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| 1 | Clinical significance of hepatic derangement in severe acute respiratory syndrome显示文摘AIM: Elevation of alanine aminotransferase (ALT) level is commonly seen among patients suffering from severe acute respiratory syndrome (SARS). We report the progression and clinical significance of liver derangement in a large cohort of SARS patient.METHODS: Serial assay of serum ALT was followed in patients who fulfilled the WHO criteria of SARS. Those with elevated ALT were compared with those with normal liver functions for clinical outcome. Serology for hepatitis B virus (HBV) infection was checked. Adverse outcomes were defined as oxygen desaturation, need of intensive care unit (ICU) and mechanical ventilation and death.RESULTS: Two hundred and ninety-four patients were included in this study. Seventy (24%) patients had elevated serum ALT on admission and 204 (69%) patients had elevated ALT during the subsequent course of illness. Using peak ALT >5×ULN as a cut-off and after adjusting for potential confounding factors, the odds ratio of peak ALT>5x ULN for oxygen desaturation was 3.24 (95%CI 1.23-8.59, P = 0.018), ICU care was 3.70 (95% CI 1.38-9.89, P = 0.009), mechanical ventilation was 6.64 (95%CI 2.22-19.81, P = 0.001) and death was 7.34(95%CI 2.28-24.89, P = 0.001). Ninety-three percent of the survived patients had ALT levels normalized or were on the improving trend during follow-up. Chronic hepatitis B was not associated with worse clinical outcomes.CONCLUSION: Reactive hepatitis is a common complication of SARS-coronavirus infection. Those patients with severe hepatitis had worse clinical outcome. | Henry Lik-Yuen Chan Ambrose Chi-Pong Kwan Ka-Fai To Sik-To Lai Paul Kay-Sheung Chan Wai-Keung Leung Nelson Lee Alan Wu Joseph Jao-Yiu Sung | 2005 | World Journal of Gastroenterology2005，11，14： | 4 |
| 2 | Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013显示文摘 | Joseph R. Mikhael David Dingli Vivek Roy Craig B. Reeder Francis K. Buadi Suzanne R. Hayman Angela Dispenzieri Rafael Fonseca Taimur Sher Robert A. Kyle Yi Lin Stephen J. Russell Shaji Kumar P. Leif Bergsagel Steven R. Zeldenrust Nelson Leung Matthew T. D | 2013 | Mayo Clinic Proceedings2013，，4： | 2 |
| 3 | Roles of paroxetine and corticosterone on adult mammalian ciliary body cell proliferation显示文摘背景在成年哺乳动物的视网膜的神经发生通常被废除,并且这显示再生 capacity.Despite 的视网膜缺乏这,有在保留学习在调查二药,皮质脂酮和 paroxetine 的效果瞄准了的在场的神经原的 potential.The 的睫的上皮的nestin积极的房间的一张小人口,在老鼠是的睫的 body.Methods 成年人 Sprague-Dawley 的房间增长上给车辆,皮质脂酮, paroxetine ,或两个 | WANG Hua LAU Benson WM YAU Suk-yu LI Suk-yee LEUNG Nelson WANG Ning-li TANG Siu-wa LEE Tatia MC SO Kwok-fai | 2010 | Chinese Medical Journal2010，，10： | 2 |
| 4 | A method for vehicle count in the presence of multiplevehicle occlusions in traffic images 显示文摘 | Clement Chun Cheong Pang William Wai Leung Lam Nelson Hon Ching Yung | 2007 | IEEE Transactions on Intelligent Transportation System2007，8，3： | 1 |
| 5 | The role of d iazepamloading for the treatment of alcohol with draw al syndrom e in hospitalized patients 显示文摘 | Muzyk A J Leung J G Nelson S | 2013 | Am J Addict2013，22，2： | 1 |
| 6 | Original Comm unication Post-natal iron status of Hong Kong Chinese worn en in a longitudinal study of maternal nutrition 显示文摘 | Chan SM Nelson EAS SSF Leung | 2001 | European Journal of Clinical Nutrition2001，55，： | 1 |
| 7 | A Method for Vehicle Count in the Presence of Multiple-Vehicle Occlusions in Traffic Images显示文摘 | Pang Clement Chun Cheong Lam William Wai Leung Yung Nelson Hon Ching | 2007 | IEEE Transaction on Intelligent Transportation Systems2007，8，3： | 1 |
