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265篇 您的检索式:作者名="Ta HM"
    题名 作者 年代 出处 被引量
1脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 2018神经损伤与功能重建2018,13,4:4
2The metabolic syn- drome and cardiovascular disease mortality in middle-aged men 显示文摘Lakka HM laaksonen DE Lakka TA 2002JAMA2002,228,21:1
3The metabolic syndrome and total and cardiovascular disease mortality in middle aged men显示文摘Lakka HM laaksonen DE Lakka TA 2002JAMA2002,288,:1
4Sentinel surveil- lance of HIV-1 transmitted drug resistance, acute infection and recent infection显示文摘Truong HM Kellogg TA McFarland W 2011PLoS One2011,6,25:1
5Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal sterol loss 显示文摘Brown JM Bell TA Alger HM 2008J Biol Chem2008,283,10:1
6Autoinflammation: translating mechanism to therapy 显示文摘Doherty TA Brydges SD Hoffman HM 2011J Leukoc Biol2011,90,:1
7The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men显示文摘Lakka HM Laaksonen DE Lakka TA 2002JAMA2002,288,21:1
8The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men显示文摘Lakka HM Laaksonen DE Lakka TA Niskanen LK Kumpusalo E Tuomilehto J Salonen JT 2002JAMA2002,288,:1
9Comparison of vagal baroreflex function in nonpregnant women and in women with normal pregnancy,preeclampsia,or gestational hypertension显示文摘Silver HM Tahvanainen KU Kuusela TA 2001Am J Obstet Gynecol2001,184,6:1
10Complicated mitral valve repairs显示文摘Burkhart HM Orszulak TA 2001Cardiol Rev2001,9,2:1
11Micro RNA sequence and expression analysis in breast tumors by deep sequencing显示文摘Farazi TA Horlings HM Ten Hoeve JJ 2011Cancer Res2011,71,13:1
12Themetabolic syndrome and total and cardiovascular disease mortality in middle-aged men 显示文摘Lakka HM Laaksonen DE Lakka TA 2002JAMA2002,288,12:1
13The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men显示文摘Lakka HM Laasksonen DE Lakka TA 2002JAMA2002,288,21:1
14Abdominal obesity is associ-ated with increased risk of acute coronary events in men显示文摘Lakka HM Lakka TA Tuomilehto J 2002Eur Heart J2002,23,9:1
15Fatal blunt aortic injuries:a review of 242 autopsy cases显示文摘Burkhart HM Gomez GA Jacobson LE Pless JE Broadie TA 0,,:1
16The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men显示文摘Lakka HM Laaksonen DE Lakka TA 2002JAMA2002,288,21:1
17Analysis of MMP-8 (collagenase-2) in melanoma and development显示文摘Giambemardi TA Toro JA Charbormeau HM 2005Proc Amer Assoc Cancer Res2005,46,:1
18The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men 显示文摘Lakka HM Laaksonen DE Lakka TA 2002JAMA2002,288,21:1
19The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men 显示文摘Lakka HM Laaksonen DE Lakka TA 2002JAMA2002,288,21:1
20The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men显示文摘Lakka HM Laaksonen DE Lakka TA 2002JAMA2002,288,21:1
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