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| 1 | 世界胃肠病学组织全球指南——发展中国家幽门螺杆菌感染显示文摘世界上有一半人口感染幽门螺杆菌(H.pylori),其感染率因地理位置、种族、年龄和社会经济状况不同而存在很大差异.在发展中国家较高.发达国家较低。但总体而言,近年世界许多地区的H.pylori感染率均呈下降趋势。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F van der Merwe S Vaz Coelho LG Fock M Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BCY Krabshuis J Le Mair A 杜颖 戴宁 | 2011 | 胃肠病学2011，16，7： | 27 |
| 2 | Effect of Lepidium meyenii (maca) roots on spermatogenesis of male rats显示文摘Aim: To determine the effect of oral administration of an aqueous extract from the roots of Lepidium meyenii (maca)on spermatogenesis in adult male rats. Methods: Male rats received an aqueous extract of the root (66.7 mg in one mL) twice a day for 14 consecutive days. Results: Treatment with Lepidium meyenii resulted in an increase in the weights of testis and epididymis but not the seminal vesicle weight. The length and frequency of stages IX-XIV seminiferous tubules, where mitosis occurred, were increased and stages Ⅰ-Ⅵ were reduced in rats treated with Lepidium meyenii. Conclusion: The Lepidium meyenii root invigorates spermatogenesis in male rats by acting on its initial stages (IX-XIV). | Gustavo F.Gonzales Ana Ruiz Carla Gonzales León Villegas Amanda Cordova | 2001 | Asian Journal of Andrology2001，3，3： | 22 |
| 3 | Effect of two different extracts of red maca in male rats with testosterone-induced prostatic hyperplasia显示文摘瞄准:在更男的 ats 决定红 maca 的二篇不同摘录的效果。方法:Prostatic 增生与睾丸激素 enanthate (TE ) 在雄的老鼠被导致。Thestudy 包括了六个组:一个控制组(组 1 ),与 TE (组 2 )对待的一个组,与 TE 对待的二个组和红 maca 的水的摘录(组织 3 和 4 ),一个组对待红 maca (组 5 )的 withhydroalcoholic 摘录,一个组与 finasteride 对待( 0.1 mg , group6 )。在沸腾的时间的长度上的水的摘录依赖者的差别,是否为 2 个 or3 小时,为组, 3 和 4 被估计。红 maca 的摘录包含了 0.1 mg ofbenzylglucosinolate。此后,在红 maca 摘录的 benzylglucosinolates (0.02-0.08 mg ) 的不同剂量的剂量反应效果被估计。结果:前列腺重量在与红 maca 的水的摘录在沸腾的 2 和 3 个小时以后准备了的 freeze-dried 对待的老鼠是类似的。红 maca 的 Freeze-dried 水的摘录,红 maca 和 finasteride 的水疗院酒鬼摘录与职业人员静电干扰增生在老鼠减少了前列腺重量。没有差别在从水的摘录或红 maca 的水疗院酒鬼摘录获得的数据之间被观察。前列腺重量的剂量依赖者减小随红 macaextracts 的 benzylglucosinolates 的剂量的增加被观察。结论:现在的学习在 prostatichyperplasia 被 TE 在导致了的雄的老鼠给那个水疗院酒鬼或红 macacontaining 的水的摘录看了 benzylglucosinolate 罐头还原剂前列腺尺寸的 0.1 mg。 | Gustavo F. Gonzales Vanessa Vasquez Daniella Rodriguez Carmen Maldonado Juliet Mormontoy Jimmy Portella Monica Pajuelo León Villegas Manuel Gasco | 2007 | Asian Journal of Andrology2007，9，2： | 14 |
| 4 | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis显示文摘AIM:To determine if subclinical abnormal glucose tolerance(SAGT)has influence on survival of non-diabetic patients with liver cirrhosis.METHODS:In total,100 patients with compensatedliver cirrhosis and normal fasting plasma glucose were included.Fasting plasma insulin(FPI)levels were measured,and oral glucose tolerance test(OGTT)was performed.According to OGTT results two groups of patients were formed:those with normal glucose tolerance(NGT)and those with SAGT.Patients were followed every three months.The mean follow-up was932 d(range of 180-1925).Survival was analyzed by the Kaplan-Meyer method,and predictive factors of death were analyzed using the Cox proportional hazard regression model.RESULTS:Of the included patients,30 showed NGT and70 SAGT.Groups were significantly different only in age,INR,FPI and HOMA2-IR.Patients with SAGT showed lower 5-year cumulated survival than NGT patients(31.7%vs 71.6%,P=0.02).Differences in survival were significant only after 3 years of follow-up.SAGT,Child-Pugh B,and high Child-Pugh and Model for EndStage Liver Disease(MELD)scores were independent predictors of death.The causes of death in 90.3%of cases were due to complications related to liver disease.CONCLUSION:SAGT was associated with lower survival.SAGT,Child-Pugh B,and high Child-Pugh and MELD scores were independent negative predictors of survival. | Diego García-Compeán Joel Omar Jáquez-Quintana Fernando Javier Lavalle-González José Alberto González-González Linda Elsa Mu?oz-Espinosa Jesús Zacarías Villarreal-PérezEndocrinology Service and Department of Internal Medicine University Hospital 'Dr. José E. González' and Medical School Universidad Autónoma de Nuevo León Monterrey 64320 México Héctor J Maldonado-Garza | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 5 | 人血浆硫氧化还原蛋白80随着年龄增长而增加,并在载脂蛋白E基因敲除小鼠中诱导炎症、血管生成和动脉粥样硬化显示文摘硫氧化还原蛋白(thioredoxin,TRX)1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法:使用特异性酶联免疫吸附试验测定血浆TRX1和TRX80水平。 | 刘莉 叶鹏 Couchie D Vaisman B Abderrazak A Mahmood DFD Hamza MM Canesi F Diderot V El Hadri K Nègre-Salvayre AE Le Page A Fulop T Remaley AT Rouis M | 2017 | 中华高血压杂志2017，25，6： | 9 |
