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| 1 | Gastric cancer: Epidemiology, risk factors and prevention strategies显示文摘Gastric cancer(GC) is a global health problem, with more than 1 million people newly diagnosed with GC worldwide each year. GC is more prevalent in less developed countries than in more developed countries. About half of all GC cases worldwide occur in East Asia, notably China. Globally, overall incidence rates of GC are declining, which is potentially attributed to a decrease in Helicobacter pylori(H. pylori) infection and the use of refrigeration to preserve foods rather than salt. GC is a multifactorial disease, and its occurrence and development were impacted by environmental and genetic factors. H. pylori infection is the primary risk factor for GC, especially for non-cardia. The prognosis of GC is poor due to stages at the first diagnosis. The 5-year survival rate is less than 10% when patients are diagnosed at an advanced stage, but the rate is as high as 85% if patients are detected at an earlier stage. Endoscopic screening can potentially prevent GC by early diagnosis and early treatment and has been widely adopted in screening programs in East Asian countries, such as Japan and Korea. This review summarizes updated epidemiological aspects, risk factors, and prevention strategies of GC in recent years to help researchers determine the most effective intervention strategies for reducing risk of GC. | Lei Yang Xiangji Ying Shuo Liu Guoqing Lyu Zekuan Xu Xi Zhang Huichao Li Qingyu Li Ning Wang Jiafu Ji | 2020 | Chinese Journal of Cancer Research2020，32，6： | 52 |
| 2 | Patterns of antiemetic prophylaxis for chemotherapy-induced nausea and vomiting in China显示文摘Background: Few studies have attempted to evaluate the use of antiemetic therapy for chemotherapyinduced nausea and vomiting(CINV) at a national level in China or to assess how treatment regimens adhere to current guidelines. Methods: We searched the China Health Insurance Research Association(CHIRA) Database to identify patients with cancer who were ≥18 years old and received either moderately or highly emetogenic chemotherapy(MEC and HEC, respectively) between 2008 and 2012. Patients' characteristics as well as usage of specific antiemetic regimens were analyzed using descriptive statistics. Results: Of the 14,548 patients included in the study, 6,477 received HEC while 8,071 were treated with MEC. Approximately 89.9% used antiemetics prophylactically to prevent acute CINV and 71.5% for delayed CINV while 9.0% were prescribed antiemetics as rescue therapy. A significantly lower proportion of patients treated with HEC received prophylactic antiemetic therapy for delayed CINV as compared to those treated with MEC(59.4% vs. 81.3%; P<0.001). The HEC group had a slightly lower proportion of patients using a mixed regimen containing a 5-HT3 antagonist to prevent both acute and delayed CINV than the MEC group(P≤0.012); however, a higher proportion received a mixed regimen containing corticosteroids(P≤0.007). Although more than half of the patients in the HEC group took three antiemetics to prevent acute and delayed CINV, these rates were significantly lower than those of the MEC group(both P<0.001). Finally, analysis of the regimens used revealed that there is over-utilization of drugs within the same class of antiemetic. Conclusions: These findings indicate that more attention is needed for treatment of delayed CINV, in terms of both overall use and the components of a typical treatment regimen. | Xianglong Zong Jie Zhang XinJi Jie Gao Jiafu Ji | 2016 | Chinese Journal of Cancer Research2016，28，2： | 49 |
| 3 | Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications显示文摘Objective:The programmed cell death-1 receptor/programmed cell death-1 ligand(PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity.This study was designed to evaluate the association between circulating PD-L1 expression and prognosis in patients with advanced gastric cancer.Methods:Totally 80 advanced gastric cancer patients and 40 health controls from Beijing Cancer Hospital were enrolled in the present study.Circulating PD-L1 expression was tested by enzymelinked immunosorbent assay(ELISA).The associations between the expression level of PD-L1 and clinicopathological features and prognosis