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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | 黄河流域未来气候-水文变化的模拟研究显示文摘将大尺度半分布式水文模型VIC应用到黄河上中游流域(花园口水文断面以上),并利用区域气候模式RegCM4.0单向嵌套全球气候模式BCC_CSM1.1,动力降尺度到黄河流域的模拟结果驱动VIC模型,开展在新的典型浓度路径下(RCP4.5和RCP8.5)黄河流域未来气候和水文变化的离线模拟。模拟结果显示,在RCP4.5和RCP8.5排放情景下,黄河流域21世纪平均地表气温相对于1971—2000年均呈显著上升趋势,2019—2048年上升1.2—1.5℃,2069—2098年上升2.19—3.9℃。未来年平均降水量有微弱的增大,2019—2048年增幅为6%左右,2069—2098年增幅为1.4%—5.6%。未来蒸发量增大明显,2069—2098年年平均蒸发量最大可增加9.6%。2019—2048年花园口水文站的年平均径流量增大3.4%—7.4%,2069—2098年年平均径流量转为减少,减幅为3.3%—5.3%。黄河上游地区未来气候和水文变化趋势与黄河流域基本一致,但未来年径流量变幅低于黄河流域,相对比较稳定。 | 康丽莉 LEUNG L Ruby 柳春 王守荣 | 2015 | 气象学报2015，73，2： | 13 |
| 3 | 青年型开角型青光眼的中国家系的新型Myocilin基因突变显示文摘目的:探讨某中国家系青年型开角型青光眼(JOAG)的致病基因。
方法:在一个青光眼家系中,三代人中患JOAG或高眼压。我们筛查了6位家族成员Myocilin(MYOC)和 optineurin(OPTN)的突变和apolipoprotein E的多态性,2位患有JOAG,2位患有高眼压,2位无症状。正常对照组包括200位与本家系无关联的受试者。用编码野生型或变异性 MYOC 互补 DNA 的表达载体转染cos-7细胞系。细胞内或分泌的MYOC蛋白用Western法进行检测。 | Bao Jian Fan Dexter Y. L Leung Dan Yi Wang Stéphane Vincent Raymond Pancy O. S. Tam Dennis S. C. Lam Chi Pui Pang 王婷(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，4： | 5 |
| 4 | Projected changes in mean and interannual variability of surface water over continental China显示文摘Five General Circulation Model(GCM) climate projections under the RCP8.5 emission scenario were used to drive the Variable Infiltration Capacity(VIC) hydrologic model to investigate the impacts of climate change on hydrologic cycle over continental China in the 21 st century. The bias-corrected climatic variables were generated for the Fifth Assessment Report of the Intergovernmental Panel on Climate Change(IPCC AR5) by the Inter-Sectoral Impact Model Intercomparison Project(ISIMIP). Results showed much larger fractional changes of annual mean Evapotranspiration(ET) per unit warming than the corresponding fractional changes of Precipitation(P) per unit warming across the country, especially for South China, which led to a notable decrease of surface water variability(P-E). Specifically, negative trends for annual mean runoff up to -0.33%/ year and soil moisture trends varying between -0.02% to -0.13%/year were found for most river basins across China. Coincidentally, interannual variability for both runoff and soil moisture exhibited significant positive trends for almost all river basins across China, implying an increase in extremes relative to the mean conditions. Noticeably, the largest positive trends for runoff variability and soil moisture variability, which were up to 0.41%/year and 0.90%/year, both occurred in Southwest China. In addition to the regional contrast, intra-seasonal variation was also large for the runoff mean and runoff variability changes, but small for the soil moisture mean and variability changes. Our results suggest that future climate change could further exacerbate existing water-related risks(e.g., floods and droughts) across China as indicated by the marked decrease of surface water amounts combined with a steady increase of interannual variability throughout the 21 st century. This study highlights the regional contrast and intra-seasonal variations for the projected hydrologic changes and could provide a multi-scale guidance for assessing effective adaptation strategies for China on a river basin, regional, or as a whole. | LENG GuoYong TANG QiuHong HUANG MaoYi HONG Yang Leung L RUBY | 2015 | Science China Earth Sciences2015，58，5： | 4 |
| 5 | Icteric flare of chronic hepatitis B in a 95-year old patient显示文摘A 95-year old gentleman developed fatal icteric flare of chronic hepatitis B despite lamivudine treatment. This article highlights the atypical presentations of chronic hepatitis B in elderly patient and the need to consider this possibility for acute fulminant hepatitis in endemic areas. | WS Wong Wai Keung Leung Henry L Y Chan | 2003 | World Journal of Gastroenterology2003，9，12： | 3 |