| 6 | Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats显示文摘Aim: To evaluate the effect of the alcoholic extract of Lepidium meyenii (Maca) on the spermatogenesisin male rats. Methods: In Holtzman rats, Maca alcoholic extract (5 %) was given by oral route at doses of 48 mg/day or 96 mg/day for 7 days, 14 days and 21 days. Testicular function was assessed by measurements of lengths of different stages of seminiferous epithelia and by epididymal sperm count. Results: Ethanolic extract of Maca increased the length of stages IX-XI of seminiferous epithelium at treatment day 7, day 14 and day 21. Progression of spermatogenesis was evident only after day 21 when lengths of stages XII-XIV of seminiferous epithelium were increased; at day 7 and day 14, no important change in spermatogenesis was observed. Epididymal sperm count was increased with 48 mg/day at all times. With 96 mg/day an increase in sperm count was observed at day 7, but it was reduced at day 14 and day 21 of treatment. Serum testosterone levels were not affected. Conclusion: The alcoholic extract of Maca activates onset ant progression of spermatogenesis at 48 mg/day or 96 mg/day in rats. | Gustavo F. Gonzales Julio Rubio Arturo Chung Manuel Gasco León Villegas | 2003 | Asian Journal of Andrology2003，5，4： | 6 |
| 7 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 8 | 巨噬细胞、细胞因子和脓毒症显示文摘巨噬细胞激活以及巨噬细胞因子白介素1(IL-1)、白介素6(IL-6)和肿瘤坏死因子(TNF)分泌的增加与脓毒症的发生发展有着密切的联系。采用这些细胞因子的桔抗物(如TNF单抗、消炎痛等)以及用小剂量内毒素诱导内毒素耐受性均能降低巨噬细胞因子分泌反应并提高脓毒症动物的生存率。本文对有关进展作综合介绍。 | Walsh CJ León P O'Riordain MG Ayala A 密磊 | 1993 | 国外医学(创伤与外科基本问题分册)1993，14，1： | 3 |
| 9 | Optical coherence tomography angiography at the acute phase of optic disc edema显示文摘Background:The differential diagnosis of optic disc edema at the acute phase can be challenging.OCT angiography(OCTA)is a new technology allowing the visualization of the peripapillary vascular network and optic disc capillaries.The peripapillary network alterations of glaucoma and chronic non-arteritic anterior ischemic optic neuropathy(NAION)were reported.However,no OCTA studies on acute optic disc edema from various causes.The aim of this project was to use OCTA to demonstrate the vascular changes the optic nerve head of various types of optic disc edema at the acute phase.Methods:In this retrospective study,patients with non-arteritic anterior ischemic optic neuropathy(NAION),papillitis or papilledema were recruited.Each patient was imaged using the AngioPlex^(TM)CIRRUS^(TM)HD-OCT device(model 5000,Carl Zeiss Meditec,Inc.,Dublin,USA)with a scanning area of 6×6 mm^(2) centered on the optic disc.A morphological analysis of the peripapillary network was performed.For some patients with unilateral optic disc edema,a quantitative analysis was performed using a swept-source OCT-A system(PLEX®Elite 9000,Carl Zeiss Meditec,Inc.,Dublin,USA).Vessel perfusion density and flux index of the peripapillary area were calculated.Results:Eight eyes with NAION(4 patients),12 eyes with papillitis(6 patients)and 25 eyes with papilledema(13 patients)were imaged.The apparent disappearance or moderate pattern alteration of the peripapillary capillary vessels were observed in patients with NAION or papillitis,respectively.For papilledema,the capillaries at the surface of the optic disc were dilated and tortuous,but no peripapillary network pattern changes were observed.The quantitative analysis did not show any difference of peripapillary network between NAION and healthy eyes.For papillitis,the flux index was higher in inflammatory eyes compared to the healthy eyes in average(p=0.03).Conclusion:At the acute phase,the morphological analysis of OCT-A appeared to be more useful than the quantification analysis,facilitating the differentiation between the three kinds of ONH edema:ischemic,inflammatory and papilledema. | Marie-Bénédicte Rougier Mélanie Le Goff Jean-François Korobelnik | 2018 | Eye and Vision2018，5，1： | 3 |