were analyzed statistically.Results:Expression of PD-L1 in advanced gastric cancer patients was significantly up-regulated compared with health people(P=0.006).The expression of PD-L1 was significantly correlated with differentiation and lymph node metastasis(P=0.026 and P=0.041,respectively).Although we didn't find significant difference in all advanced gastric cancer patients with different PD-L1 expression,the adenocarcinoma patients with higher up-regulated PD-L1 expression had much better prognosis than low expression patients(65.6% vs.44.7%,P=0.028).Conclusions:PD-L1 was elevated in advance gastric cancer patients and may play an important role in tumor immune evasion and patients prognosis. | Zhixue Zheng Zhaode Bu Xijuan Liu Lianhai Zhang Ziyu Li Aiwen Wu Xiaojiang Wu Xiaojing Cheng Xiaofang Xing Hong Du Xiaohong Wang Ying Hu Jiafu Ji | 2014 | Chinese Journal of Cancer Research2014，26，1： | 37 |
| 4 | S-wave velocity and Poisson's ratio structure of crust in Yunnan and its implication显示文摘Receiver function of body wave under the 23 stations in Yunnan was extracted from 3-component broadband digital recording of teleseismic event. Thus, the S-wave velocity structure and distribution characteristics of Poisson's ratio in crust of Yunnan are obtained by inversion.The results show that the crustal thickness is gradually thinned from north to south. The crustal thickness in Zhongdian of northwest reaches as many as 62.0 km and the one in Jinghong of further south end is only 30.2 km. What should be especially noted is that there exists a Moho upheaval running in NS in the Chuxiong region and a Moho concave is generally parallel to it in Dongchuan. In addition, there exists an obvious transversal inhomogeneity for the S-wave veIocity structure in upper mantle and crust in the Yunnan region. The low velocity layer exists not only in 10.0-15.0 km in upper crust in some regions, but also in 30.0-40.0 km in lower crust.Generally, the Poisson's ratio is on the high side, however it has a better corresponding relation to the crustal velocity structure. An obvious block distribution feature is still shown on such a high background of Poisson's ratio. It is discovered by synthetically analyzing the velocity structure and Poisson's ratio distribution that there are high Poisson's ratio and complicated crust-mantle velocity structure feature in the Sichuan-Yunnan Diamond Block with Xiaojiang fault to be the east boundary and Yulong Snow Mountain fault to be the west boundary besides the frequent seismicity. This feature differs obviously from that of surrounding areas, which would provide geophysical evidence to deeply study the eastwardly flowage of lithospheric substances in the Qinghai-Tibet Plateau. | HU Jiafu, SU Youjin, ZHU Xiongguan & CHEN Yun Geophysical Department of Yunnan University, Kunming 650091, China Seismological Bureau of Yunnan Province, Kunming 650041, China Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China | 2005 | Science China Earth Sciences2005，48，2： | 30 |
| 5 | Panax notoginseng saponins ameliorates experimental hepatic fibrosis and hepatic stellate cell proliferation by inhibiting the Jak2/Stat3 pathways显示文摘OBJECTIVE: To investigate the inhibitory effect of Panax notoginseng saponins(PNS) on liver fibrosis and explore the underlying mechanisms.METHODS: Carbon tetrachloride(CCl4)-treated rats and hepatic stellate cells(HSCs) were used. The effect of PNS on CCl4-induced liver fibrosis was studied with histochemical and biochemical analysis.Transforming growth factor(TGF)-β1, α-smooth muscle actin(α-SMA), and collagen Ι m RNA expression were determined by reverse transcriptase-polymerase chain reaction(RT-PCR). Meanwhile, the protein expression levels of α-SMA, collagen Ι, phosphorylation-Janus activated kinase signal transducer(p-Jak2) / Jak2, and phosphorylation-activator of transcription(p-Stat)3 / Stat3 were determined by immunohistochemistry and / or immunoblotting.RESULTS: PNS treatment significantly improved the liver function of rats as indicated by decreased serum enzymatic activities of alanine aminotransferase and aspartate aminotransferase. Histopathological results indicated that PNS alleviated liver damage and reduced the formation of fibrous septa. Moreover, PNS significantly decreased liver hydroxyproline and significantly attenuated expressions of collagen Ⅰ, α-SMA, TGF-β1, p-Jak2 / Jak2,and p-Stat3 / Stat3 in the rat liver fibrosis model and HSCs.CONCLUSION: PNS can relieve liver fibrosis by modulating Jak2/Stat3 signaling transduction pathway, which may be one of its mechanisms to suppress hepatic fibrosis. | Jiang Hui Gao Jiarong Wang Yongzhong Zhang Jiafu Han Yanquan Wei Liangbing Liu Xiaochuang Wu Jian | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 28 |
