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| 1 | The American Heart Association’s Get With the Guidelines(GWTG)-Stroke development and impact on stroke care显示文摘The American Heart Association’s Get With the Guidelines(GWTG)-Stroke programme has changed stroke care delivery in the USA since its establishment in 2003.GWTG is a voluntary registry and continuous quality improvement initiative that collects data on patient characteristics,hospital adherence to guidelines and inpatient outcomes.Implementation of the programme saw increased provision of evidence-based care and improved patient outcomes.This review will describe the development of the programme and discuss the impact on stroke outcomes and transformation of stroke care delivery that followed its implementation. | Cora H Ormseth Kevin N Sheth Jeffrey L Saver Gregg C Fonarow Lee H Schwamm | 2017 | Stroke & Vascular Neurology2017，2，2： | 15 |
| 2 | 黔中气溶胶传输的^210Pb和^7Be示踪:Ⅰ.周时间尺度的解释显示文摘认识环境核素在不同地域空气中的浓度分布和沉降到地表环境的通量对气溶胶污染物全球扩散模型的建立和验证、沉积过程示踪和沉积计年、流域侵蚀示踪参比,以及生态系统受天然辐照的评价等多个领域都是关键的依据。自2001年以来在贵阳观风山等地逐周连续采样,对近地面空气和降水中210Pb和7Be浓度的观测结果表明:①因气象条件变化,近地面空气210Pb和7Be周浓度具有2~6周变幅不等的短周期波动。210Pb空气浓度在年内的总趋势呈现出受气温变化的总体影响和降水的短暂调控;而7Be空气浓度出现连续不断的峰—谷交替。②两核素在近地面空气周浓度的低值同步,210Pb/7Be比率较高(≥0.8),显示出海洋性贫210Pb-7Be气团的入侵影响;它们高的周浓度也同步耦合,比率较低(≤0.7),显示出高层大气富7Be气团的输入。③210Pb和7Be的周降水浓度及水—气分配系数在秋末~春季较高,而春末—秋季明显偏低。周降水浓度随同期空气浓度呈增高趋势,其季节分界分别为0.2Bq/L和1Bq/L;而Kd值随同期空气浓度增大呈降低趋势。210Pb和7Be的降水沉降主要分布在每年的春夏季;周沉降量随同期降水量呈增大趋势,7Be增大的斜率约为210Pb的3倍;当近于零降水时,它们在降水中的初始比率约为2.5。它们出现高或者较高的周降水沉降都伴随当周或邻周空气浓度的急剧下降;降水中210Pb/7Be比率主要分布在≤0.5,并与空气中210Pb/7Be比率基本同步,显示出两核素被降水清洗的效率基本相近。④2008年冰冻极端天气过程中,210Pb-7Be空气浓度同步低谷并存在气溶胶低浓度与高比活度耦合。⑤观风山7Be周空气浓度显示低纬度、较高海拔地区的预期水平;短周期波动反映强下沉气流和低海拔上升气团影响分别在观风山和瓦里关山的滞后性。 | 万国江 郑向东 Lee H N Bai Z G 万恩源 王仕禄 杨伟 苏菲 汤洁 王长生 黄荣贵 刘鹏 | 2010 | 地球科学进展2010，25，5： | 12 |
| 3 | 新生儿复苏培训降低新生儿死亡率的效能分析:文献综述,meta分析与Delphi法的应用显示文摘[背景]全球每年13600万新生儿中,约1000万需要外界的帮助才能建立自主呼吸,每年有约814000例新生儿死亡是由分娩相关足月儿死亡(以往定义为'出生窒息')所导致的。目前尚缺乏关于新生儿复苏培训降低新生儿死亡率效能的系统性评价。[目的]对在医院和社区层面开展的快速评估及初步刺激、基本的复苏措施这两种新生儿复苏培训干预方法在降低足月新生儿分娩相关死亡率('出生窒息')、早产相关并发症死亡率这两个生命指标方面的效能进行评价。[方法]采用系统综述的方法,检索并筛选符合标准的新生儿复苏培训研究文献。采用GRADE方法对文献的质量进行评价。对符合要求的文件进行Meta分析。对数据质量较低的文献采用专家咨询法估计效能大小。[结果]通过文献检索筛选了24篇新生儿复苏培训干预研究(20篇观察性研究,2篇半试验研究,2篇随机对照研究)。对其中3篇文献进行Meta分析结果显示,以医院为基础的新生儿复苏培训可使分娩相关足月儿死亡降低30%(RR=0.70,95%CI0.59~0.84);文献中涉及早产儿死亡率效能的数据质量不高,因此采用专家咨询法进行估计。以社区为基础的新生儿复苏培训干预研究具有较高的异质性,复苏培训通常是一系列培训包的一部分,且对早产儿和足月儿的定义标准不一致。专家咨询法估计结果显示,新生儿快速评估和初步刺激可使分娩相关新生儿死亡、早产儿死亡均降低10%;以医院为基础的培训可使早产儿死亡进一步降低10%,以社区为基础的培训可使分娩相关足月儿死亡率进一步降低20%,早产儿死亡率进一步降低5%。[结论]新生儿复苏培训在医院层面可以使足月新生儿分娩相关死亡率降低30%,然而中低收入水平的国家培训覆盖率仍较低。专家咨询法估计新生儿复苏培训在社区层面降低足月儿及早产儿死亡率的效能较小。需要对新生儿复苏培训的效果、成本、实施策略等进行更深入的研究与评价。 | Anne CC Lee Simon Cousens Stephen N Wall 徐韬 | 2012 | 中国妇幼卫生杂志2012，3，2： | 11 |
