant,followed by biomass burning (21.9%),traffic emission (15.7%) and coke oven (12.0%).The source apportionment results are consistent with the results from the specific PAH diagnostic ratios and emission inventory analysis.In addition,the source apportionment results are consistent with the structure of energy material usage in Liaoning Province of China. | LIU ChunHui TIAN FuLin CHEN JingWen LI XueHua QIAO XianLiang | 2010 | Chinese Science Bulletin2010，55，10： | 10 |
| 4 | Dynamic contrast-enhanced MRI versus ^(18)F-FDG PET/CT: Which is better in differentiation between malignant and benign solitary pulmonary nodules?显示文摘Objective: To prospectively compare the discriminative capacity of dynamic contrast enhanced-magnetic resonance imaging(DCE-MRI) with that of ^(18)F-fluorodeoxyglucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT) in the differentiation of malignant and benign solitary pulmonary nodules(SPNs).Methods: Forty-nine patients with SPNs were included in this prospective study. Thirty-two of the patients had malignant SPNs, while the other 17 had benign SPNs. All these patients underwent DCE-MRI and ^(18)F-FDG PET/CT examinations. The quantitative MRI pharmacokinetic parameters, including the trans-endothelial transfer constant(K^(trans)), redistribution rate constant(K_(ep)), and fractional volume(Ve), were calculated using the Extended-Tofts Linear two-compartment model. The ^(18)F-FDG PET/CT parameter, maximum standardized uptake value(SUV_(max)), was also measured. Spearman's correlations were calculated between the MRI pharmacokinetic parameters and the SUV_(max) of each SPN. These parameters were statistically compared between the malignant and benign nodules. Receiver operating characteristic(ROC) analyses were used to compare the diagnostic capability between the DCE-MRI and ^(18)F-FDG PET/CT indexes.Results: Positive correlations were found between K^(trans) and SUV_(max), and between K_(ep) and SUV_(max)(P<0.05).There were significant differences between the malignant and benign nodules in terms of the K^(trans), K_(ep) and SUV_(max) values(P<0.05). The areas under the ROC curve(AUC) of K^(trans), K_(ep) and SUV_(max) between the malignant and benign nodules were 0.909, 0.838 and 0.759, respectively. The sensitivity and specificity in differentiating malignant from benign SPNs were 90.6% and 82.4% for K^(trans); 87.5% and 76.5% for K_(ep); and 75.0% and 70.6%for SUV_(max), respectively. The sensitivity and specificity of K^(trans) and K_(ep) were higher than those of SUV_(max), but there was no significant difference between them(P>0.05).Conclusions: DCE-MRI can be used to differentiate between benign and malignant SPNs and has the advantage of being radiation free. | Feng Feng Fulin Qiang Aijun Shen Donghui Shi Aiyan Fu Haiming Li Mingzhu Zhang Ganlin Xia Peng Cao | 2018 | Chinese Journal of Cancer Research2018，30，1： | 10 |
| 5 | Differentiation of neuron-like cells from mouse parthenogenetic embryonic stem cells显示文摘Parthenogenetic embryonic stem cells have pluripotent differentiation potentials,akin to fertilized embryo-derived embryonic stem cells.The aim of this study was to compare the neuronal differentiation potential of parthenogenetic and fertilized embryo-derived embryonic stem cells.Before differentiation,karyotype analysis was performed,with normal karyotypes detected in both parthenogenetic and fertilized embryo-derived embryonic stem cells.Sex chromosomes were identified as XX.Immunocytochemistry and quantitative real-time PCR detected high expression of the pluripotent gene,Oct4,at both the mRNA and protein levels,indicating pluripotent differentiation potential of the two embryonic stem cell subtypes.Embryonic stem cells were induced with retinoic acid to form embryoid bodies,and then dispersed into single cells.Single cells were differentiated in N2 differentiation medium for 9 days.Immunocytochemistry showed parthenogenetic and fertilized embryo-derived embryonic stem cells both express the neuronal cell markers nestin,βIII-tubulin and myelin basic protein.Quantitative real-time PCR found expression of neurogenesis related genes(Sox-1,Nestin,GABA,Pax6,Zic5 and Pitx1) in both types of embryonic stem cells,and Oct4 expression was significantly decreased.Nestin and Pax6 expression in parthenogenetic embryonic stem cells was significantly higher than that in fertilized embryo-derived embryonic stem cells.Thus,our experimental findings indicate that parthenogenetic embryonic stem cells have stronger neuronal differentiation potential than fertilized embryo-derived embryonic stem cells. | Xingrong Yan Yanhong Yang Wei Liu Wenxin Geng Huichong Du Jihong Cui Xin Xie Jinlian Hua Shumin Yu Liwen Li Fulin Chen | 2013 | Neural Regeneration Research2013，8，4： | 4 |