| 6 | Zircon SHRIMP U-Pb age, geochemical, Sr-Nd isotopic, and in-situ Hf isotopic data of the Late Carboniferous-Early Permian plutons in the northern margin of the North China Craton显示文摘The main rock types of the Boluonuo and Daguangding plutons are diorite, quartz diorite, tonalite, granodiorite, and subordinate plagioclase-bearing hornblendite and hornblende gabbro. Zircon SHRIMP U-Pb dating for a quartz diorite of the Boluonuo pluton suggests that the pluton was emplaced at about 296±4 Ma. Plagioclase-bearing hornblendites show typical cumulative textures, which, in combination with their convex-upward REE patterns and the large variation of compatible elements such as Co, V and Sc, suggests that these hornblendites formed through accumulation of hornblende during magma evolution. Microgranular mafic enclaves (MMEs) are common in the Boluonuo and Daguangding intermediate to felsic plutons. Many plagioclase grains show compositional and textural disequilibrium, with calcium-rich cores (An 46-50 ) mantled abruptly by sodium-rich plagioclase (An 26-33 ). Whole-rock samples of the plutons are characterized by quite negative ε Nd (t) values (-16.5 to -11.8) and ε Hf (t) values (-22.5 to-16.8), and the ε Nd (t) values are negatively correlated with silica contents. All these features suggest that the intermediate to felsic plutons formed through magma mixing of enriched mantle-derived, evolved basaltic magma with granitic, crustal melts, followed by fractional crystallization of mainly hornblende and small amounts of pyroxene, apatite and zircon. The hornblende-dominated fractionation contributed significantly to the adakite-like features of the intermediate to felsic plutons, like the high Sr and Sr/Y ratios and low Yb abundance. In addition, the Boluonuo and Daguang- ding plutons are highly enriched in LILEs (e.g., Ba and Sr), but depleted in HFSEs (e.g., Nb, Zr and Ti), which is typical of arc magmas. Therefore, the formation of Boluonuo and Daguangding plutons was probably related to the subduction of the Paleo-Asian oceanic slab beneath the North China Craton in the Paleozoic. | MA Xu CHEN Bin CHEN JiaFu NIU XiaoLu | 2013 | Science China Earth Sciences2013，56，1： | 25 |
| 7 | The Chrysanthemum nankingense Genome Provides Insights into the Evolution and Diversification of Chrysanthemum Flowers and Medicinal Traits显示文摘The Asteraceae (Compositae),a large plant family of approximately 24 000-35 000 species,accounts for^10% of all angiosperm species and contributes a lot to plant diversity.The most representative members of the Asteraceae are the economically important chrysanthemums (Chrysanthemum L.)that diversified through reticulate evolution.Biodiversity is typically created by multiple evolutionary mechanisms such as wholegenome duplication 0NGD)or polyploidization and locally repetitive genome expansion.However,the lack of genomic data from chrysanthemum species has prevented an in-depth analysis of the evolutionary mechanisms involved in their diversification.Here,we used Oxford Nanopore long-read technologyto sequence the diploid Chrysanthemum nankingense genome,which represents one of the progenitor genomes of domesticated chrysanthemums.Our analysis revealed that the evolution of the C.nankingense genome was driven by bursts of repetitive element expansion and WGD events including a recentWGD that distinguishes chrysanthemum from sunflower,which diverged from chrysanthemum approximately 38.8 million years ago.Variations of ornamental and medicinal traits in chrysanthemums are linked to the expansion of candidate gene families by duplication events including paralogous gene duplication.Collectively,our study of the assembled reference genome offers new knowledge and resources to dissect the history and pattern of evolution and diversification of chrysanthemum plants,and also to accelerate their breeding and improvement. | Chi Song Yifei Liu Aiping Song Gangqiang Dong Hongbo Zhao Wei Sun Shyam Ramakrishnan Ying Wang Shuaibin Wang Tingzhao Li Yan Niu Jiafu Jiang Bin Dong Ye Xia Sumei Chen Zhigang Hu Fadi Chen Shilin Chen | 2018 | Molecular Plant2018，11，12： | 24 |