| 8 | Long-term outcome of renal transplantation in light-chain deposition disease显示文摘 | Nelson Leung Donna J Lager Morie A Gertz Kirk Wilson Sharan Kanakiriya Fernando C Fervenza | 2004 | American Journal of Kidney Diseases2004，，1： | 1 |
| 9 | Recent Improvements in Survival in Primary Systemic Amyloidosis and the Importance of an Early Mortality Risk Score显示文摘 | Kumar Shaji K Gertz Morie A Lacy Martha Q Dingli David Hayman Suzanne R Buadi Francis K Short-Detweiler Kristen Zeldenrust Steven R Leung Nelson Greipp Philip R Lust John A Russell Stephen J Kyle Robert A Rajkumar S Vincent Dispenzieri Ange | 2011 | Mayo Clinic Proceedings2011，，1： | 1 |
| 10 | The role of diazepam loading {or the treatment of alcohol withdrawal syndrome in hospitalized patients显示文摘 | Muzyk A J Leung J G Nelson S | 2013 | Am J Addict2013，22，2： | 1 |
| 11 | A Method for Vehicle Count in the Pres ence of Multiple-Vehicle Occlusions in Traffic Images 显示文摘 | Clement Chun Cheong Pang William Wai Leung Lam Nelson Hon Ching Yung | 2007 | IEEE Transactions on Intelligent Transportation Systems2007，8，9： | 1 |
| 12 | Rheolytic pharmacomechanical thrombec- tomy for the management of acute limb ischemia : results from the PEARL regis- try显示文摘 | Leung DA Blitz LR Nelson T | 2015 | J Endovasc Ther2015，22，4： | 1 |
| 13 | Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013显示文摘 | Joseph R. Mikhael David Dingli Vivek Roy Craig B. Reeder Francis K. Buadi Suzanne R. Hayman Angela Dispenzieri Rafael Fonseca Taimur Sher Robert A. Kyle Yi Lin Stephen J. Russell Shaji Kumar P. Leif Bergsagel Steven R. Zeldenrust Nelson Leung Matthew T. D | 2013 | Mayo Clinic Proceedings2013，，4： | 1 |
| 14 | A Method for Vehicle Count in the Presence of Multiple -Vehicle Occlusions in Traffic Images 显示文摘 | Clement Chun Cheong Pang William Wai Leung Lam Nelson Hon Ching Yung | 2007 | IEEE Transaction on Intelligent Transportation Systems2007，8，3： | 1 |
| 15 | Population structure of plant pathogenic fungi and bacteria显示文摘 | Leung H Nelson R J Leach J E | 1993 | Advances in Plant Patlaology1993，10，： | 1 |
| 16 | Trends and outcomes of modern staging of solitary plasmacytoma of bone显示文摘 | Rahma Warsame Morie A. Gertz Martha Q. Lacy Robert A. Kyle Francis Buadi David Dingli Philip R. Greipp Suzanne R. Hayman Shaji K. Kumar John A. Lust Stephen J. Russell Thomas E. Witzig Joseph Mikhael Nelson Leung Steven R. Zeldenrust S. Vincent Rajkumar A | 2012 | Am. J. Hematol2012，，7： | 1 |
| 17 | Original Communication Post-natal iron status of HongKong Chinese women in a longitudinal study of maternal nutrition显示文摘 | Chan SM Nelson EAS SSF Leung | 2001 | European Journal of Clinical Nutrition2001，55，： | 1 |
| 18 | Troponin T level as an exclusion criterion for stem cell transplantation in light-chain amyloidosis显示文摘 | Morie Gertz Martha Lacy Angela Dispenzieri Suzanne Hayman Shaji Kumar Francis Buadi Nelson Leung Mark Litzow | 2008 | Leukemia & Lymphoma2008，，1： | 1 |
| 19 | Population structure of plant pathogenic fungi and bacteria显示文摘 | Leung H Nelson R Leach J | 1993 | Advanced Plant Pathol- ogy1993，10，1： | 1 |
| 20 | A method for vehicle count in the presence of multiple-vehicle occlusions in traffic images显示文摘 | Clement Chun Cheong Pang William Wai Leung Lam Nelson HonChing Yung | 2007 | IEEE Transaction on Intel-ligent Transportation Systems2007，8，9： | 1 |
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