| 4 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet2012，，9813： | 10 |
| 5 | Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy显示文摘Real-time vibrational spectroscopic imaging is desired for monitoring cellular states and cellular processes in a label-free manner.Raman spectroscopic imaging of highly dynamic systems is inhibited by relatively slow spectral acquisition on millisecond to second scale.Here,we report microsecond scale vibrational spectroscopic imaging by lock-in free parallel detection of spectrally dispersed stimulated Raman scattering signal.Using a homebuilt tuned amplifier array,our method enables Raman spectral acquisition,within the window defined by the broadband pulse,at the speed of 32 μs and with close to shot-noise limited detection sensitivity.Incorporated with multivariate curve resolution analysis,our platform allows compositional mapping of lipid droplets in single live cells,observation of intracellular retinoid metabolism,discrimination of fat droplets from protein-rich organelles in Caenorhabditis elegans,spectral detection of fast flowing tumor cells and monitoring drug diffusion through skin tissue in vivo.The reported technique opens new opportunities for compositional analysis of cellular compartment in a microscope setting and high-throughput spectral profiling of single cells in a flow cytometer setting. | Chien-Sheng Liao Mikhail N Slipchenko Ping Wang Junjie Li Seung-Young Lee Robert A Oglesbee Ji-Xin Cheng | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 6 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet . 2012 (9813)2012，，9813： | 7 |
| 7 | 黔中气溶胶传输的^210Pb和^7Be示踪:Ⅱ.月及年时间尺度的剖析显示文摘自2001年12月连续逐周在贵阳观风山附近对近地面空气210Pb-7Be浓度和沉降量的观测表明:区域性降水和气温制约近地面空气210Pb具高浓度'U'型年分布;降水量和平流层向下输送影响近地面空气7Be月均浓度的季节性变化;210Pb/7Be月均浓度比率受控于210Pb变化和富7Be气团下沉的影响。观风山与瓦里关山之间因纬度和海拔的关系,7Be比率急剧震荡,显示出海洋性贫7Be气团入侵对观风山地区的明显影响。2002—2008年间贵阳观风山近地面空气210Pb的年均浓度(2.8±0.6)mBq/m3,约为全球若干站点中最高平均浓度值的4倍;而7Be的年均浓度(4.8±0.6)mBq/m3,与全球高海拔站点长期观测的平均值相当,大约为北半球中纬度对流层顶部附近7Be浓度值(18.0mBq/m3)的1/3.8,显示出低纬度、较高海拔地区的预期水平。2003年,瓦里关山和观风山近地面空气7Be的年均浓度比为3.8,与预期的大气输送和混合作用基本一致。7Be月均浓度的增大趋势反映出受太阳黑子数减少的变化关系,其影响底线大约为4mBq/m3;7Be年均浓度波动的增大趋势反映出受太阳黑子数降低的可能影响。贵阳观风山降水中7Be和210Pb的体积加权浓度分别为0.72Bq/L和0.27Bq/L;年沉降通量分别为0.080Bq/(cm2.a)和0.031Bq/(cm2.a)。数值模拟显示出全球空气210Pb高浓度区和高沉降通量环带分布,印证了洱海和红枫湖沉积物7Be和137Cs蓄积的模拟结果。 | 万国江 郑向东 Lee H N Bai Z G 万恩源 王仕禄 杨伟 苏菲 汤洁 王长生 黄荣贵 刘鹏 | 2010 | 地球科学进展2010，25，5： | 6 |