| 8 | Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior显示文摘为过去的几十年,在中国的传染疾病侧面在社会、经济的方面,环境,食物的质量,水,住房,和公共健康基础结构与快速的开发一直在变。尤其是, 5 应具报的传染疾病几乎被根除了,并且 18 另外的应具报的传染疾病的发生显著地被减少了。出人意料地,包括 HIV,普鲁斯病,梅毒,和登革热发烧,超过 10 应具报的传染疾病的发生一直在增加。不过,经常的传染疾病爆发 / 事件每年几乎被报导了,并且进口了传染疾病自从 2015,增加了。已知的病原体的新病原体和超过 100 新遗传型或 serotypes 被识别了。一些传染疾病似乎被各种各样的因素加重,包括快速的都市化,大量候鸟工人,在气候的变化,生态学,和政策,例如把农田还给森林。这评论在设法出现和 re-emerging 从中国总结当前的经验和课传染疾病,特别生态学的效果,气候,和行为,它应该在帮助另外的国家控制并且阻止传染疾病有优点。 | Qiyong Liu Wenbo Xu Shan Lu Jiafu Jiang Jieping Zhou Zhujun Shao Xiaobo Liu Lei Xu Yanwen Xiong Han Zheng Sun Jin Hai Jiang Wuchun Cao Jianguo Xu | 2018 | Frontiers of Medicine2018，12，1： | 23 |
| 9 | LGR5 is a promising biomarker for patients with stage Ⅰ and Ⅱ gastric cancer显示文摘Objective: To investigate Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) expressions in gastric cancer and to evaluate its clinical significance. Methods: LGR5 expression was assessed by immunohistochemistry in 257 gastric cancer patients after surgery. The relationships between LGR5 expression and clinicopathological features and patients prognosis were statistically analyzed. Results: The expression of LGR5 was significantly higher in gastric cancers as a cancer stem cell marker than in adjacent normal tissues (P<0.001), and more frequently in patients with intestinal type, well-moderate differentiation and stage Ⅰ and Ⅱ (P<0.05). Although we found gastric cancer patients with LGR5 positive expression had a poorer prognosis, it didn't meet statistical significance (P>0.05). LGR5 negative expression was significantly related to the favorable overall survival in stage Ⅰ and Ⅱ gastric cancer patients (P<0.05). Furthermore, patients with high LGR5 expression tended to be more likely to get progression and have poorer progress-free survival (P<0.05). Multivariate Cox regression analysis revealed that LGR5 expression was an independent factor of overall survival for the patients with stage Ⅰ and Ⅱ gastric cancer (P<0.05). Conclusions: Our results show that LGR5 may play an important role in tumorigenesis and progression and would be a powerful marker to predict the prognosis of patients with stage Ⅰ and Ⅱ gastric cancer. | Zhaode Bu Zhixue Zheng Lianhai Zhang Ziyu Li Yu Sun Bin Dong Aiwen Wu Xiaojiang Wu Xiaohong Wang Xiaojing Cheng Xiaofang Xing Yingai Li Hong Du Jiafu Ji | 2013 | Chinese Journal of Cancer Research2013，25，1： | 17 |
| 10 | Depth of tumor invasion and tumor-occupied portions of stomach are predictive factors of intra-abdominal metastasis显示文摘Objective:Diagnostic laparoscopy is recommended for the pretherapeutic staging of gastric cancer to detect any unexpected or unconfirmed intra-abdominal metastasis.The aim of this study was to evaluate the role and indications of diagnostic laparoscopy in the detection of intra-abdominal metastasis.Methods:Standard diagnostic laparoscopy with peritoneal cytology examination was performed prospectively on patients who were clinically diagnosed with primary local advanced gastric cancer(c T≥2M0).We calculated the rate of intra-abdominal metastases identified by diagnostic laparoscopy,and examined the relationship between peritoneal dissemination(P)and cytology results(CY).Split-sample method was applied to find clinical risk factors for intra-abdominal metastasis.Multivariate logistic regression analysis and receiver-operator characteristic(ROC)analysis were performed in training set to find out risk factors of intra-abdominal metastasis,and then validate it in testing set.Results:Out of 249 c M0 patients,51(20.5%)patients with intra-abdominal metastasis were identified by diagnostic laparoscopy,including 20(8.0%)P1CY1,17(6.8%)P0CY1 and 14(5.6%)P1CY0 patients.In the training set,multivariate logistic regression analysis and ROC analysis showed that the depth of tumor invasion on computer tomography(CT)scan≥21 mm and tumor-occupied≥2 portions of stomach are predictive factors of metastasis.In the testing set,when diagnostic laparoscopy was performed on patients who had one or two of these risk factors,the sensitivity and positive predictive value for detecting intra-abdominal metastasis were 90.0%and32.1%,respectively.Conclusions:According to our results,depth of tumor invasion and tumor-occupied portions of stomach are predictive factors of intra-abdominal metastasis. | Ziyu Li Zhemin Li Shuqin Jia Zhaode Bu Lianhai Zhang Xiaojiang Wu Shuangxi Li Fei Shan Xin Ji Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 14 |