| 10 | Phosphorus fractions and sorption dynamics in the sediments of two Ca-SO4 water reservoirs in the central Argentine Andes显示文摘Phosphorus(P) fractionation and sorption behavior were studied in the sediments of two calcium-sulfate(Ca-SO_4: Ca^(2+)170 mg L^(-1); SO_4^(2-) 400 mg L^(-1)) water reservoirs in the southern central Argentine Andes-El Carrizal Reservoir(ECR),which stratifies in summer and El Nihuil Reservoir(ENR),which is vertically mixed throughout the year. Sediment size classes reflected the lithology of both basins and the reservoirs relative location: ECR(downstream from a valley adjacent to a mountain environment) had higher clay proportions while the sand fraction was more important in ENR(just next to a mountain environment).In both reservoirs, the chemical composition revealed low alteration and calcium enrichment. Total P content was relatively high(1.1-1.6 mg P kg^(-1) dry weight) as expected from the contribution of marine formations. P fractionation was dominated by Ca-P(ECR, 69% and ENR, 63%) followed by organic-P(23%)in summer-anoxic ECR and by iron/aluminum(Fe/Al)-P(27%) in oxic ENR. Batch experiments showed that sorption behavior in ECR had a typical Langmuir isotherm plot while in ENR that model fitted only at low dissolved P values(<5 mg PL^(-1)) and co-precipitation evidence was observed at higher P concentrations. It is proposed that lower Fe/Al-P content in anoxic(ECR) vs. oxic(ENR) sediments results from the P released from iron-bound phosphorus due to sulfate reduction-ferrous sulfide formation in an anoxic environment. This condition should enable ECR sediments to adsorb P into fresh oxidized iron,and ENR sediments to co-precipitate P with calcium due to Fe/Al-P saturation, as observed in batch experiments. This paper constitutes the first description of phosphorus content and dynamics in reservoir sediments in arid central western Argentina, where water sulfate concentrations are naturally high due to basin lithology. | José Gabriel León Fernando Luis Pedrozo Pedro Félix Temporetti | 2017 | International Journal of Sediment Research2017，32，3： | 3 |
| 11 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 12 | African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era显示文摘Chronic kidney disease(CKD) is a major public health problem worldwide with the estimated incidence growing by approximately 6% annually. There are striking ethnic differences in the prevalence of CKD such that, in the United States, African Americans have the highest prevalence of CKD, four times the incidence of end stage renal disease when compared to Americans of European ancestry suggestive of genetic predisposition. Diabetes mel itus, hypertension and human immunodeficiency virus(HIV) infection are the major causes of CKD. HIV-associated nephropathy(HIVAN) is an irreversible form of CKD with considerable morbidity and mortality and is present predominantly in people of African ancestry. The APOL1 G1 and G2 alleles were more strongly associated with the risk for CKD than the previously examined MYH9 E1 risk haplotype in individuals of African ancestry. A strong association was reported in HIVAN, suggesting that 50% of African Americans with two APOL1 risk alleles, if untreated, would develop HIVAN. However these two variants are not enough to cause disease. The prevailing belief is that modifying factors or second hits(including genetic hits) underlie the pathogenesis of kidney disease. This work reviews the history of genetic susceptibility of CKD and outlines current theories regarding the role for APOL1 in CKD in the HIV era. | Alex N Kasembeli Raquel Duarte Michèle Ramsay Saraladevi Naicker | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 13 | An ORF2 protein-based ELISA for porcine circovirus type 2 antibodies in post-weaning multisystemic wasting syndrome显示文摘 | Ph Blanchard D Mahé R Cariolet C Truong M Le Dimna C Arnauld N Rose E Eveno E Albina F Madec A Jestin | 2003 | Veterinary Microbiology2003，，3： | 2 |
| 14 | Risk Factors for Hepatocellular Carcinoma in Patients With Alcoholic or Viral C Cirrhosis显示文摘 | Gisèle N’Kontchou Jacques Paries Myint Tin Tin Htar Nathalie Ganne–Carrie Lydie Costentin Véronique Grando–Lemaire Jean–Claude Trinchet Michel Beaugrand | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 2 |
