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| 1 | African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era显示文摘Chronic kidney disease(CKD) is a major public health problem worldwide with the estimated incidence growing by approximately 6% annually. There are striking ethnic differences in the prevalence of CKD such that, in the United States, African Americans have the highest prevalence of CKD, four times the incidence of end stage renal disease when compared to Americans of European ancestry suggestive of genetic predisposition. Diabetes mel itus, hypertension and human immunodeficiency virus(HIV) infection are the major causes of CKD. HIV-associated nephropathy(HIVAN) is an irreversible form of CKD with considerable morbidity and mortality and is present predominantly in people of African ancestry. The APOL1 G1 and G2 alleles were more strongly associated with the risk for CKD than the previously examined MYH9 E1 risk haplotype in individuals of African ancestry. A strong association was reported in HIVAN, suggesting that 50% of African Americans with two APOL1 risk alleles, if untreated, would develop HIVAN. However these two variants are not enough to cause disease. The prevailing belief is that modifying factors or second hits(including genetic hits) underlie the pathogenesis of kidney disease. This work reviews the history of genetic susceptibility of CKD and outlines current theories regarding the role for APOL1 in CKD in the HIV era. | Alex N Kasembeli Raquel Duarte Michèle Ramsay Saraladevi Naicker | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 2 | Evaluation of the stability of ethanol in water certified reference material:measurement uncertainty under transport and storage conditions显示文摘 | Vanderléa Souza Janaína Marques Rodrigues Raquel Duarte C. Cunha Ban-deira Laura A.Neves Valente Marcus Vinícius Barreto Sousa Viviane Fernandes Silva Rafael Agostinho Lemos Silva | | 0，，： | 1 |
| 3 | Intra-urban variation in tuberculosis and community socioeconomic deprivation in Lisbon metropolitan area:a Bayesian approach显示文摘Background:Multidrug resistant tuberculosis(MDR-TB)is a recognized threat to global eforts to TB control and remains a priority of the National Tuberculosis Programs.Additionally,social determinants and socioeconomic dep‑rivation have since long been associated with worse health and perceived as important risk factors for TB.This study aimed to analyze the spatial distribution of non-MDR-TB and MDR-TB across parishes of the Lisbon metropolitan area of Portugal and to estimate the association between non-MDR-TB and MDR-TB and socioeconomic deprivation.Methods:In this study,we used hierarchical Bayesian spatial models to analyze the spatial distribution of notifcation of non-MDR-TB and MDR-TB cases for the period from 2000 to 2016 across 127 parishes of the seven municipalities of the Lisbon metropolitan area(Almada,Amadora,Lisboa,Loures,Odivelas,Oeiras,Sintra),using the Portuguese TB Surveillance System(SVIG-TB).In order to characterise the populations,we used the European Deprivation Index for Portugal(EDI-PT)as an indicator of poverty and estimated the association between non-MDR-TB and MDR-TB and socioeconomic deprivation.Results:The notifcation rates per 10,000 population of non-MDR TB ranged from 18.95 to 217.49 notifcations and that of MDR TB ranged from 0.83 to 3.70.We identifed 54 high-risk areas for non-MDR-TB and 13 high-risk areas for MDR-TB.Parishes in the third[relative risk(RR)=1.281,95% credible interval(CrI):1.021-1.606],fourth(RR=1.786,95%CrI:1.420-2.241)and ffth(RR=1.935,95%CrI:1.536-2.438)quintile of socioeconomic deprivation presented higher non-MDR-TB notifcations rates.Parishes in the fourth(RR=2.246,95%CrI:1.374-3.684)and ffth(RR=1.828,95%CrI:1.049-3.155)quintile of socioeconomic deprivation also presented higher MDR-TB notifcations rates.Conclusions:We demonstrated signifcant heterogeneity in the spatial distribution of both non-MDR-TB and MDRTB at the parish level and we found that socioeconomically disadvantaged parishes are disproportionally afected by both non-MDR-TB and MDR-TB.Our fndings suggest that the emergence of MDR-TB and transmission are specifc from each location and often diferent from the non-MDR-TB settings.We identifed priority areas for intervention for a more efcient plan of control and prevention of non-MDR-TB and MDR-TB. | Olena Oliveira Ana Isabel Ribeiro Raquel Duarte Margarida Correia‑Neves Teresa Rito | 2022 | Infectious Diseases of Poverty2022，11，2： | 1 |
| 4 | Brazilian Report on Primary Immunodeficiencies in Children: 166 Cases Studied Over a Follow-up Time of 15 Years显示文摘 | Anete S. Grumach Alberto J. S. Duarte Raquel Bellinati-Pires Antonio C. Pastorino Cristina M. A. Jacob Constancia L. Diogo Antonio Condino-Neto Michael Kirschfink Magda M. S. Carneiro-Sampaio | 1997 | Journal of Clinical Immunology1997，，： | 1 |
| 5 | ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway显示文摘 | Bruno Larrivée Claudia Prahst Emma Gordon Raquel del Toro Thomas Mathivet Antonio Duarte Michael Simons Anne Eichmann | 2012 | Developmental Cell2012，，3： | 1 |
| 6 | G-308A TNF-α polymorphism is associated with an increased risk of invasive cervical cancer显示文摘 | Isabel Duarte Alexandra Santos Hugo Sousa Raquel Catarino Daniela Pinto Ana Matos Deolinda Pereira José Moutinho Paulo Canedo José Carlos Machado Rui Medeiros | 2005 | Biochemical and Biophysical Research Communications2005，，2： | 1 |
| 7 | Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats显示文摘 | Juan Duarte Raquel Perez-Palencia Felix Vargas | 2001 | Br J Pharmacol2001，133，： | 1 |
| 8 | Alginate Matrix of MDA-MB-231 Breast Cancer Cell 3D Culturing Alters CD44 and CD24 mRNA Levels and Induces ALDH1 Expression显示文摘 | Layane Duarte e Souza Elisa Raquel Anastacio Ferraz Isis Soares Salviano Adenilson Souza da Fonseca Israel Felzenzswalb Andre Luiz Mencalha | 2017 | Journal of Life Sciences2017，11，5： | 0 |
| 9 | An Ontology-based System to Support Distributed Software Development显示文摘 | Rodrigo G. C. Rocha Ryan Azevedo Ana Raquel M. Alves Catarina Costa Joao Paulo Fechine Marcos Duarte Joao Emanoel Ambrosio Gomes Goncalvez Silvio Meira | 2014 | 通讯和计算机(中英文版)2014，11，1： | 0 |
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