| 11 | Release of volatile organic compounds during bio-drying of municipal solid waste显示文摘Three treatments were tested to investigate the release concentrations of volatile organic compounds (VOCs) during the bio-drying of municipal solid waste (MSW) by the aerobic and combined hydrolytic-aerobic processes.Results showed that VOCs were largely released in the first 4 days of bio-drying and the dominant components were:dimethyl disulfide,dimethyl sulfide,benzene,2-butanone,limonene and methylene chloride.Thus,the combined hydrolytic-aerobic process was suggested for MSW bio-drying due to fewer aeration quantities in this phase when compared with the aerobic process,and the treatment strategies should base on the key properties of these prominent components.Malodorous sulfur compounds and terpenes were mainly released in the early phase of bio-drying,whereas,two peaks of release concentrations appeared for aromatics and ketones during bio-drying.Notably,for the combined hydrolytic-aerobic processes there were also high concentrations of released aromatics in the shift from hydrolytic to aerobic stages.High concentrations of released chlorinateds were observed in the later phase.For the VOCs produced during MSW bio-drying,i.e.,malodorous sulfur compounds,terpenes and chlorinateds,their release concentrations were mainly determined by production rates;for the VOCs presented initially in MSW,such as aromatics,their transfer and transport in MSW mainly determined the release concentrations. | Pinjing He,Jiafu Tang,Dongqing Zhang,Yang Zeng,Liming ShaoState Key Laboratory of Pollution Control and Resource Reuse,Key Laboratory of Yangtze River Water Environment,College of Environmental Science and Engineering,Tongji University,Shanghai 200092,China. | 2010 | Journal of Environmental Sciences2010，22，5： | 13 |
| 12 | Current achievements and future prospects in the genetic breeding of chrysanthemum:a review显示文摘Chrysanthemum(Chrysanthemum morifolium Ramat.)is a leading flower with applied value worldwide.Developing new chrysanthemum cultivars with novel characteristics such as new flower colors and shapes,plant architectures,flowering times,postharvest quality,and biotic and abiotic stress tolerance in a time-and cost-efficient manner is the ultimate goal for breeders.Various breeding strategies have been employed to improve the aforementioned traits,ranging from conventional techniques,including crossbreeding and mutation breeding,to a series of molecular breeding methods,including transgenic technology,genome editing,and marker-assisted selection(MAS).In addition,the recent extensive advances in high-throughput technologies,especially genomics,transcriptomics,proteomics,metabolomics,and microbiomics,which are collectively referred to as omics platforms,have led to the collection of substantial amounts of data.Integration of these omics data with phenotypic information will enable the identification of genes/pathways responsible for important traits.Several attempts have been made to use emerging molecular and omics methods with the aim of accelerating the breeding of chrysanthemum.However,applying the findings of such studies to practical chrysanthemum breeding remains a considerable challenge,primarily due to the high heterozygosity and polyploidy of the species.This review summarizes the recent achievements in conventional and modern molecular breeding methods and emerging omics technologies and discusses their future applications for improving the agronomic and horticultural characteristics of chrysanthemum. | Jiangshuo Su Jiafu Jiang Fei Zhang Ye Liu Lian Ding Sumei Chen Fadi Chen | 2019 | Horticulture Research2019，6，1： | 13 |