| 15 | Modification in the diet can induce beneficial effects against breast cancer显示文摘The population tends to consume foods that in addition to their nutritional values can offer some benefits to their health. There are many epidemiological evidences and research studies in animal models suggesting that diet plays an important role in breast cancer prevention or progression. This review summarized some of the relevant researches about nutrition and cancer during the last years, especially in breast cancer. The analysis of probiotics and fermented products containing lactic acid bacteria in cancer prevention and/or treatment was especially discussed. It was observed that a balance of fatty acids similar to those of traditional Mediterranean diet, the consumption of fruits and vegetables, dietary fiber intake, vitamin supplementation are, along with the intake of probiotic products, the most extensivelystudied by the negative association to breast cancer risk. The consumption of probiotics and fermented products containing lactic acid bacteria was associated to reduce breast cancer risk in some epidemiological studies. The use of animal models showed the modulation of the host's immune response as one of the important effects associated to the benefices observed with most probiotics. However; future assays in human are very important before the medical community can accept the addition of probiotic or fermented milks containing lactic acid bacteria as supplements for cancer patients. | Felix Aragón Gabriela Perdigón Alejandra de Moreno de Le Blanc | 2014 | World Journal of Clinical Oncology2014，5，3： | 2 |
| 16 | Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms显示文摘 | Ida Rasmusson Olle Ringdén Berit Sundberg Katarina Le Blanc | 2005 | Experimental Cell Research2005，，1： | 2 |
| 17 | Randomized Controlled Trial of Danoprevir Plus Peginterferon Alfa-2a and Ribavirin in Treatment-Naive Patients with HCV Genotype 1 Infection显示文摘 | P. Marcellin C. Cooper L. Balart D. Larrey T. Box E. Yoshida E. Lawitz P. Buggisch P. Ferenci M. Weltman E. Labriola-Tompkins S. Le Pogam I. Nájera D. Thomas G. Hooper N.S. Shulman Y. Zhang M.T. Navarro C.Y. Lim M. Brunda N.A. Terrault E.S. Yetzer | 2013 | Gastroenterology2013，，： | 2 |
| 18 | Telecentres in Mountain Regions-A Peruvian Case Study of the Impact of Information and Communication Technologies on Remoteness and Exclusion显示文摘Communities in developing country mountain areas,in part due to their remoteness,find themselves excluded from social,political and economic systems; and excluded from access to resources. This paper aims to study the impact of information and communication technologies (ICTs) on remoteness and exclusion. It utilises two models - the resource movement framework,and the 'information chain' - to analyse a telecentre in one district of mountainous Huancavelica,Peru's poorest region,set in the high Andes. It finds ICTs enabling new and positive resource flows for the two key user groups:teenaged school students and young farmers. These help to maintain social networks. They also support information searches that have improved agricultural practice where other information chain resources have been available. But non-use and ineffective use of the telecentre are found where information chain resources are lacking. ICTs have some impacts on intangible elements of remoteness. In this particular example,they also offer access to some previously-excluded resources. But they have not really addressed the systematic exclusions faced by mountain communities. And they so far appear to be a technology of inequality; favouring those residents who begin with better resource endowments.The paper concludes by offering some recommendations for mountain ICT project practice. | Richard Heeks Laura León Kanashiro | 2009 | Journal of Mountain Science2009，6，4： | 2 |
| 19 | Myc and cell cycle control显示文摘 | Gabriel Bretones M. Dolores Delgado Javier León | 2014 | BBA - Gene Regulatory Mechanisms2014，，： | 2 |
| 20 | A randomized phase II study to compare oxaliplatin plus 5-fluorouracil and leucovorin (FOLFOX4) versus oxaliplatin plus raltitrexed (TOMOX) as first-line chemotherapy for advanced colorectal cancer显示文摘 | Cristina Gravalos Antonieta Salut Carlos García-Girón Rocío García-Carbonero Ana León Isabel Sevilla Joan Maurel Beatriz Esteban Eduardo García-Rico Adolfo Murias Hernán Cortés-Funes | 2012 | Clinical and Translational Oncology2012，，8： | 2 |
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