| 6 | The conversion factor of K_(eff) to K_(3.7) in thermoluminescence dating显示文摘In the fine-grain TL dating the full o dose must be converted into the equivalent P dose. The conversion is finished by Keff-value, which is an effective or effectiveness. But the Keff can not be measured directly for each sample and only the external radiative efficiency K3.7 can be measured. In order to obtain the Keff a special study for the conversion factor of Keff to K3.t has been made using the ultrathin TLD. The results show that the conversion factor of tile TLD for archaeological samples is 0.847, which is in agreement with calculated value 0.85. | Wang Wei-Da Zhou Zhi-Xin Xia Jun-Ding (Research Laborotory for Conservation and Archaeology, Shanghai Museum, Shanghai 200951)Leung P L Stokes M J(Department of Physics and Materials Science, City University of Hong Kong) | 1998 | Nuclear Science and Techniques1998，9，4： | 3 |
| 7 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 3 |
| 8 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 9 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 2 |
| 10 | Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients显示文摘 | Bertrand Baujat Hélène Audry Jean Bourhis Anthony T.C. Chan Haluk Onat Daniel T.T. Chua Dora L.W. Kwong Muhyi al-Sarraf Kwan-Hwa Chi Masato Hareyama Sing F. Leung Kullathorn Thephamongkhol Jean-Pierre Pignon | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，1： | 2 |
| 11 | Is artificial intelligence the final answer to missed polyps in colonoscopy?显示文摘Lesions missed by colonoscopy are one of the main reasons for post-colonoscopy colorectal cancer,which is usually associated with a worse prognosis.Because the adenoma miss rate could be as high as 26%,it has been noted that endoscopists with higher adenoma detection rates are usually associated with lower adenoma miss rates.Artificial intelligence(AI),particularly the deep learning model,is a promising innovation in colonoscopy.Recent studies have shown that AI is not only accurate in colorectal polyp detection but can also reduce the miss rate.Nevertheless,the application of AI in real-time detection has been hindered by heterogeneity of the AI models and study design as well as a lack of long-term outcomes.Herein,we discussed the principle of various AI models and systematically reviewed the current data on the use of AI on colorectal polyp detection and miss rates.The limitations and future prospects of AI on colorectal polyp detection are also discussed. | Thomas K L Lui Wai K Leung | 2020 | World Journal of Gastroenterology2020，26，35： | 2 |
| 12 | Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection 显示文摘 | TIPOE G L LEUNG T M HUNG M W | 2007 | Cardiovasc Hematol Disord Drug Targets2007，7，2： | 1 |
| 13 | Shyness and locus of control as predictors of internet addiction and internet use显示文摘 | Chak K Leung L | 2004 | Cyberpsychol Behav2004，7，5： | 1 |
| 14 | Stochastic spline ritz method based on stochastic variational principle 显示文摘 | Yang L F Leung A Y T Yan L B | 2005 | Engineering Structures2005，27，3： | 1 |
| 15 | A prospective randomized controlled trial on ureteral stenting after ureteroscopic holmium laser lithotripsy显示文摘 | CHEUNG M C LEE F LEUNG Y L | 2003 | J Urol2003，169，4： | 1 |
| 16 | Effect of supplementation of leukemia inhibitory factor and epidermal growth factor on murine embryonic development in vitro, implantation, and outcome of offspring显示文摘 | Cheung L P Leung H Y Bongso A | 2003 | Fertil Steril2003，80，2： | 1 |
| 17 | A randomized controlled trial of azithromycin and amoxycillin/clavulanate in the management of subacute childhood rhinosinusitis 显示文摘 | Ng DK Chow PY Leung L | 2000 | J Paediatr Child Health2000，36，： | 1 |
| 18 | Regulation of cell adhesion and anchorage-dependent growth by a new β1-interinlinked protein kinase显示文摘 | Hannigan G E Leung Hagecsteijn C Fitz Gibbon L | 1996 | Nature1996，379，6560： | 1 |
| 19 | Observation on the decline in sperm quality of Penaeus serilferus under laboratory conditions 显示文摘 | Leung T J R Lawrence A L | 1987 | Aquaculture1987，65，： | 1 |
| 20 | Molecular identification of the lobster muscle protein tropomyosin as a seafood allergen 显示文摘 | Leung P S Chen Y C Mykles D L | 1998 | Mol Mar Biol Biotechnol1998，7，1： | 1 |
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