| 13 | Construction and external validation of a nomogram that predicts lymph node metastasis in early gastric cancer patients using preoperative parameters显示文摘Objective: To create a nomogram to predict the incidence of lymph node metastasis(LNM) in early gastric cancer(EGC) patients and to externally validate the nomogram.Methods: To construct the nomogram,we retrospectively analyzed a primary cohort of 272 EGC patients.Univariate analysis and a binary logistic regression were performed.A nomogram predicting the incidence of LNM in EGC patients was created.The discrimination ability of the nomogram was measured using the concordance index(c-index),and the nomogram was also calibrated.Then,another prospective cohort of 81 patients was analyzed to validate the nomogram.Results: In the primary cohort,LNM was pathologically confirmed in 37(13.6%) patients.In multivariate analysis,the presence of an ulcer,the maximum lesion diameter observed via gastroscopy,the thickness of the lesion observed via endoscopic ultrasonography,and the presence of enlarged lymph nodes on computed tomography(CT) were independent risk factors for LNM.A nomogram was then created based on the regression model with the c-index of 0.905,and the calibration curve of the nomogram fell approximately on the ideal 45-degree line.The cut-off score of the nomogram was 110,and the sensitivity,specificity,positive predictive and negative predictive values of the nomogram in the primary cohort were 81.1%,86.0%,47.6% and 96.7%,respectively,and in the prospective validation cohort were 75.0%,91.0%,60.0% and 95.5%,respectively.The calibration curve of the external validation cohort was almost on the 45-degree line.Conclusions: We developed an effective nomogram predicting the incidence of LNM for EGC patients. | Yinan Zhang Yiqiang Liu Ji Zhang Xiaojiang Wu Xin Ji Tao Fu Ziyu Li Qi Wu Zhaode Bu Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，6： | 12 |
| 14 | Prognostic role of lymph node metastasis in early gastric cancer显示文摘Objective: To clarify the relationship between clinicopathological features and lymph node metastasis and to propose the potential indications of lymph node metastasis for prognosis in early gastric cancer(EGC) patients. Methods: We retrospectively observed 226 EGC patients with lymph node resection, and analyzed the associations between lymph node metastasis and clinicopathological parameters using the chi-square test in univariate analysis and logistic regression analysis in multivariate analysis. Overall survival analysis was determined using the Kaplan-Meier and log-rank test. We conducted multivariate prognosis analysis using the Cox proportional hazards model.Results: Of all the EGC patients, 7.5%(17/226) were histologically shown to have lymph node metastasis. The differentiation, lymphovascular invasion and depth of invasion were independent risk factors for lymph node metastasis in EGC. The 5- and 10-year survival rates were significantly lower in patients with lymph node metastasis than in those without and the patients also had shorter progress-free survival time. Lymph node metastasis and tumor size were independent prognostic factors for EGC. The status of the lymph nodes was a significant factor in predicting recurrence or metastasis after surgery. Conclusions: The undifferentiated carcinoma and lymphovascular and/or submucosal invasion were associated with a higher incidence of lymph node metastasis in EGC patients, whom need to perform subsequent D2 lymphadenectomy or laparoscopic lymph node dissection and more rigorous follow-up or additional chemotherapy/radiation after D2 gastrectomy for poor prognosis and high recurrence/metastasis rate. | Zhixue Zheng Yiqiang Liu Zhaode Bu Lianhai Zhang Ziyu Li Hong Du Jiafu Ji | 2014 | Chinese Journal of Cancer Research2014，26，2： | 12 |
| 15 | Cancer incidence in Beijing, 2014显示文摘Objective: To analyze cancer incidence data in Beijing in 2014 and temporal trends for selected common cancers during 2005 and 2014.Methods: A total of 144 secondary and tertiary hospitals reported newly diagnosed cancer cases to Beijing Cancer Registry, which covers 13 million residents in Beijing. The cancer incidence rate was calculated in strata by cancer type, sex, age group and area. The population composition of China in 1982 and Segi's population structure were used to calculate age-standardized rates. Extensive procedures were used to assure the quality of the data.Results: The overall data quality indicators of the percentage