| 6 | Elastin-like polypeptide modified silk fibroin porous scaffold promotes osteochondral repair显示文摘Silk fibroin(SF)is considered biocompatible and biodegradable for osteochondral repair.However,it lacks a bioactive domain for cell adhesion,proliferation and differentiation,limiting its therapeutic efficacy.To revamp SF as a biomimicking and bioactive microenvironment to regulate cell behaviours,we engineered an elastin-like polypeptide(ELP,Val-Pro-Gly-Xaa-Gly)to modify SF fibers via simple and green dehydrothermal(DHT)treatment.Our results demonstrated that the ELP successfully bound to SF,and the scaffold was reinforced by the fusion of the silk fiber intersections with ELP(S-ELP-DHT)via the DHT treatment.Both bone mesenchymal stem cells(BMSCs)and chondrocytes exhibited improved spreading and proliferation on the S-ELP-DHT scaffolds.The ex vivo and in vivo experiments further demonstrated enhanced mature bone and cartilage tissue formation using the S-ELP-DHT scaffolds compared to the naked SF scaffolds.These results indicated that a recombinant ELPmodified silk scaffold can mimic three-dimensional(3D)cell microenvironment,and improve bone and cartilage regeneration.We envision that our scaffolds have huge clinical potential for osteochondral repair. | Zhuoyue Chen Qiang Zhang Hongmin Li Qi Wei Xin Zhao Fulin Chen | 2021 | Bioactive Materials2021，6，3： | 4 |
| 7 | Scheduling Framework Using Dynamic Optimal Power Flow for Battery Energy Storage Systems显示文摘Battery energy storage systems(BESS)are instrumental in the transition to a low carbon electrical network with enhanced flexibility,however,the set objective can be accomplished only through suitable scheduling of their operation.This paper develops a dynamic optimal power flow(DOPF)-based scheduling framework to optimize the day(s)-ahead operation of a grid-scale BESS aiming to mitigate the predicted limits on the renewable energy generation as well as smooth out the network demand to be supplied by conventional generators.In DOPF,all the generating units,including the ones that model the exports and imports of the BESS,across the entire network and the complete time horizon are integrated on to a single network.Subsequently,an AC-OPF is applied to dispatch their power outputs to minimize the total generation cost,while satisfying the power balance equations,and handling the unit and network constraints at each time step coupled with intertemporal constraints associated with the state of charge(SOC).Furthermore,the DOPF developed here entails the frequently applied constant current-constant voltage charging profile,which is represented in the SOC domain.Considering the practical application of a 1 MW BESS on a particular 33 kV network,the scheduling framework is designed to meet the pragmatic requirements of the optimum utilization of the available energy capacity of BESS in each cycle,while completing up to one cycle per day. | Fulin Fan Ivana Kockar Han Xu Jingsi Li | 2022 | CSEE Journal of Power and Energy Systems2022，8，1： | 3 |
| 8 | Direct numerical simulation of impinging shock wave and turbulent boundary layer interaction over a wavy-wall显示文摘The interaction of an impinging oblique shock wave with an angle of 30°and a supersonic turbulent boundary layer at Ma_(∞)=2.9 and Re_(θ)=2400 over a wavy-wall is investigated through direct numerical simulation and compared with the interaction on a flat-plate under the same flow conditions.A sinusoidal wave with amplitude to wavelength ratio of 0.26 moves in the streamwise direction and is uniformly distributed across the spanwise direction.The influences of the wavy-wall on the interaction,including the characterization of the flow field,the skin-friction,pressure and the budget of turbulence kinetic energy,are systematically studied.The region of separation grows slightly and decomposes into four bubbles.Local peaks of skin-friction are observed at the rear part of the interaction region.The low-frequency shock motion can be seen in the wall pressure spectra.Analyses of the turbulence kinetic energy budget indicate that both diffusion and transport significantly increase near the crests,balanced by an amplified dissipation in the near-wall region.Proper orthogonal decomposition analyses show that the most energetic structures are associated with the separated shock and the shear layer over the bubbles.Only the bubbles in the first two troughs are dominated by a low-frequency enlargement or shrinkage. | Fulin TONG Dong SUN Xinliang LI | 2021 | Chinese Journal of Aeronautics2021，34，5： | 3 |