| 8 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 9 | High-performance oxygen reduction and evolution carbon catalysis: From mechanistic studies to device integration显示文摘能容易集成于存在的高效、便宜的氧减小和进化催化剂的发展设备为利用 O 2-H2 O 化学,例如再生燃料房间和金属空气电池。此处,我们报导 NH 3-activated 做 N 的层次碳(NHC ) 催化剂经由一条可伸缩的线路综合了,并且表明它的设备集成。NHC 催化剂为氧减小反应(ORR ) 和氧进化反应(OER ) 展出了好性能,当综合时,借助于电气化学的研究和评估示威了进一个再生燃料房间的氧电极。为 ORR 和 OER 观察的活动比得上最先进的磅和红外催化剂在碱的环境完成的那些。我们进一步通过密度为电气化学的活动作为活跃地点识别了碳缺点的关键角色功能的理论计算和高分辨率的 TEM 可视化。这个工作加亮 NHC 的潜力在再生燃料房间并且可能代替商业宝贵金属为断断续续的可更新的精力的划算的存储的金属空气电池。 | John W. F. To Jia Wei Desmond Ng Samira Siahrostami Ai Leen Koh Yangjin Lee Zhihua Chen Kara D. Fong Shucheng Chen Jiajun He Won-Gyu Bae Jennifer Wilcox Hu Young Jeong Kwanpyo Kim Felix Studt Jens K. Nфrskov Thomas F. Jaramillo Zhenan Bao | 2017 | Nano Research2017，10，4： | 4 |
| 10 | 根据泥炭湿地碳固定探讨晚显生宙气候调控机理显示文摘在温带泥炭湿地上,泥炭的增长被认为是整个晚显生宙主要的气候调控机制之一。自从植物生命开始在陆地上出现以后,泥炭湿地一直是显著的陆地碳汇,它可以为沉积物和冰岩芯等观察到的大气组成的变化提供较好的解释。由于碳的汇过程形成了无烟煤、褐煤和泥炭,它们都是在相同的条件下形成的。泥炭的增长和分解被认为是与晚新生代冰期和间冰期有规律的转换有一定关系,这为Milankovitch理论提供了另一种解释。人们认为冰期将景观转换为适宜于泥炭地开始发育的类型,因此形成了一个反馈机制系统。我们的模型表明,将来在没有人类产生温室气体(如CO_2)排放的自然条件下,考虑到海洋的调节作用,在不到1000年的时间里可能出现一个新的冰期。如果像目前这样温室气体浓度不断增加的情况下,冰期开始时间将很可能会随大气浓度增加而相应地推迟。在目前的CO_2水平(大约350ppm)下,我们的模型表明,新冰期开始出现时间可能至少被延迟700~1000年。在最坏的方案中,即CO_2排放不断增加、人类活动一直不停地排放CO_2直到公元2500年,在我们模型中的多数情况下,冰期开始出现的时间将至少被推迟1万年。 | Lars G.Franzén Deliang Chen Lee F.Klinger 闵庆文(译) 李文华(校) | 1996 | 人类环境杂志1996，25，7： | 4 |
| 11 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 12 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet2012，，9813： | 3 |
| 13 | Solder engineering for optoelectronic packaging显示文摘 | Y C Lee N Basavanhally | 1994 | JOM1994，4，6： | 3 |
| 14 | Clinical role of β-lactam/β-lactamase inhibitor combinations 显示文摘 | Lee N Yuen K Y Kumana C R | 2003 | Drugs2003，63，14： | 2 |
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| 18 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 19 | A major outbreak of severe acute respiratory syndrome in Hong Kong显示文摘 | LEE N HUI D WU A | 2003 | N Engl J Med2003，348，20： | 2 |
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