of morphology verification(MV)(%), the percentage of death certificate-only(DCO)(%) and the mortality to incidence ratio(M/I) were 72.15%, 0.94% and0.54 respectively. A total of 45,300 new cancer cases were diagnosed in Beijing in 2014. The incidence rate was341.92/100,000(343.50/100,000 in males, 340.33/100,000 in females), and the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 143.48/100,000 and182.99/100,000, respectively. The cumulative incidence rate for cancer before 75 years was 20.61%. Cancers of lung, colorectum, liver, stomach and prostate were the top five common cancer types for males, while cancers of breast, lung, thyroid, colorectum and uterus were the top five common cancer types for females. The different patterns were also observed between rural and urban areas. Regarding temporal trends, the incidence of thyroid cancer has the fastest growth between 2005 and 2014. The incidence of liver cancer decreased, and stomach and esophageal cancer also decreased significantly for males in the last decade. Incidence rate for lung cancer was relatively stable during that period of time.Conclusions: With more than 45,000 new cases in Beijing in 2014, cancer remains an important public health problem. Actions should be taken to diminish total cancer incidence in Beijing. | Shuo Liu Lei Yang Yannan Yuan Huichao Li Jing Tian Sijia Lu Ning Wang Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，1： | 11 |
| 16 | Cenozoic structural deformation and expression of the “Tan-Lu Fault Zone” in the West Sag of Liaohe Depression, Bohaiwan basin province, China显示文摘Based on the interpretation of 3D seismic data and structural mapping we analyzed the geometry and kinematics of the fault system and validated the expression of the'Tan-Lu Fracture Zone'in the West Sag of Liaohe Depression,Bohaiwan basin province.The Cenozoic structural deformation within the West Sag of Liaohe Depression can be divided into extensional structure system and dextral structure system.The extensional system is constituted by numerous NNE-NE trending Paleogene normal faults,where the Taian-Dawa fault(F1)is the master boundary fault(MBF)dominating the deposition during Paleogene so that the sag shows a complex half-graben with'boundary fault in the east and overlap in the west'.The dextral system is constituted by 2–3 dextral basement faults in NNE-NE trending(F2,F3,F4)and associated structure,and the time of structural action started in Oligocene and continued to Quarternary so that some associated secondary faults of the dextral system cut off the Neogene and Quaternary.Under the influence of the position and attitude of NNE-NE trending basement strike-slip faults,the central north part and the south part of the West Sag show obviously different structural features.The former appears to be a complex'graben'structure limited by the reversed strike-slip fault in the west and bounded by the inverted normal fault in the east,the latter remains the complex half-graben structure with'boundary fault in the east and overlap in the west',and the graben was mildly reconstructed by one or two normal strike-slip faults.The dextral system within the West Sag is the element of the west branch fault of the Tan-Lu Fracture Zone,which is a deep fracture zone extending along the east of the Liaodongwan Gulf.The deep fracture zone branches off into two separate faults within the Liaohe Depression.The east branch goes through from northern part of the Liaodongwan Gulf to the East Sag of Liaohe Depression and links with the Denghua-Mishan Fault near Shenyang,and the west branch passes from northern part of the Liaodongwan Gulf to the West Sag and Damintun Sag of Liaohe Depression and links with the Yilan-Yitong Fault.The principal displacement zone of the west branch of the Tan-Lu Fracture Zone cuts off the master extensional fault(F1)within the West Sag of Liaohe Depression and induces many cover faults in EW trending within the Neogene and Quaternary. | QI JiaFu LI XiaoGuang YU FuSheng YU TianCai | 2013 | Science China Earth Sciences2013，56，10： | 11 |