| 9 | HER2 gene status and the relationship with p21 protein expression in gastric cancer显示文摘我们瞄准了到分析的目的有在胃的癌的 p21 蛋白质表示的 HER2 基因地位和它的关系。在 situ 杂交(鱼) 和 immunohistochemistry (IHC ) 的方法荧光技术被用来在胃的癌症的 59 种情况中检测 HER2 基因地位和 p53 蛋白质。HER2 基因扩大率的结果鱼察觉是 16.9%(10/59 ) ,在没有拷贝数字获得的 49 种情况中的 HER2 基因扩大和基因扩大是 49.2% 的一个总数(29/59 ) 。HER2 蛋白质表示是 42.4%(25/59 ) ,在有 +++ 的病人的 HER2 基因扩大率,, ++ HER2 蛋白质表示在有 + HER2 蛋白质表示的病人是 3/3 和 5/8,它是 2/14,有重要差别(P < 0.05 ) 。p21 蛋白质表示率是 49.2%(29/59 ) , HER2 基因扩大率和 p21 蛋白质表示在肿瘤侵略深度有重要差别,淋巴节点转移(P < 0.05 ) ;在组织学的类型的有的不统计的意义,变老,性差别(P > 0.05 ) 。结论 HER2 基因扩大率和基因拷贝数字断然与 p21 蛋白质表示, HER2 基因地位和联合察觉能提供的 p21 蛋白质的表示有关联在胃的癌症转移,病人条件开发和预后的引用值,它能也指导单个治疗的临床的开发。 | Yongjie Li Yangkun Wang Xianwei Zhang Fulin Li Nianlong Meng Xutao Yuan Jinsheng Song | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，3： | 3 |
| 10 | Modifying the Power and Performance of 2-Dimensional MoS_(2)Field Effect Transistors显示文摘Over the past 60 years,the semiconductor industry has been the core driver for the development of information technology,contributing to the birth of integrated circuits,Internet,artificial intelligence,and Internet of Things.Semiconductor technology has been evolving in structure and material with co-optimization of performance–power–area–cost until the state-of-the-art sub-5-nm node.Two-dimensional(2D)semiconductors are recognized by the industry and academia as a hopeful solution to break through the quantum confinement for the future technology nodes.In the recent 10 years,the key issues on 2D semiconductors regarding material,processing,and integration have been overcome in sequence,making 2D semiconductors already on the verge of application.In this paper,the evolution of transistors is reviewed by outlining the potential of 2D semiconductors as a technological option beyond the scaled metal oxide semiconductor field-effect transistors.We mainly focus on the optimization strategies of mobility(μ),equivalent oxide thickness(EOT),and contact resistance(RC),which enables high ON current(Ion)with reduced driving voltage(Vdd).Finally,we prospect the semiconductor technology roadmap by summarizing the technological development of 2D semiconductors over the past decade. | Fulin Zhuo Jie Wu Binhong Li Moyang Li Chee Leong Tan Zhongzhong Luo Huabin Sun Yong Xu Zhihao Yu | 2023 | Research2023，，3： | 2 |
| 11 | Two-Weight Linear Codes and Their Applications in Secret Sharing显示文摘Linear codes with few weighs have many applications in secret sharing.Determining the access structure of the secret sharing scheme based on a linear code is a very difficult problem.We provides a method to construct a class of two-weight torsion codes over finite non-chain ring.We determine the minimal codewords of these torsion codes over the finite non-chain ring.Based on the two-weight codes,we find the access structures of secret sharing schemes. | WANG Yaru LI Fulin ZHU Shixin | 2019 | Chinese Journal of Electronics2019，28，4： | 2 |
| 12 | The opposite prognostic significance of nuclear and cytoplasmic p21 expression in resectable gastric cancer patients显示文摘 | Yefei Huang Weimin Wang Yansu Chen Yulin Huang Jianbing Zhang Song He Yongfei Tan Fulin Qiang Aiping Li Oluf Dimitri R?e Shouyu Wang Yan Zhou Jianwei Zhou | 2014 | Journal of Gastroenterology2014，，11： | 2 |
| 13 | Deformation Analysis and Fixture Design of Thin-walled Cylinder in Drilling Process Based on TRIZ Theory显示文摘Thin-walled cylindrical workpiece is easy to deform during machining and clamping processes due to the insufficient rigidi.Moreover,it’s also difficult to ensure the perpendicularity of flange holes during drilling process.In this paper,the element birth and death technique is used to obtain the axial deformation of the hole through finite element simulation.The measured value of the perpendicularity of the hole was compared with the simulated value to verify then the rationality of the simulation model.To reduce the perpendicularity error of the hole in the drilling process,the theory of inventive principle solution(TRIZ)was used to analyze the drilling process of