| 17 | Oxaliplatin plus S-1 or capecitabine as neoadjuvant or adjuvant chemotherapy for locally advanced gastric cancer with D2lymphadenectomy: 5-year follow-up results of a phase II-III randomized trial显示文摘Objective: To compare the effect of neoadjuvant chemotherapy(NACT) with adjuvant chemotherapy(ACT)using oxaliplatin plus S-1(SOX) or capecitabine(CapeOX) on gastric cancer patients with D2 lymphadenectomy.Methods: This was a two-by-two factorial randomized phase II-III trial, and registered on ISRCTN registry(No. ISRCTN12206108). Locally advanced gastric cancer patients were randomized to neoadjuvant SOX,neoadjuvant CapeOX, adjuvant SOX, or adjuvant CapeOX arms. Primary analysis was performed on an intentionto-treat(ITT) basis using overall survival(OS) as primary endpoint.Results: This trial started in September 2011 and closed in December 2012 with 100 patients enrolled.Treatment completion rate was 56%, 52%, 38% and 30% in the four arms, respectively. NACT group had fewer dropouts due to unacceptable toxicity(P=0.042). Surgical complication rate did not differ by the four groups(P=0.986). No survival significant difference was found comparing NACT with ACT(P=0.664; 5-year-OS: 70% vs.74% respectively), nor between the SOX and CapeOX groups(P=0.252; 5-year-OS: 78% vs. 66% respectively).Subgroup analysis showed SOX significantly improved survival in patients with diffuse type(P=0.048).Conclusions: No significant survival difference was found between NACT and ACT. SOX and CapeOX had good safety and efficacy as neoadjuvant regimens. Diffuse type patients may survive longer due to SOX. | Kan Xue Xiangji Ying Zhaode Bu Aiwen Wu Zhongwu Li Lei Tang Lianhai Zhang Yan Zhang Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 10 |
| 18 | Suitable internal control genes for qRT-PCR normalization in cotton fiber development and somatic embryogenesis显示文摘The mechanisms of cotton fiber development and somatic embryogenesis have been explored sys-tematically with microarray and suppression subtractive hybridization. Real-time RT-PCR provides the simultaneous measurement of gene expression in many different samples,with which the data from microarray or others can be confirmed in detail. To achieve accurate and reliable gene expression re-sults,normalization of real-time PCR data against one or several internal control genes is required,which should not fluctuate in different tissues during various stages of development. We assessed the gene expression of 7 frequently used housekeeping genes,including 18S rRNA,Histone3,UBQ7,Actin,Cyclophilin,Gbpolyubiquitin-1 and Gbpolyubiquitin-2,in a diverse set of 21 cotton samples. For fiber developmental series the expression of all housekeeping genes had the same down tendency after 17 DPA. But the expression of the AGP gene(arabinogalactan protein) that has high expression level at the later fiber development stage was up-regulated from 15 to 27 DPA. So the relative absolute quanti-fication should be an efficient and convenient method for the fiber developmental series. The expres-sion of nonfiber tissues series varied not so much against the fiber developmental series. And three best control genes Histone3,UBQ7 and Gbpolyubiquitin-1 have to be used in a combinated way to get better normalization. | TU LiLi ZHANG XianLong LIU DiQiu JIN ShuangXia CAO JingLin ZHU LongFu DENG FengLin TAN JiaFu ZHANG CunBin | 2007 | Chinese Science Bulletin2007，52，22： | 10 |
| 19 | Geochemistry of Platinum Group and Rare Earth Elements of the Polymetallic Layer in the Lower Cambrian,Weng'an,Guizhou Province显示文摘在华南的 Yangtze 站台上,在 Weng'an 的更低的寒武纪的 Niutitang 形成的黑页岩包含多卷的 polymetallic 硫化物存款。踪迹,稀土元素,和铂组元素(PGE ) 的全面 geochemical 调查被承担了以便讨论它有 tectono-depositional 背景的矿石开始和关联。忍受矿石的层充实铝(瞬间) ,镍(Ni ) ,钒(V) ,铅(Pb ) ,锶(Sr ) ,钡(Ba ) ,铀(U) ,砷(作为) ,并且在丰富的稀土元素元素(REE ) 。高铀 / 钍(U/Th ) 比率(U/Th>1 ) 显示那个矿化作用被热水的过程主要影响。δU 价值超过 1.9 是沉积状况,显示出减少。REE 模式在轻稀土元素元素(LREE ) 显示出高丰富(重稀土元素元素(HREE )(LREE/HREE=5 17 ) ,稍微否定的铕(Eu ) 和铈(Ce ) 异例(δEu=0.81 0.93 ) ,并且积极 Ce 异例(δCe=0.76 1.12 ) 。PGE 丰富被 PGE 类型分发模式描绘,充实铂(磅) ,钯(Pd ) ,钌(Ru ) 和锇(O ) 。Pt/Pd 比率是 0.8,它接近海水和 ultramafic 岩石的比率。这些, geochemical 展示的所有建议矿化作用被热水的活动在前触发在 Rodinian 超级大陆的分散的上下文的紧张的背景。 | FU Yong WU Chaodong GUAN Ping QU Wenjun CHEN Jiafu | 2009 | Acta Geologica Sinica(English Edition)2009，83，3： | 10 |
| 20 | COST AND SERVICE-LEVEL-BASED MODEL FOR A SERU PRODUCTION SYSTEM FORMATION PROBLEM WITH UNCERTAIN DEMAND显示文摘 | Ye Wang Jiafu Tang | 2018 | Journal of Systems Science and Systems Engineering2018，27，4： | 10 |
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