thin-walled cylinder,and the corresponding fixture was developed to adjust the supporting surface height adaptively.Three different fixture supporting layout schemes were used for numerical simulation of drilling process,and the maximum,average and standard deviation of the axial deformation of the flange holes and their maximum hole perpendicularity errors were comparatively analyzed,and the optimal arrangement was optimized.The results show that the proposed deformation control strategy can effectively improve the drilling deformation of thin-walled cylindrical workpiece,thereby significantly improving the machining quality of the parts. | Fulin WANG Bo SHENG Yongwen WU Jiawang LI Zhou XU Zhaoxia ZHU | 2021 | Mechanical Engineering Science2021，3，1： | 1 |
| 14 | Micromagnetic studies of perpendicular recording FePt media with controllable grain size distributions显示文摘A 3-dimensional (3D) micromagnetic model combined with Fast Fourier Transform (FFT) method was built up to study the writability in the L10 FePt perpendicular medium. The effects of controllable grain size distributions were studied by grain growth simulation. It is found that the cross-track-averaged magnetization changes little between the L10 FePt medium with uniform or non-uniform grain size distribution. | DONG Zhong PIAO Kun SHE Shengxian WEI Dan LI Zhenghua WEI Fulin | 2006 | Rare Metals2006，25，z1： | 1 |
| 15 | Effect of microlimestone on properties of self-consolidating concrete with manufactured sand and mineral admixture显示文摘Self-consolidating concrete(SCC)with manufactured sand(MSCC)is crucial to guarantee the quality of concrete construction technology and the associated property.The properties of MSCC with different microlimestone powder(MLS)replacements of retreated manufactured sand(TMsand)are investigated in this study.The result indicates that high-performance SCC,made using TMsand(TMSCC),achieved high workability,good mechanical properties,and durability by optimizing MLS content and adding fy ash and silica fume.In particular,the TMSCC with 12%MLS content exhibits the best workability,and the TMSCC with 4%MLS content has the highest strength in the late age,which is even better than that of SCC made with the river sand(R sand).Though MLS content slightly affects the hydration reaction of cement and mainly plays a role in the nucleation process in concrete structures compared to silica fume and fly ash,increasing MLS content can evidently have a significant impact on the early age hydration progress.TMsand with MLS content ranging from 8%to 12%may be a suitable alternative for the Rsand used in the SCC as fine aggregate.The obtained results can be used to promote the application of SCC made with manufactured sand and mineral admixtures for concrete-based infrastructure. | Fulin Qu Wengui Li Xiaohui Zeng Zhiyu Luo Kejin Wang Daichao Sheng | 2020 | Frontiers of Structural and Civil Engineering2020，14，6： | 1 |
| 16 | A comparison of optical performance between evacuated collector tubes with flat end semicylindric absorbers显示文摘 | He Zinian Ge Hongehuan Jiang Fulin Li Wei | 1997 | Solar Energy1997，60，2： | 1 |
| 17 | 靶向肾癌中的E3连接酶接头蛋白SPOP的小分子抑制剂显示文摘近年来肾癌发病率上升幅度在恶性肿瘤中排名第一。临床治疗表明,肾癌对放疗和化疗均不敏感,以索拉非尼和舒尼替尼为代表的靶向抗肿瘤药物是晚期肾癌的一线治疗药物,但对转移性肾癌的疗效十分有限,并且容易产生耐药。因此,发现并确证治疗肾癌特异性药物作用新靶标是一项十分紧迫并意义重大的任务。 | Zhong-Qiang Guo Tong Zheng Baoen Chen Cheng Luo Sisheng Ouyang Shouzhe Gong Jiafei Li Liu-Liang Mao Fulin Lian Yong Yang Yue Huang Li Li Jing Lu Bidong Zhang Luming Zhou Hong Ding Zhiwei Gao Liqun Zhou Guoqiang Li Ran Zhou Ke Chen Jingqiu Liu Yi Wen Likun Gong Yuwen Ke Shang-Dong Yang Xiao-Bo Qiu Naixia Zhang Jin Ren Dafang Zhong 杨财广 刘江 蒋华良 | 2017 | 科学新闻2017，19，4： | 1 |
| 18 | Polymorphisms involved in the miR-218 - LAMB3 pathway and susceptibility of cervical cancer, a case–control study in Chinese women显示文摘 | Xiaoyi Zhou Xiaojun Chen Lingmin Hu Suping Han Fulin Qiang Yuling Wu Li Pan Hongbing Shen Ying Li Zhibin Hu | 2010 | Gynecologic Oncology2010，，2： | 1 |
| 19 | Synthesis of hierarchical rippled Bi2O3 nanobehs for supercapacitor applications显示文摘 | Zheng Fulin Li Gaoren Ou Yannan | | 0，，27： | 1 |
| 20 | Polymorphisms involved in the miR-218 - LAMB3 pathway and susceptibility of cervical cancer, a case–control study in Chinese women显示文摘 | Xiaoyi Zhou Xiaojun Chen Lingmin Hu Suping Han Fulin Qiang Yuling Wu Li Pan Hongbing Shen Ying Li Zhibin Hu | 2010 | Gynecologic Oncology2010，，2： | 1 |
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